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Animal Models for Senile Osteoporosis

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Osteoporosis in Older Persons

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Age-related decline in bone mass is a universal phenomenon among laboratory mammals. Research on aging has been conducted using various models from yeast and nematode to mouse and non-human primates, and has rapidly progressed because of the recent development of forward and reverse genetics, as well as functional genomics. A number of mouse models bearing artificially or naturally modified genes develop bone phenotypes with various pathologies. Among those mice, some are considered to be potent models for understanding the pathophysiology of senile osteoporosis in humans. Here, available models for the study of senile osteoporosis, and mouse models in particular, are introduced and discussed.

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Authors and Affiliations

  1. Department of Bone and Joint Disease, Nationa Institute for Longevity Science (NILS), Nationa Center for Geriatrics and Gerontology (NCGG), Japan

    Ken Watanabe PhD

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Editors and Affiliations

  1. Division of Geriatric Medicine-Jewish General Hospital, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada

    Gustavo Duque

  2. Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, USA

    Douglas P. Kiel

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Watanabe, K. (2009). Animal Models for Senile Osteoporosis. In: Duque, G., Kiel, D.P. (eds) Osteoporosis in Older Persons. Springer, London. https://doi.org/10.1007/978-1-84628-697-1_5

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