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Obesity and Lung Health in Children

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Obesity and Lung Disease

Part of the book series: Respiratory Medicine ((RM,volume 19))

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Abstract

Obesity among children has increased dramatically and has received considerable recent public health attention. The impact of obesity on lung health has become a recognized problem worldwide and an area of intense research. Obese children and adolescents are at greater risk for asthma, impaired lung mechanics, sleep-disordered breathing, and obesity hypoventilation syndrome. This chapter will discuss our current understanding of these conditions and will explore the possible mechanisms underlying the increased asthma risk among obese children. Obesity may influence the phenotypic characteristics of asthma. For example, obese children with asthma may have more difficulty achieving symptom control. We will explore the current knowledge of how obesity in childhood affects the complex disease characteristics of asthma.

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References

  1. Eaton DK, Kann L, Kinchen S, Shanklin S, Ross J, Hawkins J, et al. Youth risk behavior surveillance–United States, 2007. MMWR Surveill Summ. 2008;57(4):1–131.

    PubMed  Google Scholar 

  2. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999–2004. JAMA. 2006;295(13):1549–55.

    PubMed  CAS  Google Scholar 

  3. Selassie M, Sinha AC. The epidemiology and aetiology of obesity: a global challenge. Best Pract Res Clin Anaesthesiol. 2010;25(1):1–9.

    Google Scholar 

  4. WHO: WHO World Health Statistics 2011. Geneva, Switzerland; 2011.

    Google Scholar 

  5. Krebs NF, Himes JH, Jacobson D, Nicklas TA, Guilday P, Styne D. Assessment of child and adolescent overweight and obesity. Pediatrics. 2007;120(Suppl 4):S193–228.

    PubMed  Google Scholar 

  6. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ. 2000;320(7244):1240–3.

    PubMed  CAS  Google Scholar 

  7. Koplan JP, Liverman CT, Kraak VI. Preventing childhood obesity: health in the balance: executive summary. J Am Diet Assoc. 2005;105(1):131–8.

    PubMed  Google Scholar 

  8. Barlow SE. Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics. 2007;120(Suppl 4):S164–92.

    PubMed  Google Scholar 

  9. Bibi H, Shoseyov D, Feigenbaum D, Genis M, Friger M, Peled R, et al. The relationship between asthma and obesity in children: is it real or a case of over diagnosis? J Asthma. 2004;41(4):403–10.

    PubMed  Google Scholar 

  10. Kaplan TA, Montana E. Exercise-induced bronchospasm in nonasthmatic obese children. Clin Pediatr. 1993;32(4):220–5.

    CAS  Google Scholar 

  11. Perez-Padilla R, Rojas R, Torres V, Borja-Aburto V, Olaiz G. The Empece working group. Obesity among children residing in Mexico City and its impact on lung function: a comparison with Mexican-Americans. Arch Med Res. 2006;37(1):165–71.

    PubMed  Google Scholar 

  12. Spathopoulos D, Paraskakis E, Trypsianis G, Tsalkidis A, Arvanitidou V, Emporiadou M, et al. The effect of obesity on pulmonary lung function of school aged children in Greece. Pediatr Pulmonol. 2009;44(3):273–80.

    PubMed  Google Scholar 

  13. Van Gysel D, Govaere E, Verhamme K, Doli E, De Baets F. Body mass index in Belgian schoolchildren and its relationship with sensitization and allergic symptoms. Pediatr Allergy Immunol. 2009;20(3):246–53.

    PubMed  Google Scholar 

  14. Lazarus R, Colditz G, Berkey CS, Speizer FE. Effects of body fat on ventilatory function in children and adolescents: cross-sectional findings from a random population sample of school children. Pediatr Pulmonol. 1997;24(3):187–94.

    PubMed  CAS  Google Scholar 

  15. Ulger Z, Demir E, Tanac R, Goksen D, Gulen F, Darcan S, et al. The effect of childhood obesity on respiratory function tests and airway hyperresponsiveness. Turk J Pediatr. 2006;48(1):43–50.

    PubMed  Google Scholar 

  16. Chu YT, Chen WY, Wang TN, Tseng HI, Wu JR, Ko YC. Extreme BMI predicts higher asthma prevalence and is associated with lung function impairment in school-aged children. Pediatr Pulmonol. 2009;44(5):472–9.

    PubMed  Google Scholar 

  17. Li AM, Chan D, Wong E, Yin J, Nelson EA, Fok TF. The effects of obesity on pulmonary function. Arch Dis Child. 2003;88(4):361–3.

    PubMed  CAS  Google Scholar 

  18. Gokbel H, Atas S. Exercise-induced bronchospasm in nonasthmatic obese and nonobese boys. J Sports Med Phys Fitness. 1999;39(4):361–4.

    PubMed  CAS  Google Scholar 

  19. Ford ES. Asthma, body mass index, and C-reactive protein among US adults. J Asthma. 2003;40(7):733–9.

    PubMed  Google Scholar 

  20. Nystad W, Meyer HE, Nafstad P, Tverdal A, Engeland A. Body mass index in relation to adult asthma among 135,000 Norwegian men and women. Am J Epidemiol. 2004;160(10): 969–76.

    PubMed  Google Scholar 

  21. Camargo Jr CA, Weiss ST, Zhang S, Willett WC, Speizer FE. Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Arch Intern Med. 1999;159(21):2582–8.

    PubMed  Google Scholar 

  22. Beckett WS, Jacobs Jr DR, Yu X, Iribarren C, Williams OD. Asthma is associated with weight gain in females but not males, independent of physical activity. Am J Respir Crit Care Med. 2001;164(11):2045–50.

    PubMed  CAS  Google Scholar 

  23. Chen Y, Dales R, Tang M, Krewski D. Obesity may increase the incidence of asthma in women but not in men: longitudinal observations from the Canadian National Population Health Surveys. Am J Epidemiol. 2002;155(3):191–7.

    PubMed  Google Scholar 

  24. Stanley AH, Demissie K, Rhoads GG. Asthma development with obesity exposure: observations from the cohort of the National Health and Nutrition Evaluation Survey Epidemiologic Follow-up Study (NHEFS). J Asthma. 2005;42(2):97–9.

    PubMed  Google Scholar 

  25. Huovinen E, Kaprio J, Koskenvuo M. Factors associated to lifestyle and risk of adult onset asthma. Respir Med. 2003;97(3):273–80.

    PubMed  CAS  Google Scholar 

  26. Guerra S, Sherrill DL, Bobadilla A, Martinez FD, Barbee RA. The relation of body mass index to asthma, chronic bronchitis, and emphysema. Chest. 2002;122(4):1256–63.

    PubMed  Google Scholar 

  27. Guerra S, Wright AL, Morgan WJ, Sherrill DL, Holberg CJ, Martinez FD. Persistence of asthma symptoms during adolescence: role of obesity and age at the onset of puberty. Am J Respir Crit Care Med. 2004;170(1):78–85.

    PubMed  Google Scholar 

  28. Gilliland FD, Berhane K, Islam T, McConnell R, Gauderman WJ, Gilliland SS, et al. Obesity and the risk of newly diagnosed asthma in school-age children. Am J Epidemiol. 2003;158(5): 406–15.

    PubMed  Google Scholar 

  29. Castro-Rodriguez JA, Holberg CJ, Morgan WJ, Wright AL, Martinez FD. Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years. Am J Respir Crit Care Med. 2001;163(6):1344–9.

    PubMed  CAS  Google Scholar 

  30. Gold DR, Damokosh AI, Dockery DW, Berkey CS. Body-mass index as a predictor of incident asthma in a prospective cohort of children. Pediatr Pulmonol. 2003;36(6):514–21.

    PubMed  Google Scholar 

  31. Mannino DM, Mott J, Ferdinands JM, Camargo CA, Friedman M, Greves HM, et al. Boys with high body masses have an increased risk of developing asthma: findings from the National Longitudinal Survey of Youth (NLSY). Int J Obes (Lond). 2006;30(1):6–13.

    CAS  Google Scholar 

  32. Taveras EM, Rifas-Shiman SL, Camargo Jr CA, Gold DR, Litonjua AA, Oken E, et al. Higher adiposity in infancy associated with recurrent wheeze in a prospective cohort of children. J Allergy Clin Immunol. 2008;121(5):1161–6. e3.

    PubMed  Google Scholar 

  33. Chinn S, Rona RJ. Can the increase in body mass index explain the rising trend in asthma in children? Thorax. 2001;56(11):845–50.

    PubMed  CAS  Google Scholar 

  34. Shore SA, Johnston RA. Obesity and asthma. Pharmacol Ther. 2006;110(1):83–102.

    PubMed  CAS  Google Scholar 

  35. Shore SA. Obesity and asthma: possible mechanisms. J Allergy Clin Immunol. 2008;121(5):1087–93. quiz 94–5.

    PubMed  Google Scholar 

  36. Lucas SR, Platts-Mills TA. Paediatric asthma and obesity. Paediatr Respir Rev. 2006;7(4): 233–8.

    PubMed  Google Scholar 

  37. Wilson MM, Irwin RS. The association of asthma and obesity: is it real or a matter of definition, Presbyterian minister’s salaries, and earlobe creases? Arch Intern Med. 1999;159(21):2513–4.

    PubMed  CAS  Google Scholar 

  38. Schachter LM, Salome CM, Peat JK, Woolcock AJ. Obesity is a risk for asthma and wheeze but not airway hyperresponsiveness. Thorax. 2001;56(1):4–8.

    PubMed  CAS  Google Scholar 

  39. Schachter LM, Peat JK, Salome CM. Asthma and atopy in overweight children. Thorax. 2003;58(12):1031–5.

    PubMed  CAS  Google Scholar 

  40. Aschengrau A, Seage GR. Essentials of epidemiology in public health. 2nd ed. Sudbury: Jones and Bartlett; 2008.

    Google Scholar 

  41. Lang JE, Feng H, Lima JJ. Body mass index-percentile and diagnostic accuracy of childhood asthma. J Asthma. 2009;46(3):291–9.

    PubMed  CAS  Google Scholar 

  42. Aaron SD, Vandemheen KL, Boulet LP, McIvor RA, Fitzgerald JM, Hernandez P, et al. Overdiagnosis of asthma in obese and nonobese adults. CMAJ. 2008;179(11):1121–31.

    PubMed  Google Scholar 

  43. Weiss ST, Shore S. Obesity and asthma: directions for research. Am J Respir Crit Care Med. 2004;169(8):963–8.

    PubMed  Google Scholar 

  44. Beuther DA, Weiss ST, Sutherland ER. Obesity and asthma. Am J Respir Crit Care Med. 2006;174(2):112–9.

    PubMed  Google Scholar 

  45. Simopoulos AP. Importance of the ratio of omega-6/omega-3 essential fatty acids: evolutionary aspects. World Rev Nutr Diet. 2003;92:1–22.

    PubMed  CAS  Google Scholar 

  46. Simopoulos AP. Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases. Biomed Pharmacother. 2006;60(9): 502–7.

    PubMed  CAS  Google Scholar 

  47. Simopoulos AP. Overview of evolutionary aspects of omega 3 fatty acids in the diet. World Rev Nutr Diet. 1998;83:1–11.

    PubMed  CAS  Google Scholar 

  48. Mantzioris E, Cleland LG, Gibson RA, Neumann MA, Demasi M, James MJ. Biochemical effects of a diet containing foods enriched with n-3 fatty acids. Am J Clin Nutr. 2000;72(1):42–8.

    PubMed  CAS  Google Scholar 

  49. Calder PC. Dietary modification of inflammation with lipids. Proc Nutr Soc. 2002;61(3): 345–58.

    PubMed  CAS  Google Scholar 

  50. James MJ, Gibson RA, Cleland LG. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr. 2000;71(1 Suppl):343S–8S.

    PubMed  CAS  Google Scholar 

  51. Caughey GE, Mantzioris E, Gibson RA, Cleland LG, James MJ. The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am J Clin Nutr. 1996;63(1):116–22.

    PubMed  CAS  Google Scholar 

  52. Toborek M, Barger SW, Mattson MP, Barve S, McClain CJ, Hennig B. Linoleic acid and TNF-alpha cross-amplify oxidative injury and dysfunction of endothelial cells. J Lipid Res. 1996;37(1):123–35.

    PubMed  CAS  Google Scholar 

  53. Toborek M, Lee YW, Garrido R, Kaiser S, Hennig B. Unsaturated fatty acids selectively induce an inflammatory environment in human endothelial cells. Am J Clin Nutr. 2002;75(1):119–25.

    PubMed  CAS  Google Scholar 

  54. Pepe S. Effect of dietary polyunsaturated fatty acids on age-related changes in cardiac mitochondrial membranes. Exp Gerontol. 2005;40(8–9):751–8.

    PubMed  Google Scholar 

  55. Ghosh S, Kewalramani G, Yuen G, Pulinilkunnil T, An D, Innis SM, et al. Induction of mitochondrial nitrative damage and cardiac dysfunction by chronic provision of dietary omega-6 polyunsaturated fatty acids. Free Radic Biol Med. 2006;41(9):1413–24.

    PubMed  CAS  Google Scholar 

  56. Weiland SK, von Mutius E, Husing A, Asher MI. Intake of trans fatty acids and prevalence of childhood asthma and allergies in Europe. ISAAC Steering Committee. Lancet. 1999;353(9169):2040–1.

    PubMed  CAS  Google Scholar 

  57. Nagel G, Linseisen J. Dietary intake of fatty acids, antioxidants and selected food groups and asthma in adults. Eur J Clin Nutr. 2005;59(1):8–15.

    PubMed  CAS  Google Scholar 

  58. Strom K, Janzon L, Mattisson I, Rosberg HE, Arborelius M. Asthma but not smoking-related airflow limitation is associated with a high fat diet in men: results from the population study “Men born in 1914”, Malmo, Sweden. Monaldi Arch Chest Dis. 1996;51(1):16–21.

    PubMed  CAS  Google Scholar 

  59. Soutar A, Seaton A, Brown K. Bronchial reactivity and dietary antioxidants. Thorax. 1997;52(2):166–70.

    PubMed  CAS  Google Scholar 

  60. Emelyanov A, Fedoseev G, Krasnoschekova O, Abulimity A, Trendeleva T, Barnes PJ. Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomised clinical trial. Eur Respir J. 2002;20(3):596–600.

    PubMed  CAS  Google Scholar 

  61. Okamoto M, Mitsunobu F, Ashida K, Mifune T, Hosaki Y, Tsugeno H, et al. Effects of perilla seed oil supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism. Int Arch Allergy Immunol. 2000;122(2):137–42.

    PubMed  CAS  Google Scholar 

  62. Nagakura T, Matsuda S, Shichijyo K, Sugimoto H, Hata K. Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma. Eur Respir J. 2000;16(5):861–5.

    PubMed  CAS  Google Scholar 

  63. Villani F, Comazzi R, De Maria P, Galimberti M. Effect of dietary supplementation with polyunsaturated fatty acids on bronchial hyperreactivity in subjects with seasonal asthma. Respiration. 1998;65(4):265–9.

    PubMed  CAS  Google Scholar 

  64. Dry J, Vincent D. Effect of a fish oil diet on asthma: results of a 1-year double-blind study. Int Arch Allergy Appl Immunol. 1991;95(2–3):156–7.

    PubMed  CAS  Google Scholar 

  65. Castro-Rodriguez JA, Garcia-Marcos L, Alfonseda Rojas JD, Valverde-Molina J, Sanchez-Solis M. Mediterranean diet as a protective factor for wheezing in preschool children. J Pediatr. 2008;152(6):823–8. 8 e1-2.

    PubMed  Google Scholar 

  66. Daniel CR, McCullough ML, Patel RC, Jacobs EJ, Flanders WD, Thun MJ, et al. Dietary intake of omega-6 and omega-3 fatty acids and risk of colorectal cancer in a prospective cohort of U.S. men and women. Cancer Epidemiol Biomarkers Prev. 2009;18(2):516–25.

    PubMed  CAS  Google Scholar 

  67. Karlsson M, Marild S, Brandberg J, Lonn L, Friberg P, Strandvik B. Serum phospholipid fatty acids, adipose tissue, and metabolic markers in obese adolescents. Obesity (Silver Spring). 2006;14(11):1931–9.

    CAS  Google Scholar 

  68. Wood LG, Garg ML, Gibson PG. A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma. J Allergy Clin Immunol. 2010;127(5): 1133–40.

    Google Scholar 

  69. Belcher BR, Berrigan D, Dodd KW, Emken BA, Chou CP, Spruijt-Metz D. Physical activity in US youth: effect of race/ethnicity, age, gender, and weight status. Med Sci Sports Exerc. 2010;42(12):2211–21.

    PubMed  Google Scholar 

  70. Rasmussen F, Lambrechtsen J, Siersted HC, Hansen HS, Hansen NC. Low physical fitness in childhood is associated with the development of asthma in young adulthood: the Odense schoolchild study. Eur Respir J. 2000;16(5):866–70.

    PubMed  CAS  Google Scholar 

  71. Ram FS, Robinson SM, Black PN. Effects of physical training in asthma: a systematic review. Br J Sports Med. 2000;34(3):162–7.

    PubMed  CAS  Google Scholar 

  72. van Veldhoven NH, Vermeer A, Bogaard JM, Hessels MG, Wijnroks L, Colland VT, et al. Children with asthma and physical exercise: effects of an exercise programme. Clin Rehabil. 2001;15(4):360–70.

    PubMed  Google Scholar 

  73. Welsh L, Kemp JG, Roberts RG. Effects of physical conditioning on children and adolescents with asthma. Sports Med. 2005;35(2):127–41.

    PubMed  Google Scholar 

  74. Button B, Boucher RC. Role of mechanical stress in regulating airway surface hydration and mucus clearance rates. Respir Physiol Neurobiol. 2008;163(1–3):189–201.

    PubMed  Google Scholar 

  75. Shore SA, Fredberg JJ. Obesity, smooth muscle, and airway hyperresponsiveness. J Allergy Clin Immunol. 2005;115(5):925–7.

    PubMed  CAS  Google Scholar 

  76. Fredberg JJ. Frozen objects: small airways, big breaths, and asthma. J Allergy Clin Immunol. 2000;106(4):615–24.

    PubMed  CAS  Google Scholar 

  77. Trost SG, Kerr LM, Ward DS, Pate RR. Physical activity and determinants of physical activity in obese and non-obese children. Int J Obes Relat Metab Disord. 2001;25(6):822–9.

    PubMed  CAS  Google Scholar 

  78. Marshall SJ, Biddle SJ, Gorely T, Cameron N, Murdey I. Relationships between media use, body fatness and physical activity in children and youth: a meta-analysis. Int J Obes Relat Metab Disord. 2004;28(10):1238–46.

    PubMed  CAS  Google Scholar 

  79. Weiss ST. Obesity: insight into the origins of asthma. Nat Immunol. 2005;6(6):537–9.

    PubMed  CAS  Google Scholar 

  80. Tantisira KG, Weiss ST. Complex interactions in complex traits: obesity and asthma. Thorax. 2001;56(2):ii 64–73.

    Google Scholar 

  81. Howard TD, Meyers DA, Bleecker ER. Mapping susceptibility genes for asthma and allergy. J Allergy Clin Immunol. 2000;105(2 Pt 2):S477–81.

    PubMed  CAS  Google Scholar 

  82. Yang W, Kelly T, He J. Genetic epidemiology of obesity. Epidemiol Rev. 2007;29:49–61.

    PubMed  Google Scholar 

  83. Litonjua AA, Gold DR. Asthma and obesity: common early-life influences in the inception of disease. J Allergy Clin Immunol. 2008;12(5):1075–84. quiz 85–6.

    Google Scholar 

  84. Murphy A, Tantisira KG, Soto-Quiros ME, Avila L, Klanderman BJ, Lake S, et al. PRKCA: a positional candidate gene for body mass index and asthma. Am J Hum Genet. 2009;85(1): 87–96.

    PubMed  CAS  Google Scholar 

  85. Expert panel report 3 (EPR-3): Guidelines for the diagnosis and management of asthma-summary Report 2007. J Allergy Clin Immunol. 2007;120(5 Suppl):S94–138

    Google Scholar 

  86. Pianosi PT, Davis HS. Determinants of physical fitness in children with asthma. Pediatrics. 2004;113(3 Pt 1):e225–9.

    PubMed  Google Scholar 

  87. Michelson PH, Williams LW, Benjamin DK, Barnato AE. Obesity, inflammation, and asthma severity in childhood: data from the National Health and Nutrition Examination Survey 2001–2004. Ann Allergy Asthma Immunol. 2009;103(5):381–5.

    PubMed  Google Scholar 

  88. Tai A, Volkmer R, Burton A. Association between asthma symptoms and obesity in preschool (4–5 year old) children. J Asthma. 2009;46(4):362–5.

    PubMed  Google Scholar 

  89. Vargas PA, Perry TT, Robles E, Jo CH, Simpson PM, Magee JM, et al. Relationship of body mass index with asthma indicators in head start children. Ann Allergy Asthma Immunol. 2007;99(1):22–8.

    PubMed  Google Scholar 

  90. Carroll CL, Bhandari A, Zucker AR, Schramm CM. Childhood obesity increases duration of therapy during severe asthma exacerbations. Pediatr Crit Care Med. 2006;7(6):527–31.

    PubMed  Google Scholar 

  91. Carroll CL, Stoltz P, Raykov N, Smith SR, Zucker AR. Childhood overweight increases hospital admission rates for asthma. Pediatrics. 2007;120(4):734–40.

    PubMed  Google Scholar 

  92. Cassol VE, Rizzato TM, Teche SP, Basso DF, Centenaro DF, Maldonado M, et al. Obesity and its relationship with asthma prevalence and severity in adolescents from Southern Brazil. J Asthma. 2006;43(1):57–60.

    PubMed  Google Scholar 

  93. van Gent R, van der Ent CK, Rovers MM, Kimpen JL, van Essen-Zandvliet LE, de Meer G. Excessive body weight is associated with additional loss of quality of life in children with asthma. J Allergy Clin Immunol. 2007;119(3):591–6.

    PubMed  Google Scholar 

  94. Luder E, Melnik TA, DiMaio M. Association of being overweight with greater asthma symptoms in inner city black and Hispanic children. J Pediatr. 1998;132(4):699–703.

    PubMed  CAS  Google Scholar 

  95. Ross KR, Hart MA, Storfer-Isser A, Kibler AM, Johnson NL, Rosen CL, et al. Obesity and obesity related co-morbidities in a referral population of children with asthma. Pediatr Pulmonol. 2009;44(9):877–84.

    PubMed  Google Scholar 

  96. Ginde AA, Santillan AA, Clark S, Camargo Jr CA. Body mass index and acute asthma severity among children presenting to the emergency department. Pediatr Allergy Immunol. 2010;21(3): 480–88.

    PubMed  Google Scholar 

  97. Hom J, Morley EJ, Sasso P, Sinert R. Body mass index and pediatric asthma outcomes. Pediatr Emerg Care. 2009;25(9):569–71.

    PubMed  Google Scholar 

  98. Kwong KY, Rhandhawa I, Saxena J, Morphew T, Jones CA. Ability to control persistent asthma in obese versus non-obese children enrolled in an asthma-specific disease management program (breathmobile). J Asthma. 2006;43(9):661–6.

    PubMed  CAS  Google Scholar 

  99. Mansell AL, Walders N, Wamboldt MZ, Carter R, Steele DW, Devin JA, et al. Effect of body mass index on response to methacholine bronchial provocation in healthy and asthmatic adolescents. Pediatr Pulmonol. 2006;41(5):434–40.

    PubMed  Google Scholar 

  100. Tantisira KG, Litonjua AA, Weiss ST, Fuhlbrigge AL. Association of body mass with pulmonary function in the Childhood Asthma Management Program (CAMP). Thorax. 2003;58(12):1036–41.

    PubMed  CAS  Google Scholar 

  101. van Veen IH, Ten Brinke A, Sterk PJ, Rabe KF, Bel EH. Airway inflammation in obese and nonobese patients with difficult-to-treat asthma. Allergy. 2008;63(5):570–4.

    PubMed  Google Scholar 

  102. Lessard A, Turcotte H, Cormier Y, Boulet LP. Obesity and asthma: a specific phenotype? Chest. 2008;134(2):317–23.

    PubMed  Google Scholar 

  103. Dixon AE, Shade DM, Cohen RI, Skloot GS, Holbrook JT, Smith LJ, et al. Effect of obesity on clinical presentation and response to treatment in asthma. J Asthma. 2006;43(7):553–8.

    PubMed  Google Scholar 

  104. Lang JE, Hossain J, Dixon AE, Shade D, Wise RA, Peters SP, et al. Does age impact the obese asthma phenotype?: Longitudinal asthma control, airway function and airflow perception among mild persistent asthmatics. Chest. 2011;140(6):1524–33.

    PubMed  Google Scholar 

  105. Sutherland ER, Goleva E, Strand M, Beuther DA, Leung DY. Body mass and glucocorticoid response in asthma. Am J Respir Crit Care Med. 2008;178(7):682–7.

    PubMed  CAS  Google Scholar 

  106. Boulet LP, Franssen E. Influence of obesity on response to fluticasone with or without salmeterol in moderate asthma. Respir Med. 2007;101(11):2240–7.

    PubMed  Google Scholar 

  107. Camargo Jr CA, Boulet LP, Sutherland ER, Busse WW, Yancey SW, Emmett AH, et al. Body mass index and response to asthma therapy: fluticasone propionate/salmeterol versus montelukast. J Asthma. 2010;47(1):76–82.

    PubMed  CAS  Google Scholar 

  108. Lavoie KL, Bacon SL, Labrecque M, Cartier A, Ditto B. Higher BMI is associated with worse asthma control and quality of life but not asthma severity. Respir Med. 2006;100(4): 648–57.

    PubMed  Google Scholar 

  109. Saint-Pierre P, Bourdin A, Chanez P, Daures JP, Godard P. Are overweight asthmatics more difficult to control? Allergy. 2006;61(1):79–84.

    PubMed  CAS  Google Scholar 

  110. Forno E, Lescher R, Strunk R, Weiss S, Fuhlbrigge A, Celedon JC. Decreased response to inhaled steroids in overweight and obese asthmatic children. J Allergy Clin Immunol. 2011;127(3):741–9.

    PubMed  CAS  Google Scholar 

  111. Boulet LP, Hamid Q, Bacon SL, Bergeron C, Chen Y, Dixon AE, et al. Symposium on obesity and asthma – 2 Nov 2006. Can Respir J. 2007;14(4):201–8.

    PubMed  Google Scholar 

  112. Laprise C, Laviolette M, Boutet M, Boulet LP. Asymptomatic airway hyperresponsiveness: relationships with airway inflammation and remodelling. Eur Respir J. 1999;14(1):63–73.

    PubMed  CAS  Google Scholar 

  113. Koskela HO, Hyvarinen L, Brannan JD, Chan HK, Anderson SD. Sensitivity and validity of three bronchial provocation tests to demonstrate the effect of inhaled corticosteroids in asthma. Chest. 2003;124(4):1341–9.

    PubMed  CAS  Google Scholar 

  114. Covar RA, Spahn JD, Martin RJ, Silkoff PE, Sundstrom DA, Murphy J, et al. Safety and application of induced sputum analysis in childhood asthma. J Allergy Clin Immunol. 2004;114(3):575–82.

    PubMed  Google Scholar 

  115. Huang SL, Shiao G, Chou P. Association between body mass index and allergy in teenage girls in Taiwan. Clin Exp Allergy. 1999;29(3):323–9.

    PubMed  CAS  Google Scholar 

  116. Hancox RJ, Milne BJ, Poulton R, Taylor DR, Greene JM, McLachlan CR, et al. Sex differences in the relation between body mass index and asthma and atopy in a birth cohort. Am J Respir Crit Care Med. 2005;171(5):440–5.

    PubMed  Google Scholar 

  117. von Mutius E, Schwartz J, Neas LM, Dockery D, Weiss ST. Relation of body mass index to asthma and atopy in children: the National Health and Nutrition Examination Study III. Thorax. 2001;56(11):835–8.

    Google Scholar 

  118. von Kries R, Hermann M, Grunert VP, von Mutius E. Is obesity a risk factor for childhood asthma? Allergy. 2001;56(4):318–22.

    Google Scholar 

  119. Irei AV, Sato Y, Lin TL, Wang MF, Chan YC, Hung NT, et al. Overweight is associated with allergy in school children of Taiwan and Vietnam but not Japan. J Med Invest. 2005;52(1–2):33–40.

    PubMed  Google Scholar 

  120. Vieira VJ, Ronan AM, Windt MR, Tagliaferro AR. Elevated atopy in healthy obese women. Am J Clin Nutr. 2005;82(3):504–9.

    PubMed  CAS  Google Scholar 

  121. Leung TF, Li CY, Lam CW, Au CS, Yung E, Chan IH, et al. The relation between obesity and asthmatic airway inflammation. Pediatr Allergy Immunol. 2004;15(4):344–50.

    PubMed  Google Scholar 

  122. Santamaria F, Montella S, De Stefano S, Sperli F, Barbarano F, Spadaro R, et al. Asthma, atopy, and airway inflammation in obese children. J Allergy Clin Immunol. 2007;120(4):965–7.

    PubMed  Google Scholar 

  123. Chow JS, Leung AS, Li WW, Tse TP, Sy HY, Leung TF. Airway inflammatory and spirometric measurements in obese children. Hong Kong Med J. 2009;15(5):346–52.

    PubMed  Google Scholar 

  124. Wong GW, Liu EK, Leung TF, Yung E, Ko FW, Hui DS, et al. High levels and gender difference of exhaled nitric oxide in Chinese schoolchildren. Clin Exp Allergy. 2005;35(7):889–93.

    PubMed  CAS  Google Scholar 

  125. Buchvald F, Baraldi E, Carraro S, Gaston B, De Jongste J, Pijnenburg MW, et al. Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years. J Allergy Clin Immunol. 2005;115(6):1130–6.

    PubMed  CAS  Google Scholar 

  126. Scott HA, Gibson PG, Garg ML, Wood LG. Airway inflammation is augmented by obesity and fatty acids in asthma. Eur Respir J. 2011;38(3):594–602.

    PubMed  CAS  Google Scholar 

  127. Giouleka P, Papatheodorou G, Lyberopoulos P, Karakatsani A, Alchanatis M, Roussos C, et al. Body mass index is associated with leukotriene inflammation in asthmatics. Eur J Clin Invest. 2010;41(1):30–8.

    PubMed  Google Scholar 

  128. Drazen JM. Asthma therapy with agents preventing leukotriene synthesis or action. Proc Assoc Am Physicians. 1999;111(6):547–59.

    PubMed  CAS  Google Scholar 

  129. Drazen JM, Israel E, O’Byrne PM. Treatment of asthma with drugs modifying the leukotriene pathway. N Engl J Med. 1999;340(3):197–206.

    PubMed  CAS  Google Scholar 

  130. Kaaman M, Ryden M, Axelsson T, Nordstrom E, Sicard A, Bouloumie A, et al. ALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance. Int J Obes (Lond). 2006;30(3):447–52.

    CAS  Google Scholar 

  131. Lima JJ, Zhang S, Grant A, Shao L, Tantisira KG, Allayee H, et al. Influence of leukotriene pathway polymorphisms on response to montelukast in asthma. Am J Respir Crit Care Med. 2006;173(4):379–85.

    PubMed  CAS  Google Scholar 

  132. American Lung Association Asthma Clinical Research Centers. Clinical trial of low-dose theophylline and montelukast in patients with poorly controlled asthma. Am J Respir Crit Care Med. 2007;175(3):235–42.

    Google Scholar 

  133. Dwyer JH, Allayee H, Dwyer KM, Fan J, Wu H, Mar R, et al. Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med. 2004;350(1):29–37.

    PubMed  CAS  Google Scholar 

  134. Peters-Golden M, Swern A, Bird SS, Hustad CM, Grant E, Edelman JM. Influence of body mass index on the response to asthma controller agents. Eur Respir J. 2006;27(3):495–503.

    PubMed  CAS  Google Scholar 

  135. Komakula S, Khatri S, Mermis J, Savill S, Haque S, Rojas M, et al. Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics. Respir Res. 2007;8:32.

    PubMed  Google Scholar 

  136. Simard B, Turcotte H, Marceau P, Biron S, Hould FS, Lebel S, et al. Asthma and sleep apnea in patients with morbid obesity: outcome after bariatric surgery. Obes Surg. 2004;14(10): 1381–8.

    PubMed  Google Scholar 

  137. Spivak H, Hewitt MF, Onn A, Half EE. Weight loss and improvement of obesity-related illness in 500 U.S. patients following laparoscopic adjustable gastric banding procedure. Am J Surg. 2005;189(1):27–32.

    PubMed  Google Scholar 

  138. Stenius-Aarniala B, Poussa T, Kvarnstrom J, Gronlund EL, Ylikahri M, Mustajoki P. Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study. BMJ. 2000;320(7238):827–32.

    PubMed  CAS  Google Scholar 

  139. Aaron SD, Fergusson D, Dent R, Chen Y, Vandemheen KL, Dales RE. Effect of weight reduction on respiratory function and airway reactivity in obese women. Chest. 2004;125(6): 2046–52.

    PubMed  Google Scholar 

  140. Mougey EB, Chen C, Tantisira K, Blake KV, Peters SP, Wise RA, Weiss ST, Lima JJ. Response to fluticasone and montelukast therapies are inversely associated with a common variant of the corticotropin releasing hormone receptor 1 (CRHR1) gene [publication page: A4080]. Proc Am Thoracic Soc – ATS. 2011:A4080.

    Google Scholar 

  141. Price D, Musgrave SD, Shepstone L, Hillyer EV, Sims EJ, Gilbert RF, et al. Leukotriene antagonists as first-line or add-on asthma-controller therapy. N Engl J Med. 2011;364(18): 1695–707.

    PubMed  CAS  Google Scholar 

  142. Mastronarde JG, Anthonisen NR, Castro M, Holbrook JT, Leone FT, Teague WG, et al. Efficacy of esomeprazole for treatment of poorly controlled asthma. N Engl J Med. 2009;360(15):1487–99.

    PubMed  CAS  Google Scholar 

  143. Lemanske Jr RF, Mauger DT, Sorkness CA, Jackson DJ, Boehmer SJ, Martinez FD, et al. Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids. N Engl J Med. 2010;362(11):975–85.

    PubMed  CAS  Google Scholar 

  144. Redline S, Tishler PV, Schluchter M, Aylor J, Clark K, Graham G. Risk factors for sleep-disordered breathing in children. Associations with obesity, race, and respiratory problems. Am J Respir Crit Care Med. 1999;159(5 Pt 1):1527–32.

    PubMed  CAS  Google Scholar 

  145. Verhulst SL, Schrauwen N, Haentjens D, Suys B, Rooman RP, Van Gaal L, et al. Sleep-disordered breathing in overweight and obese children and adolescents: prevalence, characteristics and the role of fat distribution. Arch Dis Child. 2007;92(3):205–8.

    PubMed  Google Scholar 

  146. Gozal D, Kheirandish-Gozal L. The multiple challenges of obstructive sleep apnea in children: morbidity and treatment. Curr Opin Pediatr. 2008;20(6):654–8.

    PubMed  Google Scholar 

  147. Gozal D, Kheirandish-Gozal L. Obesity and excessive daytime sleepiness in prepubertal children with obstructive sleep apnea. Pediatrics. 2009;123(1):13–8.

    PubMed  Google Scholar 

  148. Mitchell RB, Kelly J. Outcome of adenotonsillectomy for obstructive sleep apnea in obese and normal-weight children. Otolaryngol Head Neck Surg. 2007;137(1):43–8.

    PubMed  Google Scholar 

  149. Amin R, Anthony L, Somers V, Fenchel M, McConnell K, Jefferies J, et al. Growth velocity predicts recurrence of sleep-disordered breathing 1 year after adenotonsillectomy. Am J Respir Crit Care Med. 2008;177(6):654–9.

    PubMed  Google Scholar 

  150. Kheirandish-Gozal L, Gozal D. Intranasal budesonide treatment for children with mild obstructive sleep apnea syndrome. Pediatrics. 2008;122(1):e149–55.

    PubMed  Google Scholar 

  151. Berlucchi M, Salsi D, Valetti L, Parrinello G, Nicolai P. The role of mometasone furoate aqueous nasal spray in the treatment of adenoidal hypertrophy in the pediatric age group: preliminary results of a prospective, randomized study. Pediatrics. 2007;119(6):e1392–7.

    PubMed  Google Scholar 

  152. Goldbart AD, Goldman JL, Veling MC, Gozal D. Leukotriene modifier therapy for mild sleep-disordered breathing in children. Am J Respir Crit Care Med. 2005;172(3):364–70.

    PubMed  Google Scholar 

  153. Kheirandish L, Goldbart AD, Gozal D. Intranasal steroids and oral leukotriene modifier therapy in residual sleep-disordered breathing after tonsillectomy and adenoidectomy in children. Pediatrics. 2006;117(1):e61–6.

    PubMed  Google Scholar 

  154. Kessler R, Chaouat A, Schinkewitch P, Faller M, Casel S, Krieger J, et al. The obesity-hypoventilation syndrome revisited: a prospective study of 34 consecutive cases. Chest. 2001;120(2):369–76.

    PubMed  CAS  Google Scholar 

  155. Mokhlesi B, Tulaimat A, Faibussowitsch I, Wang Y, Evans AT. Obesity hypoventilation syndrome: prevalence and predictors in patients with obstructive sleep apnea. Sleep Breath. 2007;11(2):117–24.

    PubMed  Google Scholar 

  156. Nowbar S, Burkart KM, Gonzales R, Fedorowicz A, Gozansky WS, Gaudio JC, et al. Obesity-associated hypoventilation in hospitalized patients: prevalence, effects, and outcome. Am J Med. 2004;116(1):1–7.

    PubMed  Google Scholar 

  157. Rosen CL. Clinical features of obstructive sleep apnea hypoventilation syndrome in otherwise healthy children. Pediatr Pulmonol. 1999;27(6):403–9.

    PubMed  CAS  Google Scholar 

  158. Malhotra A, Hillman D. Obesity and the lung: 3. Obesity, respiration and intensive care. Thorax. 2008;63(10):925–31.

    PubMed  CAS  Google Scholar 

  159. Centers for Disease Control and Prevention (CDC). CDC grand rounds: childhood obesity in the United States. MMWR Morb Mortal Wkly Rep. 2011;60(2):42–6.

    Google Scholar 

  160. Barbiero SM, Pellanda LC, Cesa CC, Campagnolo P, Beltrami F, Abrantes CC. Overweight, obesity and other risk factors for IHD in Brazilian schoolchildren. Public Health Nutr. 2009;12(5):710–5.

    PubMed  Google Scholar 

  161. Lazzeri G, Rossi S, Pammolli A, Pilato V, Pozzi T, Giacchi MV. Underweight and overweight among children and adolescents in Tuscany (Italy). Prevalence and short-term trends. J Prev Med Hyg. 2008;49(1):13–21.

    PubMed  CAS  Google Scholar 

  162. Nakano T, Sei M, Ewis AA, Munakata H, Onishi C, Nakahori Y. Tracking overweight and obesity in Japanese children; a six years longitudinal study. J Med Invest. 2010;57(1–2): 114–23.

    PubMed  Google Scholar 

  163. Al-Isa AN. Body mass index, overweight and obesity among Kuwaiti intermediate school adolescents aged 10–14 years. Eur J Clin Nutr. 2004;58(9):1273–7.

    PubMed  CAS  Google Scholar 

  164. Utter J, Scragg R, Schaaf D, Fitzgerald E, Wilson N. Correlates of body mass index among a nationally representative sample of New Zealand children. Int J Pediatr Obes. 2007;2(2): 104–13.

    PubMed  Google Scholar 

  165. El Mouzan MI, Foster PJ, Al Herbish AS, Al Salloum AA, Al Omer AA, Qurachi MM, et al. Prevalence of overweight and obesity in Saudi children and adolescents. Ann Saudi Med. 2010;30(3):203–8.

    PubMed  Google Scholar 

  166. Malik M, Bakir A. Prevalence of overweight and obesity among children in the United Arab Emirates. Obes Rev. 2007;8(1):15–20.

    PubMed  CAS  Google Scholar 

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Lang, J.E. (2013). Obesity and Lung Health in Children. In: Dixon, A., Clerisme-Beaty, E. (eds) Obesity and Lung Disease. Respiratory Medicine, vol 19. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-053-3_12

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