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Flavonoids of Herba Epimedii and Bone Metabolism in Experimental Ovarian Deficiency

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Nutrition and Diet in Menopause

Part of the book series: Nutrition and Health ((NH))

Key Points

  • Flavonoids of Herba Epimedii could preserve bone health in OVX rodents, including bone histomorphology, micro-structure and bone mass.

  • BMP signaling and Wnt signaling pathways are found to be involved in mediating the actions of total flavonoids and icariin in bone cells.

  • TF inhibits osteoclast formation by increasing ratio of OPG/RANKL and stimulates bone formation by enhancing Cbfa1 expression.

  • Icariin exhibits selective estrogen-like activity, but did not induce uterotrophic effects in vivo.

  • Icariin stimulates ERα phosphorylation at Ser118 in a ligand-independent manner without activating ERE-luciferase activity in UMR 106 cells, via the ERα or the ERβ-mediated pathway.

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Abbreviations

Tb.Sp:

Trabecular separation

Tb.Th:

Trabecular thickness

Tb.N:

Trabecular number

SMI:

Structure model index

BV/TV:

Bone volume/tissue volume

Ct.Th:

Cortical thickness

OS/BS:

Osteoid surface

MAR:

Mineral apposition rate

BFR/BS:

Bone formation rate with bone surface as referent

BFR/BV:

Bone formation rate with bone volume as referent

BMD:

Bone mineral density

SSI:

Stress–strain index

OCN:

Osteocalcin

BMP:

Bone morphogenetic protein

Cbfa1:

Core binding factor 1

ER:

Estrogen receptor

SAP:

Sialoprotein

OPG:

Osteoprotegerin

RANKL:

Receptor activator of nuclear factor-κB ligand

HRT:

Hormone replacement therapy

TCM:

Traditional Chinese medicine

TF:

Total flavonoids

SRAT:

Serum of rats administered TF

ALP:

Alkaline phosphatase

BGP:

Bone gla protein

ICA:

Icariin

EPFs:

Epimedium-derived phytoestrogen flavonoids

HEP:

Herba epimedii

BM-MSCs:

Bone marrow-mesenchymal stem cells

OVX:

Ovariectomized

DPD:

Deoxypyridinoline

M-CSF:

Macrophage colony-stimulating factor

Ca:

Calcium

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Acknowledgments

This work was partially supported by Hong Kong Scholars Program (XJ2011022) and China Postdoctoral Science Foundation funded project (2012M511115) for Yan Zhang.

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Authors and Affiliations

  1. Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, PRC

    Man-Sau Wong Ph.D.

  2. University of Shanghai for Science and Technology, 445, 516# Jungong Road, Yangpu District, Shanghai, 200093, China

    Yan Zhang Ph.D.

Authors
  1. Man-Sau Wong Ph.D.
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Corresponding author

Correspondence to Man-Sau Wong Ph.D. .

Editor information

Editors and Affiliations

  1. School of Nursing, Midwifery and Social, College of Health and Social Care, Department of Midwifery, University of Salford, Salford, M5 4WT, United Kingdom

    Caroline J. Hollins Martin

  2. Mel and Enid Zuckerman College of Public, Health, and School of Medicine, University of Arizona, Arizona Health Sciences Center, Tucson, 85724-5155, Arizona, USA

    Ronald Ross Watson

  3. Dept. Nutrition & Dietetics, King's College, Stamford St. 150, London, SE1 9NH, United Kingdom

    Victor R. Preedy

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Wong, MS., Zhang, Y. (2013). Flavonoids of Herba Epimedii and Bone Metabolism in Experimental Ovarian Deficiency. In: Hollins Martin, C., Watson, R., Preedy, V. (eds) Nutrition and Diet in Menopause. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-373-2_32

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  • DOI: https://doi.org/10.1007/978-1-62703-373-2_32

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  • Publisher Name: Humana Press, Totowa, NJ

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