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Équilibre acido-basique

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Traité de nutrition artificielle de l’adulte

Abstrait

Le maintien ďune acidité adéquate (pH) des milieux biologiques, c’est-à-dire dans ďétroites limites, est une grande caractéristique des processus vivants, et les grandes variations de pH telles qu’on les rencontre en chimie sont incompatibles avec la vie. Le pH est une caractéristique physique du milieu et des différents métabolites présents. Ľimportance du pH est liée à la densité énergétique très particulière du proton et, de ce fait, au champ électrique important qu’il génère. À titre ďexemple, la phosphofructokinase, enzyme majeure du contrôle de la glycolyse, a une activité réduite de 90% lorsque le pH passe de 7,35 à 7,25 (1)! Les interactions entre substrats et enzyme, hormones ou autres types de messagers et récepteurs dépendent du pH, de même que les liaisons aux protéines. Le métabolisme énergétique est étroitement lié à ľétat acidobasique (voir chapitre 7) car il existe une forte relation fonctionnelle entre équilibre acido-basique, oxydation phosphorylante et métabolisme énergétique.

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Leverve, X. (2007). Équilibre acido-basique. In: Traité de nutrition artificielle de l’adulte. Springer, Paris. https://doi.org/10.1007/978-2-287-33475-7_18

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  • DOI: https://doi.org/10.1007/978-2-287-33475-7_18

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-287-33474-0

  • Online ISBN: 978-2-287-33475-7

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