Abstract
Basal cell carcinoma (BCC) is the most common cutaneous malignancy in the periocular area. While the mortality from BCC is low, it is capable of extensive tissue destruction, and the morbidity may be considerable. The main risk factor is ultraviolet irradiation. The most important diagnostic evaluation is histopathologic examination of the excised tissue. The main treatment modality for BCC is surgical excision of the lesion with microscopic monitoring of its margins or Mohs’ microsurgery. Long-term clinical follow-up after treatment is necessary.
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References
Margo CE, Waltz K. Basal cell carcinoma of the eyelid and periocular skin. Surv Ophthalmol. 1993;38:169–92.
Yin VT, Merritt HA, Sniegowski M, et al. Eyelid and ocular surface carcinoma: diagnosis and management. Clin Dermatol. 2015;33:159–69.
Allali J, D’Hermies F, Renard G. Basal cell carcinomas of the eyelids. Ophthalmologica. 2005;219:57–71.
Malhotra R, Huilgol SC, Huynh NT, et al. The Australian Mohs Database, Part I: periocular basal cell carcinoma. Experience over 7 years. Ophthalmology. 2004;111:624–30.
Paavilainen V, Tuominen J, Pukkala E, et al. Basal cell carcinoma of the eyelid in Finland during 1953–97. Acta Ophthalmol Scand. 2005;83:215–20.
Lim VSY, Amrith S. Declining incidence of eyelid cancers in Singapore over 13 years: population-based data from 1996 to 2008. Br J Ophthalmol. 2012;96:1462–5.
Shi Y, Jia R, Fan X. Ocular basal cell carcinoma: a brief literature review of clinical diagnosis and treatment. Onco Targets Ther. 2017;10:2483–9. https://doi.org/10.2147/OTT.S130371.. eCollection 2017. Review.
Wade TR, Ackerman AB. The many faces of basal-cell carcinoma. J Dermatol Surg Oncol. 1978;4:23–8.
Bakis S, Irwig L, Wood G, et al. Exfoliative cytology as a diagnostic test for basal cell carcinoma: a meta-analysis. Br J Dermatol. 2004;150:829–36.
Leibovitch I, McNab A, Sulivan T, et al. Orbital invasion by periocular basal cell carcinoma. Ophthalmology. 2005;112:717–23.
Allan E, Pye DA, Levine EL, et al. Non-invasive pulsed ultrasound quantification of the resolution of basal cell carcinomas after photodynamic therapy. Lasers Med Sci. 2002;17:230–7.
Nori S, Rius-Diaz F, Cuevas J, et al. Sensitivity and specificity of reflectance-mode confocal microscopy for in vivo diagnosis of basal cell carcinoma: a multicenter study. J Am Acad Dermatol. 2004;51:923–30.
Murra DE, Torres A, Schanbacher CF, et al. Detection of residual basal cell carcinoma by in vivo confocal microscopy. Dermatol Surg. 2005;31:538–41.
Cook BE Jr, Bartley GB. Treatment options and future prospects for the management of eyelid malignancies: an evidence-based update. Ophthalmology. 2001;108:2088–98.
Malhotra R, Huilgol SC, Huynh NT, et al. The Australian Mohs Database, Part II. Periocular basal cell carcinoma outcome at 5-year follow-up. Ophthalmology. 2004;111:631–6.
Morris DS, Elzaridi E, Clarke L, et al. Periocular basal cell carcinoma: 5-year outcome following slow Mohs surgery with formalin-fixed paraffin-embedded sections and delayed closure. Br J Ophthalmol. 2009;93(4):474–6.
Lindgren G, Larko O. Long-term follow-up of cryosurgery of basal cell carcinoma of the eyelid. J Am Acad Dermatol. 1997;36:742–6.
Tuppurainen K. Cryotherapy for eyelid and periocular basal cell carcinomas: outcome in 166 cases over an 8-year period. Graefes Arch Clin Exp Ophthalmol. 1995;233:205–8.
Kokoszka A, Scheinfeld N. Evidence-based review of the use of cryosurgery in treatment of basal cell carcinoma. Dermatol Surg. 2003;29:566–71.
Jaramillo-Averbe F. Cryosurgery in difficult to treat basal cell carcinoma. Int J Dermatol. 2000;39:223–9.
Lindgren G, Larko O. Cryosurgery of eyelid basal cell carcinomas including 782 cases treated over 30 years. Acta Ophthalmol. 2014;92:787–92.
Avril MF, Auperin A, Margulis A, et al. Basal cell carcinoma of the face: surgery or radiotherapy? Results of a randomized study. Br J Cancer. 1997;76:100–6.
Jefford M, Kiffer JD, Somers G, et al. Metastatic cell carcinoma: rapid symptomatic response to cisplatin and paclitaxel. ANZ J Surg. 2004;74:704–5.
Wang I, Bauer B, Andersson-Engels S, et al. Photodynamic therapy utilising topical delta-aminolevulinic acid in non-melanoma skin malignancies of the eyelid and the periocular skin. Acta Ophthalmol Scand. 1999;77:182–8.
Ingves C, Jemec GBE. Combined imiquimod and acitretin for non-surgical treatment of basal cell carcinoma. Scand J Plast Reconstr Surg Hand Surg. 2003;37:293–5.
Rhodes LE, de Rie M, Enström Y, et al. Photodynamic therapy using topical methyl aminolevulinate vs surgery for nodular basal cell carcinoma. Results of a multicenter randomized prospective trial. Arch Dermatol. 2004;140:17–23.
Garcia-Martin E, Gil-Arribas LM, Idoipe M, et al. Comparison of imiquimod 5% cream versus radiotherapy as treatment for eyelid basal cell carcinoma. Br J Ophthalmol. 2011;95:1393–6.
Sekulic A, Migden M, Oro A, et al. Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N Engl J Med. 2012;366:2171–9.
Curson C, Weedon D. Spontaneous regression in basal cell carcinoma. J Cutan Pathol. 1979;6:432–7.
Edge SE, Byrd DR, Carducci MA, et al., editors. Carcinoma of the eyelid. In: AJCC cancer staging manual. 7th ed. New York: Springer; 2010.
Crawford C, Fernelius C, Young P, et al. Application of the AJCC 7th edition carcinoma of the eyelid staging system: a medical center pathology based, 15-year review. Clin Ophthalmol. 2011;5:1645–8.
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Rosner, M., Fabian, I.D. (2019). Basal Cell Carcinoma. In: Pe'er, J., Singh, A., Damato, B. (eds) Clinical Ophthalmic Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-06046-6_4
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DOI: https://doi.org/10.1007/978-3-030-06046-6_4
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