Abstract
The definition of itch as an unpleasant sensation that elicits an urge or desire to scratch describes the close relationship between the feeling and the response. The physiological role of scratching in response to acute itch is to remove harmful agents from the skin. In the short term, mild scratching relieves itching. With more fierce and prolonged scratching in chronic pruritus, the skin becomes damaged and the changes induced intensify itch, setting up a vicious circle. In pruritus due to an underlying internal disease, these reactive skin conditions occur in normal skin, whereas in inflammatory skin disease they may be superimposed on the primary skin lesions. This chapter will summarize elicitation of scratching as well as different clinical patterns it induces, such as excoriations, lichen simplex chronicus, lichen amyloidosus and prurigo.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Schmelz M, Schmidt R, Bickel A, et al. Specific C-receptors for itch in human skin. J Neurosci. 1997;17(20):8003-8008.
Andrew D, Craig AD. Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch. Nat Neurosci. 2001;4(1):72-77.
Hsieh JC, Hägermark O, Ståhle-Bäckdahl M, et al. Urge to scratch represented in the human cerebral cortex during itch. J Neurophysiol. 1994;72(6):3004-3008.
Drzezga A, Darsow U, Treede RD, et al. Central activation by histamine-induced itch: analogies to pain processing: a correlational analysis of O-15 H2O positron emission tomography studies. Pain. 2001;92(1-2):295-305.
Mochizuki H, Tashiro M, Kano M, et al. Imaging of central itch modulation in the human brain using positron emission tomography. Pain. 2003;105(1-2):339-346.
Paus R, Schmelz M, Bíró T, Steinhoff M. Frontiers in pruritus research: scratching the brain for more effective itch therapy. J Clin Invest. 2006;116(5):1174-1186.
Ikoma A, Steinhoff M, Ständer S, et al. The neurobiology of itch. Nat Rev Neurosci. 2006;7(7):535-547.
Chamberlain SR, Blackwell AD, Fineberg NA, et al. The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neurosci Biobehav Rev. 2005;29(3):399-419.
Hendler T, Goshen E, Tzila Zwas S, et al. Brain reactivity to specific symptom provocation indicates prospective therapeutic outcome in OCD. Psychiatry Res. 2003;124(2):87-103.
Leknes SG, Bantick S, Willis CM, et al. Itch and motivation to scratch: an investigation of the central and peripheral correlates of allergen- and histamine-induced itch in humans. J Neurophysiol. 2007;97(1):415-422.
Bishop GH. The skin as an organ of senses with special reference to the itching sensation. J Invest Derm. 1948;11:143-154.
Felix R, Shuster S. A new method for the measurement of itch and the response to treatment. Br J Dermatol. 1975;93(3): 303-312.
Savin JA, Paterson WD, Oswald I, et al. Further studies of scratching during sleep. Br J Dermatol. 1975;93(3):297-302.
Aoki T, Kushimoto H, Hisikawa Y, et al. Nocturnal scratching and its relationship to the disturbed sleep of itchy subjects. Clin Exp Dermatol. 1991;16(4):268-272.
Burke RE. The use of state-dependent modulation of spinal reflexes as a tool to investigate the organization of spinal interneurons. Exp Brain Res. 1999;128(3): 263-277.
Berkowitz A. Spinal interneurons that are selectively activated during fictive flexion reflex. J Neurosci. 2007;27(17): 4634-4641.
Darsow U, Scharein E, Simon D, et al. New aspects of itch pathophysiology: component analysis of atopic itch using the “Eppendorf Itch Questionnaire”. Int Arch Allergy Immunol. 2001;124(1-3): 326-331.
Wallengren J. Vasoactive peptides in the skin. JID Symp Proc. 1997;2:49-55.
Pinkus H, Mehregan AH. A Guide to Dermatohistopathology. London: Butterworths; 1969.
Sa SM, Valdez PA, Wu J, et al. The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J Immunol. 2007;178(4):2229-2240.
Sonkoly E, Muller A, Lauerma AI, et al. IL-31: a new link between T cells and pruritus in atopic skin inflammation. J Allergy Clin Immunol. 2006;117(2):411-417.
Vaalasti A, Suomalainen H, Rechardt L. Calcitonin gene-related peptide immunoreactivity in prurigo nodularis: a comparative study with neurodermatitis circumscripta. Br J Dermatol. 1989;120(5):619-623.
Benrath J, Zimmermann M, Gillardon F. Substance P and nitric oxide mediate would healing of ultraviolet photodamaged rat skin: evidence for an effect of nitric oxide on keratinocyte proliferation. Neurosci Lett. 1995;200(1):17-20.
Seike M, Ikeda M, Morimoto A, et al. Increased synthesis of calcitonin gene-related peptide stimulates keratinocyte proliferation in murine UVB-irradiated skin. J Dermatol Sci. 2002;28(2):135-143.
Ackerman AB, Chongchitnant N, Sanches J, et al. Histologic Diagnosis of Inflammatory Skin Diseases. An Algorithmic Method Based on Pattern Analysis. 2 ed. Baltimore: Williams@Wilkins; 1997.
Crowe R, Parkhouse N, McGrouther D, et al. Neuropeptide-containing nerves in painful hypertrophic human scar tissue. Br J Dermatol. 1994;130(4):444-452.
Rajka G, Langeland T. Grading of the severity of atopic dermatitis. Acta Derm Venereol Suppl (Stockh). 1989;144:13-14.
Ikoma A, Rukwied R, Ständer S, et al. Neuronal sensitization for histamine-induced itch in lesional skin of patients with atopic dermatitis. Arch Dermatol. 2003;139(11):1455-1458.
Greaves MW. Itch in systemic disease: therapeutic options. Dermatol Ther. 2005;18(4):323-327.
Freytes DM, Arroyo-Novoa CM, Fiqueroa-Ramos MI. Skin disease in HIV-positive persons living in Puerto Rico. Adv Skin Wound Care. 2007;20(3):149-150, 152-156.
Reynolds TB. The “butterfly” sign in patients with chronic jaundice and pruritus. Ann Intern Med. 1973;78(4):545-546.
Venencie PY, Cuny M, Samuel D, et al. The “butterfly” sign in patients with primary biliary cirrhosis. J Am Acad Dermatol. 1988;19(3):571-572.
Kimura T, Miyazawa H. The “butterfly” sign in patients with atopic dermatitis: evidence for the role of scratching in the development of skin manifestations. J Am Acad Dermatol. 1989;21:579-580.
Gupta MA, Gupta AK, Haberman HF. Neurotic excoriations: a review and some new perspectives. Compr Psychiatry. 1986;27(4):381-386.
Keuthen NJ, Deckersbach T, Wilhelm S, et al. The skin picking impact scale (SPIS): scale development and psychometric analyses. Psychosomatics. 2001;42(5):397-403.
Arseculeratne G, Altmann P, Millard PR, et al. Giant lichenification of the scalp. Clin Exp Dermatol. 2003;28(3):257-259.
Goldstein RK, Bastian BC, Elsner P, et al. Giant lichenification of the vulva with marked ulcerations. A case report. J Reprod Med. 1991;36(4):309-311.
Goldblum RW, Piper WN. Artificial lichenification produced by a scratching machine. J Invest Dermatol. 1954;22(5):405-415.
Braun-Falco O, Plewig G, Wolff HH, et al. Dermatology. 2nd ed. Berlin: Springer; 2000.
Resnik KS. Verrucous - but is it a verruca? Am J Dermatopathol. 2003;25(4):347-348.
Tay CH, Dacosta JL. Lichen amyloidosis. Clinical study of 40 cases. Br J Dermatol. 1970;82(2):129-136.
Salim T, Shenoi SD, Balachandran C, et al. Lichen amyloidosus: a study of clinical, histopathologic and immunofluorescence findings in 30 cases. Indian J Dermatol Venereol Leprol. 2005;71(3):166-169.
Weyers W, Weyers I, Bonczkowitz M, et al. Lichen amyloidosus: a consequence of scratching. J Am Acad Dermatol. 1997;37(6):923-928.
Wong CK. Lichen amyloidosus. A relatively common skin disorder in Taiwan. Arch Dermatol. 1974;110(3):438-440.
Looi LM. Primary localised cutaneous amyloidosis in Malaysians. Australas J Dermatol. 1991;32(1):439-449.
Leonforte JF. Origin of macular amyloidosis. Apropos of 160 cases. Ann Dermatol Venereol. 1987;114(6-7):801-806.
Kibbi AG, Rubeiz NG, Zaynoun ST, Primary localized cutaneous amyloidosis. Int J Dermatol. 1992;31(2):95-98.
Wang WJ, Chang YT, Huang CY, Lee DD. Clinical and histopathological characteristics of primary cutaneous amyloidosis in 794 Chinese patients. Zhonghua Yi Xue Za Zhi (Taipei). 2001;64(2):101-107.
Eswaramoorthy V, Kaur I, Das A, Kumar B. Macular amyloidosis: etiological factors. J Dermatol. 1999;26(5):305-310.
Wallengren J. Neuroanatomy and neurophysiology of itch. Dermatol Ther. 2005;18:292-303.
Weber PJ, Poulos EG. Notalgia paresthetica. Case reports and histologic appraisal. J Am Acad Dermatol. 1988;18(1 pt 1):25-30.
Westermark P, Ridderström E, Vahlquist A. Macular posterior pigmentary incontinence: its relation to macular amyloidosis and notalgia paresthetica. Acta Derm Venereol. 1996;76(4):302-304.
Bernhard JD. Notalgia paresthetica, macular posterior pigmentary incontinence, macular amyloidosis and pruritus. Acta Derm Venereol. 1997;77(2):164.
Bedi TR, Datta BN. Diffuse biphasic cutaneous amyloidosis. Dermatologica. 1979;158(6):433-437.
Wallengren J. Prurigo: Diagnosis and management. Am J Clin Dermatol. 2004;5;1-11.
Murphy M, Carmichael AJ. Renal itch. Clin Exp Dermatol. 2000;25(2):103-106.
Rowland Payne CM, Wilkinson JD, McKee PH et al. Nodular prurigo - a clinicopathological study of 46 patients. Br J Dermatol. l985;113:431-439.
Fried RG, Fried S. Picking apart the picker: a clinician’s guide for management of the patient presenting with excoriations. Cutis. 2003;71(4):291-298.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag London Limited
About this chapter
Cite this chapter
Wallengren, J. (2010). Secondary Reactive Conditions in Pruritic Skin. In: Misery, L., Ständer, S. (eds) Pruritus. Springer, London. https://doi.org/10.1007/978-1-84882-322-8_20
Download citation
DOI: https://doi.org/10.1007/978-1-84882-322-8_20
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-84882-321-1
Online ISBN: 978-1-84882-322-8
eBook Packages: MedicineMedicine (R0)