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Animal Models of Atherosclerosis

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Advances in Vascular Medicine

Abstract

Atherosclerosis has been studied in animals for exactly a century, starting with the pioneering studies of Ignatowski (reviewed in ref.).1 The motivation for those early studies is unclear, as atherosclerosis was not then recognized as a major disease. However, the increasing prevalence of cardiovascular disorders within the global burden of disease2 has given the desire to understand and treat atherosclerosis ever greater impetus. Animal models have an important part to play in this, in two main regards: increasing our understanding of the pathophysiology of atherosclerosis and developing new treatments for the disease. This chapter takes the view that most of the atherosclerosis research done in animal models until now has served the first purpose well, but the second rather poorly. To support this contention, it will be necessary to consider how atherosclerosis starts and develops.

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Acknowledgments

The author is grateful to Dr. Jason Johnson for permission to reproduce the figures, for useful scientific discussions, and for critical reading of the manuscript.

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Authors and Affiliations

  1. Bristol Heart Institute, University of Bristol, Level 7, Bristol Royal Infirmary, Marlborough Street, Bristol, BS2 8HW, Avon, UK

    Christopher Jackson

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  1. Christopher Jackson
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  2. Ulrike Benbow
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  3. Andrew Bond
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  4. Deborah Galley
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  5. Claire Schwartz
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Corresponding author

Correspondence to Christopher Jackson .

Editor information

Editors and Affiliations

  1. University College London, Gower Street, London, WC1E 6BT, United Kingdom

    David Abraham

  2. The Royal Free & Univ College Med School, Gower Street, London, WC1E 6BT, United Kingdom

    Handler Clive

  3. University College London, Gower Street, London, WC1E 6BT, United Kingdom

    Michael Dashwood

  4. The Royal Free & Univ College Med School, Gower Street, London, WC1E 6BT, United Kingdom

    Gerry Coghlan

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© 2009 Springer-Verlag London

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Jackson, C., Benbow, U., Bond, A., Galley, D., Schwartz, C. (2009). Animal Models of Atherosclerosis. In: Abraham, D., Clive, H., Dashwood, M., Coghlan, G. (eds) Advances in Vascular Medicine. Springer, London. https://doi.org/10.1007/978-1-84882-637-3_4

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  • DOI: https://doi.org/10.1007/978-1-84882-637-3_4

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84882-636-6

  • Online ISBN: 978-1-84882-637-3

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