Abstract
A critical review of the literature on the seasonal variation in the metabolism of fat and carbohydrate is presented. The various observations are discussed with particular reference to Edmund Hughes’ theory of vestigial function. According to this theory the seasonal variations in physiological functions and metabolic diseases of human beings are attributable to a vestigial mechanism the function of which is analogous to that of hibernation in lower animals. The seasonal growth of children, the voluntary consumption of calories, fat, and carbohydrate from month to month, and the seasonal variation in various phases of the intermediary metabolism of fat and carbohydrate all tend to support the theory to some extent. The seasonal changes in the morbidity rate, mortality rate, and geographical distribution of diabetes mellitus also are in accord with the theory. Critical experiments deduced from this theory, however, are not available. A few such experiments are suggested.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Anon., 1951: Seasonal patterns of food consumption: city families, 1948. Bureau of Human Nutrition and Home Economics, U. S. Dept. Agric., Washington, D. C., Special Report No. 3., 16 pp.
Barach, J. H., 1952: Modern concepts of the pathophysiology of diabetes mellitus. Amer. J. Dig. Dis., 19, 61–66.
Barelli, L., 1931: II distretto epato-splenico ed il suo apparato reticolo-istiocitario nel metabolismo dei grassi. Arch. 1st. biochem. ital., 3, 215–246.
Barelli, L., 1931: II distretto epato-splenico ed il suo apparato reticolo-istiocitario nel metabolismo dei grassi. Berichte ges. Physiol. exper. Pharmakol., 64, 494–495, 1932.
Benedict, F. G. and R. C. Lee, 1938: Hibernation and mar mot physiology. Carnegie Instit. Washington Publication no. 497. Washington, D. C. 239 pp.
Bernstein, J. G., 1941: The effect of thermal environment on the morphology of the thyroid and adrenal cortical glands in the albino rat. Endocrinol., 28, 985–997.
Blix, G., 1926: Studies on diabetic lipemia. I—III. Acta med. Scand.,64, 142–174; 175–233; 234–259.
Burn, J. H. and H. W. Ling, 1928: The effect of insulin on acetonuria. J. Physiol., 65, 191–203.
Burn, J. H. and H. W. Ling, 1929: The effect of pituitary extract and adrena lin on ketonuria and liver glycogen. Quart. J. Pharm. and Pharmacol., 2, 1–16.
Campbell, H. L., 1945: Seasonal changes in food consumption and rate of growth of the albino rat. Am. J. Physiol143, 428–433.
Chrometzka, F., 1940: Sommer-Winterrhythmus in men-schlichen Stoffwechsel. Der Sommer-Winterrhythmus des diabetes Stoffwechsels. Klin. Wchnschr., 19, 972–976.
Chrometzka, F., and G. Beutmann, 1940: Ommer-Winterrhythmus im Kohlehydratstoffwechsel als Ursache divergierender Operations-Hyperglykämen bei Warmblütern. Ibid., 19, 196–300.
Cori, C. F. and G. T. Cori, 1927: The fate of sugar in the animal body. IV. The tolerance of normal and insulinized rats for intravenously injected glucose and fructose. /. Biol. Chem., 72, 597–614.
Cori, G. T. and C. F. Cori, 1927: Idem V. A seasonal oc currence of ketonuria in fasting rats accompanied by changes in carbohydrate metabolism. Ibid., 72, 615–625.
Cowgill, G. R., 1928: The energy factor in relation to food intake; experiments on the dog. Amer. J. Physiol., 85, 45–64.
Currie, A. N., 1924: The cholesterol of blood in malig nant disease. Brit. J. Exp. Path., 5, 293–299.
Davis, C. M., 1928: Self-selection of diet by newly weaned infants. Amer. J. Dis. Child., 36, 651–680.
Davis, C. M., 1933: A practical application of some lessons of the self-selection of diet study to the feeding of children in hospitals. Ibid., 46, 743–750.
Davis, C. M., 1935: Choice of formulas made by three infants throughout the nursing period. Ibid., 50, 385–394.
Davis, C. M., 1939: Results of the self-selection diets by young children. Canad. Med. Assoc. J., 41, 257–261.
Dillon, E. S. and W. W. Dyer, 1937–38: Factors influencing the prognosis of diabetic coma. Ann. Int. Med., 11, 602–617.
Donhoffer, Sz. and J. Vonotzky, 1947: The effect of en vironmental temperature on food selection. Amer. J. Physiol., 150, 329–333.
Donhoffer, Sz. and J. Vonotzky, 1947: The effect of thyroxine on food intake and selection. Ibid., 150, 334–339.
Dublin, L. I. and H. H. Marks, 1952: Mortality from dia betes throughout the World. Diabetes, 1, 205–217.
Editor, 1942: Seasonal variation in diabetes mellitus; cor relation of blood phosphorus and blood sugar. J. Amer. Med. Assoc., 119, 760.
Emerson, H. and L. D. Larimore, 1924: Diabetes mellitus: a contribution to its epidemiology based chiefly upon mortality statistics. Arch. Int. Med., 34, 585–628.
Fisher, A. M. and D. A. Scott, 1934: The insulin content of the pancreas in cattle of various ages. J. Biol. Chem., 106, 305–310.
Fitt, A. B., 1941: Seasonal influence on growth, function, and inheritance. New Zealand Council for Educational Research Series no. 17. Wellington, Whitcombe and Tombs Ltd., 182 pp.
Goldberger, J., G. A. Wheeler, E. Sydenstricker, and W. L. King, 1929: A study of endemic pellagra in some cottonmill villages of South Carolina. Hygienic Laboratory Bulletin no. 153. Washington, D. C. 85 pp.
Goldblatt, M. W., 1925: Observations on the effect of vari ous carbohydrates on the ketosis of starvation in human subjects. Biochem. J., 19, 948–957.
Gray, C. H., 1938: Determination of the ketogenic activity of extracts of endocrine organs. Ibid., 32, 743–755.
Griffith, F. R., Jr., G. W. Pucher, K. A. Brownell, J. D. Klein, and M. E. Carmer, 1929: Studies in human physiology. I. The metabolism and body temperature (oral) under basal conditions. Amer. J. Physiol., 87, 602–632.
Haist, R. E.: Factors affecting the insulin content of the pancreas. Physiol. Rev., 24, 409–444.
Hallman, L. F. and E. Orent-Keiles, 1949: Seasonal variations in human fasting blood sugar levels. Proc. Soc. ex- per. Biol. & Med., 72, 171–172.
Hara, M., 1950: Formation of sugars from fat in the ani mal body. IV. Effect of adrenaline, insulin, and phlorizin upon the formation of sugars from fat. J. Japan. Biochem. Soc., 18, 100–106. (Chew. Abst 44, 10875, 1950 ).
Harte, R. A., J. J. Travers, and P. Sarich, 1948: Voluntary caloric intake of the growing rat. J. Nutrition, 36, 667–680.
Himsworth, H. P., 1935: Diet and the incidence of diabetes mellitus. Clin. Sci., 2, 117–148.
Howe, P. E. and G. H. Berryman, 1945: Average food consumption in the training camps of the United States Army (1941–1943). Amer. J. Physiol, 144, 588–594.
Hughes, E., 1931: Seasonal variation in man. London, H. K. Lewis and Co. Ltd., 126 pp.
Janowitz, H. D. and M. I. Grossman, 1949: Effect of variations in nutritive density on intake of food of dogs and rats. Amer. J. Physiol., 158, 184–193.
Jellinek, E. M. and J. M. Looney, 1936: Studies in seasonal variation of physiologic functions. I. The seasonal variation of blood cholesterol. Biometric Bull., 1, 83–95.
Joslin, E. P., 1940: The universality of diabetes. J. Amer. Med. Assoc., 115, 2033–2038.
Joslin, E. P., L. I. Dublin, and H. H. Marks, 1933: Studies in dia betes mellitus. I. Characteristics and trends of diabetes mortality throughout the world. Amer. J. Med. Sci., 185, 753–773.
Joslin, E. P., L. I. Dublin, and H. H. Marks, 1934: Idem II. Its incidence and the factors underlying its variations. Ibid., 187, 433–457.
Joslin, E. P., L. I. Dublin, and H. H. Marks, 1935: Idem III. Interpretation of the vari ations in diabetes incidence. Ibid., 189, 168–198.
Keys, A., 1949–50: The caloric requirement of adult man. Nutrition Abst. & Rev., 19, 1–10.
Kubie, L. S., 1948: Instincts and homeostasis. Psychoso matic Med., 10, 15–30.
Lánczos, A., 1933: Über die Wirkung vegetativer Nerven-gifte auf den Fettstoffwechsel. P fluger’s Arch., 231, 571–576.
Levine, H. and A. H. Smith, 1927: Studies on ketosis in the rat. J. Biol Chem., 75, 1–22.
Looney, J. M. and H. M. Childs, 1933: The blood cholesterol in schizophrenia. Arch. Neurol Psychiat., 30, 567–579.
MacLeod, J. J. R. and M. D. Orr, 1924: Observations on the physiological assay of insulin. J. Lab. & Clin. Med., 9, 591–608.
Maignon, F. and L. Jung, 1924: Relation entre Tinfluence des saisons sur la sensibilité de l’organisme à l’intoxication azoteé et l’aptitude de cet organisme à transformer les proteines en graisse. Comp. rend. soc. de biol, 91, 1390–1393.
McEachern, J. M. and C. R. Gilmour, 1932: Studies in cholesterol metabolism. 2. Blood cholesterol in various conditions. Canad. Med. Assoc. J., 26, 158–159.
McHenry, E. W. and J. M. Patterson, 1944: Lipotropic factors. Physiol Rev., 24, 128–167.
Mills, C. A., 1930: Diabetes mellitus. Sugar consumption in its etiology. Arch. Int. Med., 46, 582–584.
Mills, C. A., 1939: Medical climatology. Springfield, C. C. Thomas, 296 pp.
Munoz, J. M., 1933: Les variations horaires et journalieres des acides gras totaux du sang. Comp. rend. soc. de biol, 114, 803–806.
Munoz, J. M., 1935: Lipemie post-absorptive selon le regime et lessaisons. Ibid., 118, 589–590.
Murlin, J. R. and F. M. Hildebrandt, 1919: Average food consumption in the training camps of the United States Army. Amer. J. Physiol, 49, 531–556.
Nakamura, S. and K. Ando, 1944: Formation of sugars from fat in the animal body. III. Respiratory Quotient (R.Q.) and D: N Ratio of the urine under fat diet and phlorizin injection. /. Japan. Biochem. Soc., 18, 97–99.
Nakamura, S. and K. Ando, 1944: Formation of sugars from fat in the animal body. III. Respiratory Quotient (R.Q.) and D: N Ratio of the urine under fat diet and phlorizin injection. /. Chem. Abst., 44, 10875, 1950.
Nitzescu, I. I., 1927: Existe-t-il une variation saisonnière dans la quantité de linsulin? Comp. rend. soc. de biol, 96, 68–69.
Odorfer, M., 1949: Seasonal structural changes in the adenohypophysis of guinea pigs. Hung. Acta Physiol, 2, 21–49.
Odorfer, M., 1949: Seasonal structural changes in the adenohypophysis of guinea pigs. Chem. Abst., 45, 8615, 1951.
Owens, L. B. and C. A. Mills, 1940: Influence of season on the severity of diabetes and sclerotic complications. Amer. J. Med., 199, 705–708.
Pannhorst, R. and A. Rieger, 1938: Manifestierung des Diabetes und Jahreszeit. Z. klin. Med., 134, 154–160.
Petersen, W. F., 1937. The patient and the weather. Vol IV, . Pt. 2. Organic disease. Ann Arbor, Edwards Bros., pp. 182–189; 192–193.
Pucher, G. W., F. R. Griffith, Jr., K. A. Brownell, J. D. Klein, and M. E. Carmer, 1934: Studies in human physiology. VI. Variations in blood chemistry over long periods of time, including those characteristic of menstruation. J. Nutrition, 7, 169–193.
Richter, C. P., 1942–43: Total self regulatory functions in animals and human beings. Harvey Led., 38, 63–103.
Sargent, F., II, 1951: A critique of homeostasis: season and metabolism. Arch. MeteorGeophys. u. Biokl., Serie B, 3, 289–296.
Sargent, F., 1952: The physiology and pathophysiology of ketone bodies, with particular reference to stress. In Preparation.
Sargent, F., and V. W. Sargent, 1950: Season, nutrition, and pellagra. New England J. Med., 247, 447–453; 507–514.
Sayers, G., 1951: Regulation of the secretory activity of the adrenal cortex. Amer. J. Med., 10, 539–548.
Sayers, G., and M. A. Sayers, 1949: The pituitary-adrenal system. Ann. N. Y. Acad. Sci., 50, 522–539.
Schiffer, F. and E. Wertheimer, 1947: Leanness in adrenal-ectonized rats. J. Endocrinol, 5, 147–151.
Schlegel, J. U., 1949: Seasonal variations in the choline content of human serum. Proc. Soc. exp. Biol & Med., 70, 695–697.
Schlegel, J. U., 1949: Fluctuations of serum choline in women. Amer. J. Physiol, 158, 345–350.
Schlegel, J. U., 1950: Seasonal variations in the choline content of human serum. Acta med. Scand., Suppl. 239, 410–413.
Soskin, S. and R. Levine, 1946: Carbohydrate metabolism. Chicago, Univ. Chicago Press, 315 pp.
Stiebeling, H. K. and E. F. Phipard, 1939: Diets of cmployed wage earners and clerical workers in cities. Circ. no. 507, U. S. Dept. of Agric., Washington, D. C. 141 pp.
Strouse, S., 1920: Some variations in normal blood sugar. Arch. Int. Med., 26, 751–758.
Taylor, H. L., J. Brozek, A. Henschel, O. Mickelsen, and A. Keys, 1945: The effect of successive fasts on the ability of men to withstand fasting during hard work. Amer. J. Physiol., 143, 148–155.
Tsukernik, M. V., 1938: Effect of hibernation on the glycogen, lactic acid, and ketone-body contents of the muscle. Biochem. J. (Ukraine), 12, 530–542. (Chem. Abst)., 33, 8746, 1939.
Tuerkischer, E. and E. Wertheimer, 1942: Glycogen and adipose tissue. J. Physiol., 100, 385–409.
Wade, O., 1948: Rapid fat production by ground squirrels preceding hibernation. Nat. Hist. Misc., Chicago Acad. Sci., no. 28. 3 pp.
Wertheimer, E. and V. Ben-Tor, 1950: Adaptation of car bohydrate metabolism to undernutrition. Brit. J. Nutrition, 4, 1–8.
Wertheimer, E, and B. Shapiro, 1948: The physiology of adipose this sue. Physiol. Rev., 28, 451–464.
Whyte, L. L., 1950: The next development in man. New York, New Amer. Lib. of World Literature, Inc., p. 22.
Wilbur, C. G., 1951: Fat metabolism in arctic as compared with temperate zone mammals. Bull. Nat. Res. Council no. 122, pp. 88–89.
Wilbur, C. G., and X. J. Musacchia, 1950: Fat metabolism in the arctic ground squirrel. J. Mammol., 31, 304–309.
Woods, R., 1949: A history of self-selection of diet. I. Borden’s Rev. of Nutr. Res., 10, 1–9.
Woods, R., 1949: Self-selection of diet. II. Experimental investigation. Ibid., 10, 1–16.
Young, P. T., 1948: Appetite, palatability and feeding habit: a critical review. Psychol. Bull., 45, 289–320.
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 1954 American Meteorological Society
About this chapter
Cite this chapter
Sargent, F. (1954). Season and the Metabolism of Fat and Carbohydrate: A Study of Vestigial Physiology. In: Sargent, F., Stone, R.G. (eds) Recent Studies in Bioclimatology. Meteorological Monographs, vol 2. American Meteorological Society, Boston, MA. https://doi.org/10.1007/978-1-940033-11-2_8
Download citation
DOI: https://doi.org/10.1007/978-1-940033-11-2_8
Publisher Name: American Meteorological Society, Boston, MA
Online ISBN: 978-1-940033-11-2
eBook Packages: Springer Book Archive