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Sealants (Adhesives) to Prevent Bleeding

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Biomaterials for Surgical Operation

Abstract

In general, surgical sealants (adhesives) are liquids and form gels when applied. Currently, several products are clinically available, including naturally derived fibrin sealants, semisynthetic products such as gelatin and albumin-based glues, and synthetic products including cyanoacrylates and poly(ethylene glycol). These products, however, have both advantages and disadvantages. While fibrin sealants have been successfully used in many surgical fields, they have several disadvantages including low adhesive strength. Other products, such as cyanoacrylates and protein-based products, have high adhesion strength but have high toxicity, and therefore, their applications are limited. Studies are still ongoing in order to develop sealants with higher adhesion strength and safer properties compared to the sealants that are currently available. This chapter reviews the chemistry and applications of clinically available sealants and recent developments in this field.

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  1. Graduate School Department of Medical Engineering, Nara Medical University, Shijo-cho 840, Kashihara-shi, 634-8521, Nara, Japan

    Shuko Suzuki & Yoshito Ikada

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  1. Shuko Suzuki
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  2. Yoshito Ikada
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Correspondence to Shuko Suzuki .

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Suzuki, S., Ikada, Y. (2012). Sealants (Adhesives) to Prevent Bleeding. In: Biomaterials for Surgical Operation. Humana Press. https://doi.org/10.1007/978-1-61779-570-1_4

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  • DOI: https://doi.org/10.1007/978-1-61779-570-1_4

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