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Diagnosis and Prevention of Bullous Diseases

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Preventive Dermatology

Abstract

Bullous diseases may be broadly divided into the inherited, autoimmune, and infectious types. This chapter will deal with each in turn: how to diagnose and how to, where possible, prevent these from occurring or worsening.

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References

  1. Aberdam D, Galliano MG, Vailly J, et al Herlitz’s junctional epidermolysis bullosa is linked to mutations in the gene (LAMC2) for the gamma 2 subunit of nicein/kalinin (laminin 5). Nat Genet. 1994;6:299–304

    Article  PubMed  CAS  Google Scholar 

  2. Ahmed AR, Graham J, Jordan RE, Provost TT. Pemphigus: current concepts. Ann Intern Med. 1980;92:396–405

    Google Scholar 

  3. Ahmed AR, Yunis EJ, Khatri K. Major histocompatibility complex haplotype studies in Ashkenazi Jewish patients with Pemphigus Vulgaris. Proc Natl Acad Sci USA. 1991; 87:7658–7662

    Article  Google Scholar 

  4. Ahmed AR, Mohimen A, Yunis EJ, et al Linkage of pemphigus vulgaris antibody to the major histocompatibility complex in healthy relatives of patients. J Exp Med. 1993; 177:419

    Article  PubMed  CAS  Google Scholar 

  5. Amagai M, Klaus-Kovtun V, Stanley JR. Auto-Ab against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell. 1991;67:869–877

    Article  PubMed  CAS  Google Scholar 

  6. Amagai M, Nishikawa T, Nousari HC, et al Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice. J Clin Invest. 1998;102:775–782

    Article  PubMed  CAS  Google Scholar 

  7. Amagai M, Hashimoto T, Komai A, et al Usefulness of enzyme-linked immunosorbent assay using recombinant desmogleins 1 and 3 for serodiagnosis of pemphigus. Br J Dermatol. 1999;140:351–357

    Article  PubMed  CAS  Google Scholar 

  8. Anhalt GJ. Paraneoplastic pemphigus. Adv Dermatol. 1997;12:77–96

    PubMed  CAS  Google Scholar 

  9. Anhalt GJ. Making sense of antigens and antibodies in pemphigus. J Am Acad Dermatol. 1999;40:763–766

    Article  PubMed  CAS  Google Scholar 

  10. Anhalt GJ, Kim SC, Stanley JR, et al Paraneoplastic pemphigus. N Engl J Med. 1990;323:1729–1735

    Article  PubMed  CAS  Google Scholar 

  11. Anton-Lamprecht I. The skin. In: Papadimitriou JM, Henderson DW, Spagnolo V, eds. Diagnostic Ultrastructure of Non-Neoplastic Diseases. 5th ed. Edinburgh: Churchill and Livingstone; 1992

    Google Scholar 

  12. Anton-Lamprecht I, Schnyder UW. Epidermolysis bullosa herpetiformis Dowling-Meara: a report of a case and pathomorphogenesis. Dermatologica. 1982;164:221–235

    Article  PubMed  CAS  Google Scholar 

  13. Aurelian L, Kokuba H, et al Understanding the pathogenesis of HSV-associated erythema multiforme. Dermatology. 1998;197(3):219–222

    Article  PubMed  CAS  Google Scholar 

  14. Avalos-Diaz E, Olague-Marchan M, Lopez-Swiderski A, Herrera-Esparza R, Diaz LA. Transplacental passage of maternal pemphigus foliaceus autoantibodies induces neonatal pemphigus. J Am Acad Dermatol. 2000;43(6):1130–1134

    Article  PubMed  CAS  Google Scholar 

  15. Baudoin C, Miquel C, Blanchet-Bardon C, et al Herlitz junctional epidermolysis bullosa keratinocytes display heterogeneous defects of nicein/kalinin gene expression. J Clin Invest. 1994;93:862–869

    Article  PubMed  CAS  Google Scholar 

  16. Bean SF, Good RA, Windhorst DB. Bullous pemphigoid in an 11-year-old boy. Arch Dermatol. 1970;102:205–208

    Article  PubMed  CAS  Google Scholar 

  17. Bedane C, Prost C, Thomine E, et al Binding of autoantibodies is not restricted to desmosomes in pemphigus vulgaris: comparison of 14 cases of pemphigus vulgaris and 10 cases of pemphigus foliaceus studied by western immunoblot and immunoelectron microscopy. Arch Dermatol Res. 1996;288: 343–352

    Article  PubMed  CAS  Google Scholar 

  18. Bekou V, Thoma-Uszynski S, Wendler O, et al Detection of laminin 5-specific auto-antibodies in mucous membrane and bullous pemphigoid sera by ELISA. J Invest Dermatol. 2005;124(4):732–740

    Article  PubMed  CAS  Google Scholar 

  19. Beltrani VS, Boguneiwicz M. Atopic dermatitis. Dermatol Online J. 2003;9:1

    PubMed  Google Scholar 

  20. Bernard P, Vaillant L, Labeille B, et al Incidence of distribution of subepidermal autoimmune skin diseases in three French regions. Arch Dermatol. 1995;131:48–52

    Article  PubMed  CAS  Google Scholar 

  21. Beutner EH, Baughman RD, Austin BM, Plunkett RW, Binder WL. A case of dermatitis herpetiformis with IgA endomysial antibodies but negative direct immunofluorescent findings. J Am Acad Dermatol. 2000;43:329–332

    Article  PubMed  CAS  Google Scholar 

  22. Bhol K, Ahmed AR, Aoki V, Mohimen A, Nagarwalla N, Natarajan K. Correlation of peptide specificity and IgG subclass with pathogenic and nonpathogenic autoantibodies in pemphigus vulgaris: a model for autoimmunity. Proc Natl Acad Sci USA. 1995;92:5239–5243

    Article  PubMed  CAS  Google Scholar 

  23. Bolte C, Gonzalez S. Rapid diagnosis of major variants of congenital epidermolysis bullosa using a monoclonal antibody against collagen type IV. Am J Dermatopathol. 1995; 17(6):580–583

    Article  PubMed  CAS  Google Scholar 

  24. Borradori L, Trueb RM, Jaunin F, et al Autoantibodies from a patient with paraneoplastic pemphigus bind periplakin, a novel member of the plakin family. J Invest Dermatol. 1998;111:338–340

    PubMed  CAS  Google Scholar 

  25. Brenner S, Bar-Nathan EA. Pemphigus vulgaris triggered by emotional stress. J Am Acad Dermatol. 1984;11:524–525

    Article  Google Scholar 

  26. Brenner S, Wolf R, Ruocco V. Drug-induced pemphigus. I. A survey. Clin Dermatol. 1993;11(4):501–505

    Article  PubMed  CAS  Google Scholar 

  27. Brenner S, Wolf R, Ruocco V. Contact pemphigus: a subgroup of induced pemphigus. Int J Dermatol. 1994;33:843–845

    Article  PubMed  CAS  Google Scholar 

  28. Brenner S, Ruocco V, Wolf R, De Angelis E, Lombardi ML. Pemphigus and dietary factors. In vitro acantholysis by allyl compounds of the genus Allium. Dermatology. 1995;190: 197–202

    Article  PubMed  CAS  Google Scholar 

  29. Brenner S, Bialy-Golan A, Ruocco V. Drug-induced pemphigus. Clin Dermatol. 1998;163:393–397

    Article  Google Scholar 

  30. Brenner S, Ruocco V, Bialy-Golan A, et al Pemphigus and pemphigoid-like effects of nifedipine on in vitro cultured normal human skin explants. Int J Dermatol. 1999;38(1):36–40

    Article  PubMed  CAS  Google Scholar 

  31. Brenner S, Tur E, Shapiro J, et al Pemphigus vulgaris: environmental factors. Occupational, behavioral, medical, and qualitative food frequency questionnaire. Int J Dermatol. 2001;40:562–569

    Article  PubMed  CAS  Google Scholar 

  32. Brenner S, Sasson A, Sharon O. Pemphigus and infections. Clin Dermatol. 2002;20:114–118

    Article  PubMed  Google Scholar 

  33. Brenner S, Mashiah J, Tamir E, Goldberg I, Wohl Y. Pemphigus: an acronym for a disease with multiple etiologies. Skinmed. 2003;2:163–167

    Article  PubMed  Google Scholar 

  34. Brenner S, Ruocco V, Ruocco E, Srebrnik A, Goldberg I. A possible mechanism for phenol-induced pemphigus. Skinmed. 2006;5(1):25-26; quiz 27–28

    Article  PubMed  Google Scholar 

  35. Bruckner-Tuderman L. Collagen VII and bullous disorders of the skin. Dermatology. 1994;189:16–20

    Article  PubMed  Google Scholar 

  36. Brust MD, Lin AN. Epidermolysis bullosa: practical management and clinical update. Dermatol Nurs. 1996;8(2):81–89

    PubMed  CAS  Google Scholar 

  37. Calvanico NJ, Martins CR, Diaz LA. Characterization of pemphigus foliaceus antigen from human epidermis. J Invest Dermatol. 1991;96(6):815–821

    Article  PubMed  CAS  Google Scholar 

  38. Caproni M, Cardinali C, Renzi D, Calabro A, Fabbri P. Tissue transglutaminase antibody assessment in dermatitis herpetiformis. Br J Dermatol. 2001;144:196–197

    PubMed  CAS  Google Scholar 

  39. Cauza K, Hinterhuber G, Sterniczky B, et al Unusual clinical manifestation of linear IgA dermatosis: a report of two cases. J Am Acad Dermatol. 2004;51:112–117

    Article  Google Scholar 

  40. Champagne G, Roca M, Martinez A. Successful treatment of a high-grade intraepithelial neoplasia with imiquimod, with vulvar pemphigus as a side effect. Eur J Obstet Gynecol Reprod Biol. 2003;109:224–227

    Article  Google Scholar 

  41. Chaudhari P, Marinkovich MP. What’s new in blistering disorders? Curr Allergy Asthma Rep. 2007;7(4):255–263

    Article  PubMed  CAS  Google Scholar 

  42. Chen M, Doostan A, Bandyopadhyay P, et al The cartilage matrix protein subdomain of type VII collagen is pathogenic for epidermolysis bullosa acquista. Am J Pathol. 2007; 170(6):2009–2018

    Article  PubMed  CAS  Google Scholar 

  43. Chimanovitch I, Schmidt E, Messer G, et al IgG1 and 0IgG3 are the major immunoglobulin subclasses targeting epitopes within the NC16A domain of BP180 in pemphigoid gestationis. J Invest Dermatol. 1999;113:140–142

    Article  PubMed  CAS  Google Scholar 

  44. Chowdhury MMU, Natarajan S. Neonatal pemphigus vulgaris associated with mild oral pemphigus vulgaris in the mother during pregnancy. Br J Dermatol. 1998;139:500–503

    Article  PubMed  CAS  Google Scholar 

  45. Collier PM, Kelly SE, Wojnarowska F. Linear IgA disease and pregnancy. Acad Dermatol. 1994;30(3):407–411

    Article  CAS  Google Scholar 

  46. Cotell S, Robinson ND, Chan LS. Autoimmune blistering skin diseases. Am J Emerg Med. 2000;18(3):288–299

    Article  PubMed  CAS  Google Scholar 

  47. Dang N, Klingberg S, Marr P, Murrell DF. Review of collagen VII sequence variants found in Australasian patients with dystrophic epidermolysis bullosa reveals nine novel COL7A1 variants. J Dermatol Sci. 2007;46(3):169–178

    Article  PubMed  CAS  Google Scholar 

  48. Diaz LA, Sampaio SA, Rivitti EA, et al Endemic pemphigus foliaceus (fogo selvagem). I: Clinical features and immunopathology. J Am Acad Dermatol. 1989;20:657–659

    Article  PubMed  CAS  Google Scholar 

  49. Diaz LA, Arteaga LA, Hilario-Vargas J, et al Antidesmoglein-1 antibodies in onchocerciasis, leishmaniasis and Chagas disease suggest a possible aetiological link to Fogo Selvagem. J Invest Dermatol. 2004;123:1045–1051

    Article  PubMed  CAS  Google Scholar 

  50. Dippel E, Orfanos CE, Zouboulis C. Linear IgA dermatosis presenting with erythema annulare centrifugum lesions: report of three cases in adults. J Eur Acad Dermatol Venereol. 2001;15(2):167–170

    Article  PubMed  CAS  Google Scholar 

  51. Dugan EM, Anhalt GJ, Diaz LA. Pemphigus. In: Jordan RE, ed. Immunologic Diseases of the Skin. Norwalk, CN: Appleton and Lange; 1991:279–291

    Google Scholar 

  52. Eady RA, Tidman MJ. Junctional epidermolysis bullosa. In: Wojnarowska F, Briggaman RA, eds. Management of Blistering Diseases. London: Chapman and Hall Medical; 1992:213–224

    Google Scholar 

  53. Egan CA, Zone JJ. Linear IgA bullous dermatosis. Int J Dermatol. 1999;38:818–827

    Article  PubMed  CAS  Google Scholar 

  54. Egan CA, Lazarova Z, Darling TN, Yee C, Yancey KB. Anti-epiligrin cicatricial pemphigoid: clinical findings, immunopathogenesis, and significant associations. Medicine. 2003;82(3):177–186

    PubMed  Google Scholar 

  55. Elias S. Use of fetoscopy for the prenatal diagnosi of hereditary skin disorders. Curr Probl Dermatol. 1987;16:1–3

    PubMed  CAS  Google Scholar 

  56. Elias S, Emerson DS, Simpsos JL, Shulman LP, Holbrook KA. Ultrasound guided fetal skin sampling for prenatal diagnosis of genodermatoses. Obstet Gynecol. 1994;83:337–341

    PubMed  CAS  Google Scholar 

  57. Emery DJ, Diaz LA, Fairley JA, Lopez A, Taylor AF, Giudice GJ. Pemphigus foliaceus and pemphigus vulgaris autoantibodies react with the extracellular domain of desmoglein-1. J Invest Dermatol. 1995;104(3):323–328

    Article  PubMed  CAS  Google Scholar 

  58. Engineer L, Bhol K, Ahmed AR. Pemphigoid gestationis: a review. Am J Obstet Gynecol. 2000;183:483–491

    Article  PubMed  CAS  Google Scholar 

  59. Fassihi H, Eady RA, Mellerio JE, et al Prenatal diagnosis for severe inherited skin disorders: 25 years’ experience. Br J Dermatol. 2006;154(1):106–113

    Article  PubMed  CAS  Google Scholar 

  60. Fassihi H, Renwickb PJ, Blackb C, McGrath JA. Single cell PCR amplification of microsatellites flanking the COL7A1 gene and suitability for preimplantation genetic diagnosis of Hallopeau-Siemens recessive dystrophic epidermolysis bullosa. J Dermatol Sci. 2006;42:241–248

    Article  PubMed  CAS  Google Scholar 

  61. Fassihi H, Grace J, Lashwood A, et al Preimplantation genetic diagnosis of skin fragility-ectodermal dysplasia syndrome. Br J Dermatol. 2006;154(3):546–550

    Article  PubMed  CAS  Google Scholar 

  62. Feliciani C, Fasciocco D, Franchi A, Amerio P. Epidermolysis bullosa acquisita in a 10-year-old Albanian boy. Br J Dermatol. 1997;137(2):307–308

    PubMed  CAS  Google Scholar 

  63. Fine JD. Laboratory tests for epidermolysis bullosa. Dermatopathol Clin. 1994;12:123–132

    CAS  Google Scholar 

  64. Fine JD, Stenn J, Johnson L, et al Autosomal recessive epidermolysis bullosa simplex: generalized phenotypic features suggestive of junctional or dystrophic epidermolysis bullosa, and association with neuromuscular diseases. Arch Dermatol. 1989;125:931–938

    Article  PubMed  CAS  Google Scholar 

  65. Fine JD, Bauer EA, Briggaman RA, et al Revised clinical and laboratory criteria for subtypes of inherited epidermolysis bullosa. A consensus report by the Subcommittee on Diagnosis and Classification of the National Epidermolysis Bullosa Registry. J Am Acad Dermatol. 1991;24:119–135

    Article  PubMed  CAS  Google Scholar 

  66. Fine JD, Bauer EA, Mcguire J, Moshell A. Non molecular diagnostic testing of epidermolysis bullosa: current techniques, major findings, and relative sensitivity and specificity. In: Fine JD, Bauer EA, McGuire J, Moshell A, eds. Epidermolysis Bullosa, Clinical, Epidemiologic, and Laboratory Advances and the Findings of the National Epidermolysis Bullosa Registry. Baltimore, MD: The John Hopkins University; 1999

    Google Scholar 

  67. Fine JD, Eady RA, Bauer EA, et al Revised classification for inherited epidermolysis bullosa: report of the second Inter_national Consensus Meeting on diagnosis and classification of epidermolysis bullosa. J Am Acad Dermatol. 2000;42:1051–1066

    Article  PubMed  CAS  Google Scholar 

  68. Fine J D, Eady RA, Bauer EA, Bauer J, Bruckner-Tuderman L, Heagerty A, Hintner H, Hovnanian A, Jonkman MF, Leigh I, McGrath JA, Mellerio JE, Murrell DF, Shimizu H, Uitto J, Vahlquist A, Woodley D, Zambruno G, Revised Consensus for Definitions of Epidermolysis Bullosa. J Am Acad Dermatol 58(June): 931–950, 2008 (in press Dec 2007; advance on line March 2008)

    Article  PubMed  CAS  Google Scholar 

  69. Fry L. Dermatitis herpetiformis. Baillieres Clin Gastroenterol. 1995;9(2):371–393

    Article  PubMed  CAS  Google Scholar 

  70. Fry F. Dermatitis herpetiformis: problems, progress, and prospects. Eur J Dermatol. 2002;12:523–531

    PubMed  Google Scholar 

  71. Gammon WR, Briggaman RA, Wheeler CE. Epidermolysis bullosa acquisita presenting as an inflammatory bullous disease. F Am Acad Dermatol. 1982;7:382–387

    Article  CAS  Google Scholar 

  72. Gammon WR, Briggaman RA, Woodley DT, et al Epidermolysis bullosa acquisita-a pemphigoid-like disease. J Am Acad Dermatol. 1984;11:820–832

    Article  PubMed  CAS  Google Scholar 

  73. Gammon WR, Woodley DT, Dole KC, Briggaman RA. Evidence that basement membrane zone antibodies in bullous eruption of systemic lupus erythematosus recognized epidermolysis bullosa acquista auto antigens. J Invest Dermatol. 1985;84:472–476

    Article  PubMed  CAS  Google Scholar 

  74. Gammon WR, Heise ER, Burke WA, Fine JD, Woodley DT, Briggaman RA. Increased frequency of HLA-DR2 in patients with autoantibodies to epidermolysis bullosa acquista antigen; evidence that the expression of autoimmunity to type VII collagen is HLA class II allele associated. J Invest Dermatol. 1988;91:228–232

    Article  PubMed  CAS  Google Scholar 

  75. Gammon WR, Murrell DF, Jenison M, et al Autoantibodies to type VII collagen recognize epitopes in a fibronectin-like region of the noncollagenous (NC1) domain. J Invest Dermatol. 1993;100:618–622

    Article  PubMed  CAS  Google Scholar 

  76. George DE, Browning JC, Hsu S. Medical pearl: dermatitis herpetiformis – potential for confusion with eczema. J Am Acad Dermatol. 2006;54(2):327–328

    Article  PubMed  Google Scholar 

  77. Ghohestani R, Kanitakis J, Nicolas JF, Cozzani E, Claudy A. Comparative sensitivity of indirect immunofluorescence to immunoblot assay for the detection of circulating antibodies to bullous pemphigoid antigens 1 and 2. Br J Dermatol. 1996;135(1):74–79

    Article  PubMed  CAS  Google Scholar 

  78. Ghohestani RF, Nicolas JF, Kanitakis J, Claudy A. Linear IgA bullous dermatosis with IgA antibodies exclusively directed against the 180- or 230-kDa epidermal antigens. J Invest Dermatol. 1997;108:854–858

    Article  PubMed  CAS  Google Scholar 

  79. Giudice GJ, Emery DJ, Zelickson BD, Anhalt GJ, Liu Z, Diaz LA. Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain. J Immunol. 1993;151:5742–5750

    PubMed  CAS  Google Scholar 

  80. Goldberg NS, DeFeo C, Krishenbaum N. Pemphigus vulgaris and pregnancy: risk factors and recommendations. J Am Acad Dermatol. 1993;28:877–879

    Article  PubMed  CAS  Google Scholar 

  81. Goldberg I, Kashman Y, Brenner S. The induction of pemphigus by phenol drugs. Int J Dermatol. 1999;38: 888–892.

    Article  PubMed  CAS  Google Scholar 

  82. Grando SA. Autoimmunity to keratinocyte acetylcholine receptors in pemphigus. Dermatology. 2000;201(4): 290–295

    Article  PubMed  CAS  Google Scholar 

  83. Green D, Maize JC. Maternal pemphigus vulgaris with in vivo bound antibodies in the stillborn fetus. J Am Acad Dermatol. 1982;7:388–392

    Article  PubMed  CAS  Google Scholar 

  84. Hakimian J, Koransky J, Murrell DF. Childhood Epidermolysis Bullosa Acquista. Proceedings of the 54th Annual American Academy of Dermatology.Washington; 1996

    Google Scholar 

  85. Halevy S, Ghislain PD, Mockenhaupt M, Fagot JP, Bouwes Bavinck JN, Sidoroff A, Naldi L, Dunant A, Viboud C, Roujeau JC, EuroSCAR Study Group. Allopurinol is the most common cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in Europe and Israel. J Am Acad Dermatol. 2008;58(1):25–32

    Article  PubMed  Google Scholar 

  86. Handyside AH, Kontogianni EH, Hardy K, Winston RML. Pregnancies from biopsied human preimplantation embryos used by Y specific DNA amplification. Nature. 1990;344:768–770

    Article  PubMed  CAS  Google Scholar 

  87. Hashimoto K, Wun TC, Baird J, Lazarus GS, Jensen PJ. Characterization of keratinocyte plasminogen activator inhibitors and demonstration of the prevention of pemphigus IgG-induced acantholysis by a purified plasminogen activator inhibitor. J Invest Dermatol. 1989;92(3):310–314

    Article  PubMed  CAS  Google Scholar 

  88. Hashimoto T, Konohana A, Nishikawa T. Immunoblot assay as an aid to the diagnoses of unclassified cases of pemphigus. Arch Dermatol. 1991;127:843–847

    Article  PubMed  CAS  Google Scholar 

  89. Hashimoto T, Amagai M, Watanabe K, et al Characterization of paraneoplastic pemphigus autoantigens by immunoblot analysis. J Invest Dermatol. 1995;104:829–834

    Article  PubMed  CAS  Google Scholar 

  90. Hashimoto T, Ishiko A, Shimizu H, et al A case of linear IgA bullous dermatosis with IgA anti-type VII collagen autoantibodies. Br J Dermatol. 1996;134:336–339

    Article  PubMed  CAS  Google Scholar 

  91. Heagerty AH, Kennedy AR, Gunner DB, Eady RA. Rapid prenatal diagnosis and exclusion of epidermolysis bullosa using novel antibody probes. J Invest Dermatol. 1986;86(5): 603–605

    Article  PubMed  CAS  Google Scholar 

  92. Heagerty AH, Eady RA, Kennedy AR, et al Rapid prenatal diagnosis of epidermolysis bullosa letalis using GB3 monoclonal antibody. Br J Dermatol. 1987;117(3):271–275

    Article  PubMed  CAS  Google Scholar 

  93. Heimbach DM, Engrav LH, Marvin JA, et al Toxic epidermal necrolysis: a step forward in treatment. JAMA. 1987; 257:2171–2175

    Article  PubMed  CAS  Google Scholar 

  94. Hern S, Vaughan Jones SA, Setterfield J, et al Pemphigus vulgaris in pregnancy with favourable fetal prognosis. Clin Exp Dermatol. 1998;23(6):260–263

    Article  PubMed  CAS  Google Scholar 

  95. Hertl M. Humoral and cellular autoimmunity in autoimmune bullous skin disorders. Int Arch Allergy Immunol. 2000; 122:91–100

    Article  PubMed  CAS  Google Scholar 

  96. Hertl M. Autoimmune bullous skin disorders. In: Autoimmune Disease of The Skin. Pathogenesis, Diagnosis, Management. New York, Springer Wien; 2005

    Google Scholar 

  97. Hervonen K, Vornanen M, Kautiainen H, Collin P, Reunala T. Lymphoma in patients with dermatitis herpetiformis and their first-degree relatives. Br J Dermatol. 2005;152(1):82–86

    Article  PubMed  CAS  Google Scholar 

  98. Hintner H, Stingl G, Schuler G, et al Immunofluorescence mapping of antigenic determinants within the dermal-epidermal junction in mechanobullous diseases. J Invest Dermatol. 1981;76:113–118

    Article  PubMed  CAS  Google Scholar 

  99. Hirako Y, Niishizawa Y, Sitaru C, et al The 97k-Da (LABD97) and 120-kDa (LAD-1) fragments of bullous pemphigoid antigen 180/type XVII collagen have different N-termini. J Invest Dermatol. 2003;121:1554–1556

    Article  PubMed  CAS  Google Scholar 

  100. Horn TD, Anhalt GJ. Histologic features of paraneolastic pemphigus. Arch Dermatol. 1992;128:1091–1095

    Article  PubMed  CAS  Google Scholar 

  101. Huff JC. Acyclovir for recurrent erythema multiforme caused by herpes simplex. J Am Acad Dermatol. 1988;18: 197–199

    Article  PubMed  CAS  Google Scholar 

  102. Huilgol SC, Black MM. Management of the immunobullous disorders. II. Pemphigus. Clin Exp Dermatol. 1995;20: 283–293

    Article  PubMed  CAS  Google Scholar 

  103. Inauen P, Hunziker TH, Gerber H, et al Childhood epidermolysis bullosa acquisita. Br J Dermatol. 1994;131: 898–900

    Article  PubMed  CAS  Google Scholar 

  104. Ishida-Yamamoto A, McGrath JA, Chapman SJ, et al Epidermolysis Bullosa simplex (Dowling-Meara type) is a genetic disease characterized by an abnormal keratin-filament network involving keratins K5 and K14. J Invest Dermatol. 1991;97:959–968

    Article  PubMed  CAS  Google Scholar 

  105. Ishii K, et al Characterization of autoantibodies in pemphigus using antigen-specific enzyme linked immunosorbent assays with baculovirus expressed recombinant desmogleins. J Immunol. 1997;159:2010–2017

    PubMed  CAS  Google Scholar 

  106. Ishii K, Amagai M, Ohata Y, et al Development of pemphigus vulgaris in a patient with pemphigus foliaceus antidesmoglein antibody profile shift confirmed by enzyme-linked immunosorbent assay. J Am Acad Dermatol. 2000;42: 859–861

    Article  PubMed  CAS  Google Scholar 

  107. Ishiko A, Shimizu H, Masunaga T, et al 97-kDa linear IgA bullous dermatosis (LAD) antigen localizes to the lamina lucida of the epidermal basement membrane. J Invest Dermatol. 1996;106:734–738

    Article  Google Scholar 

  108. Jackson JL, Gibbons R, Meyer G, Inouye L. The effect of treating herpes zoster with oral acyclovir in preventing postherpetic neuralgia. A meta-analysis. Arch Intern Med. 1997;157(8):909–912

    Article  PubMed  CAS  Google Scholar 

  109. Jacobs SE. Pemphigus erythematosus and ultraviolet light. A case report. Arch Dermatol. 1965;91:139–141

    Article  PubMed  CAS  Google Scholar 

  110. Jiao D, Bystryn JC. Sensitivity of indirect immunofluorescence, substrate specificity and immunoblotting in the diagnosis of pemphigus. J Am Acad Dermatol. 1997;37:211–216

    Article  PubMed  CAS  Google Scholar 

  111. Jonkman MF, De Jong MCJM, Heeres K, et al 180-kD bullous pemphigoid antigen (BP180) is deficient in generalized atrophic benign epidermolysis bullosa. J Clin Invest. 1995;95:1345–1352

    Article  PubMed  CAS  Google Scholar 

  112. Jonkman MF, Heeres K, Pas HH, et al Effects of keratin 14 ablation on the clinical and cellular phenotype in a kindred with recessive epidermolysis bullosa simplex. J Invest Dermatol. 1996;107:764–769

    Article  PubMed  CAS  Google Scholar 

  113. Kaplan RP, Callen JP. Pemphigus-associated diseases and induced pemphigus. Clin Dermatol. 1983;1:42–71

    Article  PubMed  CAS  Google Scholar 

  114. Katz SI. Dermatitis herpetiformis. In: Freedberg IM, Eisen AZ, Wolff K, et al, eds. Fitzpatrick’s Dermatology in General Medicine. New York, NY: McGraw-Hill; 1999

    Google Scholar 

  115. Kirtschig G, Wojnarowska F, Marsden RA, et al Acquired bullous diseases of childhood: re-evaluation of diagnosis by indirect immunofluorescence examination on 1 M NaCl split skin and immunoblotting. Br J Dermatol. 1994;130: 610–616

    Article  PubMed  CAS  Google Scholar 

  116. Kivirikko S, McGrath JA, Abderam D, et al A homozygous nonsense mutation in the alpha 3 chain gene of laminin 5 (LAMA3) in lethel (Herlitz) junctional epidermolysis bullosa. Hum Mol Genet. 1995;4:959–962

    Article  PubMed  CAS  Google Scholar 

  117. Klein PA, Callen JP. Drug-induced linear IgA bullous dermatosis after vancomycin discontinuance in a patient with renal insufficiency. J Am Acad Dermatol. 2000;42: 316–323

    Article  PubMed  CAS  Google Scholar 

  118. Klingberg S, Mortimore R, Parkes J, et al Prenatal diagnosis of dominant dystrophic epidermolysis bullosa, by COL7A1 molecular analysis. Prenat Diagn. 2000;20(8): 618–622

    Article  PubMed  CAS  Google Scholar 

  119. Kokuba H, Aurelian L, et al Herpes simplex virus associated erythema multiforme (HAEM) is mechanistically distinct from drug-induced erythema multiforme: interferon-gamma is expressed in HAEM lesions and tumor necrosis factor-alpha in drug-induced erythema multiforme lesions. J Invest Dermatol. 1999;113(5):808–815

    Article  PubMed  CAS  Google Scholar 

  120. Kricheli D, David M, Frusic-Zlotkin M. The distribution of pemphigus vulgaris IgG subclasses and reactivity with desmoglein 3 and 1 in pemphigus patients and first degree relatives. N J Dermatol. 2000;143:337–342

    Article  CAS  Google Scholar 

  121. Kuechle MK, Stegemeir E, Maynard B, et al Drug-induced linear IgA bullous dermatosis: report of six cases and review of the literature. J Am Acad Dermatol. 1994;30: 187–192

    Article  PubMed  CAS  Google Scholar 

  122. Lapiere JC, Woodley DT, Parente MG, et al Epitope mapping of type VII collagen. Identification of discrete peptide sequences recognized by sera from patients with acquired epidermolysis bullosa. J Clin Invest. 1993;92:1831–1839

    Article  PubMed  CAS  Google Scholar 

  123. Lee E, Lendas KA, Chow S, et al Disease relevant HLA class II alleles isolated by genotypic, haplotypic, and sequence analysis in North American Caucasians with pemphigus vulgaris. Hum Immunol. 2006;67(1–2):125–139

    Article  PubMed  CAS  Google Scholar 

  124. Lever WF. Pemphigus. Medicine. 1953;32:1–123

    Article  PubMed  CAS  Google Scholar 

  125. Lever WF. Pemphigus and pemphigoid. J Am Acad Dermatol. 1979;1:2–31

    Article  PubMed  CAS  Google Scholar 

  126. Leverkus M, Bhol K, Hirako Y, et al Cicatricial pemphigoid with circulating autoantibodies to beta4 integrin, bullous pemphigoid 180 and bullous pemphigoid 230. Br J Dermatol. 2001;145(6):998–1004

    Article  PubMed  CAS  Google Scholar 

  127. Levy RS, Fisher M, Alter NA. Penicillamine: review and cutaneous manifestations. J Am Acad Dermatol. 1983;8: 548–558

    Article  PubMed  CAS  Google Scholar 

  128. Lin MS, Gharia M, Fu CL, et al Molecular mapping of the major epitopes of BP180 recognized by herpes gestationis autoantibodies. Clin Immunol. 1999;92:285–292

    Article  PubMed  CAS  Google Scholar 

  129. Lin R, Ladd DJ, Powell DJ, Way BV. Localized pemphigus foliaceus induced by topical imiquimod. Arch Dermatol. 2004;140:889–890

    Article  PubMed  Google Scholar 

  130. Liu Z. Bullous pemphigoid: using animal models to study the immunopathology. J Invest Dermatol Symp Proc. 2004; 9(1):41–46

    Article  Google Scholar 

  131. Mackenzie-Wood A, Kirkham B, Hart K, Murrell DF. Second Case of Bullous Pemphigoid like Eruption Induced by D-Penicillamine. Mini Consults in Dermatology Volume VI, American Academy of Dermatology. Mosby-Year Book; 1999

    Google Scholar 

  132. Marinkovich MP, Taylor TB, Keene DR, et al LAD-1, the linear IgA bullous dermatosis autoantigen, is a novel 120-kDa anchoring filament protein synthesized by epidermal cells. J Invest Dermatol. 1996;106:734–738

    Article  PubMed  CAS  Google Scholar 

  133. Martin LK, Murrell DF. Treatment of pemphigus: the need for more evidence. Arch Dermatol. 2008;144(1):100–101

    Article  PubMed  CAS  Google Scholar 

  134. Mashiah J, Brenner S. Medical pearl: first step in managing pemphigus – addressing the etiology. J Am Acad Dermatol. 2005;53(4):706–707

    Article  PubMed  Google Scholar 

  135. McGrath JA, Ishida-Yamamoto A, Tidman MJ, Heagerty AHM, Schofield OMV, Eady RAJ. Epidermolysis bullosa simplex (Dowling-Meara). A clinicopathological review. Br J Dermatol. 1992;126:421–430

    Article  PubMed  CAS  Google Scholar 

  136. McGrath JA, Gatalica B, Crhistiano AM, et al Mutations in the 180kD bullous pemphigoid antigen (BPAG2), a hemidesmosomal transmembrane collagen (COL17A1), in generalised atrophic benign epidermolysis bullosa. Nat Genet. 1995;11:83–86

    Article  PubMed  CAS  Google Scholar 

  137. McGrath JA, Pulkkinen L, Christiano AM, et al Altered laminin 5 expression due to mutations in the gene encoding the beta 3 chain (LAMB3) in generalised atrophic benign epidermolysis bullosa. J Invest Dermatol. 1995;104: 467–474

    Article  PubMed  CAS  Google Scholar 

  138. McGrath JA, Dunnill MG, Christiano AM, et al First trimester DNA-based exclusion of recessive dystrophic epidermolysis bullosa from chorionic villous sampling. Br J Dermatol. 1996;134(4):734–739

    Article  PubMed  CAS  Google Scholar 

  139. Mihai S, Sitaru C. Immunopathology and molecular diagnosis of autoimmune bullous diseases. J Cell Mol Med. 2007;11(3):462–481

    Article  PubMed  CAS  Google Scholar 

  140. Mofid MZ, Costarangos C, Bernstein B, et al Drug-induced linear immunoglobulin A bullous disease that clinically mimics toxic epidermal necrolysis. J Burn Care Rehabil. 2000;21:246–247

    Article  PubMed  CAS  Google Scholar 

  141. Murrell DF, Pasmooij AM, Pas HH, et al Retrospective diagnosis of fatal BP180-deficient non-Herlitz junctional epidermolysis bullosa suggested by immunofluorescence (IF) antigen-mapping of parental carriers bearing enamel defects. J Invest Dermatol. 2007;127(7):1772–1775

    PubMed  CAS  Google Scholar 

  142. Murrell DF, Amagai M, Barnadas MA, et al Consensus statement on definitions of disease endpoints and therapeutic response for pemphigus. JAAD. 2008;58(6):1043–1046

    Article  Google Scholar 

  143. Mutasim DF. Autoimmune bullous diseases: diagnosis and management. Dermatol Nurs. 1999;11:15–21

    PubMed  CAS  Google Scholar 

  144. Neughebauer BI, Negron G, Pelton S, Plunkett RW, Beutner EH, Magnussen R. Bullous skin disease: an unusual allergic reaction to vancomycin. Am J Med Sci. 2002;323(5): 273–278

    Article  PubMed  Google Scholar 

  145. Ng PP, Sun YJ. Detection of herpes simplex virus genomic DNA in various subsets of erythema multiforme by polymerase chain reaction. Dermatology. 2003;207(4):349–353

    Article  PubMed  CAS  Google Scholar 

  146. Nicolas ME, Krause PK, Gibson LE, Murray JA. Dermatitis herpetiformis. Int J Dermatol. 2003;42:588–600

    Article  PubMed  Google Scholar 

  147. Niemi K-M, Sommer H, Kero M, et al Epidermolysis bullosa simplex associated with muscular dystrophy with recessive inheritance. Arch Dermatol. 1988;124:551–554

    Article  PubMed  CAS  Google Scholar 

  148. Nousari HC, Kimyai-Asadi A, Caeiro JP, et al Clinical, demographic, and immunohistologic features of vancomycin-induced linear IgA bullous disease of the skin. Medicine. 1999;78:1–8

    Article  PubMed  CAS  Google Scholar 

  149. Nuemberger S, Driscoll A, Gabel P, et al Orf virus infection in humans-New York, Illinois, California and Tennessee 2004–2005. JAMA. 2006;55:65–68

    Google Scholar 

  150. Oxman MN, Levin MJ, Johnson GR, et al A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engl J Med. 2005;253(22):2271–2284

    Article  Google Scholar 

  151. Park SB, Cho KH, Youn JL, Hwang DH, Kim SC, Chung JH. Epidermolysis bullosa acquisita in childhood-a case mimicking chronic bullous dermatosis of childhood. Clin Exp Dermatol. 1997;22(5):220–222

    Article  PubMed  CAS  Google Scholar 

  152. Parlowsky T, Welzel J, Amagai M, Zillikens D, Wygold T. Neonatal pemphigus vulgaris: IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns. J Am Acad Dermatol. 2003;48(4):623–625

    Article  PubMed  Google Scholar 

  153. Pas HH, De Jong MC, Jonkman MF, Heeres K, Slijper-Pal IJ, Van der Meer JB. Bulllous pemphigoid: serum antibody titre and antigen specificity. Exp Dermatol. 1995;4: 372–376

    Article  PubMed  CAS  Google Scholar 

  154. Pearson RW. Studies on the pathogenesis of epidermolysis bullosa. J Invest Dermatol. 1962;39:551–575

    Article  PubMed  CAS  Google Scholar 

  155. Pearson RW, Spargo B. Electron microscopic studies of dermal-epidermal separation in human skin. J Invest Dermatol. 1961;36:213–224

    PubMed  CAS  Google Scholar 

  156. Peters MS, McEvoy MT. IgA antiendomysial antibodies in dermatitis herpetiformis. J Am Acad Dermatol. 1989;21: 1225–1231

    Article  PubMed  CAS  Google Scholar 

  157. Pfendner E, Uitto J. Plectin gene mutations can cause epidermolysis bullosa with pyloric atresia. J Invest Dermatol. 2005;124(1):111–115

    Article  PubMed  CAS  Google Scholar 

  158. Pfendner EG, Nakano A, Pulkkinen L, Christiano AM, Uitto J. Prenatal diagnosis for epidermolysis bullosa: a study of 144 consecutive pregnancies at risk. Prenat Diagn. 2003;23(6):447-456

    Article  PubMed  Google Scholar 

  159. Phelps RG, Miller MK, Singh F. The varieties of eczema: clinicopathologic correlation. Clin Dermatol. 2003;25: 95–100

    Article  Google Scholar 

  160. Plunkett RW, Chiarello SE, Beutner EH. Linear IgA bullous dermatosis in one of two piroxicam-induced eruptions: a distinct direct immunofluorescence trend revealed by the literature. J Am Acad Dermatol. 2001;45:691–696

    Article  PubMed  CAS  Google Scholar 

  161. Powell GR, Bruckner AL, Weston WL. Dermatitis herpetiformis presenting as chronic urticaria. Pediatr Dermatol. 2004;21(5):564–567

    Article  PubMed  Google Scholar 

  162. Powell AM, Sakuma-Oyama Y, Oyama N, et al Usefulness of BP180 NC16a enzyme-linked immunosorbent assay in the serodiagnosis of pemphigoid gestationis and in differentiating between pemphigoid gestationis and pruritic urticarial papules and plaques of pregnancy. Arch Dermatol. 2005;141(6):705–710

    Article  PubMed  Google Scholar 

  163. Premaratne C, Klingberg S, Glass I, Wright K, Murrell D. Epidermolysis bullosa simplex Dowling-Meara due to an arginine to cysteine substitution in exon 1 of keratin 14. Australas J Dermatol. 2002;43(1):28–34

    Article  PubMed  Google Scholar 

  164. Proby C, Fujii Y, Owaribe K, et al Human autoantibodies against HD1/plectin in paraneoplatic pemphigus. J Invest Dermatol. 1999;112:153–156

    Article  PubMed  CAS  Google Scholar 

  165. Pulkkinen L, Christiano AM, Gerecke D, et al A homozygous nonsense mutation in the beta 3 chain gene of laminin 5 (LAMB3) in Herlitz junctional epidermolysis bullosa. Genomics. 1994;24:357–360

    Article  PubMed  CAS  Google Scholar 

  166. Rabinowitz LG, Esterly NB. Inflammatory bullous diseases in children. Dermatol Clin. 1993;11:565–581

    PubMed  CAS  Google Scholar 

  167. Rao CL, Hall RP. III, Linear IgA dermatosis and chronic bullous disease of childhood. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, eds. Dermatology in General Medicine. New York: McGraw-Hill; 2003

    Google Scholar 

  168. Richards SS, Hall S, Yokel B, et al A bullous eruption in an elderly woman. Vancomycin-associated linear IgA dermatosis (LAD). Arch Dermatol. 1995;131:1447–1451

    Article  PubMed  CAS  Google Scholar 

  169. Rocha-Alvarez R, Friedman H, Campbell IT, Souza-Aguiar L, Martins-Castro R, Diaz LA. Pregnant women with endemic pemphigus foliaceus (fogo selvagem) give birth to disease-free babies. J Invest Dermatol. 1992;99:78–82

    Article  PubMed  CAS  Google Scholar 

  170. Rock B, Martins CR, Theofilopoulos AN, et al The pathogenic effect of IgG4 autoantibodies in endemic pemphigus foliaceus (fogo selvagem). N Eng J Med. 1989;320: 1463–1469

    Article  CAS  Google Scholar 

  171. Rodeck CH, Eady RA, Gosden CM. Prenatal diagnosis of epidermolysis bullosa letalis. Lancet. 1980;1(8175): 949–952

    Article  PubMed  CAS  Google Scholar 

  172. Roenigk HH, Ryan JG, Bergfeld WF. Epidermolysis bullosa acquista: Report of three cases and review of all published cases. Arch Dermatol. 1971;103:1–10

    Article  PubMed  Google Scholar 

  173. Roujeau JC, Kelly JP, Naldi L, et al Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. N Engl J Med. 1995;333:1600–1607

    Article  PubMed  CAS  Google Scholar 

  174. Ruach M, Ohel G, Rahav D, Samueloff A. Pemphigus vulgaris and pregnancy. Obstet Gynecol Surv. 1995;50(10): 755–760

    Article  PubMed  CAS  Google Scholar 

  175. Ruocco V, Rossi A, Astarita C, et al A congenital acantholytic bullous eruption in the newborn infant of a pemphigus mother. Ital Gen Rev Dermatol. 1975;12:169–174

    Google Scholar 

  176. Scott JE, Ahmed AR. The blistering diseases. Med Clin North Am. 1998;82:1239–1283

    Article  PubMed  CAS  Google Scholar 

  177. Scully C. A review of mucocutaneous disorders affecting the mouth and lips. Ann Acad Med Singap. 1999;28: 704–707

    PubMed  CAS  Google Scholar 

  178. Shachar E, Bialy-Golan A, Srebrnik A, Brenner S. “Two-step” drug-induced bullous pemphigoid. Int J Dermatol. 1998;37(12):938–939

    PubMed  CAS  Google Scholar 

  179. Shimanovich I, Bröcker EB, Zillikens D. Pemphigoid gestationis: new insights into the pathogenesis lead to novel diagnostic tools. Br J Obstet Gynaecol. 2002;109: 970–976

    Article  Google Scholar 

  180. Shimizu H, Suzumori L. Prenatal diagnosis as a test for genodermatoses: its past, present and future. J Dermatol Sci. 1999;19:1–8

    Article  PubMed  CAS  Google Scholar 

  181. Sison-Fonacier L, Bystryn JC. Heterogeneity of pemphigus vulgaris antigens. Arch Dermatol. 1987;123:1507–1510

    Article  PubMed  CAS  Google Scholar 

  182. Sitaru C, Powell J, Shimanovich I, et al Pemphigoid gestationis: maternal sera recognise epitopes restricted to the N-terminal portion of the extracellular domain of BP180 not present on its shed ectodomain. Br J Dermatol. 2003; 149:420–422

    Article  PubMed  CAS  Google Scholar 

  183. Sitaru C, Powell J, Messer G, Brocker EB, Wojnarowska F, Zillikens D. Immunoblotting and enzyme-linked immunosorbent assay for the diagnosis of pemphigoid gestationis. Obstet Gynecol. 2004;103(4):757–763

    Article  PubMed  Google Scholar 

  184. Sitaru C, Dahnrich C, Probst C, et al Enzyme-linked immunosorbent assay using multimers of the 16th non-collagenous domain of the BP180 antigen for sensitive and specific detection of pemphigoid autoantibodies. Exp Dermatol. 2007;16(9):770–777

    Article  PubMed  CAS  Google Scholar 

  185. Späth S, Riechers R, Borradori L, Zillikens D, Bdinger L, Hertl M. Detection of autoantibodies of various subclasses (IgG1, IgG4, IgA, IgE) against desmoglein 3 in patients with acute onset and chronic pemphigus vulgaris. Br J Dermatol. 2001;144:1183–1188

    Article  Google Scholar 

  186. Stanley JR. Pemphigus. In: Freedberg IM, ed. Fitzpatrick’s Dermatology in General Medicine. 6th ed. New York: McGraw Hill; 1999:654–666

    Google Scholar 

  187. Stanley JR. Bullous pemphigoid. In: Freedberg IM, ed. Fitzpatrick’s Dermatology in General Medicine. 6th ed. New York: McGraw Hill; 1999:574–580

    Google Scholar 

  188. Szafer F, Brautbar C, Tzfoni E, et al Detection of disease-specific restriction fragment length polymorphisms in pemphigus vulgaris linked to the DQw1 and DQw3 alleles of the HLA-D region. Proc Natl Acad Sci USA. 1987;84: 6542

    Article  PubMed  CAS  Google Scholar 

  189. Tidman M, Eady RA. Hemidesmosomes heterogeneity in junctional epidermolysis bullosa revealed by morphometric analysis. J Invest Dermatol. 1986;86:51–56

    Article  PubMed  CAS  Google Scholar 

  190. Tidman M, Eady RA. Diagnosis and diagnostic techniques. In: Wojnarowska F, Briggaman RA, eds. Management of Blistering Diseases. London: Chapman and Hall; 1990

    Google Scholar 

  191. Todd JA, Acha-Orbea H, Bell JI, et al A molecular basis for MHC class II–associated autoimmunity. Science. 1988; 240:1003

    Article  PubMed  CAS  Google Scholar 

  192. Tsuji-Abe Y, Akiyama M, Yamanaka Y, Kikuchi T, Sato-Matsumura KC, Shimizu H. Correlation of clinical severity and ELISA indices for the NC16A domain of BP180 measured using BP180 ELISA kit in bullous pemphigoid. J Dermatol Sci. 2005;37(3):145–149

    Article  PubMed  CAS  Google Scholar 

  193. Tur E, Brenner S. Diet and pemphigus. In pursuit of exogenous factors in pemphigus and fogo selvagem. Arch Dermatol. 1998;134:1406–1410

    Article  PubMed  CAS  Google Scholar 

  194. Vailley J, Szepetowski P, Pedeutour F, et al The genes for nicein/kalinin 125kDa and 100kDa subunits, candidates for junctional epidermolysis bullosa, map to chromosome 1q32 and 1q25–q31. Genomics. 1994;21:286–288

    Article  Google Scholar 

  195. Vidal F, Aberdam D, Miquel C, et al Integrin beta 4 mutations associated with junctional epidermolysis bullosa with pyloric atresia. Nat Genet. 1995;10:229–234

    Article  PubMed  CAS  Google Scholar 

  196. Vu TN, Lee TX, Ndoye A, et al The pathophysiological significance of nondesmoglein targets of pemphigus autoimmunity. Development of antibodies against keratinocyte cholinergic receptors in patients with pemphigus vulgaris and pemphigus foliaceus. Arch Dermatol. 1998;134(8): 971–980

    Article  PubMed  CAS  Google Scholar 

  197. Waananukul S, Pongprasit P. Childhood pemphigus. Int J Dermatol. 1999;38:29–35

    Article  Google Scholar 

  198. Warren SJ, Cockerell CJ. Characterization of a subgroup of patients with dermatitis herpetiformis with nonclassical histologic features. Am J Dermatopathol. 2002;24(4): 305–308

    Article  PubMed  Google Scholar 

  199. Wasserstrum N, Laros RK Jr. Transplacental transmission of pemphigus. JAMA. 1983;249(11):1480–1482

    Article  PubMed  CAS  Google Scholar 

  200. Weinberg ED. Pregnancy-associated depression of cell-mediated immunity. Rev Infect Dis. 1984;6:814–831

    Article  PubMed  CAS  Google Scholar 

  201. Weinberg JM. Herpes zoster: epidemiology, natural history, and common complications. J Am Acad Dermatol. 2007;57 (6):130–135

    Article  Google Scholar 

  202. Weller R, White MI. Bullous pemphigoid and penicillamine. Clin Exp Dermatol. 1996;21(2):121–122

    Article  PubMed  CAS  Google Scholar 

  203. Whitley RJ, Weiss H, Gnann JW Jr, et al Acyclovir with and without prednisone for the treatment of herpes zoster. A randomized, placebo-controlled trial. The National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. Ann Intern Med. 1996;125(5): 376–383

    PubMed  CAS  Google Scholar 

  204. Wojnarowska F, Marsden RA, Bhogal B, Black MM. Chronic bullous disease of childhood, childhood cicatricial pemphigoid, and linear IgA disease of adults. A comparative study demonstrating clinical and immunopathologic overlap. J Am Acad Dermatol. 1988;19:792–805

    Article  PubMed  CAS  Google Scholar 

  205. Wojnarowska F, Whitehead P, Leigh IM, Bhogal BS, Black MM. Identification of the target antigen in chronic bullous disease of childhood and linear IgA disease of adults. Br J Dermatol. 1991;124:157–162

    Article  PubMed  CAS  Google Scholar 

  206. Wojnarowska F, Allen J, Collier P. Linear IgA disease: a heterogenous disease. Dermatology. 1994;189:52–56

    Article  PubMed  Google Scholar 

  207. Wood MJ, Kay R, Dworkin RH, Soong SJ, Whitley RJ. Oral acyclovir therapy accelerates pain resolution in patients with herpes zoster: a meta-analysis of placebo controlled trials. Clin Infect Dis. 1996;22:341–347

    Article  PubMed  CAS  Google Scholar 

  208. Woodley DT. Epidermolysis bullosa acquista. Prog Dermatol. 1988;22:1

    Google Scholar 

  209. Woodley DT, Briggaman RA, O’Keefe EJ, Inman AO, Queen LL, Gammon WR. Identification of the skin basement-membrane autoantigen in epidermolysis bullosa acquisita. N Engl J Med. 1984;310:1007–1013

    Article  PubMed  CAS  Google Scholar 

  210. Woodley DT, Burgeson RE, Lunstrum G, et al Epidermolysis bullosa acquisita antigen is globular carboxyl terminus of type VII procollagen. J Clin Invest. 1988;81:683–687

    Article  PubMed  CAS  Google Scholar 

  211. Wu H, Wang ZH, Yan A, et al Protection against pemphigus foliaceus by desmoglein 3 in neonates. N Engl J Med. 2000;343:31–35

    Article  PubMed  CAS  Google Scholar 

  212. Yamane Y, Sato H, Higashi K, Yaoita H. Linear immunoglobulin A (IgA) bullous dermatosis of childhood: identification of the target antigens and study of the cellular sources. Br J Dermatol. 1996;135:785–790

    Article  PubMed  CAS  Google Scholar 

  213. Yiasemedes E, Walton J, Marr P, Villaneuva EV, Murrell DF. A comparative study between transmission electron microscopy and immunofluorescence mapping in the diagnosis of epidermolysis bullosa. Am J Dermatopathol. 2006;28(5):387–394

    Article  Google Scholar 

  214. Yiasemides E, Trisnowati N, Su J, Dang NN, Klingberg S, Marr P, Chow CW, Orchard D, Varigos G, Murrell DF: Clinical heterogeneity in recessive epidermolysis bullosa due to mutations in the keratin 14 gene, KRT14. Clin Exp Dermatol. Nov 2008; 33(6):689–97

    Article  PubMed  CAS  Google Scholar 

  215. Yoshida M, Hamada T, Amagai M, et al Enzyme-linked immunosorbent assay using bacterial recombinant proteins of human BP230 as a diagnostic tool for bullous pemphigoid. J Dermatol Sci. 2006;41(1):21–30

    Article  PubMed  CAS  Google Scholar 

  216. Zhou S, Wakelin SH, Allen J, Wojnarowska F. Blister fluid for the diagnosis of subepidermal immunobullous diseases: a comparative study of basement membrane zone autoantibodies detected in blister fluid and serum. Br J Dermatol. 1998;139(1):27–32

    Article  PubMed  CAS  Google Scholar 

  217. Zillikens D. Acquired skin disease of hemidesmosomes. J Dermatol Sci. 1999;20:134–154

    Article  PubMed  CAS  Google Scholar 

  218. Zillikens D, Wever S, Roth A, Hashimoto T, Brocker EB. Incidence of autoimmune subepidermal blistering dermatosis in a region of central Germany. Arch Dermatol. 1995; 131:957–958

    Article  PubMed  CAS  Google Scholar 

  219. Zillikens D, Herzele K, Georgi M, et al Autoantibodies in a subgroup of patients with linear IgA disease react with the NC16A domain of BP180. J Invest Dermatol. 1999; 113:947–953

    Article  PubMed  CAS  Google Scholar 

  220. Zone JJ. Skin manifestations of celiac disease. Gastroenterology. 2005;128:S87–S91

    Article  PubMed  Google Scholar 

  221. Zone JJ, Taylor TB, Meyer LJ, Petersen MJ. The 97 kDa linear IgA bullous disease antigen is identical to a portion of the extracellular domain of the 180 kDa bullous pemphigoid antigen, BPAG 2. J Invest Dermatol. 1998;110: 207–210

    Article  PubMed  CAS  Google Scholar 

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Venugopal, S.S., Murrell, D.F. (2011). Diagnosis and Prevention of Bullous Diseases. In: Norman, R. (eds) Preventive Dermatology. Springer, London. https://doi.org/10.1007/978-1-84996-021-2_12

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