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Intestinal Calcium Absorption Efficiency in Women and the Influence of Menopause

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Nutrition and Diet in Menopause

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Abbreviations

TRPV6:

Transient receptor potential vanilloid type 6

VDR:

Vitamin D receptor

ERα:

Estrogen receptor alpha

KO:

Knockout

FSH:

Follicular stimulating hormone

mRNA:

Messenger ribonucleic acid

PTH:

Parathyroid hormone

EAR:

Estimated average requirement

RDA:

Recommended daily allowance

References

  1. Christakos S. Vitamin D: molecular mechanism of action. Ann N Y Acad Sci. 2007;1116:340–8.

    Article  PubMed  CAS  Google Scholar 

  2. Van Cromphaut SJ. Intestinal calcium transporter genes are upregulated by estrogens and the reproductive cycle through vitamin D receptor-independent mechanisms. J Bone Miner Res. 2003;10:1725–36.

    Article  Google Scholar 

  3. Arjmandi BH. Evidence for estrogen receptor-linked calcium transport in the intestine. Bone Miner. 1993;21:63–74.

    Article  PubMed  CAS  Google Scholar 

  4. O’Loughlin PD. Oestrogen deficiency impairs intestinal calcium absorption in the rat. J Physiol. 1998;15:313–22.

    Article  Google Scholar 

  5. Fujita H. Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Mol Biol Cell. 2008;19:1912–21.

    Article  PubMed  CAS  Google Scholar 

  6. Heaney RP. Calcium absorption as a function of calcium intake. J Lab Clin Med. 1975;85:881–90.

    PubMed  CAS  Google Scholar 

  7. Nordin BE. Calcium homeostasis. Clin Biochem. 1990;23:3–10.

    Article  PubMed  CAS  Google Scholar 

  8. Heaney RP. Influence of calcium load on absorption fraction. J Bone Miner Res. 1990;5:1135–8.

    Article  PubMed  CAS  Google Scholar 

  9. Nordin BE. Calcium absorption revisited. Am J Clin Nutr. 2010;92:673–4.

    Article  PubMed  CAS  Google Scholar 

  10. Avioli LV. The influence of age on the intestinal absorption of 47-Ca absorption in post-menopausal osteoporosis. J Clin Invest. 1965;44:1960–7.

    Article  PubMed  CAS  Google Scholar 

  11. Nordin BE. Calculation of calcium absorption rate from plasma radioactivity. Clin Sci. 1968;35:177–82.

    PubMed  CAS  Google Scholar 

  12. Nordin BEC. Modification and validation of a single-isotope radiocalcium absorption test. J Nucl Med. 1998;39:108–13.

    PubMed  CAS  Google Scholar 

  13. Heaney RP. Estimation of true calcium absorption. Ann Intern Med. 1985;103:516–21.

    Article  PubMed  CAS  Google Scholar 

  14. DeGrazia JA. A double isotope method for measurement of intestinal absorption of calcium in man. J Lab Clin Med. 1965;66:822–9.

    PubMed  CAS  Google Scholar 

  15. Bullamore JR. Effect of age on calcium absorption. Lancet. 1970;2:535–7.

    Article  PubMed  CAS  Google Scholar 

  16. Heaney RP. Calcium absorption in women: relationships to calcium intake, estrogen status, and age. J Bone Miner Res. 1989;4:469–75.

    Article  PubMed  CAS  Google Scholar 

  17. Abrams SA. Calcium metabolism in girls: current dietary intakes lead to low rates of calcium absorption and retention during puberty. Am J Clin Nutr. 1994;60:739–43.

    PubMed  CAS  Google Scholar 

  18. Kovacs CS. Calcium and bone metabolism in pregnancy and lactation. J Clin Endocrinol Metab. 2001;86:2344–8.

    Article  PubMed  CAS  Google Scholar 

  19. Nordin BE. Effect of age on calcium absorption in postmenopausal women. Am J Clin Nutr. 2004;80:998–1002.

    PubMed  CAS  Google Scholar 

  20. Aloia JF. Serum vitamin D metabolites and intestinal calcium absorption efficiency in women. Am J Clin Nutr. 2010;92:835–40.

    Article  PubMed  CAS  Google Scholar 

  21. Hunt CD. Calcium requirements: new estimations for men and women by cross-sectional statistical analyses of calcium balance data from metabolic studies. Am J Clin Nutr. 2007;86:1054–63.

    PubMed  CAS  Google Scholar 

  22. McKinlay SM. Smoking and age at menopause in women. Ann Intern Med. 1985;103:350–6.

    Article  PubMed  CAS  Google Scholar 

  23. Wishart JM. Effect of perimenopause on calcium absorption: a longitudinal study. Climacteric. 2000;3:102–8.

    Article  PubMed  CAS  Google Scholar 

  24. Gallagher JC, Riggs BL, DeLuca HF. Effect of estrogen on calcium absorption and serum vitamin D metabolites in postmenopausal osteoporosis. J Clin Endocrinol Metab. 1980;51:1359–64.

    Article  PubMed  CAS  Google Scholar 

  25. Civitelli R. Effects of one-year treatment with estrogens on bone mass, intestinal calcium absorption, and 25-hydroxyvitamin D-1 alpha-hydroxylase reserve in postmenopausal osteoporosis. Calcif Tissue Int. 1988;42:77–86.

    Article  PubMed  CAS  Google Scholar 

  26. Aloia JF. Biochemical short-term changes produced by hormonal replacement therapy. J Endocrinol Invest. 1991;14:927–34.

    PubMed  CAS  Google Scholar 

  27. Heaney RP. Calcium nutrition and bone health in the elderly. Am J Clin Nutr. 1982;36:986–1013.

    PubMed  CAS  Google Scholar 

  28. Falch JA. Early postmenopausal bone loss is not associated with a decrease in circulating levels of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, or vitamin D-binding protein. J Clin Endocrinol Metab. 1987;64:836–41.

    Article  PubMed  CAS  Google Scholar 

  29. Hartwell D. Changes in vitamin D metabolism during natural and medical menopause. J Clin Endocrinol Metab. 1990;71:127–32.

    Article  PubMed  CAS  Google Scholar 

  30. Prince RL. The effects of the menopause on calcitriol and parathyroid hormone: responses to a low dietary calcium stress test. J Clin Endocrinol Metab. 1990;70:1119–23.

    Article  PubMed  CAS  Google Scholar 

  31. Prince RL. The effects of menopause and age on calcitropic hormones: a cross-sectional study of 655 healthy women aged 35 to 90. J Bone Miner Res. 1995;10:835–42.

    Article  PubMed  CAS  Google Scholar 

  32. Nordin BE. A longitudinal study of bone-related biochemical changes at the menopause. Clin Endocrinol (Oxf). 2004;61:123–30.

    Article  CAS  Google Scholar 

  33. Khan A. Medical management of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop. J Clin Endocrinol Metab. 2009;94:373–81.

    Article  PubMed  CAS  Google Scholar 

  34. Nordin BE. Calcium malabsorption does not cause secondary hyperparathyroidism. Calcif Tissue Int. 2009;85:31–6.

    Article  PubMed  CAS  Google Scholar 

  35. Chan SD. Oophorectomy leads to a selective decrease in 1,25-dihydroxycholecalciferol receptors in rat jejunal villous cells. Clin Sci (Lond). 1984;66:745–8.

    CAS  Google Scholar 

  36. Gennari C. Estrogen preserves a normal intestinal responsiveness to 1,25-dihydroxyvitamin D3 in oophorectomized women. J Clin Endocrinol Metab. 1990;71:1288–93.

    Article  PubMed  CAS  Google Scholar 

  37. Ebeling PR. Evidence of an age-related decrease in intestinal responsiveness to vitamin D: relationship between serum 1,25-dihydroxyvitamin D3 and intestinal vitamin D receptor concentrations in normal women. J Clin Endocrinol Metab. 1992;75:176–82.

    Article  PubMed  CAS  Google Scholar 

  38. Marshall DH. Calcium, phosphorus and magnesium requirement. Proc Nutr Soc. 1976;35:163–73.

    Article  CAS  Google Scholar 

  39. Heaney RP. Menopausal changes in calcium balance performance. J Lab Clin Med. 1978;92:953–63.

    PubMed  CAS  Google Scholar 

  40. Gallagher JC. Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: effect of age and dietary calcium. J Clin Invest. 1979;64:729–36.

    Article  PubMed  CAS  Google Scholar 

  41. Nordin BE. The relation between calcium absorption, serum dehydroepiandrosterone, and vertebral mineral density in postmenopausal women. J Clin Endocrinol Metab. 1985;60:651–7.

    Article  PubMed  CAS  Google Scholar 

  42. Gallagher JC. The crush fracture syndrome in postmenopausal women. Clin Endocrinol Metab. 1973;2:293–315.

    Article  PubMed  CAS  Google Scholar 

  43. Francis RM. Calcium malabsorption in elderly women with vertebral fractures: evidence for resistance to the action of vitamin D metabolites on the bowel. Clin Sci. 1984;66:103–10.

    PubMed  CAS  Google Scholar 

  44. Morris HA. Calcium absorption in normal and osteoporotic postmenopausal women. Calcif Tissue Int. 1991;49:240–3.

    Article  PubMed  CAS  Google Scholar 

  45. Nordin BE. Radiocalcium absorption is reduced in postmenopausal women with vertebral and most types of peripheral fractures. Osteoporos Int. 2004;15:27–31.

    Article  PubMed  CAS  Google Scholar 

  46. IOM (Institute of Medicine). Dietary reference intakes for calcium and vitamin D. Washington, DC: The National Academies Press; 2011.

    Google Scholar 

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Correspondence to John Aloia M.D. .

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Aloia, J., Shieh, A. (2013). Intestinal Calcium Absorption Efficiency in Women and the Influence of Menopause. In: Hollins Martin, C., Watson, R., Preedy, V. (eds) Nutrition and Diet in Menopause. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-373-2_5

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  • DOI: https://doi.org/10.1007/978-1-62703-373-2_5

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