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Pathophysiology of Acute Decompensated Heart Failure

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Short Stay Management of Acute Heart Failure

Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

The frequency of ADHF is increasing and its mortality and early readmission rates are high. It is usually superimposed on chronic HF, but it can be the initial manifestation of this disease. There is a wide variety of inciting factors as well as significant comorbidities in most patients with ADHF. The maladaptive compensatory NH mechanisms that contribute to chronic HF are also operative in ADHF. Conventional therapy with diuretics and positive inotropic agents has early beneficial effects, but these methods can further augment adverse NH activation. The cardiorenal syndrome is a particularly challenging complication whose mechanisms have not been clarified. It is anticipated that current studies on mechanisms of this syndrome and its therapy will result in enhanced management.

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Author information

Authors and Affiliations

  1. Division of Cardiovascular Medicine, Department of Internal Medicine, Davis Medical Center, University of California, 4860 Y Street, Sacramento, CA, 95817, USA

    Ezra A. Amsterdam MD & Kathleen L. Tong MD

  2. Division of Cardiovascular Medicine, Department of Internal Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA

    Richard Summers MD

Authors
  1. Ezra A. Amsterdam MD
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  2. Kathleen L. Tong MD
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  3. Richard Summers MD
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Corresponding author

Correspondence to Ezra A. Amsterdam MD .

Editor information

Editors and Affiliations

  1. Mail Code E-19, Cleveland Clinic Foundation Dept. Emergency Medicine, Cleveland, Ohio, USA

    W. Frank Peacock

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Amsterdam, E.A., Tong, K.L., Summers, R. (2012). Pathophysiology of Acute Decompensated Heart Failure. In: Peacock, W. (eds) Short Stay Management of Acute Heart Failure. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-627-2_7

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  • DOI: https://doi.org/10.1007/978-1-61779-627-2_7

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61779-626-5

  • Online ISBN: 978-1-61779-627-2

  • eBook Packages: MedicineMedicine (R0)

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