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Mechanisms and Consequences of Centrosome Clustering in Cancer Cells

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The Centrosome

Abstract

Ever since initially proposed by Theodor Boveri in 1914, centrosome abnormalities have been accused to be involved in the induction of chromosomal instability and tumorigenesis. New evidence especially on a mechanism termed centrosomal clustering now again supports Boveri's idea and adds fuel to the old debate on a mechanistic link between supernumerary centrosomes and malignant transformation. On top, inhibiting centrosome clustering might well turn out to be one of the long sought after possibilities to specifically interfere with tumor cells while leaving healthy tissues untouched.

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Acknowledgment

We apologize to those authors whose work is not cited because of space limitations. This work was supported by the Deutsche Forschungsgemeinschaft, the Deutsche Krebshilfe, the Deutsche José Carreras Leukämie-Stiftung and the Interdisciplinary Research Program of the National Center for Tumor Diseases Heidelberg.

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Authors and Affiliations

  1. Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center and Department of Internal Medicine University of Heidelberg, Heidelberg, Germany

    Alwin Krämer, Simon Anderhub & Bettina Maier

Authors
  1. Alwin Krämer
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  2. Simon Anderhub
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  3. Bettina Maier
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Correspondence to Alwin Krämer .

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Editors and Affiliations

  1. Dept. Veterinary Pathobiology, University of Missouri-Columbia, East Rollins Street 1600, Columbia, 65211, Missouri, USA

    Heide Schatten

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© 2012 Humana Press, a part of Springer Science+Business Media, LLC

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Krämer, A., Anderhub, S., Maier, B. (2012). Mechanisms and Consequences of Centrosome Clustering in Cancer Cells. In: Schatten, H. (eds) The Centrosome. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-035-9_17

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