Skip to main content
SpringerLink
Log in

Cucurbitacées

  • Chapter
Plantes toxiques à usage médicinal du pourtour méditerranéen

Part of the book series: Collection Phytothérapie pratique ((COLLPHYTO))

  • 1258 Accesses

Résumé

La grande famille des Cucurbitacées est essentiellement représentée dans les régions tropicales humides et chaudes. Différentes espèces constituent un apport alimentaire riche et varié: courge, concombre, melon, pastèque; d’autres, à graine oléagineuse fournissent de l’huile; certaines fournissent des éponges végétales (« loofah ») très appréciées pour les soins corporels; d’autres constituent des récipients (gourdes). Enfin, certaines espèces donnent lieu à des intoxications sévères: Bryone, Coloquinte, Concombre d’âne.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Références

  1. Gry J, Søborg I, Andersson HC (2006) Cucurbitacins in plant food. TemaNord, 556. Nordic Council of Ministers, Copenhagen

    Google Scholar 

  2. Paris RR, Moyse H (1981) Précis de matière médicale. Masson, Paris

    Google Scholar 

  3. Mirô M (1995) Cucurbitacins ans their pharmacological effects. Phytotherapy research 9: 159–68

    Article  Google Scholar 

  4. Oobayashi K, Yoshikawa K, Arihara S (1992) Structural revision of bryonoside and structure elucidation of minor saponins from Bryonia dioica. Phytochemistry 31: 943–6

    Article  CAS  PubMed  Google Scholar 

  5. Hartwell J (1969) Plants used against cancer. A survey. Lloydia 32: 78–107

    CAS  Google Scholar 

  6. Edery H, Schatzberg-Porath G, Gitter S (1961) Pharmacodynamic activity of Elatericin (cucurbitacin D). Arch Int Pharmacodyn Ther 130: 315–35

    CAS  PubMed  Google Scholar 

  7. Fatope MO, Takeda Y, Yamashta H et al. (1990) Nex cucurbitacine triterpenoids from Momordica charantia. J Nat Prod 53: 1491–7

    Article  CAS  Google Scholar 

  8. Yesilada E, Tanaka S, Sezik E, Tabata M (1988) Isolation of an anti-inflammatory principle from the juice of Ecballium elaterium. J Nat Prod 51: 504–8

    Article  CAS  PubMed  Google Scholar 

  9. Tannin-Spitz T, Bergman M, Shlomo Grossman S (2007b) Cucurbitacin glucosides: Antioxidant and free-radical scavenging activities. Biochemical and Biophysical Research Communications 364: 181–6

    Article  CAS  PubMed  Google Scholar 

  10. Lavie D, Willner D, Merenlender Z (1964) Constituents of Citrullus colocynthis Schrad. Phytochemistry 3: 51–6

    Article  CAS  Google Scholar 

  11. Liu T, Zhang M, Zhang H et al. (2008) Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinoma. European Archives of Oto-Rhino-Laryngology 265: 1225–32

    Article  PubMed  Google Scholar 

  12. Konopa J, Zieliński J, Matuszkiewicz A (1974a) Cucurbitacins, cytotoxic and antitumor substances from Bryonia alba L. Part I: isolation and identification. Arzneimittelforschung 24: 1554–7

    CAS  PubMed  Google Scholar 

  13. Konopa J, Matuszkiewicz A, Hrabowsla M, Onoszka K (1974b) Cucurbitacines, cytotoxic and antitumor substances from Bryonia alba L. Part II: Biological studies Arzneimittelforschung 24: 1741–3

    CAS  Google Scholar 

  14. Viterbo A, Yagen B, Mayer AM (1993) Cucurbitacins, “attack” enzymes and laccase in Botrytis cinerea. Phytochemistry 32: 61–5

    Article  Google Scholar 

  15. Le Men J, Buffard G, Provost J et al. (1969) Relations entre la structure de quelques cucurbitacines, leur toxicité et leur activité laxative. Chimie Thérapeutique 4: 459–65

    Google Scholar 

  16. Bruneton J (2009) Pharmacognosie, phytochimie, plantes médicinales. Tech & Doc, Paris

    Google Scholar 

  17. Dinan L, Harmatha J, Lafont R (2001) Chromatographic procedures for the isolation of plants steroids. J Chromatographic A 935: 105–23

    Article  CAS  Google Scholar 

  18. Wagner H, Bladt S, Zgainski EM (1984) Plants Drug Analysis, A thin Layer Chromatography Atlas. Springer-Verlag, Berlin-Heidelberg-New York

    Google Scholar 

  19. Van Keulen HA (1981) Fluorodensitometric estimation of cucurbitacin-C in leaves of Cucumis sativus L. Plant Foods for Human Nutrition (Formerly Qualitas Plantarum) 31: 129–37

    Article  Google Scholar 

  20. Hutt TF, Herrington ME (1985) The determination of bitter principles in zucchinis. J Sci Food Agric 36: 1107–12

    Article  CAS  Google Scholar 

  21. Matsuo K, DeMilo AB, Schroder RFW, Martin PAW (1999) Rapid High-Performance Liquid Chromatography Method to Quantita-te Elaterinide in Juice and Reconstitu-ted Residues from a Bitter Mutant of Hawkesbury Watermelon. J Agric Food Chem 47: 2755–9

    Article  CAS  PubMed  Google Scholar 

  22. Sturm S, Stuppner H (2000) Analysis of cucurbitacins in medicinal plants by HPLC and MS. Phytochem Analysis 11: 121–7

    Article  CAS  Google Scholar 

Références

  1. Hammiche V et Maiza K (2006) Traditional medicine in central Sahara: Pharmacopoeia of Tassili n’Ajjer. J Ethnopharmacol 105: 358–67

    Article  PubMed  Google Scholar 

  2. Bellakhdar J (1997) La Pharmacopée marocaine traditionnelle. Ibis Press, Paris

    Google Scholar 

  3. Gmelin R (1964) The bitter principles of the roots of red bryony, Bryonia dioica jacq. isolation of cucurbitacines L, J, and K as well as tetrahydrocucurbitacine I, a new natural cucurbitacine. Arzneimittel-Forschung 14: 1021–5

    CAS  PubMed  Google Scholar 

  4. Oobayashi K, Yoshikawa K, Arihara S (1992) Structural revision of bryonoside and structure elucidation of minor saponins from Bryonia dioica. Phytochemistry 31: 943–6

    Article  CAS  PubMed  Google Scholar 

  5. Muñoz SM, Salvarelli SM, Saiz I, Conde FP (1992) A toxic protein from Bryonia dioica Jacq. Fruits: the bryodiofin. Biochem Biophys Res Comm 183: 1011–8

    Google Scholar 

  6. Akihisa T, Kimura Y, Koike K et al. (1998) Cycloartane triterpenoids from aerial part of Bryonia dioica. Phytochem 49: 1757–60

    Article  CAS  Google Scholar 

  7. Krauze-Baranowska M, Cisowski W (1995) Flavon C-glycosides from Bryonia alba and B. dioica. Phytochemistry 39: 727–9

    Article  CAS  Google Scholar 

  8. Ukiya M, Akihisa T, Yasukawa K et al. (2002) Anti-inflammatory and anti-tumorpromoting effects of cucurbitane glycosides from the roots of Bryonia dioica. J Nat Prod 65: 179–83

    Article  CAS  PubMed  Google Scholar 

  9. Fransisco JA, Gawlak SL, Miller M et al. (1997) Expression and characterization of bryodin 1 and a bryodin 1-based single-chain immunotoxin from tobacco cell culture. Bioconjug Chem 8: 708–13

    Article  Google Scholar 

  10. Siegall CB, Gawlak SL, Chace D et al. (1994) Characterization of Ribosome-Inactivating Proteins isolated from Bryonia dioica and their utility as carcinoma-Reactive Immunoconjugates. Bioconjugate Chem 5: 423–9

    Article  CAS  Google Scholar 

  11. Wachinger M, Samtleben R, Gerhäuser C et al. (1993) Bryodin, a single-chain ribosome-inactivating protein, selectively inhibits the growth of HIV-1-infected cells and reduces HIV-1 production. Res Exp Med (Berlin) 193: 1, 1–12

    Article  CAS  Google Scholar 

  12. Boustie J, Caubet A, Paris M (2002) Atlas des intoxications d’origine végétale. Encyclopédie médico-chirurgicale, Toxicologie-Pathologie professionnelle. Elsevier, Paris

    Google Scholar 

  13. Delaveau P (1998) Les risques des plantes toxiques les plus couramment responsables d’accidents. Concours Médical 120: 1874–8

    Google Scholar 

  14. Bruneton J (2005) Plantes toxiques, végétaux dangereux pour l’homme et les animaux. Tech & Doc, Paris

    Google Scholar 

  15. Mondolo-Cosson L (1998) Les plantes toxiques. Le moniteur des pharmacies 2259: 49–60

    Google Scholar 

  16. Whur P (1986) White bryony poisoning in a dog. Vet Rec 119: 411

    Article  CAS  PubMed  Google Scholar 

Références

  1. Paris RR, Moyse H (1981) Précis de matière Mmdicale. Masson, Paris

    Google Scholar 

  2. Duke JA (2006) Handbook of Energy Crops. Available on-line, at: http://www.Ars-grin.gov/cgi-bin/duke/farmacy2.pl/cgi-bin/duke/farmacy2.pl

  3. Maiza K, Brac de la Perrière RA, Hammiche V (1993) Traditional Saharian pharmacopoeia. Acta Horticulturae ISHS 332: 7–42

    Google Scholar 

  4. Maiza K, Brac de la Perrière RA, Hammiche V (1995) Pharmacopée traditionnelle saharienne: Sahara septentrional. Revue de Médecines et Pharmacopées Africaines 9: 71–5

    Google Scholar 

  5. Maiza K, Smati D, Brac de la Perrière RA, Hammiche V (2006) Médecine traditionnelle au Sahara Central: Pharmacopée de l’Ahaggar. Revue de Médecines et Pharmacopées Africaines 19: 141–56

    Google Scholar 

  6. Hammiche V, Maiza K (2006) Traditional medicine in central Sahara: Pharmacopoeia of Tassili n’Ajjer. J Ethnopharmacol 105: 358–67

    Article  PubMed  Google Scholar 

  7. Bellakhdar J (1997) La Pharmacopée marocaine traditionnelle. Ibis Press, Paris

    Google Scholar 

  8. Boukef K (1986) Les plantes dans la médecine traditionnelle Tunisienne. ACCT, Paris

    Google Scholar 

  9. Dhiman k, Gupta A, Sharma DK et al. (2012) A review on the medicinally important plants of the family Cucurbitaceae. Asian Journal of Clinical Nutrition 1: 16–26

    Article  Google Scholar 

  10. Marzouk B, Marzouk Z, Haloui E et al. (2010) Screening of analgesic and anti-inflammatory activities of Citrullus colocynthis from southern Tunisia. Journal of Ethnopharmacology 128: 15–9

    Article  PubMed  Google Scholar 

  11. Kumar S, Kumar D, Man Jusha M et al. (2008) Antioxidant and free radical scavenging potential of Citrullus colocynthis (L.) Schrad. methanolic fruit extract. Acta Pharmaceutica 58: 215–20

    CAS  PubMed  Google Scholar 

  12. Gill NS, Kaur S, Arora R, Bali M (2011) Screening of Antioxidant and Antiulcer Potential of Citrullus colocynthis Methanolic Seed Extract. Research Journal of Phytochemistry 2: 98–106

    Article  Google Scholar 

  13. Asghar MN, Khan IU, Bano N (2011) In vitro antioxidant and radical-scavenging capacities of Citrullus colocynthis (L) and Artemisia absinthium extracts using promethazine hydrochloride radical cation and contemporary assays. Food Sci Technol Int 5: 481–94

    Article  Google Scholar 

  14. Nmila R, Gross R, Rchid H et al. (2000) Insulinotropic effect of Citrullus colocynthis fruit extracts. Planta Med 66: 418–23

    Article  CAS  PubMed  Google Scholar 

  15. Sakine MNA, Mahmout Y, Gbenou J et al. (2011) Effet antihyperglycémiant des extraits de Boscia senegalensis (Pers.) Lam. ex Poiret et de Colocynthis vulgaris (L.) Schrad. Phytothérapie 9: 268–73

    Article  Google Scholar 

  16. Roy RK, Thakur M, Dixit VK (2007) Development and evaluation of polyherbal formulation for hair growth-promoting activity. J Cosmet Dermatol 6: 108–12

    Article  PubMed  Google Scholar 

  17. Tannin-Spitz T, Grossman S, Dovrat S et al. (2007a) Growth inhibitory activity of cucurbitacin glucosides isolated from Citrullus colocynthis on human breast cancer cells. Biochemical Pharmacology 73: 56–67

    Article  CAS  PubMed  Google Scholar 

  18. Darwish-Sayed M, Balbaa SI, Afifi MS (1974) The glycosidal content of the different organs of Citrullus colocynthis. Planta Med 26: 293–8

    Article  CAS  PubMed  Google Scholar 

  19. Seger C, Sturm S, Mair ME et al. (2005) 1H and 13C NMR signal assignment of cucurbitacin derivatives from Citrullus colocynthis (L.) Schrader amd Ecballium elaterium L. (Cucurbitaceae). Magn Reson Chem 43: 489–91

    Article  CAS  PubMed  Google Scholar 

  20. Gamlath CB, Gunatilaka AAL, Alvi KA et al. (1988) Cucurbitacins of Colocynthis vulgaris. Phytochemistry 27: 3225–9

    Article  CAS  Google Scholar 

  21. Gry J, Søborg I, Andersson HC (2006) Cucurbitacins in plant food. TemaNord, 556. Nordic Council of Ministers, Copenhagen

    Google Scholar 

  22. Maatooq GT, El-Sharkawi SH, Afifi MS, Rosazza N (1997) C-p-hyroxybenzoyl glycoflavone from Citrullus colocynthis. Phytochemistry 44: 187–90

    Article  CAS  Google Scholar 

  23. Chaturvedi M, Mali PC, Ansari AS (2003) Induction of reversible antifertility with a crude ethanol extract of Citrullus colocynthis Schrad fruit in male rats. Pharmacology 68: 38–48

    Article  CAS  PubMed  Google Scholar 

  24. Dehghani F, Panjehshahin MR, Azizi M. et al. (2003) Effect of Citrulus colocynthis on fertility rate and the number of embryo in mouse. Toxicol Lett 144 (Suppl. 1), S110

    Article  Google Scholar 

  25. Mullai K, Jebanesan A. (2007). Larvicidal, ovicidal and repellent activities of the leaf extract of two cucurbitacious plants against filarial vector Culex quinquefasciatus (Say) (Diptera: Culicidae). Trop Biomed 24: 1–6

    CAS  PubMed  Google Scholar 

  26. Abdul Rahuman A, Venkatesan P (2008) Larvicidal efficacy of five cucurbitaceous plant leaf extracts against mosquito species. Parasitology Research 103: 133–9

    Article  PubMed  Google Scholar 

  27. Bruneton J (2005) Plantes toxiques, végétaux dangereux pour l’homme et les animaux. Tech & Doc, Paris

    Google Scholar 

  28. Elawad AA, Abdel Bari EM, Mahmoud OM, Adam SEI (1984) The effect of Citrullus colocynthis on sheep. Vet Hum Toxicol 26: 481–5

    CAS  PubMed  Google Scholar 

  29. Berrut C, Bisetti A, Widgren S et al. (1987) Colite pseudo-membraneuse causée par l’ingestion de coloquinte. Schweiz Med Wochenschr 117: 135–8

    CAS  PubMed  Google Scholar 

  30. Golfain D, Lavergne A, Galian A et al. (1989) Peculiar acute toxic colitis after ingestion of colocynth: a clinicopathological study of three cases. Gut 30: 1412–28

    Article  Google Scholar 

Références

  1. Font Quer (1980) El Dioscorides Renovado. 6th ed, 768–770, Labor, Barcelona

    Google Scholar 

  2. Mirô M (1995) Cucurbitacins ans their pharmacological effects. Phytotherapy research 9: 159–68

    Article  Google Scholar 

  3. Bellakhdar J (1997) La Pharmacopée Marocaine Traditionnelle. Ibis Press, Paris

    Google Scholar 

  4. Fourment P, Roques H (1942) Répertoire des plantes médicinales et aromatiques d’Algérie. Documents et renseignements agricoles

    Google Scholar 

  5. Paris RR, Moyse H (1981) Précis de matière médicale. Masson, Paris

    Google Scholar 

  6. Agil A, Miró M, Jimenez J et al. (1999) Isolation of an anti-hepatotoxic principle from the juice of Ecballium elaterium. Planta Med 65: 673–5

    Article  CAS  PubMed  Google Scholar 

  7. Greige-Gerges H, Abou Khalil R, Abou Mansour E et al. (2007) Cucurbitacins from Ecballium elaterium juice increase the binding of bilirubin and ibuprofen to albumin in human plasma. Chemico-Biological Interactions 169: 53–62

    Article  CAS  PubMed  Google Scholar 

  8. Yesilada E, Tanaka S, Sezik E, Tabata M (1988) Isolation of an anti-inflammatory principle from the juice of Ecballium elaterium. J Nat Prod 51: 504–8

    Article  CAS  PubMed  Google Scholar 

  9. Lavie D, Willner D, Merenlender Z (1964) Constituents of Citrullus colocynthis Schrad. Phytochemistry 3: 51–6

    Article  CAS  Google Scholar 

  10. Konopa J, Zieliński J, Matuszkiewicz A (1974a) Cucurbitacins, cytotoxic and antitumor substances from Bryonia alba L. Part I: isolation and identification. Arzneimittelforschung 24: 1554–7

    CAS  PubMed  Google Scholar 

  11. Konopa J, Matuszkiewicz A, Hrabowsla M, Onoszka K (1974b) Cucurbitacines, cytotoxic and antitumor substances from Bryonia alba L. Part II: Biological studies Arzneimittelforschung 24: 1741–3

    CAS  Google Scholar 

  12. Rencüzogullari E, Ila HB, Kayraldiz A et al. (2006) The mutagenic and anti-mutagenic effects of Ecballium elaterium fruit juice in human peripheral lymphocytes. Genetika 42: 768–72

    PubMed  Google Scholar 

  13. Sezik E (1997) Research on the Tur-kish medicinal plant Ecballium elaterium. Chem Nat Comp 33: 541–2

    Article  CAS  Google Scholar 

  14. Oskoui MT (1986) Cycloeucalenol from the leaves of Ecballium elaterium. Planta Med 52: 159

    Article  Google Scholar 

  15. Koçak I, Karabela Y, Karaman M, Kaya F (2006) Late onset diffuse lamellar keratitis as a result of the toxic effect of Ecballium elaterium herb. J Refract Surg 22: 826–7

    PubMed  Google Scholar 

  16. Raikhlin-Eisenkraft B, Bentur Y (2000) Ecbalium elaterium (squirting cucumber)-remedy or poison? J Toxicol Clin Toxicol 38: 305–8

    Article  CAS  PubMed  Google Scholar 

  17. Vlachos P, Kanitsakis NN, Kokonas N (1994) Fatal cardiac and renal failure due to Ecballium elaterium (squirting cucumber). J Toxicol Clin Toxicol 32: 737–8

    Article  CAS  PubMed  Google Scholar 

  18. Caiozzi G, Cabrera D, Mardónez JM, Saldías F (2002) Hierbas medicinales y graves efectos adversos: Angioedema úvula causado por uso de Ecballium elaterium. Rev Med Chil 130: 1407–10

    Article  PubMed  Google Scholar 

  19. Eken C, Ozbek K, Yildirim CK, Eray O (2008). Severe uvular edema and nasal mucosal necrosis due to Ecballium elaterium (squirting cucumber): an allergic reaction or direct toxic effect? Clin Toxicol (Phila) 46: 257–8

    Article  Google Scholar 

  20. Plouvier B, Trottin F, Deram R et al. (1981) Concombre d’âne (Ecballium elaterium), une cause peu banale d’œdème de Quincke. Nouvelle Presse Méd 10: 2590

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Faculté de médecine, Département de pharmacie, Laboratoire de botanique médicale Université d’Alger, 18, avenue Pasteur, 16000, Alger, Algérie

    Victoria Hammiche

  2. Service de pharmacie, CHU Mustapha, Centre Pierre et Marie Curie, 1, place du Premier Mai 1945, 16000, Alger, Algérie

    Victoria Hammiche

  3. Faculté de médecine, Département de pharmacie, Laboratoire de toxicologie Université d’Alger, 18, avenue Pasteur, 16000, Alger, Algérie

    Rachida Merad & Mohamed Azzouz

  4. Service de toxicologie, CHU Mustapha, 1, place du Premier Mai 1945, 16000, Alger, Algérie

    Rachida Merad

  5. CHU Bab El Oued, Boulevard Said Touati, 16000, Alger, Algérie

    Rachida Merad

  6. Service de biologie-toxicologie, EHS Ait Idir., Alger, Algérie

    Mohamed Azzouz

Authors
  1. Victoria Hammiche
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rachida Merad
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mohamed Azzouz
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to V. Hammiche , R. Merad or M. Azzouz .

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag France, Paris

About this chapter

Cite this chapter

Hammiche, V., Merad, R., Azzouz, M. (2013). Cucurbitacées. In: Plantes toxiques à usage médicinal du pourtour méditerranéen. Collection Phytothérapie pratique. Springer, Paris. https://doi.org/10.1007/978-2-8178-0375-3_15

Download citation

  • DOI: https://doi.org/10.1007/978-2-8178-0375-3_15

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0374-6

  • Online ISBN: 978-2-8178-0375-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation