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Chance and Causality in Ageing and Longevity

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Centenarians

Abstract

The improvement of the quality of life of elderly people is going to become a priority because of the continuous increase in the number of oldest people. This renders the studies of the processes involved in longevity, a complex process influenced by several biological, environmental, and lifestyle factors as well as by chance, of critical importance. Centenarians have been proposed as a model of “positive biology” because they have reached the extreme limits of lifespan, avoiding or delaying major age-related diseases. The identification of the factors that predispose to long and healthy life is of tremendous interest for translational medicine. Here we briefly describe the results obtained so far and their meaning, focusing on the role of chance and causality.

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Author notes

  1. Giulia Accardi and Anna Aiello contributed equally with all other contributors.

Authors and Affiliations

  1. Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy

    Giulia Accardi, Anna Aiello & Calogero Caruso

  2. Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy

    Sonya Vasto

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  1. Giulia Accardi
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  2. Anna Aiello
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  4. Calogero Caruso
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Correspondence to Calogero Caruso .

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  1. Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy

    Calogero Caruso

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Accardi, G., Aiello, A., Vasto, S., Caruso, C. (2019). Chance and Causality in Ageing and Longevity. In: Caruso, C. (eds) Centenarians. Springer, Cham. https://doi.org/10.1007/978-3-030-20762-5_1

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