Résumé
Les lésions frontières du sein sont définies comme les lésions prénéoplasiques du sein et qui, laissées en place, évolueraient spontanément vers des lésions néoplasiques vraies. Ces lésions sont aussi les « sentinelles » de lésions plus péjoratives lorsqu’elles sont mises en évidence sur des biopsies à l’aiguille [1]. Ces lésions se développent dans les unités ductulo-terminales et sont le plus souvent révélées par des microcalcifications. La généralisation du dépistage mammographique a donc entraînéquence. Sont identifiées d’une part les maladies de type canalaire avec les lésions de métaplasie cylindrique atypique et l’hyperplasie canalaire atypique et d’autre part les néoplasies lobulaires in situ : hyperplasie lobulaire atypique et carcinome lobulaire atypique.
This is a preview of subscription content, log in via an institution to check access.
Preview
Unable to display preview. Download preview PDF.
Références
Jacobs TW, Connolly JL, Schnitt SJ (2002) Nonmalignant lesions in breast core needle biopsies: to excise or not to excise? Am J Surg Pathol 26: 1095–1110
Reis-Filho JS, Lakhani SR (2003) The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions. Breast Cancer Res 5: 313–319
Simpson PT, Gale T, Fulford LG, Reis-Filho JS, Lakhani SR (2003) The diagnosis and management of pre-invasive breast disease: pathology of atypical lobular hyperplasia and lobular carcinoma in situ. Breast Cancer Res 5: 258–262
Simpson PT, Gale T, Reis-Filho JS et al. (2005) Columnar cell lesions of the breast: the missing link in breast cancer progression? A morphological and molecular analysis. Am J Surg Pathol 29: 734–746
Schnitt SJ, Vincent-Salomon A (2003) Columnar cell lesions of the breast. Adv Anat Pathol 10: 113–124
Aulmann S, Braun L, Mietzsch F et al. (2012) Transitions Between Flat Epithelial Atypia and Low-grade Ductal Carcinoma In situ of the Breast. Am J Surg Pathol 36: 1247–1252
Simpson P, Gale T, Reis-Filho J et al. (2005) Columnar Cell Lesions of the Breast: The Missing Link in Breast Cancer Progression? A Morphological and Molecular Analysis. Am J Surg Pathol 29: 734–746
de Mascarel I, Brouste V, Asad-Syed M, Hurtevent G, Macgrogan G (2012) All atypia diagnosed at stereotactic vacuum-assisted breast biopsy do not need surgical excision. Mod Pathol 24: 1198–1206
de Mascarel I, MacGrogan G, Vincent-Salomon A et al. (2008) Epithelial atypia: a marker risk of concomitant or subsequent breast carcinoma? J Clin Oncol 26: 4514–4515; author reply 4515
Page DL, Dupont WD, Rogers LW, Rados MS (1985) Atypical hyperplastic lesions of the female breast. A long-term follow-up study. Cancer 55: 2698–2708
MacGrogan G, Arnould L, de Mascarel I et al. (2008) Impact of immunohistochemical markers, CK5/6 and E-cadherin on diagnostic agreement in non-invasive proliferative breast lesions. Histopathology 52: 689–697
Simpson PT, Reis-Filho JS, Gale T, Lakhani SR (2005) Molecular evolution of breast cancer. J Pathol 205: 248–254
Schnitt SJ, Morrow M (1999) Lobular carcinoma in situ: current concepts and controversies. Semin Diagn Pathol 16: 209–223
Chen YY, Hwang ES, Roy R et al. (2009) Genetic and phenotypic characteristics of pleomorphic lobular carcinoma in situ of the breast. Am J Surg Pathol 33: 1683–1694
Vincent-Salomon A, Hajage D, Rouquette A et al. (2012) High Ki67 expression is a risk marker of invasive relapse for classical lobular carcinoma in situ patients. Breast 21: 380–383
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag France, Paris
About this paper
Cite this paper
Vincent-Salomon, A. (2013). Acquis et limites dans les lésions frontières. In: Acquis et limites en sénologie / Assets and limits in breast diseases. Springer, Paris. https://doi.org/10.1007/978-2-8178-0396-8_7
Download citation
DOI: https://doi.org/10.1007/978-2-8178-0396-8_7
Publisher Name: Springer, Paris
Print ISBN: 978-2-8178-0395-1
Online ISBN: 978-2-8178-0396-8