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Carbohydrates in Regenerative Medicine: From Scaffolds to Cell Fate Modulators

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Regenerative Medicine and Plastic Surgery

Abstract

In the last few decades, tremendous progresses have been achieved in the field of regenerative medicine, as a consequence of the better understanding of cell biology, the advances in material science, chemistry, and engineering, and the integration of all of these disciplines within a highly synergistic and multidisciplinary context. Within this extremely multidisciplinary and interdisciplinary field, carbohydrates can play key roles, from being materials that can be shaped into scaffolds able to sustain cell adhesion and proliferation, to signaling biocues capable to drive cell differentiation or homing: carbohydrates chemistry and biology may open new avenues in regenerative medicine. In this chapter, carbohydrates will be presented as biomaterials offering a wide range of useful mechanical and biological properties, as bioactivating cues of materials of different chemical nature and finally as targets of cell surface engineering strategies able to modulate cell fate, in view of advanced cell therapies applications.

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Authors and Affiliations

  1. Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

    Roberto Guizzardi, Mattia Vacchini & Laura Cipolla

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  1. Roberto Guizzardi
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  2. Mattia Vacchini
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  3. Laura Cipolla
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Correspondence to Laura Cipolla .

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Editors and Affiliations

  1. Department for Plastic Surgery and Hand Surgery, Division of Experimental Plastic Surgery, Technical University of Munich, Munich, Germany

    Dominik Duscher

  2. Private Practice, Tustin, CA, USA

    Melvin A. Shiffman

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Guizzardi, R., Vacchini, M., Cipolla, L. (2019). Carbohydrates in Regenerative Medicine: From Scaffolds to Cell Fate Modulators. In: Duscher, D., Shiffman, M.A. (eds) Regenerative Medicine and Plastic Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-19958-6_13

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