Skip to main content
SpringerLink
Log in

Sleep-Related Symptoms

  • Chapter
  • First Online:
Handbook of Non-Motor Symptoms in Parkinson's Disease

  • 1136 Accesses

Abstract

Nearly all Parkinson’s disease (PD) patients have sleep disturbances that usually start early in the disease onset, with studies indicating a prevalence of 60–98 % [1–3]. The more common are rapid eye movement (REM), sleep behavior disorder (RBD), insomnia, nightmares, snoring, restless legs syndrome (RLS) and sleep ambulism. The pathogenesis of sleep disruption is multifactorial, but degeneration of central sleep regulation centers in the brain stem and thalamocortical pathways is likely to be important. The pedunculopontine nucleus, locus ceruleus and retrorubral nucleus influence normal REM atonia and phasic generator circuitry, and have been implicated in the pathogenesis of RBD [4, 5]. Other factors that may contribute to sleep disruption include motor symptoms, anxiety, depression and dopaminergic treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Lees AJ, Blackburn NA, Campbell VL. The nighttime problems of Parkinson’s disease. Clin Neuropharmacol 1988;11:512-519.

    Google Scholar 

  2. Chaudhuri KR. Nocturnal symptom complex in PD and its management. Neurology 2003;61:S17-S23.

    Google Scholar 

  3. Garcia-Borreguero D, Larosa O, Bravo M. Parkinson’s disease and sleep. Sleep Med Rev 2003a;7:115-129.

    Google Scholar 

  4. Lai YY, Siegel JM. Muscle tone suppression and stepping produced by stimulation of midbrain and rostral pontine reticular formation. J Neurol 1990;10:2727-2734.

    Google Scholar 

  5. Rye DB, Jankovic J. Emerging views of dopamine in modulating sleep/wake state from an unlikely source: PD. Neurology 2002;58:341-346.

    Google Scholar 

  6. Arnulf I, Konofal E, Merino-Andreu M, et al. Parkinson’s disease and sleepiness – an integral part of PD. Neurology 2002;58:1019-1024.

    Google Scholar 

  7. Mehta SH, Morgan JC, Sethi KD. Sleep disorders associated with Parkinson’s disease: role of dopamine, epidemiology, and clinical scales of assessment. CNS Spectr 200813(Suppl 4):6-11.

    Google Scholar 

  8. Kunz D, Mahlberg R. A two-part, double-blind, placebo-controlled trial of exogenous melatonin in REM sleep behavior disorder. J Sleep Res 2010; 19:591-596.

    Google Scholar 

  9. Schapira AH. Restless legs syndrome: an update on treatment options. Drugs 2004;64:149-158.

    Google Scholar 

  10. Muzerengi S, Lewis H, Chaudhuri KR. Restless legs syndrome: a review of diagnosis and management. Int J Sleep Disord 2006;1:34-46.

    Google Scholar 

  11. Peralta CM, Frauscher B, Seppi K, et al. Restless legs syndrome in Parkinson’s disease. Mov Disord 2009;24:2076-2080.

    Google Scholar 

  12. Mitra T, Chaudhuri K. Sleep dysfunction and role of dysautonomia in Parkinson’s disease. Parkinsonism Relat Disord 2009;15:S93-S95.

    Google Scholar 

  13. Möller JC, Unger M, Stiasny-Kolster K, Oertel WH. Restless legs syndrome (RLS) and Parkinson’s disease (PD)-related disorders or different entities? J Neurol Sci 2010;289:135-137.

    Google Scholar 

  14. Ondo WG, Vuong KD, Jankovic J. Exploring the relationship between Parkinsons’disease and restless legs syndrome. Arch Neurol 2002;59:421-424.

    Google Scholar 

  15. Garcia-Borreguero D, Odin P, Serrano C. Restless legs syndrome and Parkinson: A review of the evidence for a possible association. Neurology 2003b;61:49-55.

    Google Scholar 

  16. Reuter I, Ellis CM, Chaudhuri KR. Nocturnal subcutaneous apomorphine infusion in Parkinson’s disease and restless legs syndrome. Acta Neurol Scand 1999;100:163-167.

    Google Scholar 

  17. Högl B, Rotdach A, Wetter TC, Trenkwalder C. The effect of cabergoline on sleep, periodic leg movements in sleep and early morning motor function in patients with Parkinson’s disease. Neuropsychopharmacology 2003;28:1866-1870.

    Google Scholar 

  18. Zesiewicz TA, Sullivan KL, Arnulf I; for Quality Standards Subcommittee of the American Academy of Neurology Practice. Parameter: treatment of nonmotor symptoms of Parkinson disease: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2010;74:924-931.

    Google Scholar 

  19. Chaudhuri K, Schapira A. Non-motor symptoms of Parkinson’s disease: dopaminergic pathophysiology and treatment. Lancet Neurol 2009;8:464-474.

    Google Scholar 

  20. Dhawan V, Healy DG, Pal S, Chaudhuri KR. Sleep-related problems in Parkinson’s disease. Age Aging 2006;35:220-228.

    Google Scholar 

  21. Leeman AL, O’Neill CJ, Nicholson PW, et al. Parkinson’s disease in the elderly: response to and optimal spacing of night-time dosing with levodopa. Br J Clin Pharmacol 1987;24:637-643.

    Google Scholar 

  22. Stocchi F, Barbato L, Nordera G, et al. Sleep disorders in Parkinson’s disease. J Neurol 1998;245:S15-S18.

    Google Scholar 

  23. Van der Kerchowe M, Jacquy J, Gonce M, et al. Sustained-release levodopa in parkinsonian patients with nocturnal disabilities. Acta Neurol Belg 1993;93:32-39.

    Google Scholar 

  24. Chaudhuri KR, Bhattacharya K, Agapito C, et al. The use of cabergoline in nocturnal parkinsonian disabilities causing sleep disruption: a parallel study with controlled-release levodopa. Eur J Neurol 1999;6:S11-S15.

    Google Scholar 

  25. Poewe W, Rascol O, Quinn N, et al; on behalf of the Sp515 investigators. Efficacy of pramipexole and transdermal rotigotine in advanced Parkinson’s disease: a double blind, double dummy randomized controlled trial. Lancet Neurol 2007;6:513-520.

    Google Scholar 

  26. Pahwa R, Stady MA, Factor SA, et al; on behalf of the EASE-PD adjunct study investigators. Ropinirole 24 hours prolonged release randomized controlled study in advanced Parkinson’s disease. Neurology 2007;68:1108-1115.

    Google Scholar 

  27. Trenkwalder C, Kies B, Rudsinska M, et al; and the RECOVER study group. Rotigotine effects on early morning motor function and sleep in Parkinson’s disease: A double-blind, randomised, placebo-controlled study (RECOVER). Mov Disord 2011;26:90-99.

    Google Scholar 

  28. Chaudhuri KR, Martinez-Martin P, Rolfe KA, et al. Improvements in nocturnal symptoms with ropinirole prolonged release in patients with advanced Parkinson’s disease. Eur J Neurol 2011. E-Pub. doi: 10.1111/j.1468-1331.2011.03442.x.

  29. Trenkwalder C, Zucconi M, Tolosa E, et al. Effects of transdermal rotigotine on sleep and nocturnal symptoms over a 1-year period in Parkinson’s disease: an open-label extension of the RECOVER study. In: Proceedings from the World Association of Sleep Medicine and Canadian Sleep Society Congress; September 10-15, 2011; Quebec City, Canada. Abstract M-E-053.

    Google Scholar 

  30. Ghys L, Surmann E, Whitesides J, Boroojerdi B. Effect of rotigotine on sleep and quality of life in Parkinson’s disease patients: post hoc analysis of RECOVER patients who were symptomatic at baseline. Expert Opin Pharmacother 2011;12:1985-1998.

    Google Scholar 

  31. Korczyn AD. Management of sleep problems in Parkinson’s disease. J Neurol Sci 2006;248:163-166.

    Google Scholar 

  32. Abbott RD, Ross GW, White LR, et al. Excessive daytime sleepiness and the risk of Parkinson’s disease. Mov Disord 2005;20:S101.

    Google Scholar 

  33. Schapira AH. Excessive daytime sleepiness in Parkinson’s disease. Neurology 2004;63:S24-S27.

    Google Scholar 

  34. Macmahon D. Why excessive daytime sleepiness is an important issue in Parkinson’s disease. Adv Clin Neurol Rehab 2005;5:46-49.

    Google Scholar 

  35. Saper C, Chou TC, Scammell TE. The sleep switch: Hypothalamic control of sleep and wakefulness. Trends Neurosci 2001;24:726-731.

    Google Scholar 

  36. Haq I, Naidu Y, Reddy P, Chaudhuri KR. Narcolepsy in Parkinson’s disease. Exp Rev Neurother 2010;10:879-884.

    Google Scholar 

  37. Andreu N, Chale J–J, Senard J-M, et al. L-Dopa-induced sedation: a double-blind cross-over controlled study versus trazolam and placebo in healthy volunteers. Clin Neuropharmacol 1999;22:15-23.

    Google Scholar 

  38. Frucht S, Rogers JD, Greene PE, et al. Falling asleep at the wheel: motor vehicle mishaps in persons taking pramipexole and ropinirole. Neurology 1999;52:1908-1910.

    Google Scholar 

  39. Ferreira JJ, Galitzky M, Montastruc JL, Rascol O. Sleep attacks in Parkinson’s disease. Lancet 2000;355:1333-1334.

    Google Scholar 

  40. Arnulf I, Leu-Semenescu S. Sleepiness in Parkinson’s disease. Parkinsonism Relat Disord 2009;15(suppl 3):S101-S104.

    Google Scholar 

  41. Boeve BF, Silber MH, Saper B, et al. Pathophysiology of REM sleep behavior disorder and relevance to neurodegenerative disease. Brain 2007;130:2770-2788.

    Google Scholar 

  42. Comella C. Sleep disorders in Parkinson’s disease: an overview. Mov Disord 2007;22:S367-S373.

    Google Scholar 

  43. Schenck CH, Bundle SR, Mahowald MW. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder. Neurology 1996;46:388-393.

    Google Scholar 

  44. Chaudhuri KR, Healy DG, Schapira AH. Non-motor symptoms of Parkinson’s disease: Diagnosis and management. Lancet Neurol 2006;5:235-245.

    Google Scholar 

  45. Tan A, Salgado M, Fahn S. Rapid eye movement sleep behavior disorder preceding Parkinson’s disease with therapeutic response to levodopa. Mov Disord 1996;11:214-216.

    Google Scholar 

  46. Schenck CH, Mahowald ME. REM-sleep behavior disorder: clinical, developmental and neuroscience perspectives 16 years after its formal identification in SLEEP. Sleep 2002;25:120-138.

    Google Scholar 

  47. Iranzo A, Molinuevo JL, Santamaria J, et al. Rapid-eye movement sleep behavior disorder as an early marker for neurodegenerative disorder: a descriptive study. Lancet Neurol 2006;5:572-577.

    Google Scholar 

  48. Eisensehr I, Linke R, Noachtar S, et al. Reduced striatal dopamine transporters in idiopathic rapid eye movement sleep behavior disorder: Comparison with Parkinson’s disease and controls. Brain 2000;123:1155-1160.

    Google Scholar 

  49. Stiasny-Kolster K, Doerr Y, Moller JC, et al. Combination of idiopathic RE M sleep behavior disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT. Brain 2005;128:126-137.

    Google Scholar 

  50. Unger MM, Moeller JC, Stiasny-Kolster K, et al. Assessment of idiopathic rapid-eye-movement sleep behavior disorder by transcranial sonography, olfactory function test, and FP-CIT-SPECT. Mov Disord 2008;23:596-599.

    Google Scholar 

  51. Postuma RB, Gagnon JF, Rompre S, Montplaisir JY. Severity of RE M atonia loss in idiopathic REM sleep behavior disorder predicts Parkinson disease. Neurology 2010;74:239-244.

    Google Scholar 

  52. Wolters E, Braak J. Parkinson’s disease: Premotor clinico-pathological correlations. J Neurol Transm 2006;79:309-319.

    Google Scholar 

  53. Olson EJ, Boeve BF, Silber MH. Rapid eye movement sleep behavior disorder: demographic, clinical and laboratory findings in 93 cases. Brain 2000;123:331-339.

    Google Scholar 

  54. Cochen De Cock V, Abouda M, Leu S, et al. Is obstructive sleep apnea a problem in Parkinson’s disease? Sleep Med 2010;11:247-252.

    Google Scholar 

  55. Högl B. Sleep apnea in Parkinson’s disease: when is it significant? Sleep Med 2010;11:233-235.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, Bremerhaven, Germany

    Per Odin

Authors
  1. Per Odin
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Healthcare, a part of Springer Science+Business Media

About this chapter

Cite this chapter

Odin, P. (2011). Sleep-Related Symptoms. In: Handbook of Non-Motor Symptoms in Parkinson's Disease. Springer Healthcare, Heidelberg. https://doi.org/10.1007/978-1-908517-60-9_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-908517-60-9_6

  • Published:

  • Publisher Name: Springer Healthcare, Heidelberg

  • Print ISBN: 978-1-907673-23-8

  • Online ISBN: 978-1-908517-60-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation