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Abstract

The traditional aim of therapy in epilepsies is total freedom from seizures with no clinically significant adverse effects. This has now been broadened to include optimal outcomes of health-related quality of life with regard to physical, mental, educational, social and psychological functioning of the patient. The mainstay of treatment is usually with antiepileptic drugs (AEDs) in continuous prophylactic schemes. However, AEDs are ineffective for about 20% of patients. These patients are candidates for neuro surgical interventions, other pharmacological or non-pharmacological treatments.

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References

  1. Bodde NM, Brooks JL, Baker GA, Boon PA, Hendriksen JG, Mulder OG et al. Psychogenic non-epileptic seizures—diagnostic issues: a critical review. Clin Neurol Neurosurg 2009;111:1–9.

    Article  PubMed  CAS  Google Scholar 

  2. National Institute for Health and Clinical Excellence (NICE). The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care. www.niceorguk/pageaspx?o=227586, 2004. Last accessed 27 September 2009.

    Google Scholar 

  3. Tegretol® (carbamazepine). Summary of product characteristics. Novartis Pharmaceuticals UK Ltd, 2009.

    Google Scholar 

  4. Frisium® (clobazam). Summary of product characteristics. Sanofiaventis, 2009.

    Google Scholar 

  5. Rivotril® (clonazepam). Summary of product characteristics. Roche Products Ltd, 2009.

    Google Scholar 

  6. Zarontin® (ethosuximide). Summary of product characteristics. Pfizer Ltd, 2009.

    Google Scholar 

  7. Neurontin® (gabapentin). Summary of product characteristics. Pfizer Ltd, 2009.

    Google Scholar 

  8. Vimpat® (lacosamide). Summary of product characteristics. UCB Pharma Ltd, 2009.

    Google Scholar 

  9. Lamictal® (lamotrigine). Summary of product characteristics. GlaxoSmithKline UK Ltd, 2009.

    Google Scholar 

  10. Keppra® (levetiracetam). Summary of product characteristics. UCB Pharma Ltd, 2009.

    Google Scholar 

  11. Trileptal® (oxcarbazepine). Summary of product characteristics. Novartis Pharmaceuticals UK Ltd, 2009.

    Google Scholar 

  12. Phenobarbital. Summary of product characteristics. Actavis UK Ltd, 2009.

    Google Scholar 

  13. Epanutin® (phenytoin). Summary of product characteristics. Pfizer Ltd, 2009.

    Google Scholar 

  14. Lyrica® (pregabalin). Summary of product characteristics. Pfizer Ltd, 2009.

    Google Scholar 

  15. Gabitril® (tiagabine). Summary of product characteristics. Cephalon (UK) Ltd, 2009.

    Google Scholar 

  16. Topamax® (topiramate). Summary of product characteristics. Janssen-Cilag Ltd, 2009.

    Google Scholar 

  17. Epilim® (sodium valproate). Summary of product characteristics. Sanofi-aventis, 2009.

    Google Scholar 

  18. Sabril® (vigabatrin). Summary of product characteristics. Sanofiaventis, 2009.

    Google Scholar 

  19. Zonegran® (zonisamide). Summary of product characteristics. Eisai Ltd, 2009.

    Google Scholar 

  20. Panayiotopoulos CP, Chroni E, Daskalopoulos C, Baker A, Rowlinson S, Walsh P. Typical absence seizures in adults: clinical, EEG, video-EEG findings and diagnostic/syndromic considerations. J Neurol Neurosurg Psychiatr 1992;55:1002–1008.

    Article  PubMed  CAS  Google Scholar 

  21. Liporace JD, Sperling MR, Dichter MA. Absence seizures and carbamazepine in adults. Epilepsia 1994;35:1026–1028.

    Article  PubMed  CAS  Google Scholar 

  22. Parker AP, Agathonikou A, Robinson RO, Panayiotopoulos CP. Inappropriate use of carbamazepine and vigabatrin in typical absence seizures. Dev Med Child Neurol 1998;40:517–519.

    PubMed  CAS  Google Scholar 

  23. Genton P, Gelisse P, Thomas P, Dravet C. Do carbamazepine and phenytoin aggravate juvenile myoclonic epilepsy? Neurology 2000;55:1106–1109.

    PubMed  CAS  Google Scholar 

  24. Thomas P, Valton L, Genton P. Absence and myoclonic status epilepticus precipitated by antiepileptic drugs in idiopathic generalized epilepsy. Brain 2006;129:1281–1292.

    Article  PubMed  Google Scholar 

  25. Gayatri NA, Livingston JH. Aggravation of epilepsy by anti-epileptic drugs. Dev Med Child Neurol 2006;48:394–398.

    Article  PubMed  CAS  Google Scholar 

  26. Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy. Canadian Study Group for Childhood Epilepsy. Epilepsia 1998;39:952–959.

    Google Scholar 

  27. Montenegro MA, Cendes F, Noronha AL, Mory SB, Carvalho MI, Marques LH, et al. Efficacy of clobazam as add-on therapy in patients with refractory partial epilepsy. Epilepsia 2001;42:539–542.

    Article  PubMed  CAS  Google Scholar 

  28. Sugai K. Clobazam as a new antiepileptic drug and clorazepate dipotassium as an alternative antiepileptic drug in Japan. Epilepsia 2004;45Suppl:20–25.

    Article  PubMed  CAS  Google Scholar 

  29. Obeid T, Panayiotopoulos CP. Clonazepam in juvenile myoclonic epilepsy. Epilepsia 1989;30:603–606.

    Article  PubMed  CAS  Google Scholar 

  30. Oguni H, Uehara T, Tanaka T, Sunahara M, Hara M, Osawa M. Dramatic effect of ethosuximide on epileptic negative myoclonus: implications for the neurophysiological mechanism. Neuropediatrics 1998;29:29–34.

    Article  PubMed  CAS  Google Scholar 

  31. Guerrini R, Dravet C, Genton P, Belmonte A, Kaminska A, Dulac O. Lamotrigine and seizure aggravation in severe myoclonic epilepsy. Epilepsia 1998;39:508–512.

    Article  PubMed  CAS  Google Scholar 

  32. Guerrini R, Belmonte A, Parmeggiani L, Perucca E. Myoclonic status epilepticus following high-dosage lamotrigine therapy. Brain Dev 1999;21:420–424.

    Article  PubMed  CAS  Google Scholar 

  33. Biraben A, Allain H, Scarabin JM, Schuck S, Edan G. Exacerbation of juvenile myoclonic epilepsy with lamotrigine. Neurology 2000;55:1758.

    PubMed  CAS  Google Scholar 

  34. Carrazana EJ, Wheeler SD. Exacerbation of juvenile myoclonic epilepsy with lamotrigine. Neurology 2001;56:1424–1425.

    PubMed  CAS  Google Scholar 

  35. Verrotti A, Domizio S, Franzoni E, Mohn A, Franzoni E, Coppola G et al. Levetiracetam in absence epilepsy: long-term efficacy in newly diagnosed patients. Dev Med Child Neurol 2008;50:850–853.

    Article  PubMed  Google Scholar 

  36. Di Bonaventura C, Fattouch J, Mari F, Egeo G, Vaudano AE, Prencipe M, et al. Clinical experience with levetiracetam in idiopathic generalized epilepsy according to different syndrome subtypes. Epileptic Disord 2005;7:231–235.

    PubMed  Google Scholar 

  37. Kaddurah AK, Holmes GL. Possible precipitation of myoclonic seizures with oxcarbazepine. Epilepsy Behav 2006;8:289–293.

    Article  PubMed  Google Scholar 

  38. Gelisse P, Genton P, Kuate D, Pesenti A, Baldy-Moulinier M, Crespel A. Worsening of seizures by oxcarbazepine in juvenile idiopathic generalized epilepsies. Epilepsia 2004;45:1282–1288.

    Article  PubMed  CAS  Google Scholar 

  39. Vendrame M, Khurana DS, Cruz M, Melvin J, Valencia I, Legido A, et al. Aggravation of seizures and/or EEG features in children treated with oxcarbazepine monotherapy. Epilepsia 2007;48:2116–2120.

    Article  PubMed  CAS  Google Scholar 

  40. Huppertz HJ, Feuerstein TJ, Schulze-Bonhage A. Myoclonus in epilepsy patients with anticonvulsive add-on therapy with pregabalin. Epilepsia 2001;42:790–792.

    Article  PubMed  CAS  Google Scholar 

  41. Knake S, Klein KM, Hattemer K, Wellek A, Oertel WH, Hamer HM, et al. Pregabalin-induced generalized myoclonic status epilepticus in patients with chronic pain. Epilepsy Behav 2007;11:471–473.

    Article  PubMed  CAS  Google Scholar 

  42. Striano P, Coppola A, Madia F, Pezzella M, Ciampa C, Zara F, et al. Life-threatening status epilepticus following gabapentin administration in a patient with benign adult familial myoclonic epilepsy. Epilepsia 2007;48:1995–1998.

    Article  PubMed  CAS  Google Scholar 

  43. Arzimanoglou A, Rahbani A. Zonisamide for the treatment of epilepsy. Expert Rev Neurother 2006;6:1283–1292.

    Article  PubMed  CAS  Google Scholar 

  44. Glauser T, Ben-Menachem E, Bourgeois B, Cnaan A, Chadwick D, Guerreiro C, et al. ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia 2006;47:1094–1120.

    Article  PubMed  Google Scholar 

  45. French JA. Now we know the drug of first choice — or do we? Epilepsy Curr 2007;7:125–127.

    Article  PubMed  Google Scholar 

  46. Gelisse P, Juntas-Morales R, Genton P, Hillaire-Buys D, Diaz O, Coubes P, et al. Dramatic weight loss with levetiracetam. Epilepsia 2008;49:308–315.

    Article  PubMed  CAS  Google Scholar 

  47. Perucca E, Johannessen SI. The ideal pharmacokinetic properties of an antiepileptic drug: how close does levetiracetam come? Epileptic Disord 2003;5Suppl 1:S17–S26.

    PubMed  Google Scholar 

  48. Patsalos PN. Properties of antiepileptic drugs in the treatment of idiopathic generalized epilepsies. Epilepsia 2005;46Suppl 9:140–148.

    Article  PubMed  CAS  Google Scholar 

  49. Patsalos PN. Levetiracetam. Rev Contemp Pharm 2004;13:1–168.

    CAS  Google Scholar 

  50. Tran TA, Leppik IE, Blesi K, Sathanandan ST, Remmel R. Lamotrigine clearance during pregnancy. Neurology 2002;59:251–255.

    PubMed  CAS  Google Scholar 

  51. Ferrie CD, Robinson RO, Knott C, Panayiotopoulos CP. Lamotrigine as an add-on drug in typical absence seizures. Acta Neurol Scand 1995;91:200–202.

    Article  PubMed  CAS  Google Scholar 

  52. Reutens DC, Duncan JS, Patsalos PN. Disabling tremor after lamotrigine with sodium valproate. Lancet 1993;342:185–186.

    Article  PubMed  CAS  Google Scholar 

  53. Morrow J, Russell A, Guthrie E, Parsons L, Robertson I, Waddell R, et al. Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2006;77:193–198.

    Article  PubMed  CAS  Google Scholar 

  54. Czapinski P, Blaszczyk B, Czuczwar SJ. Mechanisms of action of antiepileptic drugs. Curr Top Med Chem 2005;5:3–14.

    Article  PubMed  CAS  Google Scholar 

  55. Luszczki JJ. Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions. Pharmacol Rep 2009;61:197–216.

    PubMed  CAS  Google Scholar 

  56. Stefan H, Feuerstein TJ. Novel anticonvulsant drugs. Pharmacol Ther 2007;113:165–183.

    Article  PubMed  CAS  Google Scholar 

  57. Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS. Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res 2009;83:1–43.

    Article  PubMed  Google Scholar 

  58. Kaminski RM, Matagne A, Patsalos PN, Klitgaard H. Benefit of combination therapy in epilepsy: a review of the preclinical evidence with levetiracetam. Epilepsia 2009;50:387–397.

    Article  PubMed  CAS  Google Scholar 

  59. Deckers CL, Czuczwar SJ, Hekster YA, Keyser A, Kubova H, Meinardi H et al. Selection of antiepileptic drug polytherapy based on mechanisms of action: the evidence reviewed. Epilepsia 2000;41:1364–1374.

    Article  PubMed  CAS  Google Scholar 

  60. Kwan P, Brodie MJ. Combination therapy in epilepsy: when and what to use. Drugs 2006;66:1817–1829.

    Article  PubMed  CAS  Google Scholar 

  61. Cross SA, Curran MP. Lacosamide: in partial-onset seizures. Drugs 2009;69:449–459.

    Article  PubMed  CAS  Google Scholar 

  62. Privitera MD, Brodie MJ, Mattson RH, Chadwick DW, Neto W, Wang S. Topiramate, carbamazepine and valproate monotherapy: double blind comparison in newly diagnosed epilepsy. Acta Neurol Scand 2003;107:165–175.

    Article  PubMed  CAS  Google Scholar 

  63. Kwan P, Brodie MJ. Effectiveness of first antiepileptic drug. Epilepsia 2001;42:1255–1260.

    Article  PubMed  CAS  Google Scholar 

  64. Schiller Y, Najjar Y. Quantifying the response to antiepileptic drugs: effect of past treatment history. Neurology 2008;70:54–65.

    Article  PubMed  Google Scholar 

  65. Schmidt D, Elger C, Holmes GL. Pharmacological overtreatment in epilepsy: mechanisms and management. Epilepsy Res 2002;52:3–14.

    Article  PubMed  Google Scholar 

  66. Deckers CL, Knoester PD, de Haan GJ, Keyser A, Renier WO, Hekster YA. Selection criteria for the clinical use of the newer antiepileptic drugs. CNS Drugs 2003;17:405–421.

    Article  PubMed  CAS  Google Scholar 

  67. Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, et al. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc Natl Acad Sci USA 2004;101:9861–9866.

    Article  PubMed  CAS  Google Scholar 

  68. Liow K. Understanding patients’ perspective in the use of generic antiepileptic drugs: compelling lessons for physicians to improve physician/patient communication. BMC Neurol 2009;9:11.

    Article  PubMed  Google Scholar 

  69. Van PW, Hauman H, Lagae L. The use of generic medication in epilepsy: a review of potential issues and challenges. Eur J Paediatr Neurol 2009;13:87–92.

    Article  Google Scholar 

  70. Berg MJ, Gross RA, Haskins LS, Zingaro WM, Tomaszewski KJ. Generic substitution in the treatment of epilepsy: patient and physician perceptions. Epilepsy Behav 2008;13:693–699.

    Article  PubMed  Google Scholar 

  71. Gidal BE, Tomson T. Debate: Substitution of generic drugs in epilepsy: is there cause for concern? Epilepsia 2008;49Suppl 9:56–62.

    Article  PubMed  Google Scholar 

  72. Privitera MD. Generic antiepileptic drugs: current controversies and future directions. Epilepsy Curr 2008;8:113–117.

    Article  PubMed  Google Scholar 

  73. Andermann F, Duh MS, Gosselin A, Paradis PE. Compulsory generic switching of antiepileptic drugs: high switchback rates to branded compounds compared with other drug classes. Epilepsia 2007;48:464–469.

    Article  PubMed  CAS  Google Scholar 

  74. Heaney DC, Sander JW. Antiepileptic drugs: generic versus branded treatments. Lancet Neurol 2007;6:465–468.

    Article  PubMed  Google Scholar 

  75. Miller JW, Anderson GD, Doherty MJ, Poolos NP. Position statement on the coverage of anticonvulsant drugs for the treatment of epilepsy: what’s the problem with generic antiepileptic drugs? A call to action. Neurology 2007;69:1806–1808.

    Article  PubMed  Google Scholar 

  76. Bialer M. Generic products of antiepileptic drugs (AEDs): is it an issue? Epilepsia 2007;48:1825–1832.

    Article  PubMed  Google Scholar 

  77. Bochner F, Hooper WD, Tyrer JH, Eadie MJ. Factors involved in an outbreak of phenytoin intoxication. J Neurol Sci 1972;16:481–487.

    Article  PubMed  CAS  Google Scholar 

  78. Patsalos PN, Berry DJ, Bourgeois BF, Cloyd JC, Glauser TA, Johannessen SI et al. Antiepileptic drugs—best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies. Epilepsia 2008;49:1239–1276.

    Article  PubMed  CAS  Google Scholar 

  79. Shorvon S. We live in the age of the clinical guideline. Epilepsia 2006;47:1091–1093.

    Article  PubMed  Google Scholar 

  80. Sackett DL, Rosenberg WM, Gray JA, Haynes RB, Richardson WS. Evidence based medicine: what it is and what it isn’t. BMJ 1996;312:71–72.

    PubMed  CAS  Google Scholar 

  81. Dickersin K, Straus SE, Bero LA. Evidence based medicine: increasing, not dictating, choice. BMJ 2007;334Suppl 1:s10.

    Article  PubMed  Google Scholar 

  82. French JA. First-choice drug for newly diagnosed epilepsy. Lancet 2007;369:970–971.

    Article  PubMed  Google Scholar 

  83. French JA. Response: efficacy and tolerability of the new antiepileptic drugs. Epilepsia 2004;45:1649–1651.

    Article  Google Scholar 

  84. Marson AG, Al-Kharusi AM, Alwaidh M, Appleton R, Baker GA, Chadwick DW, et al. The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial. Lancet 2007;369:1016–1026.

    Article  PubMed  CAS  Google Scholar 

  85. Marson AG, Williamson PR, Clough H, Hutton JL, Chadwick DW. Carbamazepine versus valproate monotherapy for epilepsy: a metaanalysis. Epilepsia 2002;43:505–513.

    Article  PubMed  CAS  Google Scholar 

  86. Chadwick D. Safety and efficacy of vigabatrin and carbamazepine in newly diagnosed epilepsy: a multicentre randomised doubleblind study. Vigabatrin European Monotherapy Study Group. Lancet 1999;354:13–19.

    Article  PubMed  CAS  Google Scholar 

  87. Eke T, Talbot JF, Lawden MC. Severe persistent visual field constriction associated with vigabatrin. BMJ 1997;314:180–181.

    PubMed  CAS  Google Scholar 

  88. Panayiotopoulos CP, Benbadis SR, Covanis A, Dulac O, Duncan JS, Eeg-Olofsson O, et al. Efficacy and tolerability of the new antiepileptic drugs; commentary on the recently published practice parameters. Epilepsia 2004;45:1646–1649.

    Article  PubMed  Google Scholar 

  89. Walker MC, Sander JW. Difficulties in extrapolating from clinical trial data to clinical practice: the case of antiepileptic drugs. Neurology 1997;49:333–337.

    PubMed  CAS  Google Scholar 

  90. Beghi E. Efficacy and tolerability of the new antiepileptic drugs: comparison of two recent guidelines. Lancet Neurol 2004;3:618–621.

    Article  PubMed  CAS  Google Scholar 

  91. French JA, Kanner AM, Bautista J, Abou-Khalil B, Browne T, Harden CL, et al. Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2004;62:1252–1260.

    PubMed  CAS  Google Scholar 

  92. Patsalos PN. Clinical pharmacokinetics of levetiracetam. Clin Pharmacokinet 2004;43:707–724.

    Article  PubMed  CAS  Google Scholar 

  93. Patsalos PN. The pharmacokinetic characteristics of levetiracetam. Methods Find Exp Clin Pharmacol 2003;25:123–129.

    Article  PubMed  CAS  Google Scholar 

  94. Brodie MJ, Perucca E, Ryvlin P, Ben-Menachem E, Meencke HJ. Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy. Neurology 2007;68:402–408.

    Article  PubMed  CAS  Google Scholar 

  95. Berkovic SF, Knowlton RC, Leroy RF, Schiemann J, Falter U. Placebocontrolled study of levetiracetam in idiopathic generalized epilepsy. Neurology 2007;69:1751–1760.

    Article  PubMed  CAS  Google Scholar 

  96. Guidelines for therapeutic monitoring on antiepileptic drugs. Commission on Antiepileptic Drugs, International League Against Epilepsy. Epilepsia 1993;34:585–587.

    Article  Google Scholar 

  97. Johannessen SI, Tomson T. Pharmacokinetic variability of newer antiepileptic drugs: when is monitoring needed? Clin Pharmacokinet 2006;45:1061–1075.

    Article  PubMed  CAS  Google Scholar 

  98. Glauser TA, Pippenger CE. Controversies in blood-level monitoring: reexamining its role in the treatment of epilepsy. Epilepsia 2000;41Suppl 8:S6–S15.

    Article  PubMed  CAS  Google Scholar 

  99. Battino D, Croci D, Rossini A, Messina S, Mamoli D, Perucca E. Topiramate pharmacokinetics in children and adults with epilepsy: a case-matched comparison based on therapeutic drug monitoring data. Clin Pharmacokinet 2005;44:407–416.

    Article  PubMed  CAS  Google Scholar 

  100. Johannessen SI, Battino D, Berry DJ, Bialer M, Kramer G, Tomson T, et al. Therapeutic drug monitoring of the newer antiepileptic drugs. Ther Drug Monit 2003;25:347–363.

    Article  PubMed  CAS  Google Scholar 

  101. Jannuzzi G, Cian P, Fattore C, Gatti G, Bartoli A, Monaco F, et al. A multicenter randomized controlled trial on the clinical impact of therapeutic drug monitoring in patients with newly diagnosed epilepsy. The Italian TDM Study Group in Epilepsy. Epilepsia 2000;41:222–230.

    Article  PubMed  CAS  Google Scholar 

  102. Elzagallaai AA, Knowles SR, Rieder MJ, Bend JR, Shear NH, Koren G. In vitro testing for the diagnosis of anticonvulsant hypersensitivity syndrome: a systematic review. Mol Diagn Ther 2009;13:313–330.

    PubMed  CAS  Google Scholar 

  103. Bohan KH, Mansuri TF, Wilson NM. Anticonvulsant hypersensitivity syndrome: implications for pharmaceutical care. Pharmacotherapy 2007;27:1425–1439.

    Article  PubMed  CAS  Google Scholar 

  104. Cumbo-Nacheli G, Weinberger J, Alkhalil M, Thati N, Baptist AP. Anticonvulsant hypersensitivity syndrome: is there a role for immunomodulation? Epilepsia 2008;49:2108–2112.

    Article  PubMed  CAS  Google Scholar 

  105. Elzagallaai AA, Knowles SR, Rieder MJ, Bend JR, Shear NH, Koren G. Patch testing for the diagnosis of anticonvulsant hypersensitivity syndrome: a systematic review. Drug Saf 2009;32:391–408.

    Article  PubMed  CAS  Google Scholar 

  106. Mansur AT, Pekcan YS, Goktay F. Anticonvulsant hypersensitivity syndrome: clinical and laboratory features. Int J Dermatol 2008;47:1184–1189.

    Article  PubMed  Google Scholar 

  107. Sabroe TP, Sabers A. Progressive anticonvulsant hypersensitivity syndrome associated with change of drug product. Acta Neurol Scand 2008;117:428–431.

    Article  PubMed  CAS  Google Scholar 

  108. Seitz CS, Pfeuffer P, Raith P, Brocker EB, Trautmann A. Anticonvulsant hypersensitivity syndrome: cross-reactivity with tricyclic antidepressant agents. Ann Allergy Asthma Immunol 2006;97:698–702.

    Article  PubMed  CAS  Google Scholar 

  109. Ting TY. Anticonvulsant hypersensitivity syndrome: identification and management. Curr Treat Options Neurol 2007;9:243–248.

    Article  PubMed  Google Scholar 

  110. US Food and Drug Administration. Dangerous or even fatal skin reactions: carbamazepine (marketed as Carbatrol, Equetro, Tegretol, and generics). Available online at http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm124718.htm. Last accessed 27 November 2009.

    Google Scholar 

  111. US Food and Drug Administration. Suicidal behavior and ideation and antiepileptic drugs. Available online at http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm100192.htm Last accessed 27 November 2009.

    Google Scholar 

  112. Bell GS, Sander JW. Suicide and epilepsy. Curr Opin Neurol 2009;22:174–178.

    Article  PubMed  Google Scholar 

  113. Bell GS, Mula M, Sander JW. Suicidality in people taking antiepileptic drugs: What is the evidence? CNS Drugs 2009;23:281–292.

    Article  PubMed  CAS  Google Scholar 

  114. Kanner AM. Depression in epilepsy: a complex relation with unexpected consequences. Curr Opin Neurol 2008;21:190–194.

    Article  PubMed  Google Scholar 

  115. Mula M, Sander JW. Suicidal ideation in epilepsy and levetiracetam therapy. Epilepsy Behav 2007;11:130–132.

    Article  PubMed  Google Scholar 

  116. Kanner AM. Depression and Epilepsy: A New Perspective on Two Closely Related Disorders. Epilepsy Curr 2006;6:141–146.

    Article  PubMed  Google Scholar 

  117. Zaccara G, Balestieri F, Ragazzoni A. Management of side effects of antiepileptic dugs. In: Shorvon S, Perucca E, Engel J Jr, eds. The treatment of epilepsy (3nd edition). Philadelphia: Wiley-Blackwell, 2009:289–299.

    Google Scholar 

  118. Zaccara G, Gangemi PF, Cincotta M. Central nervous system adverse effects of new antiepileptic drugs. A meta-analysis of placebo-controlled studies. Seizure 2008;17:405–421.

    Article  PubMed  CAS  Google Scholar 

  119. Arif H, Buchsbaum R, Weintraub D, Pierro J, Resor SR, Jr., Hirsch LJ. Patient-reported cognitive side effects of antiepileptic drugs: predictors and comparison of all commonly used antiepileptic drugs. Epilepsy Behav 2009;14:202–209.

    Article  PubMed  Google Scholar 

  120. Mula M, Trimble MR. Antiepileptic drug-induced cognitive adverse effects: potential mechanisms and contributing factors. CNS Drugs 2009;23:121–137.

    Article  PubMed  CAS  Google Scholar 

  121. Taylor J, Kolamunnage-Dona R, Marson AG, Smith PE, Aldenkamp AP, Baker GA. Patients with epilepsy: Cognitively compromised before the start of antiepileptic drug treatment? Epilepsia 2009 (in press).

    Google Scholar 

  122. Berg AT, Langfitt JT, Testa FM, Levy SR, DiMario F, Westerveld M et al. Global cognitive function in children with epilepsy: a communitybased study. Epilepsia 2008;49:608–614.

    Article  PubMed  Google Scholar 

  123. Helmstaedter C, Witt JA. The effects of levetiracetam on cognition: a non-interventional surveillance study. Epilepsy Behav 2008;13:642–649.

    Article  PubMed  Google Scholar 

  124. Kanner AM. Can antiepileptic drugs unmask a susceptibility to psychiatric disorders? Nat Clin Pract Neurol 2009;5:132–133.

    Article  PubMed  CAS  Google Scholar 

  125. Mula M, Trimble MR, Sander JW. Are psychiatric adverse events of antiepileptic drugs a unique entity? A study on topiramate and levetiracetam. Epilepsia 2007;48:2322–2326.

    PubMed  CAS  Google Scholar 

  126. Weintraub D, Buchsbaum R, Resor SR, Jr., Hirsch LJ. Psychiatric and behavioral side effects of the newer antiepileptic drugs in adults with epilepsy. Epilepsy Behav 2007;10:105–110.

    Article  PubMed  CAS  Google Scholar 

  127. Gilliam FG, Santos JM. Adverse psychiatric effects of antiepileptic drugs. Epilepsy Res 2006;68:67–69.

    Article  PubMed  Google Scholar 

  128. Besag FM. Behavioural effects of the newer antiepileptic drugs: an update. Expert Opin Drug Saf 2004;3:1–8.

    Article  PubMed  CAS  Google Scholar 

  129. Glauser TA. Effects of antiepileptic medications on psychiatric and behavioral comorbidities in children and adolescents with epilepsy. Epilepsy Behav 2004;5Suppl 3:S25–S32.

    Article  PubMed  Google Scholar 

  130. Trimble MR, Rusch N, Betts T, Crawford PM. Psychiatric symptoms after therapy with new antiepileptic drugs: psychopathological and seizure related variables. Seizure 2000;9:249–254.

    Article  PubMed  CAS  Google Scholar 

  131. Schmitz B. Psychiatric syndromes related to antiepileptic drugs. Epilepsia 1999;40Suppl 10:S65–S70.

    Article  PubMed  CAS  Google Scholar 

  132. Elliott B, Amarouche M, Shorvon SD. Psychiatric features of epilepsy and their management. In: Shorvon S, Perucca E, Engel J Jr, eds. The treatment of epilepsy, 3nd edition, pp 273–287. Philadelphia: Wiley-Blackwell.

    Google Scholar 

  133. Ettinger AB, Argoff CE. Use of antiepileptic drugs for nonepileptic conditions: psychiatric disorders and chronic pain. Neurotherapeutics 2007;4:75–83.

    Article  PubMed  CAS  Google Scholar 

  134. Clemens B. Forced normalisation precipitated by lamotrigine. Seizure 2005;14:485–489.

    Article  PubMed  Google Scholar 

  135. Witchel HJ, Hancox JC, Nutt DJ. Psychotropic drugs, cardiac arrhythmia, and sudden death. J Clin Psychopharmacol 2003;23:58–77.

    Article  PubMed  CAS  Google Scholar 

  136. Woosley RL. Drugs that prolong the QT interval and/or induce Torsades de Pointes. Available online at http://www.azcert.org/medicalpros/drug-lists/printable-drug-list.cfm. Last accessed 27 November 2009.

    Google Scholar 

  137. Singh G. Management of medical co-morbidity associated with epilepsy. In: Shorvon S, Perucca E, Engel J Jr, eds. The treatment of epilepsy, 3nd edition, pp 268–269. Philadelphia: Wiley-Blackwell, 2009.

    Google Scholar 

  138. Holbrook M, Malik M, Shah RR, Valentin JP. Drug induced shortening of the QT/QTc interval: an emerging safety issue warranting further modelling and evaluation in drug research and development? J Pharmacol Toxicol Methods 2009;59:21–28.

    Article  PubMed  CAS  Google Scholar 

  139. DeSilvey DL, Moss AJ. Primidone in the treatment of the long QT syndrome: QT shortening and ventricular arrhythmia suppression. Ann Intern Med 1980;93:53–54.

    PubMed  CAS  Google Scholar 

  140. Christidis D, Kalogerakis D, Chan TY, Mauri D, Alexiou G, Terzoudi A. Is primidone the drug of choice for epileptic patients with QT-prolongation? A comprehensive analysis of literature. Seizure 2006;15:64–66.

    Article  PubMed  CAS  Google Scholar 

  141. Shah RR. Cardiac effects of antiepileptic drugs. In: Panayiotopoulos CP, ed. Atlas of epilepsies (in press). London: Springer, 2010.

    Google Scholar 

  142. Erikssen J, Otterstad JE. Natural course of a prolonged PR interval and the relation between PR and incidence of coronary heart disease. A 7-year follow-up study of 1832 apparently healthy men aged 40–59 years. Clin Cardiol 1984;7:6–13.

    Article  PubMed  CAS  Google Scholar 

  143. Matsuo F, Bergen D, Faught E, Messenheimer JA, Dren AT, Rudd GD et al. Placebo-controlled study of the efficacy and safety of lamotrigine in patients with partial seizures. U.S. Lamotrigine Protocol 0.5 Clinical Trial Group. Neurology 1993;43:2284–2291.

    PubMed  CAS  Google Scholar 

  144. French JA, Kanner AM, Bautista J, Abou-Khalil B, Browne T, Harden CL et al. Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2004;62:1252–1260.

    PubMed  CAS  Google Scholar 

  145. French JA, Kanner AM, Bautista J, Abou-Khalil B, Browne T, Harden CL et al. Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2004;62:1261–1273.

    PubMed  CAS  Google Scholar 

  146. Tomson T, Kenneback G. Arrhythmia, heart rate variability, and antiepileptic drugs. Epilepsia 1997;38:S48–S51.

    Article  PubMed  CAS  Google Scholar 

  147. Saetre E, Abdelnoor M, Amlie JP, Tossebro M, Perucca E, Taubøll E et al. Cardiac function and antiepileptic drug treatment in the elderly: A comparison between lamotrigine and sustained-release carbamazepine. Epilepsia 2009;50:1841–1849.

    Article  PubMed  CAS  Google Scholar 

  148. Saetre E, Perucca E, Isojarvi J, Gjerstad L. An international multicenter randomized double-blind controlled trial of lamotrigine and sustainedrelease carbamazepine in the treatment of newly diagnosed epilepsy in the elderly. Epilepsia 2007;48:1292–1302.

    Article  PubMed  CAS  Google Scholar 

  149. Danielsson BR, Lansdell K, Patmore L, Tomson T. Effects of the antiepileptic drugs lamotrigine, topiramate and gabapentin on hERG potassium currents. Epilepsy Res 2005;63:17–25.

    Article  PubMed  CAS  Google Scholar 

  150. Brown AM. HERG block, QT liability and sudden cardiac death. Novartis Found Symp 2005;266:118–131.

    Article  PubMed  CAS  Google Scholar 

  151. Sanguinetti MC, Tristani-Firouzi M. hERG potassium channels and cardiac arrhythmia. Nature 2006;440:463–469.

    Article  PubMed  CAS  Google Scholar 

  152. Aurlien D, Tauboll E, Gjerstad L. Lamotrigine in idiopathic epilepsy — increased risk of cardiac death? Acta Neurol Scand 2007;115:199–203.

    Article  PubMed  CAS  Google Scholar 

  153. Aurlien D, Leren TP, Tauboll E, Gjerstad L. New SCN5A mutation in a SUDEP victim with idiopathic epilepsy. Seizure 2009;18:158–160.

    Article  PubMed  Google Scholar 

  154. Danielsson C, Azarbayjani F, Skold AC, Sjogren N, Danielsson BR. Polytherapy with hERG-blocking antiepileptic drugs: increased risk for embryonic cardiac arrhythmia and teratogenicity. Birth Defects Res A Clin Mol Teratol 2007;79:595–603.

    Article  PubMed  CAS  Google Scholar 

  155. Panayiotopoulos CP, Crawford P, Tomson T, (eds). Volume 4: Epilepsies in girls and women. Oxford: Medicinae, 2008.

    Google Scholar 

  156. Morrow J. The XX factor. Treating women with anti-epileptic drugs. Cressing, Essex: National Services for Helth Improvement, 2007.

    Google Scholar 

  157. Harden CL, Pennell PB, Koppel BS, Hovinga CA, Gidal B, Meador KJ et al. Practice parameter update: management issues for women with epilepsy—focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society. Neurology 2009;73:142–149.

    Article  PubMed  CAS  Google Scholar 

  158. Harden CL, Meador KJ, Pennell PB, Hauser WA, Gronseth GS, French JA et al. Practice parameter update: management issues for women with epilepsy—focus on pregnancy (an evidence-based review): teratogenesis and perinatal outcomes: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society. Neurology 2009;73:133–141.

    Article  PubMed  CAS  Google Scholar 

  159. Harden CL, Hopp J, Ting TY, Pennell PB, French JA, Hauser WA et al. Practice parameter update: management issues for women with epilepsy—focus on pregnancy (an evidence-based review): obstetrical complications and change in seizure frequency: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society. Neurology 2009;73:126–132.

    Article  PubMed  CAS  Google Scholar 

  160. Aguglia U, Barboni G, Battino D, Cavazzuti GB, Citernesi A, Corosu R et al. Italian consensus conference on epilepsy and pregnancy, labor and puerperium. Epilepsia 2009;50Suppl 1:7–23.

    Article  PubMed  Google Scholar 

  161. Vajda FJ. Treatment options for pregnant women with epilepsy. Expert Opin Pharmacother 2008;9:1859–1868.

    Article  PubMed  CAS  Google Scholar 

  162. Battino D, Tomson T. Management of epilepsy during pregnancy. Drugs 2007;67:2727–2746.

    Article  PubMed  CAS  Google Scholar 

  163. Tomson T, Battino D, French J, Harden C, Holmes L, Morrow J et al. Antiepileptic drug exposure and major congenital malformations: the role of pregnancy registries. Epilepsy Behav 2007;11:277–282.

    Article  PubMed  Google Scholar 

  164. Tomson T, Hiilesmaa V. Epilepsy in pregnancy. BMJ 2007;335:769–773.

    Article  PubMed  Google Scholar 

  165. Perucca E. Birth defects after prenatal exposure to antiepileptic drugs. Lancet Neurol 2005;4:781–786.

    Article  PubMed  CAS  Google Scholar 

  166. Tomson T, Battino D. Pregnancy and epilepsy: what should we tell our patients? J Neurol 2009 (in press).

    Google Scholar 

  167. Walker SP, Permezel M, Berkovic SF. The management of epilepsy in pregnancy. BJOG 2009;116:758–767.

    Article  PubMed  CAS  Google Scholar 

  168. Beach RL, Kaplan PW. Seizures in pregnancy: diagnosis and management. Int Rev Neurobiol 2008;83:259–271.

    Article  PubMed  Google Scholar 

  169. Brodtkorb E, Reimers A. Seizure control and pharmacokinetics of antiepileptic drugs in pregnant women with epilepsy. Seizure 2008;17:160–165.

    Article  PubMed  Google Scholar 

  170. Pennell PB, Hovinga CA. Antiepileptic drug therapy in pregnancy I: gestation-induced effects on AED pharmacokinetics. Int Rev Neurobiol 2008;83:227–240.

    Article  PubMed  Google Scholar 

  171. Pennell PB. Antiepileptic drugs during pregnancy: what is known and which AEDs seem to be safest? Epilepsia 2008;49Suppl 9:43–55.

    Article  PubMed  CAS  Google Scholar 

  172. Pennell PB, Peng L, Newport DJ, Ritchie JC, Koganti A, Holley DK et al. Lamotrigine in pregnancy: clearance, therapeutic drug monitoring, and seizure frequency. Neurology 2008;70:2130–2136.

    Article  PubMed  CAS  Google Scholar 

  173. Robinson JN, Cleary-Goldman J. Management of epilepsy and pregnancy: an obstetrical perspective. Int Rev Neurobiol 2008;83:273–282.

    Article  PubMed  Google Scholar 

  174. Tomson T, Crawford P. Practical pre-pregnancy counseling. In: Panayiotopoulos CP, Crawford P, Tomson T, eds. Volume 4: Epilepsies in girls and women. Oxford: Medicinae, 2008:170–173.

    Google Scholar 

  175. Kaplan PW, Norwitz ER, Ben-Menachem E, Pennell PB, Druzin M, Robinson JN et al. Obstetric risks for women with epilepsy during pregnancy. Epilepsy Behav 2007;11:283–291.

    Article  PubMed  Google Scholar 

  176. Crawford PM. Managing epilepsy in women of childbearing age. Drug Saf 2009;32:293–307.

    Article  PubMed  Google Scholar 

  177. Meador KJ, Pennell PB, Harden CL, Gordon JC, Tomson T, Kaplan PW et al. Pregnancy registries in epilepsy: a consensus statement on health outcomes. Neurology 2008;71:1109–1117.

    Article  PubMed  CAS  Google Scholar 

  178. Battino D, Tomson T. The management of epilepsy in pregnancy. In: Shorvon S, Pedley TA, eds. The epilepsies3, pp:241–64. Philadelphia: Saunders, Elsevier, 2008.

    Google Scholar 

  179. Sabers A. Interactions between anti-epileptic drugs and hormonal contraception. In: Panayiotopoulos CP, Crawford P, Tomson T, eds. Volume 4: Epilepsies in girls and women, pp 93–97. Oxford: Medicinae, 2008.

    Google Scholar 

  180. Dutton C, Foldvary-Schaefer N. Contraception in women with epilepsy: pharmacokinetic interactions, contraceptive options, and management. Int Rev Neurobiol 2008;83:113–134.

    Article  PubMed  Google Scholar 

  181. O’Brien MD, Guillebaud J. Contraception for women with epilepsy. Epilepsia 2006;47:1419–1422.

    Article  PubMed  CAS  Google Scholar 

  182. Adab N, Kini U, Vinten J, Ayres J, Baker G, Clayton-Smith J. The longer term outcome of children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry 2004;75:1575–1583.

    Article  PubMed  CAS  Google Scholar 

  183. Johannessen LC, Patsalos PN. Pharmacokinetics of AEDs in pregnancy. In: Panayiotopoulos CP, Crawford P, Tomson T, eds. Volume 4: Epilepsies in girls and women. Oxford: Medicinae, 2008:143–149.

    Google Scholar 

  184. Tomson T, Battino D. Pharmacokinetics and therapeutic drug monitoring of newer antiepileptic drugs during pregnancy and the puerperium. Clin Pharmacokinet 2007;46:209–219.

    Article  PubMed  CAS  Google Scholar 

  185. Lamictal® (lamotrigine). Product information (Australia). Glaxo-Smith-Klein, 2009.

    Google Scholar 

  186. Palmieri C, Canger R. Teratogenic potential of the newer antiepileptic drugs: what is known and how should this influence prescribing? CNS Drugs 2002;16:755–764.

    Article  PubMed  CAS  Google Scholar 

  187. Holmes LB, Baldwin EJ, Smith CR, Habecker E, Glassman L, Wong SL et al. Increased frequency of isolated cleft palate in infants exposed to lamotrigine during pregnancy. Neurology 2008;70:2152–2158.

    Article  PubMed  CAS  Google Scholar 

  188. Nelson K, Holmes LB. Malformations due to presumed spontaneous mutations in newborn infants. N Engl J Med 1989;320:19–23.

    Article  PubMed  CAS  Google Scholar 

  189. Cunnington M, Tennis P. Lamotrigine and the risk of malformations in pregnancy. Neurology 2005;64:955–960.

    PubMed  CAS  Google Scholar 

  190. Honein MA, Paulozzi LJ, Cragan JD, Correa A. Evaluation of selected characteristics of pregnancy drug registries. Teratology 1999;60:356–364.

    Article  PubMed  CAS  Google Scholar 

  191. Hauser WA, Tomson T. Lamotrigine and the risk of malformations in pregnancy. Neurology 2006;66:153–154.

    Article  PubMed  Google Scholar 

  192. Morrow J, Russell A, Guthrie E, Parsons L, Robertson I, Waddell R et al. Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2006;77:193–198.

    Article  PubMed  CAS  Google Scholar 

  193. Meador KJ, Baker GA, Browning N, Clayton-Smith J, Combs-Cantrell DT, Cohen M et al. Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. N Engl J Med 2009;360:1597–1605.

    Article  PubMed  CAS  Google Scholar 

  194. Practice parameter: management issues for women with epilepsy (summary statement). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 1998;51:944–948.

    Google Scholar 

  195. McElhatton PR. The effects of benzodiazepine use during pregnancy and lactation. Reprod Toxicol 1994;8:461–475.

    Article  PubMed  CAS  Google Scholar 

  196. Diaz-Romero RM, Garza-Morales S, Mayen-Molina DG, Ibarra-Puig J, Avila-Rosas H. Facial anthropometric measurements in offspring of epileptic mothers. Arch Med Res 1999;30:186–189.

    Article  PubMed  CAS  Google Scholar 

  197. Eros E, Czeizel AE, Rockenbauer M, Sorensen HT, Olsen J. A population-based case-control teratologic study of nitrazepam, medazepam, tofisopam, alprazolum and clonazepam treatment during pregnancy. Eur J Obstet Gynecol Reprod Biol 2002;101:147–154.

    Article  PubMed  CAS  Google Scholar 

  198. Lin AE, Peller AJ, Westgate MN, Houde K, Franz A, Holmes LB. Clonazepam use in pregnancy and the risk of malformations. Birth Defects Res A Clin Mol Teratol 2004;70:534–536.

    Article  PubMed  CAS  Google Scholar 

  199. Hunt SJ, Craig JJ, Morrow JI. Increased frequency of isolated cleft palate in infants exposed to lamotrigine during pregnancy. Neurology 2009;72:1108–1109.

    Article  PubMed  Google Scholar 

  200. Dolk H, Jentink J, Loane M, Morris J, de Jong-van den Berg LT. Does lamotrigine use in pregnancy increase orofacial cleft risk relative to other malformations? Neurology 2008;71:714–722.

    Article  PubMed  CAS  Google Scholar 

  201. Eurap Study Group. Utilization of antiepileptic drugs during pregnancy: comparative patterns in 38 countries based on data from the EURAP registry. Epilepsia 2009;50:2305–2309.

    Article  Google Scholar 

  202. Hunt S, Craig J, Russell A, Guthrie E, Parsons L, Robertson I et al. Levetiracetam in pregnancy: preliminary experience from the UK Epilepsy and Pregnancy Register. Neurology 2006;67:1876–1879.

    Article  PubMed  CAS  Google Scholar 

  203. Ornoy A, Zvi N, Arnon J, Wajnberg R, Shechtman S, Diav-Citrin O. The outcome of pregnancy following topiramate treatment: a study on 52 pregnancies. Reprod Toxicol 2008;25:388–389.

    Article  PubMed  CAS  Google Scholar 

  204. Hunt S, Russell A, Smithson WH, Parsons L, Robertson I, Waddell R et al. Topiramate in pregnancy: preliminary experience from the UK Epilepsy and Pregnancy Register. Neurology 2008;71:272–276.

    Article  PubMed  CAS  Google Scholar 

  205. Fountain NB. A pregnant pause to consider teratogenicity of topiramate. Epilepsy Curr 2009;9:36–38.

    Article  PubMed  Google Scholar 

  206. Petrenaite V, Sabers A, Hansen-Schwartz J. Seizure deterioration in women treated with oxcarbazepine during pregnancy. Epilepsy Res 2009;84:245–249.

    Article  PubMed  CAS  Google Scholar 

  207. Ng YT. The fetal anticonvulsant syndrome. In: Gilman S, ed. Medlink Neurology. San Diego SA: Arbor Publishing Corp, 2009.

    Google Scholar 

  208. The EURAP study group. Seizure control and treatment in pregnancy: observations from the EURAP epilepsy pregnancy registry. Neurology 2006;66:354–360.

    Article  Google Scholar 

  209. Battino D, Tomson T. Seizure control in pregnancy. In: Panayiotopoulos CP, Crawford P, Tomson T, eds. Volume 4: Epilepsies in girls and women. Oxford: Medicinae, 2008:138–142.

    Google Scholar 

  210. Janz D. Die epilepsien:Spezielle pathologie and therapie. Stuttgart: Georg Thieme, 1969.

    Google Scholar 

  211. Shorvon SD. Status epilepticus:its clinical features and treatment in children and adults. Cambridge: Cambridge University Press, 1994.

    Book  Google Scholar 

  212. Vajda FJ, Hitchcock A, Graham J, Solinas C, O’Brien TJ, Lander CM et al. Foetal malformations and seizure control: 52 months data of the Australian Pregnancy Registry. Eur J Neurol 2006;13:645–654.

    Article  PubMed  CAS  Google Scholar 

  213. Johannessen SI, Tomson T. Pharmacokinetic variability of newer antiepileptic drugs: when is monitoring needed? Clin Pharmacokinet 2006;45:1061–1075.

    Article  PubMed  CAS  Google Scholar 

  214. Pennell PB, Peng L, Newport DJ, Ritchie JC, Koganti A, Holley DK et al. Lamotrigine in pregnancy: clearance, therapeutic drug monitoring, and seizure frequency. Neurology 2008;70:2130–2136.

    Article  PubMed  CAS  Google Scholar 

  215. Adab N, Tudur SC, Vinten J, Williamson P, Winterbottom J. Common antiepileptic drugs in pregnancy in women with epilepsy. Cochrane Database Syst Rev 2004;CD004848.

    Google Scholar 

  216. Zahn CA, Morrell MJ, Collins SD, Labiner DM, Yerby MS. Management issues for women with epilepsy: a review of the literature. Neurology 1998;51:949–956.

    PubMed  CAS  Google Scholar 

  217. Morrow JI, Hunt SJ, Russell AJ, Smithson WH, Parsons L, Robertson I et al. Folic acid use and major congenital malformations in offspring of women with epilepsy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2009;80:506–511.

    Article  PubMed  CAS  Google Scholar 

  218. Johannessen SI, Tomson T. Anti-epileptic drugs and breastfeeding. In: Panayiotopoulos CP, Crawford P, Tomson T, eds. Volume 4: Epilepsies in girls and women. Oxford: Medicinae, 2008:156–163.

    Google Scholar 

  219. Sabers A, Tomson T. Managing antiepileptic drugs during pregnancy and lactation. Curr Opin Neurol 2009;22:157–161.

    Article  PubMed  CAS  Google Scholar 

  220. Spencer JP, Gonzalez LS, III, Barnhart DJ. Medications in the breastfeeding mother. Am Fam Physician 2001;64:119–126.

    PubMed  CAS  Google Scholar 

  221. Kooper AJ, de B D, van Ravenwaaij-Arts CM, Faas BH, Creemers JW, Thomas CM et al. Fetal anomaly scan potentially will replace routine AFAFP assays for the detection of neural tube defects. Prenat Diagn 2007;27:29–33.

    Article  PubMed  Google Scholar 

  222. Leppik IE. Treatment of epilepsy in the elderly. Curr Treat Options Neurol 2008;10:239–245.

    Article  PubMed  Google Scholar 

  223. Sirven JI. Treatment of the elderly with epilepsy. In: French JA, Delanty N, eds. Therapeutic Strategies in Epilepsy. Oxford: Clinical Publishing, 2009:173–185.

    Google Scholar 

  224. Mendiratta A, Pedley TA. Seizures and epilepsy in the elderly. In: Shorvon S, Pedley TA, eds. The epilepsies 3. Philadelphia: Saunders, Elsevier, 2009:177–193.

    Chapter  Google Scholar 

  225. Cloyd J, Hauser W, Towne A, Ramsay R, Mattson R, Gilliam F et al. Epidemiological and medical aspects of epilepsy in the elderly. Epilepsy Res 2006;68Suppl 1:S39–S48.

    Article  PubMed  Google Scholar 

  226. Ramsay RE, Macias FM, Rowan AJ. Diagnosing epilepsy in the elderly. Int Rev Neurobiol 2007;81:129–151.

    Article  PubMed  Google Scholar 

  227. Leppik IE. Introduction to the International Geriatric Epilepsy Symposium (IGES). Epilepsy Res 2006;68Suppl 1:S1–S4.

    PubMed  Google Scholar 

  228. Brodie MJ, Stephen LJ. Outcomes in elderly patients with newly diagnosed and treated epilepsy. Int Rev Neurobiol 2007;81:253–263.

    Article  PubMed  Google Scholar 

  229. Sheth RD, Drazkowski JF, Sirven JI, Gidal BE, Hermann BP. Protracted ictal confusion in elderly patients. Arch Neurol 2006;63:529–532.

    Article  PubMed  Google Scholar 

  230. Thomas P, Beaumanoir A, Genton P, Dolisi C, Chatel M. ‘De novo’ absence status of late onset: report of 11 cases [see comments]. Neurology 1992;42:104–110.

    PubMed  CAS  Google Scholar 

  231. Perucca E, Berlowitz D, Birnbaum A, Cloyd JC, Garrard J, Hanlon JT et al. Pharmacological and clinical aspects of antiepileptic drug use in the elderly. Epilepsy Res 2006;68Suppl 1:S49–S63.

    Article  PubMed  CAS  Google Scholar 

  232. Bergey GK. Initial treatment of epilepsy: special issues in treating the elderly. Neurology 2004;63:S40–S48.

    PubMed  Google Scholar 

  233. Patsalos PN. Anti-Epileptic Drug Interactions: A Clinical Guide. Cranleigh, U.K.: Clarius Press Ltd; 2005.

    Google Scholar 

  234. Leppik IE, Brodie MJ, Saetre ER, Rowan AJ, Ramsay RE, Jacobs MP. Outcomes research: clinical trials in the elderly. Epilepsy Res 2006;68Suppl 1:S71–S76.

    Article  PubMed  CAS  Google Scholar 

  235. Leppik I. Antiepileptic drug trials in the elderly. Epilepsy Res 2006;68:45–48.

    Article  PubMed  CAS  Google Scholar 

  236. Rowan AJ, Ramsay RE, Collins JF, Pryor F, Boardman KD, Uthman BM et al. New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. Neurology 2005;64:1868–1873.

    Article  PubMed  CAS  Google Scholar 

  237. Brodie MJ, Overstall PW, Giorgi L. Multicentre, double-blind, randomised comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy. The UK Lamotrigine Elderly Study Group. Epilepsy Res 1999;37:81–87.

    Article  PubMed  CAS  Google Scholar 

  238. Engel J, Jr., Wiebe S, French J, Sperling M, Williamson P, Spencer D, et al. Practice parameter: temporal lobe and localized neocortical resections for epilepsy: report of the Quality Standards Subcommittee of the American Academy of Neurology, in association with the American Epilepsy Society and the American Association of Neurological Surgeons. Neurology 2003;60:538–547.

    PubMed  Google Scholar 

  239. Polkey CE. Clinical outcome of epilepsy surgery. Curr Opin Neurol 2004;17:173–178.

    Article  PubMed  Google Scholar 

  240. Tellez-Zenteno JF, Dhar R, Wiebe S. Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis. Brain 2005;128 Pt 5:1188–1198.

    Article  PubMed  Google Scholar 

  241. Hirsch E, Arzimanoglou A. [Children with drug-resistant partial epilepsy: criteria for the identification of surgical candidates.] Rev Neurol (Paris) 2004;160:5S210–5S219.

    Article  PubMed  Google Scholar 

  242. Cross JH, Jayakar P, Nordli D, Delalande O, Duchowny M, Wieser HG, et al. Proposed criteria for referral and evaluation of children for epilepsy surgery: recommendations of the Subcommission for Pediatric Epilepsy Surgery. Epilepsia 2006;47:952–959.

    Article  PubMed  Google Scholar 

  243. Berg AT. Understanding the delay before epilepsy surgery: who develops intractable focal epilepsy and when? CNS Spectr 2004;9:136–144.

    PubMed  Google Scholar 

  244. Shorvon S, Perucca E, Engel J. Jr. The treatment of epilepsy (third edition). In: Shorvon S, Perucca E, Engel J. Jr, eds. The treatment of epilepsy, 3nd edition, pp. 1–1056. Philadelphia: Wiley-Blackwell, 2009.

    Google Scholar 

  245. Wieser HG, Blume WT, Fish D, Goldensohn E, Hufnagel A, King D, et al. ILAE Commission Report. Proposal for a new classification of outcome with respect to epileptic seizures following epilepsy surgery. Epilepsia 2001;42:282–286.

    Article  PubMed  CAS  Google Scholar 

  246. Berg AT, Kelly MM. Defining intractability: comparisons among published definitions. Epilepsia 2006;47:431–436.

    Article  PubMed  Google Scholar 

  247. Berg AT, Vickrey BG, Testa FM, Levy SR, Shinnar S, DiMario F, et al. How long does it take for epilepsy to become intractable? A prospective investigation. Ann Neurol 2006;60:73–79.

    Article  PubMed  Google Scholar 

  248. Engel J, Jr. Surgery for seizures. N Engl J Med 1996;334:647–552.

    Article  PubMed  Google Scholar 

  249. Wheatley BM. Palliative surgery for intractable epilepsy. Adv Neurol 2006;97:549–556.

    PubMed  Google Scholar 

  250. Morrell F, Whisler WW, Smith MC, Hoeppner TJ, de Toledo-Morrell L, Pierre-Louis SJ, et al. Landau-Kleffner syndrome. Treatment with subpial intracortical transection. Brain 1995;118 Pt 6:1529–1546.

    Article  PubMed  Google Scholar 

  251. Morrell F, Kanner AM, Toledo-Morrell L, Hoeppner T, Whisler WW. Multiple subpial transaction. Adv Neurol 1999;81:259–270. of Neurology and the American Epilepsy Society. Neurology 2004;62:1252–60.

    PubMed  CAS  Google Scholar 

  252. Heck C, Helmers SL, DeGiorgio CM. Vagus nerve stimulation therapy, epilepsy, and device parameters: scientific basis and recommendations for use. Neurology 2002;59Suppl 4:S31–S37.

    PubMed  CAS  Google Scholar 

  253. Privitera MD, Welty TE, Ficker DM, Welge J. Vagus nerve stimulation for partial seizures. Cochrane Database Syst Rev 2002;(1):CD002896.

    Google Scholar 

  254. Schachter SC. Vagus nerve stimulation: where are we? Curr Opin Neurol 2002;15:201–206.

    Article  PubMed  Google Scholar 

  255. Labar D. Vagus nerve stimulation for 1 year in 269 patients on unchanged antiepileptic drugs. Seizure 2004;13:392–398.

    Article  PubMed  Google Scholar 

  256. Tecoma ES, Iragui VJ. Vagus nerve stimulation use and effect in epilepsy: what have we learned? Epilepsy Behav 2006;8:127–136.

    Article  PubMed  Google Scholar 

  257. Boon P, Vonck K, De Reuck J, Caemaert J. Vagus nerve stimulation for refractory epilepsy. Seizure 2002;11Suppl A:448–455.

    PubMed  Google Scholar 

  258. Ben Menachem E. Vagus-nerve stimulation for the treatment of epilepsy. Lancet Neurol 2002;1:477–482.

    Article  PubMed  Google Scholar 

  259. Parker AP, Polkey CE, Binnie CD, Madigan C, Ferrie CD, Robinson RO. Vagal nerve stimulation in epileptic encephalopathies. Pediatrics 1999;103 Pt 1:778–782.

    Article  PubMed  CAS  Google Scholar 

  260. Parker AP, Polkey CE, Robinson RO. Vagal nerve stimulation in the epileptic encephalopathies: 3-year follow-up. Pediatrics 2001;108:221.

    Article  PubMed  CAS  Google Scholar 

  261. Kossoff EH, Pyzik PL, Rubenstein JE, Bergqvist AG, Buchhalter JR, Donner EJ, et al. Combined ketogenic diet and vagus nerve stimulation: rational polytherapy? Epilepsia 2007;48:77–81.

    Article  PubMed  Google Scholar 

  262. Freeman JM, Kossoff EH, Hartman AL. The ketogenic diet: one decade later. Pediatrics 2007;119:535–543.

    Article  PubMed  Google Scholar 

  263. Nordli D. The ketogenic diet: uses and abuses. Neurology 2002;58Suppl 7:S21–S24.

    PubMed  CAS  Google Scholar 

  264. Hartman AL, Vining EP. Clinical aspects of the ketogenic diet. Epilepsia 2007;48:31–42.

    Article  PubMed  CAS  Google Scholar 

  265. Levy R, Cooper P. Ketogenic diet for epilepsy. Cochrane Database Syst Rev 2003;(3):CD001903.

    Google Scholar 

  266. Mackay MT, Bicknell-Royle J, Nation J, Humphrey M, Harvey AS. The ketogenic diet in refractory childhood epilepsy. J Paediatr Child Health 2005;41:353–357.

    Article  PubMed  Google Scholar 

  267. Bough KJ, Rho JM. Anticonvulsant mechanisms of the ketogenic diet. Epilepsia 2007;48:43–58.

    Article  PubMed  CAS  Google Scholar 

  268. Sinha SR, Kossoff EH. The ketogenic diet. Neurologist 2005;11:161–170.

    Article  PubMed  Google Scholar 

  269. Villeneuve N, Pinton F, Bahi-Buisson N, Dulac O, Chiron C, Nabbout R. The ketogenic diet improves recently worsened focal epilepsy. Dev Med Child Neurol 2009;51:276–281.

    Article  PubMed  Google Scholar 

  270. Baranano KW, Hartman AL. The ketogenic diet: uses in epilepsy and other neurologic illnesses. Curr Treat Options Neurol 2008;10:410–419.

    Article  PubMed  Google Scholar 

  271. Kim dY, Rho JM. The ketogenic diet and epilepsy. Curr Opin Clin Nutr Metab Care 2008;11:113–120.

    Article  CAS  Google Scholar 

  272. Neal EG, Chaffe H, Schwartz RH, Lawson MS, Edwards N, Fitzsimmons G et al. The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. Lancet Neurol 2008;7:500–506.

    Article  PubMed  Google Scholar 

  273. Stafstrom CE, Zupec-Kania B, Rho JM (eds). Ketogenic diet and related dietary treatments. Epilepsia 2008;49(Suppl 8):1–133.

    Google Scholar 

  274. Coman DJ, Sinclair KG, Burke CJ, Appleton DB, Pelekanos JT, O’Neil CM, et al. Seizures, ataxia, developmental delay and the general paediatrician: glucose transporter 1 deficiency syndrome. J Paediatr Child Health 2006;42:263–267.

    Article  PubMed  Google Scholar 

  275. Wirrell EC, Darwish HZ, Williams-Dyjur C, Blackman M, Lange V. Is a fast necessary when initiating the ketogenic diet? J Child Neurol 2002;17:179–182.

    Article  PubMed  Google Scholar 

  276. Kossoff EH. More fat and fewer seizures: dietary therapies for epilepsy. Lancet Neurol 2004;3:415–420.

    Article  PubMed  Google Scholar 

  277. Kang HC, Lee HS, You SJ, Kang du C, Ko TS, Kim HD. Use of a modified Atkins diet in intractable childhood epilepsy. Epilepsia 2007;48:182–186.

    PubMed  CAS  Google Scholar 

  278. Kossoff EH, Turner Z, Bluml RM, Pyzik PL, Vining EP. A randomized, crossover comparison of daily carbohydrate limits using the modified Atkins diet. Epilepsy Behav 2007;10:432–436.

    Article  PubMed  Google Scholar 

  279. Gupta R, Appleton R. Corticosteroids in the management of the paediatric epilepsies. Arch Dis Child 2005;90:379–384.

    Article  PubMed  CAS  Google Scholar 

  280. Gayatri N, Ferrie C, Cross H. Corticosteroids including ACTH for childhood epilepsy other than epileptic spasms. Cochrane Database Syst Rev 2007;(1):CD005222.

    Google Scholar 

  281. Buzatu M, Bulteau C, Altuzarra C, Dulac O, Van BP. Corticosteroids as treatment of epileptic syndromes with continuous spike-waves during slow-wave sleep. Epilepsia 2009;50Suppl 7:68–72.

    Article  PubMed  CAS  Google Scholar 

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Panayiotopoulos, C.P. (2010). Principles of therapy in the epilepsies. In: A Clinical Guide to Epileptic Syndromes and their Treatment. Springer, London. https://doi.org/10.1007/978-1-84628-644-5_7

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