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Acromégalie et grossesse

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Pathologie hypophysaire et grossesse

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Ľacromégalie représente ľensemble des signes cliniques et biologiques liés à une hypersécrétion autonome ďhormone de croissance (GH) responsable ďune augmentation de la concentration de ľinsuline-like growth factor (IGF-1), le plus souvent par un adénome hypophysaire. Affection rare dont la prévalence est de 40 à 70 cas par million ďhabitants, ľacromégalie est diagnostiquée chez la femme le plus souvent au cours de la quatrième ou cinquième décennie de vie. Ľhypersécrétion de GH et ďIGF-1 est responsable ďun syndrome clinique avec une modification des extrémitées des complications métaboliques (intolérance aux hydrates de carbone, diabète), cardiovasculaires (hypertension artérielle, cardiomyopathie, insuffisance coronarienne) et néoplasiques qui font le pronostic de ľaffection. Le retentissement de ľhypersécrétion somatotrope et du syndrome tumoral hypophysaire sur ľaxe gonadotrope explique la fréquence des troubles ovariens (aménorrhée, galactorrhée) et les problèmes ďinfertilité observés chez les patientes présentant une acromégalie.

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Caron, P. (2007). Acromégalie et grossesse. In: Pathologie hypophysaire et grossesse. Springer, Paris. https://doi.org/10.1007/978-2-287-35572-1_6

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  • DOI: https://doi.org/10.1007/978-2-287-35572-1_6

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-287-35571-4

  • Online ISBN: 978-2-287-35572-1

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