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L’interaction gamétique au cours de la fécondation

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Physiologie, pathologie et thérapie de la reproduction chez l’humain

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Résumé

L’ovocyte qui va être fécondé a grandi en taille au sein de son follicule et s’est entouré de la zone pellucide, structure amorphe acellulaire composée de glycoprotéines au nombre de quatre dans l’espèce humaine (1). Cette zone pellucide va avoir plusieurs fonctions: la reconnaissance et la sélection du spermatozoïde fécondant, ainsi que le déclenchement de sa réaction acrosomique lui permettant de libérer les enzymes qu’il transporte dans l’acrosome. Ceux-ci vont lui permettre de rompre les liaisons entre la ZP1 et les polymères de ZP2-ZP3 afi n de se frayer un passage et de se propulser au travers de la zone pellucide grâce à ses battements flagellaires jusque dans l’espace périvitellin (2).

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Authors and Affiliations

  1. Service d’histologie embryologie à orientation en biologie de la reproduction, Hôpital Cochin - Université Paris Descartes, 123, boulevard Port-Royal, 75014, Paris

    J.-P. Wolf, A. Ziyyat & J.-C. Pont

  2. Service d’histologie embryologie à orientation en biologie de la reproduction, Hôpital Cochin - Université Paris Descartes, 213, boulevard Port-Royal, 75014, Paris

    V. Barraud-Lange, C. Serres, J. Auer & B. Lefèvre

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  1. J.-P. Wolf
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  3. A. Ziyyat
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  7. B. Lefèvre
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Wolf, JP. et al. (2011). L’interaction gamétique au cours de la fécondation. In: Physiologie, pathologie et thérapie de la reproduction chez l’humain. Springer, Paris. https://doi.org/10.1007/978-2-8178-0061-5_4

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  • DOI: https://doi.org/10.1007/978-2-8178-0061-5_4

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0060-8

  • Online ISBN: 978-2-8178-0061-5

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