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Extracellular Vesicles Derived from Mesenchymal Stem/Stromal Cells: Current Approaches to Enhance Their Release and Therapeutic Potential

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Regenerative Medicine and Plastic Surgery

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Abstract

Multiple preclinical and clinical studies demonstrate the potential of mesenchymal stem/stromal cells (MSCs) to support organ and tissue regeneration. Besides transplantation of cellular MSC grafts, conditioned media from MSC cultures or extracellular vesicles (EVs) derived from MSCs show similar regenerative effects. In vitro pretreatment of MSCs affects their paracrine properties and can improve their reparative and regenerative capacities. In this chapter effects of MSC pretreatment on MSC-EVs and different strategies to increase their release and to improve their therapeutic efficacy will be discussed.

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Authors and Affiliations

  1. Institute for Transfusion Medicine and Immunohematology, German Red Cross Blood Donor Service Baden-Württemberg-Hessen gGmbH, Goethe University Hospital, Frankfurt am Main, Germany

    Richard Schäfer

  2. Division of Nephrology, Department of Internal Medicine III, Goethe-University, Frankfurt am Main, Germany

    Benjamin Koch & Patrick C. Baer

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  1. Richard Schäfer
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  2. Benjamin Koch
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Correspondence to Richard Schäfer .

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  1. Department for Plastic Surgery and Hand Surgery, Division of Experimental Plastic Surgery, Technical University of Munich, Munich, Germany

    Dominik Duscher

  2. Private Practice, Tustin, CA, USA

    Melvin A. Shiffman

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Schäfer, R., Koch, B., Baer, P.C. (2019). Extracellular Vesicles Derived from Mesenchymal Stem/Stromal Cells: Current Approaches to Enhance Their Release and Therapeutic Potential. In: Duscher, D., Shiffman, M.A. (eds) Regenerative Medicine and Plastic Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-19958-6_10

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