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Preoperative Imaging of Liver Cancers: Hilar Cholangiocarcinoma

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Venous Embolization of the Liver

Abstract

Patients with suspected hilar cholagiocarcinoma frequently present with obstructive jaundice. The conventional algorithm for imaging studies of those patients usually starts with an ultrasonography of the abdomen to exclude more common and benign conditions, such as choledocholithiasis, gallstones, cholecystitis, and Mirizzi syndrome.2,29,30 An MR cholangiography and CT of the abdomen has been advocated and increasingly used in clinical practices to fully evaluate the causes of jaundice. Once the benign conditions are excluded, or in patients with a highly suspicious malignant cause of obstructive jaundice such as a hilar cholangiocarcinoma, pancreatic carcinoma, or gallbladder carcinoma, a more tailored examination will be needed to evaluate the cause, the extent, and the staging of the malignant disease. The primary signs of hilar cholangiocarcinoma on CT or MR imaging are the presence of soft tissue mass and the focal thickening of the ductal wall with periductal infiltration associated with constriction of the lumen, and the intraluminal nodule in the dilated duct.

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References

  1. Carriega MT, Henson DE. Liver, gallbladder, extrahepatic bile ducts and pancreas. Cancer. 1995;75:171-190.

    Article  Google Scholar 

  2. Ito F, Cho CS, Rikkers LF, Weber SM. Hilar cholangiocarcinoma: current management. Ann Surg. 2009;250:210-218.

    Article  PubMed  Google Scholar 

  3. Blechacz B, Gores GJ. Cholangiocarcinoma: advances in pathogenesis, diagnosis and treatment. Hepatology. 2008;48:308-321.

    Article  PubMed  CAS  Google Scholar 

  4. Japanese Society of Biliary Surgery. General Rules for Surgical and Pathological Studies on Cancer of the Biliary Tract. Tokyo: Kanehara; 1986.

    Google Scholar 

  5. Nakeeb A, Pitt HA, Sohn T, et al. Cholangiocarcinoma: a spectrum of intrahepatic, perihilar, and distal tumors. Ann Surg. 1996;224:463-475.

    Article  PubMed  CAS  Google Scholar 

  6. Klatskin G. Adenocarcinoma of the hepatic duct at its bifurcation within the porta hepatis. An unusual tumor with distinctive clinical and pathological features. Am J Med. 1965;38:241-256.

    Article  PubMed  CAS  Google Scholar 

  7. Kosogue T, Yamamoto J, Shimada K, et al. Improved surgical results for hilar cholangiocarcinoma with procedures including major hepatic resection. Ann Surg. 1999;230:663-671.

    Article  Google Scholar 

  8. Neuhaus P, Jonas S, Bechstein WO, et al. Extended resection for hilar cholangiocarcinoma. Ann Surg. 1999;230:808-818.

    Article  PubMed  CAS  Google Scholar 

  9. Launois B, Reding R, Lebeau G, et al. Surgery for hilar cholangiocarcinoma: French experience in a collective survey of 552 extrahepatic bile duct cancer. J Hepatobiliary Pancreat Surg. 2000;7:128-134.

    Article  PubMed  CAS  Google Scholar 

  10. Jarnagin WR, Fong Y, DeMatteo RP, et al. Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma. Ann Surg. 2001;234:507-517.

    Article  PubMed  CAS  Google Scholar 

  11. Seyema Y, Kubota K, Sano K, et al. Long-term outcome of extended hemihepatectomy for hilar bile duct cancer with no mortality and high survival rate. Ann Surg. 2003;238:73-83.

    Google Scholar 

  12. Ebata T, Nagino M, Kamiya J, et al. Hepatectomy with portal vein resection for hilar cholangiocarcinoma: audit of 52 consecutive cases. Ann Surg. 2003;238:720-727.

    Article  PubMed  Google Scholar 

  13. Hemming AW, Reed AI, Fujita S, et al. Surgical management of hilar cholangiocarcinoma. Ann Surg. 2005;241:693-699.

    Article  PubMed  Google Scholar 

  14. Hemming AW, Kim RD, Mekeel KL, et al. Portal vein resection for hilar cholangiocarcinoma. Am Surg. 2006;72:599-604.

    PubMed  Google Scholar 

  15. Lee HY, Kim SH, Lee JM, et al. Preoperative assessment of resectability of hilar cholangiocarcinoma: combined CT and cholangiography with revised criteria. Radiology. 2006;239:113-121.

    Article  PubMed  Google Scholar 

  16. Chen HW, Pan AZ, Zhen ZY, et al. Preoperative evaluation of resectability of Klatskin tumor with 16-MDCT angiography and cholangiography. AJR. 2006;186:1580-1586.

    Article  PubMed  CAS  Google Scholar 

  17. Kim HJ, Lee JM, Kim SH, et al. Evaluation of the longitudinal tumor extent of bile duct cancer: value of adding gadolinium-enhanced dynamic imaging to unenhanced imaged and magnetic resonance cholangiography. J Comput Assist Tomogr. 2007;31:469-474.

    Article  PubMed  Google Scholar 

  18. Aloia TA, Charnsangavej C, Faria S, et al. High-resolution computed tomography accurately predicts resectability in hilar cholangiocarcinoma. Am J Surg. 2007;193:702-706.

    Article  PubMed  Google Scholar 

  19. Choi J-Y, Kim M-J, Lee JM, et al. Hilar cholangiocarcinoma: role of preoperative imaging with sonography, MDCT, MRI, and direct cholangiography. AJR. 2008;191:1448-1457.

    Article  PubMed  Google Scholar 

  20. Park HS, Lee JM, Choi J-Y, et al. Preoperative evaluation of bile duct cancer: MRI combined with MR cholangiopancreatography. AJR. 2008;190:396-405.

    Article  PubMed  Google Scholar 

  21. Vilgrain V. Staging cholangiocarcinoma by imaging studies. HPB (Oxford). 2008;10:106-109.

    Article  CAS  Google Scholar 

  22. Masselli G, Manfredi R, Vecchioli A, Gualdi G. MR imaging and MR cholangiopancreatography in the preoperative evaluation of hilar cholangiocarcinoma: correlation with surgical and pathologic findings. Eur Radiol. 2008;18:2213-2221.

    Article  PubMed  Google Scholar 

  23. Weber SM, DeMatteo RP, Fong Y, et al. Staging laparoscopy in patients with extrahepatic biliary carcinoma. Analysis of 100 patients. Ann Surg. 2002;235:392-399.

    Article  PubMed  Google Scholar 

  24. Edge SB, Byrd DR, Compton CC, et al., eds. Perihilar bile duct and distal bile duct. In: Cancer Staging Manual. 7th ed. New York: Springer; 2010:219–233.

    Google Scholar 

  25. Weinbren K, Mutum SS. Pathological aspects of cholangiocarcinoma. J Pathol. 1983;139:217-238.

    Article  PubMed  CAS  Google Scholar 

  26. Hayashi S, Miyazaki M, Kondo Y, et al. Invasive growth patterns of hepatic hilar ductal carcinoma. A histologic analysis of 18 surgical cases. Cancer. 1994;73:2922-2929.

    Article  PubMed  CAS  Google Scholar 

  27. Jarnagin WR, Bowne W, Klimstra DS, et al. Papillary phenotype confers improved survival after resection of hilar cholangiocarcinoma. Ann Surg. 2005;241:703-712.

    Article  PubMed  Google Scholar 

  28. Lim JH. Cholangiocarcinoma: morphologic classification according to growth pattern and imaging findings. AJR. 2003;181:819-827.

    PubMed  Google Scholar 

  29. Verbeek PC, van Leeuwen DJ, de Wit LT, et al. Benign fibrosing disease at the hepatic confluence mimicking Klatskin tumors. Surgery. 1992;112:866-871.

    PubMed  CAS  Google Scholar 

  30. Wetter LA, Ring EJ, Pellegrini CA, et al. Differential diagnosis of sclerosing cholangiocarcinomas of the common hepatic duct (Klatskin tumors). Am J Surg. 1991;161:57-62.

    Article  PubMed  CAS  Google Scholar 

  31. Kim JY, Lee JM, Han JK, et al. Contrast-enhanced MRI combined with MR cholangiopancreatography for the evaluation of patients with biliary strictures: differentiation of malignant from benign bile duct strictures. J Magn Reson Imaging. 2007;26:304-312.

    Article  PubMed  Google Scholar 

  32. Healy JE, Scroy PC. Anatomy of the biliary ducts within the human liver: analysis of the prevailing pattern of branching and the major variations of the biliary ducts. Arch Surg. 1953;66:599-616.

    Article  Google Scholar 

  33. Charnsangavej C. Anatomy of the liver, bile duct and pancreas. In: Gazelle GC, Saini S, Mueller PR, eds. Hepatobiliary and Pancreatic Radiology, Imaging and Intervention. New York: Thieme Medical Publishers, Inc.; 1998:1-23.

    Google Scholar 

  34. Abdalla EK, Vauthey JN, Couinaud C. The caudate lobe of the liver: implications of embryology and anatomy for surgery. Surg Oncol Clin N Am. 2002;11:835-848.

    Article  PubMed  Google Scholar 

  35. Sakamoto E, Nimura Y, Hayakawa N, et al. The pattern of infiltration at the proximal border of hilar bile duct carcinoma: a histologic analysis of 62 resected cases. Ann Surg. 1998;227:405-411.

    Article  PubMed  CAS  Google Scholar 

  36. Parikh A, Abdala E, Vauthey JN. Operative considerations in the resection of hilar cholangiocarcinoma. HPB (Oxford). 2005;7:254-258.

    Article  Google Scholar 

  37. Loyer EM, David CL, DuBrow RA, Evans DB, Charnsangavej C. Vascular involvement in pancreatic adenocarcinoma: reassessment by thin-section CT. Abdom Imaging. 1996;21:202-206.

    Article  PubMed  CAS  Google Scholar 

  38. Katz MHG, Pisters PWT, Evans DB, et al. Borderline resectable pancreatic cancer: the importance of this emerging stage of disease. J Am Coll Surg. 2008;206:833-848.

    Article  PubMed  Google Scholar 

  39. Michels NA. Observations on the blood supply of the liver (200 dissections). In: Blood Supply and Anatomy of the Upper Abdominal Organs. Philadelphia: Lippincott JB; 1995:139-165.

    Google Scholar 

  40. Kitagawa Y, Nagino M, Kayima J, et al. Lymph node metastasis from hilar cholangiocarcinoma: audit of 110 patients who underwent regional and paraaortic node dissection. Ann Surg. 2001;233:385-392.

    Article  PubMed  CAS  Google Scholar 

  41. Vauthey JN, Chaoui A, Do KA, et al. Standardized measurement of the future liver remnant prior to extended liver resection; methodology and clinical associations. Surgery. 2000;127:512-519.

    Article  PubMed  CAS  Google Scholar 

  42. Hemming AW, Reed AI, Howard RJ, et al. Preoperative portal vein embolization for extended hepatectomy. Ann Surg. 2003;237:686-691.

    PubMed  Google Scholar 

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Correspondence to Chusilp Charnsangavej .

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Kaur, H., Loyer, E.M., Charnsangavej, C. (2011). Preoperative Imaging of Liver Cancers: Hilar Cholangiocarcinoma. In: Madoff, D., Makuuchi, M., Nagino, M., Vauthey, JN. (eds) Venous Embolization of the Liver. Springer, London. https://doi.org/10.1007/978-1-84882-122-4_8

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  • DOI: https://doi.org/10.1007/978-1-84882-122-4_8

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