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Endoplasmic Reticulum Stress and Adipose Tissue Function

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Adipose Tissue and Adipokines in Health and Disease

Part of the book series: Nutrition and Health ((NH))

Abstract

White adipose tissue consists of adipocytes embedded in a connective tissue matrix and includes a well-organized vasculature and nerve supply. Though a principal feature of adipose tissue is to store and release energy, it also regulates cellular function in tissues/organs such as skeletal muscle, liver, and brain. This regulation occurs, at least in part, through endocrine-mediated mechanisms that involve the synthesis, processing, and secretion of biologically active proteins or adipokines. Impairments in energy storage, energy mobilization, and secretory function in white adipose tissue are a characteristic feature of obesity. Although the mechanisms leading to these impairments are complex, an increasing body of literature points to the involvement of the endoplasmic reticulum (ER), a subcellular organelle involved in lipid synthesis and protein processing. In this chapter the potential role of ER stress and the unfolded protein response (UPR) will be discussed in the context of adipose tissue biology and obesity.

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Authors and Affiliations

  1. Department of Food Science and Human Nutrition, Colorado State University, Gifford 234, Fort Collins, CO, 80523-1571, USA

    Michael Pagliassotti Ph.D., Gretchen Moran, Andrea Estrada & Michelle T. Foster Ph.D.

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  1. Michael Pagliassotti Ph.D.
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  2. Gretchen Moran
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  3. Andrea Estrada
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  4. Michelle T. Foster Ph.D.
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Correspondence to Michael Pagliassotti Ph.D. .

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Editors and Affiliations

  1. Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA

    Giamila Fantuzzi

  2. Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA

    Carol Braunschweig

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Pagliassotti, M., Moran, G., Estrada, A., Foster, M.T. (2014). Endoplasmic Reticulum Stress and Adipose Tissue Function. In: Fantuzzi, G., Braunschweig, C. (eds) Adipose Tissue and Adipokines in Health and Disease. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-770-9_8

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  • DOI: https://doi.org/10.1007/978-1-62703-770-9_8

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