Abstract
Antimicrobial compounds are widely used in human and veterinary medicine to protect human and animal health, to prevent economic losses, and to help to ensure a safe food supply. After administration, the antibiotics and their transformant products (TPs) may pass through the sewage system and end up in the environment, mainly in the water bodies. Apart from antibiotics and their TPs, antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs), which have been identified as emerging pollutants of concern, enter ecosystems with treated wastewater and livestock manure. In the environment altered by human activity, the occurrence of bacteria resistant to almost all known antibiotics has been confirmed. Despite being universally considered relatively important, land runoff, drainage and seepage are not the sites with the most striking occurrence of the transfer of resistance genes among different species of bacteria. The most significant hot-spots are wastewater treatment plants (WWTPs). Together with treated wastewater which is released from WWTPs, antibiotics, their TPs, ARB, and ARGs can penetrate the surface water, rural groundwater supplies, drinking water, soil, and plants growing in soil irrigated with contaminated water. It creates a direct risk to human and animal health because drugs, ARGs, and ARB transported to the environment can be transferred back to people and animals. The authors of this article aim to familiarize readers with the phenomenon of antibiotic resistance in Poland: its occurrence, ranges of antibiotic concentration, and the number of ARB and ARGs occurring in Polish surface waters as well as main sources of these contaminants.
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References
Brown KD, Kulis J, Thomson B et al (2006) Occurrence of antibiotics in hospital, residential, and dairy, effluent, municipal wastewater, and the Rio Grande in New Mexico. Sci Total Environ 366:772–783
Gulkowska A, Leung HW, So MK et al (2008) Removal of antibiotics from wastewater by sewage treatment facilities in Hong Kong and Shenzhen, China. Water Res 42:395–403
Kemper N (2008) Veterinary antibiotics in the aquatic and terrestrial environment. Ecol Indic 8:1–13
Pan X, Qiang Z, Ben W, Chen M (2011) Residual veterinary antibiotics in swine manure from concentrated animal feeding operations in Shandong Province, China. Chemosphere 84:695–700
Wei R, Ge F, Huang S et al (2011) Occurrence of veterinary antibiotics in animal wastewater and surface water around farms in Jiangsu Province, China. Chemosphere 82:1408–1414
Ji X, Shen Q, Liu F et al (2012) Antibiotic resistance gene abundances associated with antibiotics and heavy metals in animal manures and agricultural soils adjacent to feedlots in Shanghai; China. J Hazard Mater 235:178–185
Batt AL, Kim S, Aga DS (2006) Enhanced biodegradation of iopromide and trimethoprim in nitrifying activated sludge. Environ Sci Technol 40:7367–7373
Giebułtowicz J, Tyski S, Wolinowska R et al (2018) Occurrence of antimicrobial agents, drug-resistant bacteria, and genes in the sewage-impacted Vistula River (Poland). Environ Sci Pollut Res 25:5788–5807
Jiang L, Hu X, Yin D et al (2011) Occurrence, distribution and seasonal variation of antibiotics in the Huangpu River, Shanghai, China. Chemosphere 82:822–828
Zou S, Xu W, Zhang R et al (2011) Occurrence and distribution of antibiotics in coastal water of the Bohai Bay, China: impacts of river discharge and aquaculture activities. Environ Pollut 159:2913–2920
Harnisz M (2013) Total resistance of native bacteria as an indicator of changes in the water environment. Environ Pollut 174:85–92
Wu X, Dodgen LK, Conkle JL et al (2015) Plant uptake of pharmaceutical and personal care products from recycled water and biosolids: a review. Sci Total Environ 536:655–666
Carter LJ, Williams M, Böttcher C et al (2015) Uptake of pharmaceuticals influences plant development and affects nutrient and hormone homeostases. Environ Sci Technol 49(20):12509–12518
Paltiel O, Fedorova G, Tadmor G et al (2016) Human exposure to wastewater-derived pharmaceuticals in fresh produce: a randomized controlled trial focusing on carbamazepine. Environ Sci Technol 50(8):4476–4482
Arnnok P, Singh RR, Burakham R et al (2017) Selective uptake and bioaccumulation of antidepressants in fish from effluent-impacted Niagara River. Environ Sci Technol 51(18):10652–10662
Aminov RI, Mackie RI (2007) Evolution and ecology of antibiotic resistance genes. FEMS Microbiol Lett 271:147–161
Baran W, Adamek E, Ziemianska J et al (2011) Effects of the presence of sulfonamides in the environment and their influence on human health. J Hazard Mater 196:1–15
Schmitt H, van Beelen P, Tolls J et al (2004) Pollution-induced community tolerance of soil microbial communities caused by the antibiotic sulfachloropyridazine. Environ Sci Technol 38:1148–1153
Costanzo SD, Murby J, Bates J (2005) Ecosystem response to antibiotics entering the aquatic environment. Mar Pollut Bull 51:218–223
Jiao S, Zheng S, Yin D et al (2008) Aqueous photolysis of tetracycline and toxicity of photolytic products to luminescent bacteria. Chemosphere 73:377–382
O’Neill J (2014) The review on antimicrobial resistance antimicrobial resistance: tackling a crisis for the health and wealth of nations. https://amr-review.org/sites/default/files/160518_Final%20paper_with%20cover.pdf
Wellington EMH, Boxall ABA, Cross P et al (2013) The role of the natural environment in the emergence of antibiotic resistance in gram-negative bacteria. Lancet Infect Dis 13:155–165
Cecchini M, Langer J, Slawomirski L (2015) Antimicrobial resistance in G7 countries and beyond: economic issues, policies and options for action. OECD, Paris. https://www.oecd.org/els/health-systems/Antimicrobial-Resistance-in-G7-Countries-and-Beyond.pdf
World Health Organization (WHO) (2015) Global action plan on antimicrobial resistance. http://www.who.int/antimicrobial-resistance/global-action-plan/en/
Xu J, Xu Y, Wang H et al (2015) Occurrence of antibiotics and antibiotic resistance genes in a sewage treatment plant and its effluent-receiving river. Chemosphere 119:1379–1385
Gao P, Munir M, Xagoraraki I (2012) Correlation of tetracycline and sulfonamide antibiotics with corresponding resistance genes and resistant bacteria in a conventional municipal wastewater treatment plant. Sci Total Environ 421–422:173–183
Tello A, Austin B, Telfer TC (2012) Selective pressure of antibiotic pollution on bacteria of importance to public health. Environ Health Perspect 120:1100–1106
Bouki C, Venieri D, Diamadopoulos E (2013) Detection and fate of antibiotic resistant bacteria in wastewater treatment plants: a review. Ecotoxicol Environ Safe 91:1–9
Zhu YG, Johnson TA, Su JQ et al (2013) Diverse and abundant antibiotic resistance genes in Chinese swine farms. PNAS 110:3435–3440
Takasu H, Suzuki S, Reungsang A (2011) Fluoroquinolone (FQ) contamination does not correlate with occurrence of FQ-resistant bacteria in aquatic environments of Vietnam and Thailand. Microbes Environ 26:135–143
Guo X, Feng C, Zhang J (2017) Role of dams in the phase transfer of antibiotics in an urban river receiving wastewater treatment plant effluent. Sci Total Environ 607–608:1173–1179
Guo X, Yan Z, Zhang Y (2018) Behavior of antibiotic resistance genes under extremely high-level antibiotic selection pressures in pharmaceutical wastewater treatment plants. Sci Total Environ 612:119–128
Le Corre KS, Ort C, Kateley D (2012) Consumption-based approach for assessing the contribution of hospitals towards the load of pharmaceutical residues in municipal wastewater. Environ Int 45:99–111
Marti R, Tien YC, Murray R (2014) Safely coupling livestock and crop production systems: how rapidly do antibiotic resistance genes dissipate in soil following a commercial application of swine or dairy manure? Appl Environ Microbiol 80:3258–3265
Tien YC, Li B, Zhang T (2017) Impact of dairy manure pre-application treatment on manure composition, soil dynamics of antibiotic resistance genes, and abundance of antibiotic-resistance genes on vegetables at harvest. Sci Total Environ 581–582:32–39
EPA (2017) United States Environmental Protection Agency. https://www.epa.gov/nps/what-nonpoint-source
Manaia CM, Rocha J, Scaccia N et al (2018) Antibiotic resistance in wastewater treatment plants: tackling the black box. Environ Int 115:312–324
Osińska A, Korzeniewska E, Harnisz M et al (2017) Impact of type of wastewater treatment process on the antibiotic resistance of bacterial populations. In: EKO-DOK E38 web of conferences 17:00070
Harnisz M, Korzeniewska E, Ciesielski S et al (2015) Tet genes as indicators of changes in the water environment: relationships between culture-dependent and culture-independent approaches. Sci Total Environ 505:704–711
Berendonk TU, Manaia CM, Merlin C et al (2015) Tackling antibiotic resistance: the environmental framework. Nat Rev Microbiol 13:310–317
Wei Z, Feng K, Li S et al (2018) Exploring abundance, diversity and variation of a widespread antibiotic resistance gene in wastewater treatment plants. Environ Int 117:186–195
Korzeniewska E, Harnisz M (2018) Relationship between modification of activated sludge wastewater treatment and changes in antibiotic resistance of bacteria. Sci Total Environ 639:304–315
Harnisz M, Korzeniewska E (2018) The prevalence of multidrug-resistant Aeromonas spp. in the municipal wastewater system and their dissemination in the environment. Sci Total Environ 626:377–383
Ahn Y, Choi J (2016) Bacterial communities and antibiotic resistance communities in a full-scale hospital wastewater treatment plant by high-throughput pyrosequencing. Water 8:580
Korzeniewska E, Harnisz M (2013) Beta-lactamase producing Enterobacteriaceae in hospital effluents. J Environ Manag 123:1–7
Lien LTQ, Lan PT, Chuc NTK et al (2017) Antibiotic resistance and antibiotic resistance genes in Escherichia coli isolates from hospital wastewater in Vietnam. Int J Environ Res Public Health 14:69
Wang Q, Wang P, Yang Q (2018) Occurrence and diversity of antibiotic resistance in untreated hospital wastewater. Sci Total Environ 621:990–999
Lekunberri I, Villagrasa M, Balcázar JL et al (2017) Contribution of bacteriophage and plasmid DNA to the mobilization of antibiotic resistance genes in a river receiving treated wastewater discharges. Sci Total Environ 601–602:206–209
Osińska A, Korzeniewska E, Harnisz M et al (2017) The prevalence and characterization of antibiotic-resistant and virulent Escherichia coli strains in the municipal wastewater system and their environmental fate. Sci Total Environ 577:367–375
Osińska A, Monika Harnisz M, Korzeniewska E (2016) Prevalence of plasmid-mediated multidrug resistance determinants in fluoroquinolone-resistant bacteria isolated from sewage and surface water. Environ Sci Pollut Res 23:10818–10831
GUS (2017) Główny Urząd Statystyczny, Ochrona środowiska (Central Statistical Office, Environment protection). Statistical Information and Elaborations, Warsaw
Wang X, Cheng B, Ji C et al (2017) Effects of hydraulic retention time on adsorption behaviours of EPS in an A/O-MBR: biofouling study with QCM-D. Sci Rep 7:2895
Kumar K, Singh GK, Dastidar MG et al (2014) Effect of mixed liquor volatile suspended solids (MLVSS) and hydraulic retention time (HRT) on the performance of activated sludge process during the biotreatment of real textile wastewater. Water Res Ind 5:1–8
Korzeniewska E, Harnisz M (2013) Extended-spectrum beta-lactamase (ESBL)-positive Enterobacteriaceae in municipal sewage and their emission to the environment. J Environ Manag 128:904–911
EMA (2018) European Medicines Agency. Science Medicine Health. http://www.ema.europa.eu/ema/index.jsp
Li J, Xin Z, Zhang Y et al (2017) Long-term manure application increased the levels of antibiotics and antibiotic resistance genes in a greenhouse soil. Appl Soil Ecol 121:193–200
Grossberger A, Hadar Y, Borch T et al (2014) Biodegradability of pharmaceutical compounds in agricultural soils irrigated with treated wastewater. Environ Pollut 185:68–177
Marti R, Scott A, Tien YC (2013) Impact of manure fertilization on the abundance of antibiotic-resistant bacteria and frequency of detection of antibiotic resistance genes in soil and on vegetables at harvest. Appl Environ Microbiol 79(18):5701–5709
Popowska M, Rzeczycka M, Miernik A et al (2012) Influence of soil use on prevalence of tetracycline, streptomycin, and erythromycin resistance and associated resistance genes. Antimicrob Agents Chemother 56:1434–1443
Mokracka J, Koczura R, Kaznowski A (2012) Transferable integrons of gram-negative bacteria isolated from the gut of a wild boar in the buffer zone of a national park. Ann Microbiol 62:877–880
ECDC (2018) European Centre for Disease Prevention and Control. An agency of the European Union. Country overview of antimicrobial consumption. http://www.ecdc.europa.eu/en/activities/surveillance/esac-net/pages/index.aspx
Ziembińska-Buczyńska A, Felis E, Folkert J (2015) Detection of antibiotic resistance genes in wastewater treatment plant – molecular and classical approach. Arch Environ Prot 41(4):23–32
Rodriguez-Mozaz S, Chamorro S, Marti E (2015) Occurrence of antibiotics and antibiotic resistance genes in hospital and urban wastewaters and their impact on the receiving river. Water Res 69:234–242
Hu J, Zhou J, Zhou S (2018) Occurrence and fate of antibiotics in a wastewater treatment plant and their biological effects on receiving waters in Guizhou. Process Safe Environ Prot 113:483–490
Lin H, Lia H, Chena L et al (2018) Mass loading and emission of thirty-seven pharmaceuticals in a typical municipal wastewater treatment plant in Hunan Province, Southern China. Ecotoxicol Environ Safe 147:530–536
Gbylik-Sikorska M, Posyniak A, Mitrowska K et al (2014) Occurrence of veterinary antibiotics and chemotherapeutics in fresh water, sediment, and fish of the rivers and lakes in Poland. Bull Vet Inst Pulawy 58:399–404
Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ (2007) Multi-residue method for the determination of basic/neutral pharmaceuticals and illicit drugs in surface water by solid-phase extraction and ultra performance liquid chromatography–positive electrospray ionisation tandem mass spectrometry. J Chromat A 1161:132–145
Adamek E, Baran W, Sobczak A (2016) Assessment of the biodegradability of selected sulfa drugs in two polluted rivers in Poland: effects of seasonal variations, accidental contamination, turbidity and salinity. J Hazard Mater 313:147–158
Carvalho IT, Santos L (2016) Antibiotics in the aquatic environments: a review of the European scenario. Environ Int 94:736–757
Deng Y, Bao X, Ji L et al (2015) Resistance integrons: class 1, 2 and 3 integrons. Ann Clin Microbiol Antimicrob 14:45–55
Seveno NA, Kallifidas D, Smalla K et al (2002) Occurrence and reservoirs of antibiotic resistance genes in the environment. Rev Med Microbiol 13:15–27
Makowska N, Koczura R, Mokracka J (2016) Class 1 integrase, sulfonamide and tetracycline resistance genes in wastewater treatment plant and surface water. Chemosphere 144:1665–1673
Korzeniewska E, Korzeniewska A, Harnisz M (2013) Antibiotic resistant Escherichia coli in hospital and municipal sewage and their emission to the environment. Ecotoxicol Environ Safe 91:96–102
Koczura R, Mokracka J, Jabłońska L et al (2012) Antimicrobial resistance of integron-harboring Escherichia coli isolates from clinical samples, wastewater treatment plant and river water. Sci Total Environ 414:680–685
Koczura R, Mokracka J, Taraszewska A et al (2016) Abundance of class 1 integron-integrase and sulfonamide resistance genes in river water and sediment is affected by anthropogenic pressure and environmental factors. Microb Ecol 72:909–916
Koczura R, Krysiak N, Taraszewska A et al (2015) Coliform bacteria isolated from recreational lakes carry class 1 and class 2 integrons and virulence-associated genes. J Appl Microbiol 119:594–603
Acknowledgments
This study was supported by grants No. 2017/27/B/NZ9/00267 and No. 2016/23/BNZ9/03669 from the National Science Center (Poland).
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Korzeniewska, E., Harnisz, M. (2020). Sources, Occurrence, and Environmental Risk Assessment of Antibiotics and Antimicrobial-Resistant Bacteria in Aquatic Environments of Poland. In: Korzeniewska, E., Harnisz, M. (eds) Polish River Basins and Lakes – Part II. The Handbook of Environmental Chemistry, vol 87. Springer, Cham. https://doi.org/10.1007/978-3-030-12139-6_9
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