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Basic Principles and Current Approach for Soft Tissue Regeneration

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Regenerative Medicine and Plastic Surgery

Abstract

Due to an unstoppable and ongoing shift in the distribution of western population towards old age, we recently experience a dramatic increase in comorbidities such as diabetes or cardiovascular insufficiency. Being accompanied with a raising number of chronic wounds, this aging shift has become not only an individual medical but also a significant economic burden, consuming more than 4% of health care budgets worldwide. Wound healing requires an exact interplay of several cell types, intra- and extracellular mechanisms, proteins, and signaling pathways. To either reverse age-related alterations or to significantly improve endogenous healing capacity, drugs need to interfere with these complex endogenous mechanisms involved in the response to injury. In this chapter, we summarize the most promising advances in wound healing therapeutics with its challenges and shed light on possible solutions for effective application.

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Authors and Affiliations

  1. Experimental Plastic Surgery, Department of Plastic and Hand Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

    Matthias M. Aitzetmüller & Elizabeth A. Brett

  2. Section of Plastic and Reconstructive Surgery, Department of Trauma, Hand and Reconstructive Surgery, Westfaelische Wilhelms, University of Muenster, Muenster, Germany

    Matthias M. Aitzetmüller

  3. Experimental Plastic Surgery, Department of Plastic and Hand Surgery, Klinikum rechts der Isar, Technical University of Munich, München, Germany

    Matthias Sauter

  4. Department for Plastic Surgery and Hand Surgery, Division of Experimental Plastic Surgery, Technical University of Munich, Munich, Germany

    Dominik Duscher

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  1. Matthias M. Aitzetmüller
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  2. Elizabeth A. Brett
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Correspondence to Matthias M. Aitzetmüller .

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Editors and Affiliations

  1. Department for Plastic Surgery and Hand Surgery, Division of Experimental Plastic Surgery, Technical University of Munich, Munich, Germany

    Dominik Duscher

  2. Private Practice, Tustin, CA, USA

    Melvin A. Shiffman

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Aitzetmüller, M.M., Brett, E.A., Sauter, M., Duscher, D. (2019). Basic Principles and Current Approach for Soft Tissue Regeneration. In: Duscher, D., Shiffman, M.A. (eds) Regenerative Medicine and Plastic Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-19958-6_3

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