Résumé
Le paysage de la prise en charge des lymphomes de Hodgkin (LH) avancés s’est sensiblement modifié durant les 10 dernières années. L’introduction de nouveaux schémas thérapeutiques plus intenses permet d’améliorer le contrôle de la maladie, mais la meilleure balance entre efficacité et toxicité des traitements reste à trouver. Par ailleurs, la récente introduction de l’imagerie fonctionnelle dont la sensibilité est meilleure que celle du scanner, a permis d’une part d’identifier plus fréquemment des patients ayant un stade avancé [1], et d’autre part de développer des stratégies thérapeutiques adaptées au risque d’échec du traitement évalué par la sensibilité précoce à la chimiothérapie.
Preview
Unable to display preview. Download preview PDF.
Références
Hutchings M, Loft A, Hansen M, et al. (2006) Position emission tomography with or without computed tomography in the primary staging of Hodgkin’s lymphoma. Haematologica 91(4): 482–9
Engert A, Diehl V, Franklin J, et al. (2009) Escalated-dose BEACOPP in the treatment of patients with advanced-stage Hodgkin’s lymphoma: 10 years of follow-up of the GHSG HD9 study. J Clin Oncol 27(27): 4548–54
Borchmann P, Haverkamp H, Diehl V, et al. (2011) Eight cycles of escalated-dose BEACOPP compared with four cycles of escalated-dose BEACOPP followed by four cycles of baseline-dose BEACOPP with or without radiotherapy in patients with advanced-stage Hodgkin’s lymphoma: final analysis of the HD12 trial of the German Hodgkin Study Group. J Clin Oncol 29(32): 4234–42
Chisesi T, Bellei M, Luminari S, et al. (2011) Long-term follow-up analysis of HD9601 trial comparing ABVD versus Stanford V versus MOPP/EBV/CAD in patients with newly diagnosed advanced-stage Hodgkin’s lymphoma: a study from the Intergruppo Italiano Linfomi. J Clin Oncol 29(32): 4227–33
Federico M, Luminari S, Iannitto E, et al. (2009) ABVD compared with BEACOPP compared with CEC for the initial treatment of patients with advanced Hodgkin’s lymphoma: results from the HD2000 Gruppo Italiano per lo Studio dei Linfbmi Trial. J Clin Oncol 27(5): 805–11
Viviani S, Zinzani PL, Rambaldi A, et al. (2011) ABVD versus BEACOPP for Hodgkin’s lymphoma when high-dose salvage is planned. N Engl J Med 365(3): 203–12
Fermé C, Mounier N, Casasnovas O, et al. (2006) Long-term results and competing risk analysis of the H89 trial in patients with advanced-stage Hodgkin lymphoma: a study by the Groupe d’Étude des Lymphomes de l’Adulte (GELA). Blood 107(12): 4636–42
Aleman BMP, Raemaekers JMM, Tirelli U, et al. (2003) Involved-field radiotherapy for advanced Hodgkin’s lymphoma. N Engl J Med 348(24): 2396–2406
Canellos GP, Anderson JR, Propert KJ, et al. (1992) Chemotherapy of advanced Hodgkin’s disease with MOPP, ABVD, or MOPP alternating with ABVD. N Engl J Med 327(21): 1478–84
Duggan DB, Petroni GR, Johnson JL, et al. (2003) Randomized comparison of ABVD and MOPP/ABV hybrid for the treatment of advanced Hodgkin’s disease: report of an intergroup trial. J Clin Oncol 21(4): 607–14
Glick JH, Young ML, Harrington D, et al. (1998) MOPP/ABV hybrid chemotherapy for advanced Hodgkin’s disease significantly improves failure-free and overall survival: the 8-year results of the intergroup trial. J Clin Oncol 16(1): 19–26
Diehl V, Franklin J, Pfreundschuh M, et al. (2003) Standard and increased-dose BEACOPP chemotherapy compared with COPP-ABVD for advanced Hodgkin’s disease. N Engl J Med 348(24): 2386–95
Carde P, Karrasch M, Fortpied C, et al. (2012) ABVD (8 cycles) vs. BEACOPP (4 escalated cycles ⇒ 4 baseline) in stage III–IV high risk Hodgkin Lymphoma (HL): first results of EORTC Intergroup 20012 study. ASCO 2012
Morschhauser F, Brice P, Fermé C, et al. (2008) Risk-adapted salvage treatment with single or tandem autologous stem-cell transplantation for first relapse/refractory Hodgkin’s lymphoma: results of the prospective multicenter H96 trial by the GELA/SFGM study group. J Clin Oncol 26(36): 5980–7
Bauer K, Skoetz N, Monsef I, et al. (2011) Comparison of chemotherapy including escalated BEACOPP versus chemotherapy including ABVD for patients with early unfavourable or advanced stage Hodgkin lymphoma. Cochrane Database Syst Rev (8): CD007941
16. Engert A (2012) Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin’s lymphoma (HD15 trial): a randomized, open-label, phase 3 non-inferiority trial. Lancet Online 4th April 2012
Gobbi PG, Levis A, Chisesi T, et al. (2005) ABVD versus modified Stanford V versus MOPPEBVCAD with optional and limited radiotherapy in intermediate-and advanced-stage Hodgkin’s lymphoma: final results of a multicenter randomized trial by the Intergruppo Italiano Linfomi. J Clin Oncol 23(36): 9198–9207
Johnson PWM, Radford JA, Cullen MH, et al. (2005) Comparison of ABVD and alternating or hybrid multidrug regimens for the treatment of advanced Hodgkin’s lymphoma: results of the United Kingdom Lymphoma Group LY09 Trial (ISRCTN97144519). J Clin Oncol 23(36): 9208–18
Radford JA, Rohatiner AZS, Ryder WDJ, et al. (2002) ChlVPP/EVA hybrid versus the weekly VAPEC-B regimen for previously untreated Hodgkin’s disease. J Clin Oncol 20(13): 2988–94
Steidl C, Telenius A, Shah SP, et al. (2010) Genome-wide copy number analysis of Hodgkin Reed-Sternberg cells identifies recurrent imbalances with correlations to treatment outcome. Blood 116(3): 418–27
Steidl C, Lee T, Shah SP, et al. (2010) Tumor-associated macrophages and survival in classic Hodgkin’s lymphoma. N Engl J Med 362(10): 875–85
Xie L, Ushmorov A, Leithäuser F, et al. (2012) FOXO1 is a tumor suppressor in classical Hodgkin lymphoma. Blood (doi: 10.1182/blood-2011-09-381905)
Chetaille B, Bertucci F, Finetti P, et al. (2009) Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome. Blood 113(12): 2765–3775
Sánchez-Espiridión B, Montalbán C, López A, et al. (2010) A molecular risk score based on 4 functional pathways for advanced classical Hodgkin lymphoma. Blood 116(8): e12–7
Casasnovas RO, Mounier N, Brice P, et al. (2007) Plasma cytokine and soluble receptor signature predicts outcome of patients with classical Hodgkin’s lymphoma: a study from the Groupe d’Étude des Lymphomes de l’Adulte. J Clin Oncol 25(13): 1732–40
Weihrauch MR, Manzke O, Beyer M, et al. (2005) Elevated serum levels of CC thymus and activation-related chemokine (TARC) in primary Hodgkin’s disease: potential for a prognostic factor. Cancer Res 65(13): 5516–9
Gallamini A, Patti C, Viviani S, et al. (2011) Early chemotherapy intensification with BEACOPP in advanced-stage Hodgkin lymphoma patients with a interim-PET positive after two ABVD courses. Br J Haematol 152(5): 551–60
Federico M, Bellei M, Brice P, et al. (2003) High-dose therapy and autologous stem-cell transplantation versus conventional therapy for patients with advanced Hodgkin’s lymphoma responding to front-line therapy. J Clin Oncol 21(12): 2320–5
Straus DJ, Gaynor JJ, Myers J, et al. (1990) Prognostic factors among 185 adults with newly diagnosed advanced Hodgkin’s disease treated with alternating potentially noncross-resistant chemotherapy and intermediate-dose radiation therapy. J Clin Oncol 8(7): 1173–86
Arakelyan N, Berthou C, Desablens B, et al. (2008) Early versus late intensification for patients with high-risk Hodgkin lymphoma-3 cycles of intensive chemotherapy plus low-dose lymph node radiation therapy versus 4 cycles of combined doxorubicin, bleomycin, vinblastine, and dacarbazine plus myeloablative chemotherapy with autologous stem cell transplantation: five-year results of a randomized trial on behalf of the GOELAMS Group. Cancer 113(12): 3323–30
Ng AK, Kenney LB, Gilbert ES, Travis LB (2010) Secondary malignancies across the age spectrum. Semin Radiat Oncol 20(1): 67–78
Johnson PW, Sydes MR, Hancock BW, et al. (2010) Consolidation radiotherapy in patients with advanced Hodgkin’s lymphoma: survival data from the UKLG LY09 randomized controlled trial (ISRCTN97144519). J Clin Oncol 28(20): 3352–9
Kobe C, Dietlein M, Franklin J, et al. (2008) Positron emission tomography has a high negative predictive value for progression or early relapse for patients with residual disease after first-line chemotherapy in advanced-stage Hodgkin lymphoma. Blood 112(10): 3989–94
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2013 Springer-Verlag Paris
About this chapter
Cite this chapter
Casasnovas, R.O. (2013). Lymphome de Hodgkin : traitement de première ligne des stades avancés. In: Actualités thérapeutiques dans les lymphomes. Springer, Paris. https://doi.org/10.1007/978-2-8178-0371-5_2
Download citation
DOI: https://doi.org/10.1007/978-2-8178-0371-5_2
Publisher Name: Springer, Paris
Print ISBN: 978-2-8178-0370-8
Online ISBN: 978-2-8178-0371-5