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Development and Growth of the Nervous System

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Noback's Human Nervous System, Seventh Edition

Abstract

Individuals are as old as their neurons in the sense that almost all neurons are generated by early postnatal life and, except for a few locations such as the olfactory bulb and subplate of portions of the cerebral cortex, are not generally replaced by new ones during a lifetime. On the other hand, development of the complex circuitry of the nervous system continues throughout life, tempered and honed by readjustments and responses to the influences and demands from both the internal and external environments.

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Suggested Readings

  • Ambron RT, Dulin MF, Zhang XP, Schmied R, Walters ET. 1995. Axoplasm enriched in a protein mobilized by nerve injury induces memory-like alterations in Aplysia neurons. J Neurosci. 15:3440–3446.

    PubMed  CAS  Google Scholar 

  • Anderson DJ 1993. Molecular control of cell fate in the neural crest: the sympatho-adrenal lineage. Ann Rev. Neurosci. 16:129–158.

    Article  PubMed  CAS  Google Scholar 

  • Bagri A, Marin O, Plump AS, et al. 2002. Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain. Neuron. 33: 233–248.

    Article  PubMed  CAS  Google Scholar 

  • Barinaga M. 2000. Fetal neuron grafts pave the way for stem cell therapies. Science. 287:1421–1422.

    Article  PubMed  CAS  Google Scholar 

  • Barry MF, Ziff EB. 2002. Receptor trafficking and the plasticity of excitatory synapses. Curr Opin Neurobiol.12:279–286.

    Google Scholar 

  • Bishop KM, Rubenstein JLR, O’Leary DDM. 2002. Distinct actions of Emx1, Emx2, and Pax6 in regulating the specification of areas in the developing neocortex. J Neurosci. 22:7627–7638.

    PubMed  CAS  Google Scholar 

  • Brose K, Tessier-Lavigne M. 2000. Slit proteins: key regulators of axon guidance, axonal branching, and cell migration. Curr Opin Neurobiol. 10:95–102.

    Article  PubMed  CAS  Google Scholar 

  • Cepko CL. 1999. The roles of intrinsic and extrinsic cues and bHLH genes in the determination of retinal cell fates. Curr Opin Neurobiol. 9:37–46.

    Google Scholar 

  • Cohen-Cory S. 2002. The developing synapse: construction and modulation of synaptic structures and circuits. Science. 298:770–776.

    Article  PubMed  CAS  Google Scholar 

  • Dickson BJ. 2002. Molecular mechanisms of axon guidance. Science. 298:1959–1964.

    Article  PubMed  CAS  Google Scholar 

  • Dowling J. 1993. Neurons and Networks: An Introduction to Neuroscience. Cambridge, MA: Harvard University Press.

    Google Scholar 

  • Edgerton V, Bigbee L, deLeon R. 2004. Plasticity of the spinal neural circuitry. Ann Rev Neurosci. 27: 145–167.

    Article  PubMed  CAS  Google Scholar 

  • Gottlieb DI. 2002. Large-scale sources of neural stem cells. Annu Rev Neurosci. 25:381–407.

    Article  PubMed  CAS  Google Scholar 

  • Gould E, Gross CG. 2002. Neurogenesis in adult mammals: some progress and problems. J Neurosci. 22:619–623.

    PubMed  CAS  Google Scholar 

  • Gould E, Reeves AJ, Graziano MS, Gross CG. 1999. Neurogenesis in the neocortex of adult primates. Science. 286:548–552.

    Article  PubMed  CAS  Google Scholar 

  • Gould E, Vail N, Wagers M, Gross CG. 2001. Adult-generated hippocampal and neocortical neurons in macaques have a transient existence Proc Natl Acad Sci USA. 98:10,910–910, 917.

    Google Scholar 

  • Hatten ME. 1999. Central nervous system neuronal migration. Annu Rev Neurosci. 22:511–539.

    Article  PubMed  CAS  Google Scholar 

  • Hatten ME. 2002. New directions in neuronal migration. Science. 297:1660–1663.

    Article  PubMed  CAS  Google Scholar 

  • Holden C. 2003. Stem cell research. Cells find destiny though merger. Science. 300:35.

    Article  PubMed  CAS  Google Scholar 

  • Irvine KD, Rauskolb C. 2001. Boundaries in development: formation and function. Annu Rev Cell Dev Biol. 17:189–214.

    Article  PubMed  CAS  Google Scholar 

  • Jessell TM, Sanes JR. 2000. Development. The decade of the developing brain. Curr Opin Neurobiol. 10:599–611.

    Google Scholar 

  • Jessen KR, Mirsky R. 1997. Embryonic Schwann cell development: the biology of Schwann cell precursors and early Schwann cells. J Anat. 141:501–505.

    Article  Google Scholar 

  • Jones EG. 2000. Cortical and subcortical contributions to activity-dependent plasticity in primate somatosensory cortex. Annu Rev Neurosci. 23:1–37.

    Article  PubMed  CAS  Google Scholar 

  • Kennedy TE, Serafini T, de la Torre JR, Tessier-Lavigne M. 1994. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell. 12:425–35.

    Article  PubMed  CAS  Google Scholar 

  • Kozorovitskiy Y, Gould E. 2003. Adult neurogenesis: a mechanism for brain repair? J Clin Exp Neuropsychol. 25:721–732.

    Article  PubMed  Google Scholar 

  • Lyuksyutova AI, Lu CC, Milanesio N, King LA, Guo N, Wang Y, Nathans J, Tessier-Lavigne M, Zou Y. 2003. Anterior–posterior guidance of commissural axons by Wnt-frizzled signaling. Science. 302:1984–1988.

    Article  PubMed  CAS  Google Scholar 

  • McAllister AK, Katz LC, Lo DC. 1999. Neurotrophins and synaptic plasticity. Annu Rev Neurosci. 22:295–318.

    Article  PubMed  CAS  Google Scholar 

  • Mueller BK. 1999. Growth cone guidance: first steps towards a deeper understanding Annu Rev Neurosci. 22:351–388.

    Google Scholar 

  • Nguyen-Ba-Charvet KT, Picard-Riera N, et al. 2004. Multiple roles for slits in the control of cell migration in the rostral migratory stream. J Neurosci. 24:1497–1506.

    Google Scholar 

  • Nijhawan D, Honarpour N, Wang X. 2002. Apoptosis in neural development and disease. Annu Rev Neurosci. 23:73–87.

    Google Scholar 

  • Rakic P. 2002. Adult neurogenesis in mammals: an identity crisis. J Neurosci. 22:614–618.

    Google Scholar 

  • Rakic P. 2002. Neurogenesis in adult primates. Prog Brain Res. 138:3–14.

    Google Scholar 

  • Rubenstein JL, Shimamura K, Martinez S, Puelles L. 1998. Regionalization of the prosencephalic neural plate. Annu Rev Neurosci. 21:445–477.

    Article  Google Scholar 

  • Sanes DH, Reh TA, Harris WA. 2000. Development of the Nervous System. San Diego, CA: Academic Press.

    Google Scholar 

  • Schnorrer F, Dickson BJ. 2004. Axon guidance: morphogens show the way. Curr Biol. 4:R19–R21.

    Google Scholar 

  • Sellek, MA, TY Scherson and M Bronstein-Fraser 1993. Origins of neural crest cell diversity. Dev Biol. 159:1–11.

    Article  Google Scholar 

  • Shirasaki R, Pfaff SL. 2002. Transcriptional codes and the control of neuronal identity. Annu Rev Neurosci. 25:251–281.

    Article  PubMed  CAS  Google Scholar 

  • Stein E, Tessier-Lavigne M. 2001. Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex. Science. 291:1928–1938.

    Article  PubMed  CAS  Google Scholar 

  • Tessier-Lavigne M, Goodman CS. 1996. The molecular biology of axon guidance. Science. 274:1123–1133.

    Article  PubMed  CAS  Google Scholar 

  • Weissman IL, Anderson DJ, Gage F. 2001. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu Rev Cell Dev Biol. 17:387–403.

    Google Scholar 

  • Zhang XP, Ambron RT. 2000. Positive injury signals induce growth and prolong survival in Aplysia neurons. J Neurobiol. 45:84–94.

    Article  PubMed  CAS  Google Scholar 

  • Zigova T, Sanberg PR, Sanchez-Ramos J, eds. 2002. Neural Stem Cells: Methods and Protocols. Totowa, NJ: Humana.

    Google Scholar 

  • Zigova T, Snyder E, Sanberg P, eds. 2003. Neural Stem Cells for Brain and Spinal Cord Repair. Totowa, NJ: Humana.

    Google Scholar 

  • Zou Y, Stoeckli E, Chen H, Tessier-Lavigne M. 2002. Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord. Cell. 102:363–375.

    Article  Google Scholar 

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Strominger, N.L., Demarest, R.J., Laemle, L.B. (2012). Development and Growth of the Nervous System. In: Noback's Human Nervous System, Seventh Edition. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-779-8_6

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