Abstract
The renin–angiotensin–aldosterone system (RAAS) is a hormonal loop that regulates blood pressure and fluid balance. This system plays a prominent role in the pathophysiology of cardiac diseases, especially hypertension and systolic heart failure. Aldosterone leads to local effects of vasoconstriction and sodium resorption, and potentiates inflammation and fibrosis in several organs, including the heart. Inhibitors of the RAAS, particularly angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs), are commonly recommended and prescribed to patients with cardiac disease. The role of the RAAS in heart disease and the hemodynamic effects of specific inhibitors of this system will be reviewed here.
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Bavishi, C., Ramirez, R., Messerli, F.H. (2019). Renin–Angiotensin–Aldosterone Axis Modulators and Other Vasodilators. In: Askari, A., Messerli, A. (eds) Cardiovascular Hemodynamics. Contemporary Cardiology. Humana, Cham. https://doi.org/10.1007/978-3-030-19131-3_5
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DOI: https://doi.org/10.1007/978-3-030-19131-3_5
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