Abstract
Type 2 diabetes mellitus (DM) is a major global public health burden, affecting more than 170 million individuals worldwide [1]. Overall, it is estimated that the prevalence of diabetes will increase by 42 % among adults living in developed countries and by 170 % among adults in developing countries by 2025 [2, 3]. More alarmingly, by the time type 2 DM is diagnosed, most individuals have developed complications such as peripheral artery disease, renal failure, and neuropathy, and the vast majority of diabetic patients die of these complications [4]. Given the rising global burden of type 2 DM and its devastating complications, there is a great urgency to develop effective strategies to curb the epidemic by identifying individuals at high risk and optimizing prevention and early treatment. The predisposition to type 2 DM varies widely in the population and is largely determined by complex gene–environment interactions.
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Abbreviations
- Type 2 DM:
-
Type 2 diabetes mellitus
- TRPM6:
-
Transient receptor potential membrane melastatin 6
- TRPM7:
-
Transient receptor potential membrane melastatin 7
- PLCN-1:
-
Paracellin-1
- SLC41A1:
-
Solute carrier family 41 member 1
- MRS2:
-
Mitochondrial RNA splicing 2
- FXYD2:
-
Sodium-potassium-ATPase, gamma-1 polypeptide
- SLC12A3:
-
Solute carrier family 12 (sodium/chloride transporter)
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Song, Y., Zhang, C., Wang, L., Dai, Q., Liu, S. (2013). Magnesium Intake, Genetic Variants, and Diabetes Risk. In: Watson, R., Preedy, V., Zibadi, S. (eds) Magnesium in Human Health and Disease. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-044-1_6
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