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Molecular Biology of EBV in Relationship to HIV/AIDS-Associated Oncogenesis

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HIV/AIDS-Associated Viral Oncogenesis

Part of the book series: Cancer Treatment and Research ((CTAR,volume 177))

Abstract

Herpesvirus-induced disease is one of the most lethal factors which leads to high mortality in HIV/AIDS patients. EBV, also known as human herpesvirus 4, can transform naive B cells into immortalized cells in vitro through the regulation of cell cycle, cell proliferation, and apoptosis. EBV infection is associated with several lymphoma and epithelial cancers in humans, which occurs at a much higher rate in immune deficient individuals than in healthy people, demonstrating that the immune system plays a vital role in inhibiting EBV activities. EBV latency infection proteins can mimic suppression cytokines or upregulate PD-1 on B cells to repress the cytotoxic T cells response. Many malignancies, including Hodgkin Lymphoma and non-Hodgkin’s lymphomas occur at a much higher frequency in EBV positive individuals than in EBV negative people during the development of HIV infection. Importantly, understanding EBV pathogenesis at the molecular level will aid the development of novel therapies for EBV-induced diseases in HIV/AIDS patients.

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Authors and Affiliations

  1. Department of Otorhinolaryngology–Head and Neck Surgery and Tumor Virology and Global Cancer Programs, Abramson Cancer Center, Philadelphia, USA

    Fengchao Lang, Yonggang Pei, Zachary L. Lamplugh & Erle S. Robertson

  2. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Fengchao Lang, Yonggang Pei, Zachary L. Lamplugh & Erle S. Robertson

  3. 3610 Hamilton Walk, 201E Johnson Pavilion, Philadelphia, PA, 19104, USA

    Erle S. Robertson

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  1. Fengchao Lang
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    Craig Meyers

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Lang, F., Pei, Y., Lamplugh, Z.L., Robertson, E.S. (2019). Molecular Biology of EBV in Relationship to HIV/AIDS-Associated Oncogenesis. In: Meyers, C. (eds) HIV/AIDS-Associated Viral Oncogenesis. Cancer Treatment and Research, vol 177. Springer, Cham. https://doi.org/10.1007/978-3-030-03502-0_4

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