Abstract
It has been observed for centuries that a patient who survives an episode of certain infectious diseases such as smallpox or measles becomes immune for life against a further infection. For smallpox, the idea therefore arose to infect persons artificially by a “mild” form of the disease. This practice seems to have originated very early in China where dried smallpox scabs were blown into the nose of an individual who then contracted a mild form of the disease and was immune upon recovery. Starting in the eighteenth century, a modified procedure named “variolation” was used in Europe. Here the dried scabs were injected under the skin.
This lesson presents some mathematical methods and demonstrates their practical usefulness.
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Krickeberg, K., Van Trong, P., Thi My Hanh, P. (2019). Infectious Diseases: Modelling, Immunity. In: Epidemiology. Statistics for Biology and Health. Springer, Cham. https://doi.org/10.1007/978-3-030-16368-6_5
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DOI: https://doi.org/10.1007/978-3-030-16368-6_5
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Online ISBN: 978-3-030-16368-6
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