Abstract
Hemorrhagic cystitis is a common and potentially devastating urological disorder. Among the risk factors associated with the disease, previous pelvic irradiation and chemotherapeutic drugs such as cyclophosphamide are the most common etiologies of HC. Clinically, HC presents as hematuria often with progression to clot retention. Histologically, chronic fibrosis and progressive endarteritis are seen. Treatment for HC varies with the degree of hematuria. Treatment may include: urinary drainage, intravesical irrigation with topical astringents, and direct fulguration. Ultimately, the most durable and effective therapy for HC may be systemic hyperbaric oxygen therapy.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Cheng C, Foo KT. Management of severe chronic radiation cystitis. Ann Acad Med Singapore. 1992; 21(3):368–71.
Wong TM, Yeo W, Chan LW, Mok TS. Hemorrhagic pyelitis, ureteritis and cystitis secondary to cyclophosphamide: case report and review of literature. Gynecol Oncol. 2000;76(2):223–5.
Levenback C, Eifel PJ, Burke TW, Morris M, Gershenson DM. Hemorrhagic cystitis following radiotherapy for stage Ib cancer of the cervix. Gynecol Oncol. 1994;55(2):206–10.
Sell A, Bertelsen K, Andersen JE, Stroyer I, Panduro J. Randomized study of whole-abdomen irradiation vs pelvic irradiation plus cyclophosphamide in treatment of early ovarian cancer. Gynecol Oncol. 1990; 37(3):367–73.
de Vries CR, Freiha FS. Hemorrhagic cystitis: a review. J Urol. 1990;143(1):1–9.
Rieger KE, Hong WJ, Tusher VJ, et al. Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage. Proc Natl Acad Sci U S A. 2004;101(17):6635–40.
Sencer SF, Haake RJ, Weisdorf DJ. Hemorrhagic cystitis after bone marrow transplantation. Risk factors and complications. Transplantation. 1993;56(4):875–9.
Stillwell TJ, Benson Jr RC. Cyclophosphamide-induced hemorrhagic cystitis. A review of 100 patients. Cancer. 1988;61(3):451–7.
Brugieres L, Hartmann O, Travagli JP, et al. Hemorrhagic cystitis following high-dose chemotherapy and bone marrow transplantation in children with malignancies: incidence, clinical course, and outcome. J Clin Oncol. 1989;7(2):194–9.
Mahjoubi M, Azab M, Ghosn M, Theodore C, Droz JP. Phase II trial of ifosfamide in the treatment of metastatic hormone-refractory patients with prostatic cancer. Cancer Invest. 1990;8(5):477–81.
Sarosy G. Ifosfamide—pharmacologic overview. Semin Oncol. 1989;16(1 Suppl 3):2–8.
Shanholtz C. Acute life-threatening toxicity of cancer treatment. Crit Care Clin. 2001;17(3):483–502.
Pihusch R, Salat C, Schmidt E, et al. Hemostatic complications in bone marrow transplantation: a retrospective analysis of 447 patients. Transplantation. 2002;74(9):1303–9.
Hong WK, Nicaise C, Lawson R, et al. Etoposide combined with cyclophosphamide plus vincristine compared with doxorubicin plus cyclophosphamide plus vincristine and with high-dose cyclophosphamide plus vincristine in the treatment of small-cell carcinoma of the lung: a randomized trial of the Bristol Lung Cancer Study Group. J Clin Oncol. 1989;7(4):450–6.
Stillwell TJ, Benson Jr RC, DeRemee RA, McDonald TJ, Weiland LH. Cyclophosphamide-induced bladder toxicity in Wegener’s granulomatosis. Arthritis Rheum. 1988;31(4):465–70.
Hu RQ, Mehter H, Nadasdy T, et al. Severe hemorrhagic cystitis associated with prolonged oral cyclophosphamide therapy: case report and literature review. Rheumatol Int. 2008;28:1161–4.
Stillwell TJ, Benson Jr RC, Burgert Jr EO. Cyclophosphamide-induced hemorrhagic cystitis in Ewing’s sarcoma. J Clin Oncol. 1988;6(1):76–82.
Williams SF, Bitran JD, Hoffman PC, et al. High-dose, multi-alkylator chemotherapy with autologous bone marrow reinfusion in patients with advanced non-small cell lung cancer. Cancer. 1989;63(2):238–42.
Heyn R, Raney Jr RB, Hays DM, Tefft M, Gehan E, Webber B, et al. Late effects of therapy in patients with paratesticular rhabdomyosarcoma. Intergroup Rhabdomyosarcoma Study Committee. J Clin Oncol. 1992;10(4):614–23.
Allen JC. Complications of chemotherapy in patients with brain and spinal cord tumors. Pediatr Neurosurg. 1991;17(4):218–24.
Crilley P, Topolsky D, Bulova S, Bigler R, Brodsky I. Bone marrow transplantation following busulfan and cyclophosphamide for acute myelogenous leukemia. Bone Marrow Transplant. 1990;5(3):187–91.
Islam R, Isaacson BJ, Zickerman PM, Ratanawong C, Tipping SJ. Hemorrhagic cystitis as an unexpected adverse reaction to temozolomide: case report. Am J Clin Oncol. 2002;25(5):513–4.
Mylonakis E, Goes N, Rubin RH, Cosimi AB, Colvin RB, Fishman JA. BK virus in solid organ transplant recipients: an emerging syndrome. Transplantation. 2001;72(10):1587–92.
Reploeg MD, Storch GA, Clifford DB. BK virus: a clinical review. Clin Infect Dis. 2001;33(2):191–202.
Iwamoto S, Azuma E, Hori H, et al. BK virus-associated fatal renal failure following late-onset hemorrhagic cystitis in an unrelated bone marrow transplantation. Pediatr Hematol Oncol. 2002; 19(4):255–61.
Bielorai B, Shulman LM, Rechavi G, Toren A. CMV reactivation induced BK virus-associated late onset hemorrhagic cystitis after peripheral blood stem cell transplantation. Bone Marrow Transplant. 2001; 28(6):613–4.
Akiyama H, Kurosu T, Sakashita C, et al. Adenovirus is a key pathogen in hemorrhagic cystitis associated with bone marrow transplantation. Clin Infect Dis. 2001;32(9):1325–30.
Echavarria MS, Ray SC, Ambinder R, Dumler JS, Charache P. PCR detection of adenovirus in a bone marrow transplant recipient: hemorrhagic cystitis as a presenting manifestation of disseminated disease. J Clin Microbiol. 1999;37(3):686–9.
Boubenider S, Hiesse C, Marchand S, Hafi A, Kriaa F, Charpentier B. Post-transplantation polyomavirus infections. J Nephrol. 1999;12(1):24–9.
Leung AY, Suen CK, Lie AK, Liang RH, Yuen KY, Kwong YL. Quantification of polyoma BK viruria in hemorrhagic cystitis complicating bone marrow transplantation. Blood. 2001;98(6):1971–8.
Azzi A, Fanci R, Bosi A, et al. Monitoring of polyomavirus BK viruria in bone marrow transplantation patients by DNA hybridization assay and by polymerase chain reaction: an approach to assess the relationship between BK viruria and hemorrhagic cystitis. Bone Marrow Transplant. 1994;14(2):235–40.
Londergan TA, Walzak MP. Hemorrhagic cystitis due to adenovirus infection following bone marrow transplantation. J Urol. 1994;151(4):1013–4.
Bil-Lula I, Ussowicz M, Rybka B, et al. Hematuria due to adenoviral infection in bone marrow transplant patients. Transplant Proc. 2010;42:3729–34.
Barouch DH, Faquin WC, Chen Y, Koralnik IK, Robbins GK, Davis BT. BK virus-associated hemorrhagic cystitis in a human immunodeficiency virus-infected patient. Clin Infect Dis. 2002;35(3):326–9.
Toma Y, Ishiki T, Nagahama K, et al. Penicillin-G induced hemorrhagic cystitis with hydronephrosis. Intern Med. 2009;48:1667–9.
Lopez AE, Rodriguez S, Flores I. Management of ischemic hemorrhagic cystitis with hyperbaric oxygen therapy. Undersea Hyperb Med. 2001; 28(1):35–6.
Koh LP. Boon’s disease: hemorrhagic cystitis in conjunction with massive exfoliation of degenerated urothelial cells (apoptosis?) during intercontinental flights in an otherwise healthy person. Diagn Cytopathol. 2001;25(6):361–4.
Messing EM, Catalona W. Urothelial tumors of the urinary tract. In: Walsh PC, Retik AB, Vaughan Jr ED, Wein AJ, editors. Campbell’s urology, vol. 3. 7th ed. Philadelphia: Saunders; 1998. p. 2327–410.
Pedersen-Bjergaard J, Ersboll J, Hansen VL, et al. Carcinoma of the urinary bladder after treatment with cyclophosphamide for non-Hodgkin’s lymphoma. N Engl J Med. 1988;318(16):1028–32.
Kondo M, Kojima S, Kato K, Matsuyama T. Late-onset hemorrhagic cystitis after hemotopoietic stem cell transplantation in children. Bone Marrow Transplant. 1998;22(10):995–8.
Nevo S, Swan V, Enger C, et al. Acute bleeding after bone marrow transplantation (BMT)—incidence and effect on survival. A quantitative analysis in 1402 patients. Blood. 1998;91(4):1469–77.
Avidor Y, Nadu A, Matzkin H. Clinical significance of gross hematuria and its evaluation in patients receiving anticoagulant and aspirin treatment. Urology. 2000;55(1):22–4.
Worawattanakul S, Semelka RC, Kelekis NL. Post radiation hemorrhagic cystitis: MR findings. Magn Reson Imaging. 1997;15(9):1103–6.
Cartoni C, Arcese W, Avvisati G, Corinto L, Capua A, Meloni G. Role of ultrasonography in the diagnosis and follow-up of hemorrhagic cystitis after bone marrow transplantation. Bone Marrow Transplant. 1993;12(5):463–7.
Katz A, Epelman S, Anelli A, et al. A prospective randomized evaluation of three schedules of mesna administration in patients receiving an ifosfamide-containing chemotherapy regime: sustained efficiency and simplified administration. J Cancer Res Clin Oncol. 1995;121(2):128–31.
Meisenberg B, Lassiter M, Hussein A, Ross M, Vredenburgh JJ, Peters WP. Prevention of hemorrhagic cystitis after high-dose alkylating agent chemotherapy and autologous bone marrow support. Bone Marrow Transplant. 1994;14(2):287–91.
Luce JK, Simons JA. Efficacy of mesna in preventing further cyclophosphamide-induced hemorrhagic cystitis. Med Pediatr Oncol. 1988;16(6):372–4.
Haselberger MB, Schwinghammer TL. Efficacy of mesna for prevention of hemorrhagic cystitis after high-dose cyclophosphamide therapy. Ann Pharmacother. 1995;29(9):918–21.
Reinhold-Keller E, Mohr J, Christophers E, Nordmann K, Gross WL. Mesna side effects which imitate vasculitis. Clin Investig. 1992;70(8):698–704.
Vose JM, Reed EC, Pippert GC, et al. Mesna compared with continuous bladder irrigation as uroprotection during high-dose chemotherapy and transplantation: a randomized trial. J Clin Oncol. 1993;11(7):1306–10.
Shepherd JD, Pringle LE, Barnett MJ, Klingemann HG, Reece DE, Phillips GL. Mesna vs hyperhydration for the prevention of cyclophosphamide-induced hemorrhagic cystitis in bone marrow transplantation. J Clin Oncol. 1991;9(11):2016–20.
Ballen KK, Becker P, Levebvre K, et al. Safety and cost of hyperhydration for the prevention of hemorrhagic cystitis in bone marrow transplant recipients. Oncology. 1999;57(4):287–92.
Moon RE, Camporesi EM. Hyperbaric oxygen therapy: from the 19th to the 21st century. Respir Care Clin N Am. 1999;5(1):1–5.
Hampson NB, editor. Hyperbaric oxygen therapy: 1999 Committee report. Kensington, MD: Undersea and Hyperbaric Medical Society; 1999.
Robertson PW, Hart BB. Assessment of tissue oxygenation. Respir Care Clin N Am. 1999;5(2):221–63.
Marx RE, Ehler WJ, Tayapongsak P, et al. Relationship of oxygen dose to angiogenesis induction in irradiated tissue. Am J Surg. 1990;160(5):519–24.
Shoshani O, Shupak A, Ullmann Y, et al. The effect of hyperbaric oxygenation on the viability of human fat injected into nude mice. Plast Reconstr Surg. 2000; 106(6):1390–6.
Thorn JJ, Kallehave F, Westergaard P, et al. The effect of hyperbaric oxygen on irradiated oral tissues: transmucosal oxygen tension measurements. J Oral Maxillofac Surg. 1997;55(10):1103–7.
Matthew R, Rajan N, Josefson L, et al. Hyperbaric oxygen therapy for radiation induced hemorrhagic cystitis. J Urol. 1999;161(2):435–7.
Bevers RF, Bakker DJ, Kurth KH. Hyperbaric oxygen treatment for hemorrhagic radiation cystitis. Lancet. 1995;346(8978):803–5.
Norkool DM, Hampson NB, Gibbons RP, et al. Hyperbaric oxygen therapy for radiation-induced hemorrhagic cystitis. J Urol. 1993;150(2 Pt 1):332–4.
Weiss JP, Mattei DM, Neville EC, et al. Primary treatment of radiation-induced cystitis with hyperbaric oxygen: 10-year experience. J Urol. 1994; 151(6):1514–7.
Crew JP, Jephcott CR, Reynard JM. Radiation-induced hemorrhagic cystitis. Eur Urol. 2002;40(2):111–23.
Ennis RD. Hyperbaric oxygen for the treatment of radiation cystitis and proctitis. Curr Urol Rep. 2000;3(3):229–31.
O’Reilly KJ, Hampson NB, Corman JM. Hyperbaric oxygen in urology, AUA update series lesson 4, vol. 21. Houston: American Urological Association; 2002. p. 26–31.
Feldmeier JJ, Hampson NB. A systematic review of the literature reporting the application of hyperbaric oxygen prevention and treatment of delayed radiation injuries: an evidence based approach. Undersea Hyperb Med. 2002;29(1):4–30.
Corman JM, McClure RD, Pritchett TR, Kozlowski P, Hampson NB. Treatment of radiation-induced hemorrhagic cystitis with hyperbaric oxygen. J Urol. 2003;169:2200–2.
Al-Ali BM, Trummer H, Shamloul R, et al. Is treatment of hemorrhagic radiation cystitis with hyperbaric oxygen effective? Urol Int. 2010;84:467–70.
Yoshida T, Kawashima A, Ujike T, et al. Hyperbaric oxygen therapy for radiation-induced hemorrhagic cystitis. Int J Urol. 2008;15:639–41.
Jou YC, Lien FC, Cheng MC, et al. Hyperbaric oxygen therapy for cyclophosphamide-induced intractable refractory hemorrhagic cystitis in a systemic lupus erythematous patient. J Chin Med Assoc. 2008; 71:218–20.
Gol AK, Rao MS, Bhagwat AG, et al. Intravesical irrigation with alum for the control of massive bladder hemorrhage. J Urol. 1985;133:956–7.
Gattegno B, Guillemenot F, Fiatte P, et al. Treatment of HC caused by cyclophosphamide using intravesical installation of potassium alum: a propos of 5 cases. Ann Urol. 1990;24:190–2.
Bogris S, Johal NS, Musgtaq I. Commentary to “pediatric hemorrhagic cystitis”. J Pediatr Urol. 2010;6:98.
Kanwar VS, Jenkins JJ, Mandrell BN. Aluminium toxicity following intravesical alum irrigation for hemorrhagic cystitis. Med Pediatr Oncol. 1996; 27(1):64–7.
Sarnak MJ, Long J, King AJ. Intravesicular formaldehyde instillation and renal complications. Clin Nephrol. 1999;51(2):122–5.
Stefanini M, English HA, Taylor AE. Safe and effective, prolonged administration of epsilon-aminocaproic acid in bleeding from the urinary tract. J Urol. 1990;143(3):559–61.
Pitts TO, Spero JA, Bontempo FA, et al. Acute renal failure due to high grade obstruction following therapy with epsilon-aminocaproic acid. Am J Kidney Dis. 1986;8:441–4.
Ippoliti C, Przepiorka D, Mehra R, et al. Intravesical carboprost for the treatment of hemorrhagic cystitis after marrow transplantation. Urology. 1995; 46(6):811–5.
Laszlo D, Bosi A, Guidi S, et al. Prostaglandin E2 bladder instillation for the treatment of hemorrhagic cystitis after allogenic bone marrow transplantation. Haematologica. 1995;80(5):421–5.
Trigg ME, O’Reilly J, Rumelhart S, Morgan D, Holida M, de Alarcon P. Prostaglandin E1 bladder instillations to control severe hemorrhagic cystitis. J Urol. 1990;143(1):92–4.
Raghavaiah NV, Soloway MS. Anuria following silver nitrate irrigation for intractable bladder hemorrhage. J Urol. 1977;118:681–2.
Andrei G, Snoeck R, Vandeputte M, et al. Activities of various compounds against murine and primate polyomaviruses. Antimicrob Agents Chemother. 1997;41:587–93.
Bridges B, Donegan S, Badros A. Cidofovir instillation for the treatment of BK hemorrhagic cystitis after allogenic stem cell transplantation. Am J Hematol. 2006;81:535–7.
Mullholland SG, Hanno P, Parsons CL, et al. Pentosan polysulfate sodium for therapy of interstitial cystitis. Urology. 1990;35:552–8.
Hampson SJ, Woodhouse CR. Sodium pentosan polysulfate in the management of hemorrhagic cystitis: experience with 14 patients. Eur Urol. 1994;25:40–2.
Toren PJ, Norman RW. Cyclophosphamide-induced hemorrhagic cystitis successfully treated with pentosanpolysulfate. J Urol. 2005;173:103.
Ritch CR, Poon SA, Sulis ML, et al. Cutaneous vesicostomy for palliative management of hemorrhagic cystitis and urinary clot retention. J Urol. 2010;76:166–8.
Lang EK. Transcatheter embolization of pelvic vessels for control of intractable hemorrhage. Radiology. 1981;140:331–9.
Han Y, Wu D, Sun A, et al. Selective embolization of the internal iliac arteries for the treatment of severe hemorrhagic cystitis following hematopoietic SCT. Bone Marrow Transplant. 2008;41:881–6.
Koc S, Hagglund H, Ireton RC, Perez-Simon JA, Collins SJ, Appelbaum FR. Successful treatment of severe hemorrhagic cystitis with cystectomy following matched donor allogenic hematopoietic cell transplantation. Bone Marrow Transplant. 2000;26(8):899–901.
Miyamura K, Hamaguchi M, Taji H, et al. Successful ribavirin therapy for severe adenovirus hemorrhagic cystitis after allogenic marrow transplant from close HLA donors rather than distant donors. Bone Marrow Transplant. 2000;25(5):545–8.
Seabra C, Perez-Simon JA, Sierra M, et al. Intramuscular vidarabine therapy for polyomavirus-associated hemorrhagic cystitis following allogenic hemopoietic stem cell transplantation. Bone Marrow Transplant. 2000;26(11):1229–30.
Miller J, Burfield GD, Moretti KL. Oral conjugated estrogen therapy for treatment of hemorrhagic cystitis. J Urol. 1994;151(5):1348–50.
Demesmay K, Tissot E, Bulabois CE, et al. Factor XIII replacement in stem-cell transplant recipients with severe hemorrhagic cystitis: a report of four cases. Transplantation. 2002;74(8):1190–2.
Connolly SS, D’Arcy FT, Corcoran MO. Recombinant activated factor VII to control life-threatening hemorrhagic radiation cystitis. Ir J Med Sci. 2010;179:431–3.
Vela-Ojeda J, Tripp-Villanueva F, Sanchez-Cortes E, et al. Intravesical rhGM-CSF for the treatment of late onset hemorrhagic cystitis after bone marrow transplant. Bone Marrow Transplant. 1999;24(12):1307–10.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media New York
About this chapter
Cite this chapter
Lewinshtein, D.J., Chong, K.T., Corman, J.M. (2013). Hemorrhagic Cystitis. In: Wessells, H. (eds) Urological Emergencies. Current Clinical Urology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-423-4_14
Download citation
DOI: https://doi.org/10.1007/978-1-62703-423-4_14
Published:
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-62703-422-7
Online ISBN: 978-1-62703-423-4
eBook Packages: MedicineMedicine (R0)