Abstract
With the aging of the population, cognitive impairment is increasingly common, and dementia, the most common disorder that affects the brain of elderly adults, is increasing worldwide. At present, no cure is available against dementia and prevention strategies to delay cognitive decline are sought. Epidemiological studies have reported several risk factors and a consensus emerged that low educational level, vascular factors and dietary habits may be important factors. Among the latter, intake of dietary antioxidants could contribute to limit oxidative damage associated with brain aging and neurodegenerative disease. The aim of this chapter is to critically review evidence from observational and intervention studies regarding the link between intake of antioxidants and cognitive function in older adults.
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References
Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956;11:298–300.
Sastre J, Pallardó F, Viña J. The role of mitochondrial oxidative stress in aging. Free Radic Biol Med. 2003;35:1–8.
Halliwell B. Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs Aging. 2001;18:685–716.
McCay P. Vitamin E: interactions with free radicals and ascorbate. Annu Rev Nutr. 1985;5:322–40.
Middleton E. Effect of plant flavonoids on immune and inflammatory cell function. Adv Exp Med Biol. 1998;439:175–82.
Floyd RA, Hensley K. Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol Aging. 2002;23:795–807.
Goodwin JS, Goodwin JM, Garry PJ. Association between nutritional status and cognitive functioning in a healthy elderly population. J Am Med Assoc. 1983;249:2917–21.
Haller J, Weggemans RM, Ferry M, Guigoz Y. Mental health: mini mental state examination and geriatric depression score of elderly Europeans in the SENECA study of 1993. Eur J Clin Nutr. 1996;50 suppl 2:s112–6.
Berr C, Richard M, Gourlet V, Garrel C, Favier A. Enzymatic antioxydant balance and cognitive decline in aging. The EVA study. Neuroepidemiology. 2004;19:133–8.
Perkins A, Hendrie H, Callahan C, Gao S, Unverzagt F, et al. Association of antioxidants with memory in a multiethnic elderly sample using the Third National Health and Nutrition Examination Survey. Am J Epidemiol. 1999;150:37–44.
Riviere S, Birlouez-Aragon I, Nourhashemi F, Vellas B. Low plasma vitamin C in Alzheimer patients despite an adequate diet. Int J Geriatr Psychiatry. 1998;13:749–54.
Sinclair AJ, Bayer AJ, Johnston J, Warner C, Maxwell SR. Altered plasma antioxidant status in subjects with Alzheimer’s disease and vascular dementia. Int J Geriatr Psychiatry. 1998;13:840–5.
Rinaldi P, Polidori MC, Metastasio A, Mariani E, Mattioli A, et al. Plasma antioxidants are similarly depleted in mild cognitive impairment and Alzheimer’s disease. Neurobiol Aging. 2003;24:915–9.
Berr C, Richard M, Roussel A, Bonithon-Kopp C. Systemic oxidative stress and cognitive performance in the population-based EVA study. Free Radic Biol Med. 1998;24:1202–8.
Cardoso B, Prates Ong T, Jacob-Filho W, Jallul O, D’Avila-Freitas I, et al. Nutritional status of selenium in Alzheimer’s disease patients. Br J Nutr. 2009;103:803–6.
Gao S, Jin Y, Hall K, Liang C, Unverzagt F, et al. Selenium level and cognitive fonction in rural elderly Chinese. Am J Epidemiol. 2007;165:955–65.
Helmer C, Peuchant E, Letenneur L, Bourdel-Marchasson I, Larrieu S, et al. Assocaition between antioxidant nutritional indicators and the incidence of dementia: results from the PAQUID prospective cohort study. Eur J Clin Nutr. 2003;57:1555–61.
Mangialasche F, Kivipelto M, Mecocci P, Rizzuto D, Palmer K, et al. High plasma level of vitamin E forms and reduced Alzheimer’s disease risk in advanced age. J Alzheimers Dis. 2010;20:1029–37.
Akbaraly T, Hininger-Favier I, Carrière I, Arnaud J, Gourlet V, et al. Plasma selenium over time and cognitive decline in the elderly. Epidemiology. 2007;18:52–8.
Jama JW, Launer LJ, Witteman JC, den Breeijen JH, Breteler M, et al. Dietary antioxidants and cognitive function in a population-based sample of older persons. The Rotterdam Study. Am J Epidemiol. 1996;144:275–80.
Ortega R, Requejo A, Andrès P, Ldpez-Sobaler A, Elena Quintas M, et al. Dietary intake and cognitive function in a group of elderly people. Am J Clin Nutr. 1997;66:803–9.
Kalmijn S, Feskens E, Launer LJ, Kromhout D. Polyunsaturated fatty acids, antioxidants, and cognitive function in very old men. Am J Epidemiol. 1997;145:33–41.
Letenneur L, Proust-Lima C, Le Gouge A, Dartigues JF, Barberger-Gateau P. Flavonoid intake and cognitive decline over a 10 year period. Am J Epidemiol. 2007;165:1364–71.
Kang JH, Ascherio A, Grodstein F. Fruit and vegetable consumption and cognitive decline in aging women. Ann Neurol. 2005;57:713–20.
Luchsinger JA, Tang M, Shea S, Mayeux R. Antioxidant vitamin intake and risk of Alzheimer disease. Arch Neurol. 2003;60:203–8.
Morris M, Evans D, Bienias J, Tangney C, Bennet D, et al. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community. JAMA. 2002;287:3230–7.
Dai Q, Borenstein A, Wu Y, Jackson J, Larson E. Fruit and vegetable juices and Alzheimer’s Disease: The Kame Project. Am J Med. 2006;119:751–9.
Barberger Gateau P, Raffaitin C, Letenneur L, Berr C, Tzourio C, et al. Dietary patterns and risk of dementia: The Three-City cohort study. Neurology. 2007;69:1921–30.
Barberger Gateau P, Féart C, Samieri C, Letenneur L. Dietary patterns and dementia. In: Yaffe K, editor. Chronic medical disease and cognitive aging: toward a healthy body and brain. Oxford: Oxford University Press; 2013.
Kang JH, Cook N, Manson J, Buring J, Grodstein F. A randomized trial of vitamin E supplementation and cognitive function in women. Arch Intern Med. 2006;166:2462–8.
Grodstein F, Kang JH, Glynn R, Cook N, Gaziano M. A randomized trial of beta carotene suplementation and cognitive function in men. Arch Intern Med. 2007;167:2184–90.
Virtamo J, Pietinen P, Huttunen J, Korhonen P, Malila N, et al. Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supplementation: a postintervention follow-up. JAMA. 2003;290:476–85.
Kesse-Guyot E, Fezeu L, Jeandel C, Ferry M, Andreeva V, et al. French adults’ cognitive performance after daily supplementation with antioxidant vitamins and minerals at nutritional doses: a post hoc analysis of the Supplementation in Vitamins and Mineral Antioxidants (SU.VI.MAX) trial. Am J Clin Nutr. 2011;94:892–9.
Petersen R, Thomas R, Grundman M, Bennet D, Doody R, et al. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med. 2005;352:2379–88.
Jack C, Petersen R, Grundman M, Jin S, Gamst A, et al. Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI. Neurobiol Aging. 2008;29:1285–95.
Sano M, Ernesto C, Thomas R, Klauber M, Schafer K, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer’s disease. N Engl J Med. 1997;336:1216–22.
Lloret A, Badia MC, Mora N, Pallardo F, Alonso MD, et al. Vitamin E paradox in Alzheimer’s disease: it does not prevent loss of cognition and may even be detrimental. J Alzheimers Dis. 2009;17:143–9.
Chan A, Remington R, Kotyla E, Lepore A, Zemianek J, et al. A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. J Nutr Health Aging. 2010;14:224–30.
Galasko D, Peskind E, Clark C, Quinn J, Ringman J, et al. Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. Arch Neurol. 2012. doi:10.1001/archneurol.2012.85.
Scarmeas N, Stern Y, Tang M, Mayeux R, Luchsinger JA. Mediterranean diet and risk for Alzheimer’s disease. Ann Neurol. 2006;59:912–21.
Féart C, Samieri C, Rondeau V, Amieva H, Portet F, et al. Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. JAMA. 2009;302:638–48.
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Letenneur, L., Feart, C., Barberger-Gateau, P. (2013). Are Antioxidant Food and Nutrients Useful in Preventing Cognitive Decline?. In: Praticὸ, D., Mecocci, P. (eds) Studies on Alzheimer's Disease. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-598-9_15
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DOI: https://doi.org/10.1007/978-1-62703-598-9_15
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