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Experimental Basis and Clinical Studies of Brain Protection in Aortic Arch Surgery

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Brain Protection in Cardiac Surgery

Abstract

The management of complex aortic arch disease has been and continues to be dependent upon reproducible neuronal protection strategies. Over the last 2 decades, numerous brain protection strategies have been investigated and employed in clinical practice. Since 1975, prolonged interruption of antegrade brain perfusion for the resection of aortic arch and ascending aortic aneurysms has relied principally on hypothermic circulatory arrest (HCA).1 This method of brain protection has been embraced and still remains the primary brain protection strategy used by adult and pediatric cardiac surgeons worldwide. As surgical techniques have become more sophisticated, and our understanding of brain metabolism has improved, however, other strategies for brain protection have been introduced. Regardless of the methodology, the common denominator in almost all the strategies is hypothermia.

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Author information

Authors and Affiliations

  1. Department of Cardiothoracic Surgery, Mount Sinai School of Medicine, New York, USA

    Gabriele Di Luozzo

Authors
  1. Gabriele Di Luozzo
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  2. Randall B. Griepp
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Correspondence to Gabriele Di Luozzo .

Editor information

Editors and Affiliations

  1. Dept. Cardiothoracic Surgeon, Queen Elizabeth Hospital, Birmingham, B15 2TH, United Kingdom

    Robert S. Bonser

  2. Cardiothoracic Surgery, Beaumont Road 208, Birmingham, B30 1NX, United Kingdom

    Domenico Pagano

  3. Klinik für Herz-, Thorax-,, Transplantations- und Gefäßchirurgie, Medizinische Hochschule Hannover (MHH), Carl-Neuberg-Str. 1, Hannover, 30625, Germany

    Axel Haverich

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Di Luozzo, G., Griepp, R.B. (2011). Experimental Basis and Clinical Studies of Brain Protection in Aortic Arch Surgery. In: Bonser, R., Pagano, D., Haverich, A. (eds) Brain Protection in Cardiac Surgery. Springer, London. https://doi.org/10.1007/978-1-84996-293-3_18

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  • DOI: https://doi.org/10.1007/978-1-84996-293-3_18

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84996-292-6

  • Online ISBN: 978-1-84996-293-3

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