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Adult Stem Cells and Regeneration of Adipose Tissue

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Tissue Engineering in Regenerative Medicine

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Defects in soft tissue may arise from trauma, chronic diseases, tumor resection, and congenital anomalies. Current practices of autologous grafting and native or synthetic fillers including silicone gel or saline implants have limitations and, like most foreign substances, do not represent long-term solutions. In this chapter, we discuss some of the latest findings in the field of soft tissue regeneration and interventional adipogenesis. We suggest that the field can be advanced by the (1) identification of critical areas of clinical demand and corresponding strategies for different clinical entities; (2) translational approaches that promote angiogenesis and survival of adipose tissue grafts; (3) scale-up of bioengineered adipose tissue grafts; (4) development and adoption of large animal models for testing adipose tissue grafts; and (5) establishment of success criteria for adipose tissue regeneration including the maintenance of volume and shape over time.

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Abbreviations

ASC:

Adipose tissue-derived stem cell

BAT:

Brown adipose tissue

bFGF:

Basic fibroblast growth factor

ECM:

Extracellular matrix

MSC:

Mesenchymal stem cell

PEG:

Poly(ethylene glycol)

PEGDA:

Poly(ethylene)glycol-diacrylate

PGA:

Poly(glycolic acid)

PLA:

Poly(lactic acid)

PLGA:

Poly(l-lactic-co-glycolic acid)

RGD:

Arginine-glycine-aspartic acid

WAT:

White adipose tissue

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Acknowledgments

We thank Michael Diggs, Qiongfen Guo, and Kening Hua for administrative assistance. The work described in this chapter is supported by the Swedish Society for Medical Research to D.A.H. and NIH grants RC2DE020767 and R01EB006261.

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Authors and Affiliations

  1. Tissue Engineering and Regenerative Medicine Laboratory, Columbia University Medical Center, New York, NY, USA

    Daniel A. Hägg, Bhranti Shah & Jeremy J. Mao

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  1. Daniel A. Hägg
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  2. Bhranti Shah
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  3. Jeremy J. Mao
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Correspondence to Jeremy J. Mao .

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  1. Eli and Edythe Broad Center of Regenerat, Department of Pediatrics, UCSF, Cardiovascular Research Institute, 513 Parnassus Avenue HSE 1422, San Francisco, 94143, USA

    Harold S. Bernstein

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Hägg, D.A., Shah, B., Mao, J.J. (2011). Adult Stem Cells and Regeneration of Adipose Tissue. In: Bernstein, H. (eds) Tissue Engineering in Regenerative Medicine. Stem Cell Biology and Regenerative Medicine. Humana Press. https://doi.org/10.1007/978-1-61779-322-6_14

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