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Overview of Axial Spondyloarthritis

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Clinician’s Manual on Axial Spondyloarthritis

Abstract

The term “spondyloarthritis” (SpA) comprises ankylosing spondylitis (AS), reactive arthritis, arthritis/spondylitis associated with psoriasis, and arthritis/spondylitis associated with inflammatory bowel disease (IBD).

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References

  1. Rudwaleit M, Khan MA, Sieper J. The challenge of diagnosis and classification in early ankylosing spondylitis: do we need new criteria? Arthritis Rheum. 2005;52:1000-1008.

    Google Scholar 

  2. Dougados M, van der Linden S, Juhlin R, et al. The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy. Arthritis Rheum. 1991;34:1218‑1227.

    Google Scholar 

  3. Amor B, Dougados M, Mijiyawa M. [Criteria of the classification of spondylarthropathies]. Rev Rhum Mal Osteoartic.1990;57:85-89.

    Google Scholar 

  4. Rudwaleit M, van der Heijde D, Landewe R, et al. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis. 2009;68:777-783.

    Google Scholar 

  5. Feldtkeller E, Bruckel J, Khan MA. Scientific contributions of ankylosing spondylitis patient advocacy groups. Curr Opin Rheumatol. 2000;12:239-247.

    Google Scholar 

  6. Rudwaleit M, Haibel H, Baraliakos X, et al. The early disease stage in axial spondylarthritis: results from the German Spondyloarthritis Inception Cohort. Arthritis Rheum. 2009;60:717‑727.

    Google Scholar 

  7. Calin A, Fries JF. Striking prevalence of ankylosing spondylitis in “healthy” w27 positive males and females. N Engl J Med. 1975;293:835-839.

    Google Scholar 

  8. van der Linden SM, Valkenburg HA, de Jongh BM, Cats A. The risk of developing ankylosing spondylitis in HLA-B27 positive individuals. A comparison of relatives of spondylitis patients with the general population. Arthritis Rheum. 1984;27:241-249.

    Google Scholar 

  9. Braun J, Listing J, Sieper J, et al. Reply. Arthritis Rheum. 2005;52:4049-4059.

    Google Scholar 

  10. Gran JT, Husby G, Hordvik M. Prevalence of ankylosing spondylitis in males and females in a young middle-aged population of Tromso, northern Norway. Ann Rheum Dis. 1985;44:359‑367.

    Google Scholar 

  11. Gofton JP, Robinson HS, Trueman GE. Ankylosing spondylitis in a Canadian Indian population. Ann Rheum Dis. 1966;25:525-527.

    Google Scholar 

  12. Saraux A, Guillemin F, Guggenbuhl P, et al. Prevalence of spondyloarthropathies in France: 2001. Ann Rheum Dis. 2005;64:1431-1435.

    Google Scholar 

  13. Guillemin F, Saraux A, Guggenbuhl P, et al. Prevalence of rheumatoid arthritis in France: 2001. Ann Rheum Dis. 2005;64:1427-1430.

    Google Scholar 

  14. Adomaviciute D, Pileckyte M, Baranauskaite A, Morvan J, Dadoniene J, Guillemin F. Prevalence survey of rheumatoid arthritis and spondyloarthropathy in Lithuania. Scand J Rheumatol. 2008;37:113-119.

    Google Scholar 

  15. Helmick CG, Felson DT, Lawrence RC, et al; National Arthritis Data Workgroup. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis Rheum. 2008;58:15-25.

    Google Scholar 

  16. Sieper J, Rudwaleit M, Khan MA, Braun J. Concepts and epidemiology of spondyloarthritis. Best Pract Res Clin Rheumatol. 2006;20:401-417.

    Google Scholar 

  17. Reveille JD, Witter JP, Weisman MH. Prevalence of axial spondylarthritis in the United States: Estimates from a cross-sectional survey. Arthritis Rheum. 2012;64:905-910.

    Google Scholar 

  18. Rudwaleit M, Sieper J. Referral strategies for early diagnosis of axial spondyloarthritis. Nat Rev Rheumatol. 2012;8:262-268.

    Google Scholar 

  19. Poddubnyy D, Brandt H, Vahldiek J, et al. The frequency of non-radiographic axial spondyloarthritis in relation to symptom duration in patients referred because of chronic back pain: results from the Berlin early spondyloarthritis clinic. Ann Rheum Dis. 2012;71:1998-2001.

    Google Scholar 

  20. Brewerton DA, Hart FD, Nicholls A, Caffrey M, James DC, Sturrock RD. Ankylosing spondylitis and HL-A 27. Lancet. 1973;1:904-907.

    Google Scholar 

  21. Sieper J, Braun J, Kingsley GH. Report on the Fourth International Workshop on Reactive Arthritis. Arthritis Rheum. 2000;43:720-734.

    Google Scholar 

  22. Maksymowych WP. Ankylosing spondylitis--at the interface of bone and cartilage. J Rheumatol. 2000;27:2295-2301.

    Google Scholar 

  23. Appel H, Kuhne M, Spiekermann S,et al. Immunohistochemical analysis of hip arthritis in ankylosing spondylitis: evaluation of the bone-cartilage interface and subchondral bone marrow. Arthritis Rheum. 2006;54:1805-1813.

    Google Scholar 

  24. Appel H, Sieper J. Spondyloarthritis at the crossroads of imaging, pathology, and structural damage in the era of biologics. Curr Rheumatol Rep. 2008;10:356-363.

    Google Scholar 

  25. Appel H, Maier R, Wu P, et al. Analysis of IL-17 + cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response. Arthritis Res Ther. 2011;13:R95.

    Google Scholar 

  26. Appel H, Maier R, Bleil J, et al. In situ analysis of interleukin–23– and interleukin-12–positive cells in the spine of patients with ankylosing spondylitis. Arthritis Rheum. 2013;65:1522-1529.

    Google Scholar 

  27. Sherlock JP, Joyce-Shaikh B, Turner SP, et al. IL-23 induces spondyloarthropathy by acting on ROR -γt + CD 3 + CD 4-CD 8- entheseal resident T cells. Nat Med. 2012;18:1069-1076.

    Google Scholar 

  28. Sieper J, Appel H, Braun J, Rudwaleit M. Critical appraisal of assessment of structural damage in ankylosing spondylitis: implications for treatment outcomes. Arthritis Rheum. 2008;58:649‑656.

    Google Scholar 

  29. Maksymowych WP, Chiowchanwisawakit P, Clare T, Pedersen SJ, Østergaard M, Lambert RG. Inflammatory lesions of the spine on magnetic resonance imaging predict the development of new syndesmophytes in ankylosing spondylitis: evidence of a relationship between inflammation and new bone formation. Arthritis Rheum. 2009;60:93-102.

    Google Scholar 

  30. Baraliakos X, Listing J, Rudwaleit M, et al. Progression of radiographic damage in patients with ankylosing spondylitis: defining the central role of syndesmophytes. Ann Rheum Dis. 2007;66:910-915.

    Google Scholar 

  31. Amor B, Santos RS, Nahal R, Listrat V, Dougados M. Predictive factors for the longterm outcome of spondyloarthropathies. J Rheumatol. 1994;21:1883-1887.

    Google Scholar 

  32. Poddubnyy D, Rudwaleit M, Haibel H, et al. Rates and predictors of radiographic sacroiliitis progression over 2 years in patients with axial spondyloarthritis. Ann Rheum Dis. 2011;70:1369-1374.

    Google Scholar 

  33. Poddubnyy D, Haibel H, Listing J, et al. Baseline radiographic damage, elevated acute-phase reactant levels, and cigarette smoking status predict spinal radiographic progression in early axial spondylarthritis. Arthritis Rheum. 2012;64:1388-1398.

    Google Scholar 

  34. Brown MA, Kennedy LG, MacGregor AJ,et al. Susceptibility to ankylosing spondylitis in twins: the role of genes, HLA, and the environment. Arthritis Rheum. 1997;40:1823-1828.

    Google Scholar 

  35. Burton PR, Clayton DG, Cardon LR, et al; Wellcome Trust Case Control Consortium; Australo-Anglo-American Spondylitis Consortium (TASC). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet. 2007;39:1329-1337.

    Google Scholar 

  36. Evans DM, Spencer CC, Pointon JJ, et al; Australo-Anglo-American Spondyloarthritis Consortium (TASC); Wellcome Trust Case Control Consortium 2 (WTCCC2). Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet. 2011;43:761-767.

    Google Scholar 

  37. Brown MA, Laval SH, Brophy S, Calin A. Recurrence risk modelling of the genetic susceptibility to ankylosing spondylitis. Ann Rheum Dis. 2000;59:883-886.

    Google Scholar 

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Sieper, J., Braun, J. (2014). Overview of Axial Spondyloarthritis. In: Clinician’s Manual on Axial Spondyloarthritis. Springer Healthcare, Tarporley. https://doi.org/10.1007/978-1-907673-85-6_2

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  • DOI: https://doi.org/10.1007/978-1-907673-85-6_2

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  • Publisher Name: Springer Healthcare, Tarporley

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