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Peroxisome Proliferator-Activated Receptors

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Peroxisome Proliferator-Activated Receptors

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Abstract

Existence of a specific mediator for the effect of peroxisome proliferators was suggested by the tissue and cell specificity of the pleiotropic effects of these chemicals. In attempting to identify such a molecular target, a cytosolic protein displaying reversible stereospecific binding to nafenopin was detected in rat liver, and a receptor-mediated mechanism for peroxisome proliferation was consequently postulated (Lalwani et al. 1983). A peroxisome proliferator-binding protein was later purified from rat liver cytosol and was identified as a dimer protein with a molecular weight of 140,000–160,000 KDa. This protein was capable of binding to peroxisome proliferators structurally related to clofibrate and was suggested to play an important role in the regulation of peroxisome proliferator-induced pleiotropic response (Lalwani et al. 1987). Further analysis of the isolated protein revealed that it is homologous with the heat shock protein HSP70, but its role in the process of peroxisome proliferation remained unclear at that time (Alvares et al. 1990).

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Authors and Affiliations

  1. School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA

    Jihan A. Youssef & Mostafa Z. Badr

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  1. Jihan A. Youssef
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  2. Mostafa Z. Badr
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Youssef, J.A., Badr, M.Z. (2013). Peroxisome Proliferator-Activated Receptors. In: Peroxisome Proliferator-Activated Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-420-3_3

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