Skip to main content
SpringerLink
Log in

Pour une meilleure évaluation des risques en cas de métaplasie cylindrique atypique en pathologie mammaire

For a better risk assessment of fl at epithelial atypia in breast pathology

  • Conference paper
Cancer du sein : surdiagnostic, surtraitement

  • 170 Accesses

Résumé

La métaplasie cylindrique atypique (MCA) est une lésion fréquemment retrouvée dans des macrobiopsies réalisées sur foyers de microcalcifications le plus souvent de type ACR3 et ACR4. Elle a été décrite avec des terminologies différentes au cours des 30 dernières années, dont les plus connues sont : lobules atypiques de type A, carcinome intracanalaire de type crampon monomorphe, atypies épithéliales planes, métaplasie et hyperplasie cylindrique avec atypies [1]. Cette lésion est fréquemment associée à d’autres proliférations intraépithéliales néoplasiques de bas grade mais aussi à des carcinomes infiltrants de phénotype luminal. Elle pose le problème de la conduite à tenir en cas de découverte isolée sur macrobiopsie de foyers de microcalcifications.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Références

  1. Schnitt SJ, Vincent-Salomon A (2003) Columnar cell lesions of the breast. Adv Anat Pathol 10: 113–124

    Article  PubMed  Google Scholar 

  2. Abdel-Fatah TM, Powe DG, Hodi Z, Lee AH, Reis-Filho JS, Ellis IO (2007) High frequency of coexistence of columnar cell lesions, lobular neoplasia, and low grade ductal carcinoma in situ with invasive tubular carcinoma and invasive lobular carcinoma. Am J Surg Pathol 31: 417–426

    Article  PubMed  Google Scholar 

  3. Moinfar F (2010) Flat ductal intraepithelial neoplasia of the breast: evolution of Azzopardi’s “clinging” concept. Semin Diagn Pathol 27: 37–48

    Article  PubMed  Google Scholar 

  4. Simpson PT, Gale T, Reis-Filho JS et al. (2005) Columnar cell lesions of the breast: the missing link in breast cancer progression? A morphological and molecular analysis. Am J Surg Pathol 29: 734–746

    Article  PubMed  Google Scholar 

  5. Kunju LP, Kleer CG (2007) Significance of flat epithelial atypia on mammotome core needle biopsy: Should it be excised? Hum Pathol 38: 35–41

    Article  PubMed  Google Scholar 

  6. Leibl S, Regitnig P, Moinfar F (2007) Flat epithelial atypia (DIN 1a, atypical columnar change): an underdiagnosed entity very frequently coexisting with lobular neoplasia. Histopathology 50: 859–865

    Article  PubMed  CAS  Google Scholar 

  7. de Mascarel I, MacGrogan G, Mathoulin-Pelissier S et al. (2007) Epithelial atypia in biopsies performed for microcalcifications. practical considerations about 2, 833 serially sectioned surgical biopsies with a long follow-up. Virchows Arch 451: 1–10

    Article  PubMed  Google Scholar 

  8. Eusebi V, Feudale E, Foschini MP et al. (1994) Long-term follow-up of in situ carcinoma of the breast. Semin Diagn Pathol 11: 223–235

    PubMed  CAS  Google Scholar 

  9. Bijker N, Peterse JL, Duchateau L et al. (2001) Risk factors for recurrence and metastasis after breast-conserving therapy for ductal carcinoma-in-situ: analysis of European Organization for Research and Treatment of Cancer Trial 10853. J Clin Oncol 19: 2263–2271

    PubMed  CAS  Google Scholar 

  10. de Mascarel I, Brouste V, sad-Syed M, Hurtevent G, MacGrogan G (2011) All atypia diagnosed at stereotactic vacuum-assisted breast biopsy do not need surgical excision. Mod Pathol (in press)

    Google Scholar 

  11. Senetta R, Campanino PP, Mariscotti F et al. (2009) Columnar cell lesions associated with breast calcifications on vacuum-assisted core biopsies: clinical, radiographic, and histological correlations. Mod Pathol 22: 762–769

    PubMed  Google Scholar 

  12. David N, Labbe-Devilliers C, Moreau D, Loussouarn D, Campion L (2006) Diagnosis of flat epithelial atypia (FEA) after stereotactic vacuum-assisted biopsy (VAB) of the breast: What is the best management: systematic surgery for all or follow-up? J Radiol 87: 1671–1677

    Article  PubMed  CAS  Google Scholar 

  13. Guerra-Wallace MM, Christensen WN, White RL, Jr. (2004) A retrospective study of columnar alteration with prominent apical snouts and secretions and the association with cancer. Am J Surg 188: 395–398

    Article  PubMed  Google Scholar 

  14. Bonnett M, Wallis T, Rossmann M et al. (2003) Histopathologic analysis of atypical lesions in image-guided core breast biopsies. Mod Pathol 16: 154–160

    Article  PubMed  Google Scholar 

  15. Lavoue V, Roger CM, Poilblanc M et al. (2011) Pure flat epithelial atypia (DIN 1a) on core needle biopsy: study of 60 biopsies with follow-up surgical excision. Breast Cancer Res Treat 125: 121–126

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Département de pathologie, Institut Bergonié, 229, cours de l’Argonne, 33076, Bordeaux Cedex

    G. MacGrogan

  2. Département de pathologie, Institut Bergonié Bordeaux, 229, cours de l’Argonne, 33076, Bordeaux Cedex

    I. de Mascarel

Authors
  1. G. MacGrogan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. de Mascarel
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag France, Paris

About this paper

Cite this paper

MacGrogan, G., de Mascarel, I. (2012). Pour une meilleure évaluation des risques en cas de métaplasie cylindrique atypique en pathologie mammaire. In: Cancer du sein : surdiagnostic, surtraitement. Springer, Paris. https://doi.org/10.1007/978-2-8178-0249-7_9

Download citation

  • DOI: https://doi.org/10.1007/978-2-8178-0249-7_9

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0248-0

  • Online ISBN: 978-2-8178-0249-7

Publish with us

Policies and ethics

Search

Navigation