Abstract
Adherence or compliance with a medication regimen is generally defined as the extent to which patients take medications as prescribed. The term “compliance” has fallen out of favor as it implies a power imbalance between clinician and patient. The pejorative labeling of a patient as “noncompliant” is not therapeutically productive. The term “adherence” is more consistent with a shared decision-making model and the establishment of a therapeutic alliance. It is common in research studies of adherence to categorize a patient as adherent if they take at least 80 % of their prescribed medication.
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References
Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005;353:487–497.
Velligan DI, Weiden PJ, Sajatovic M, et al. The expert consensus guideline series: adherence problems in patients with serious and persistent mental illness. J Clin Psychiatry. 2009;70(suppl 4):1–46.
Velligan DI, Wang M, Diamond P, et al. Relationships among subjective and objective measures of adherence to oral antipsychotic medications. Psychiatr Serv. 2007;58:1187–1192.
Velligan DI, Lam YW, Glahn DC, et al. Defining and assessing adherence to oral antipsychotics: a review of the literature. Schizophr Bull. 2006;32:724–742.
Valenstein M, Ganoczy D, McCarthy JF, Kim HM, Lee TA , Blow FC . Antipsychotic adherence over time among patients receiving treatment for schizophrenia: a retrospective review. J Clin Psychiatry. 2006;67:1542–1550.
Byerly MJ, Nakonezny PA, Lescouflair E. Antipsychotic medication adherence in schizophrenia. Psychiatr Clin North Am. 2007;30:437–452.
Perkins DO. Predictors of noncompliance in patients with schizophrenia. J Clin Psychiatry. 2002;63:1121–1128.
Lacro JP, Dunn LB, Dolder CR, Leckband SG, Jeste DV. Prevalence of and risk factors for medication nonadherence in patients with schizophrenia: a comprehensive review of recent literature. J Clin Psychiatry. 2002;63:892–909.
Weiden P, Rapkin B, Zygmunt A, Mott T, Goldman D, Frances A. Postdischarge medication compliance of inpatients converted from an oral to a depot neuroleptic regimen. Psychiatr Serv. 1995;46:1049–1054.
Weiden PJ. Understanding and addressing adherence issues in schizophrenia: from theory to practice. J Clin Psychiatry. 2007;68(suppl 14):14–19.
Frank AF , Gunderson JG. The role of the therapeutic alliance in the treatment of schizophrenia. Relationship to course and outcome. Arch Gen Psychiatry. 1990;47:228–236.
Lincoln TM , Lüllmann E, Rief W. Correlates and long-term consequences of poor insight in patients with schizophrenia. A systematic review. Schizophr Bull. 2007;33:1324–1342.
Citrome L. Treatment-refractory schizophrenia: what is it and what has been done about it? Neuropsychiatry. 2011;1:325–347.
Weiden PJ, Buckley PF. Reducing the burden of side effects during long-term antipsychotic therapy: the role of “switching” medications. J Clin Psychiatry. 2007;68(suppl 6):14–23.
Tandon R. Safety and tolerability: how do newer generation “atypical” antipsychotics compare? Psychiatr Q. 2002;73:297–311.
Ascher-Svanum H, Zhu B, Faries D, Lacro JP, Dolder CR . A prospective study of risk factors for nonadherence with antipsychotic medication in the treatment of schizophrenia. J Clin Psychiatry. 2006;67:1114–1123.
Regier DA , Farmer ME , Rae DS , et al. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA ) Study. JAMA. 1990;264:2511–2518.
Lybrand J, Caroff S. Management of schizophrenia with substance use disorders. Psychiatr Clin North Am. 2009;32:821–833.
Lieberman JA, Stroup TS , McEvoy JP, et al; Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE ) Investigators. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med. 2005;353:1209–1223.
Van Dorn RA, Desmarais SL, Scott Young M, Sellers BG, Swartz MS. Assessing illicit drug use among adults with schizophrenia. Psychiatry Res. 2012;200:228–236.
Kerfoot KE , Rosenheck RA , Petrakis IL, et al; CATIE Investigators. Substance use and schizophrenia: adverse correlates in the CATIE study sample. Schizophr Res. 2011;132:177–182.
Velligan DI, Weiden PJ, Sajatovic M, et al. Assessment of adherence problems in patients with serious and persistent mental illness: recommendations from the Expert Consensus Guidelines. J Psychiatr Pract. 2010;16:34–45.
Weiden PJ. Why did John Nash stop his medication? J Psychiatr Pract. 2002;8:386–392.
McCabe R, Heath C, Burns T, Priebe S. Engagement of patients with psychosis in the consultation: conversation analytic study. BMJ. 2002;325:1148–1151.
Velligan D, Diamond PM, Mintz J, et al. The use of individually tailored environmental supports to improve medication adherence and outcomes in schizophrenia. Schizophr Bull. 2008;34:483–493.
McEvoy JP. Risks versus benefits of different types of long-acting injectable antipsychotics. J Clin Psychiatry. 2006;67(suppl 5):15–18.
Kane JM, Leucht S, Carpenter D, Docherty JP. Optimizing pharmacologic treatment of psychotic disorders. Introduction: methods, commentary, and summary. J Clin Psychiatry. 2003;64(suppl 12):5–19.
Leucht C, Heres S, Kane JM et al. Oral versus depot antipsychotic drugs for schizophrenia - a critical systematic review and meta-analysis of randomised long-term trials. Schizophr Res. 2011;127:83–92.
Patel MX , De Zoysa N, Baker D, David AS . Antipsychotic depot medication and attitudes of community psychiatric nurses. J Psychiatr Ment Health Nurs. 2005;12:237–244.
Citrome L. Patient perspectives in the development and use of long-acting antipsychotics in schizophrenia: focus on olanzapine long-acting injection. Patient Prefer Adherence. 2009;3:345–355.
Citrome L. Paliperidone palmitate – review of the efficacy, safety and cost of a new second-generation depot antipsychotic medication. Int J Clin Pract. 2010;64:216–239.
Citrome L, Levine J, Allingham B. Utilization of depot neuroleptic medication in psychiatric inpatients. Psychopharmacol Bull. 1996;32:321–326.
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Citrome, L. (2013). Adherence: The Great Masquerader of Treatment-Resistance. In: Handbook of Treatment-resistant Schizophrenia. Springer Healthcare, Tarporley. https://doi.org/10.1007/978-1-908517-88-3_3
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DOI: https://doi.org/10.1007/978-1-908517-88-3_3
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