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Normal-Tissue Tolerance to IOERT, EBRT, or Both: Animal and Clinical Studies

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Intraoperative Irradiation

Part of the book series: Current Clinical Oncology ((CCO))

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Abstract

Early clinical investigations of intraoperative electron irradiation (IOERT) as an alternative to conventional external-beam irradiation (EBRT) were based on a limited number of preclinical studies to provide important information regarding the radiobiologic response of normal and surgically manipulated tissue to high, single doses of radiation. Since the overall goal of IOERT was to maximize the total radiation dose that can be safely delivered to the tumor, there was a strong need to establish tissue-specific guidelines for the clinical use of IOERT to minimize normal-tissue toxicity.

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Duke University Medical Center, DUMC 3085, Durham, NC, 27710, USA

    Zeljko Vujaskovic & Christopher G. Willett

  2. Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, NC, USA

    Joel E. Tepper

  3. Department of Radiation Oncology, Warren Alpert Medical School of Brown University and the Rhode Island Hospital, Providence, RI, USA

    Timothy J. Kinsella

  4. Department of Radiation Oncology, Mayo Clinic College of Medicine and Mayo Clinic Arizona, Scottsdale, AZ, USA

    Leonard L. Gunderson

Authors
  1. Zeljko Vujaskovic
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  2. Christopher G. Willett
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  3. Joel E. Tepper
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  4. Timothy J. Kinsella
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  5. Leonard L. Gunderson
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Corresponding author

Correspondence to Zeljko Vujaskovic .

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Mayo Clinic, East Shea Blvd 13400, Scottsdale, 85259, Arizona, USA

    Leonard L. Gunderson

  2. Dept. Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA

    Christopher G. Willett

  3. Gregorio Marañón, Depto. Radiación de Oncología, Hospital General Universitario, C/ Dr. Esquerdo 46, Madrid, 28007, Spain

    Felipe A. Calvo

  4. Albert Einstein College of Medicine, Radiation Oncology, Beth Israel Medical Center, Union Square East 10, New York, 10003, New York, USA

    Louis B. Harrison

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Vujaskovic, Z., Willett, C.G., Tepper, J.E., Kinsella, T.J., Gunderson, L.L. (2011). Normal-Tissue Tolerance to IOERT, EBRT, or Both: Animal and Clinical Studies. In: Gunderson, L., Willett, C., Calvo, F., Harrison, L. (eds) Intraoperative Irradiation. Current Clinical Oncology. Humana Press. https://doi.org/10.1007/978-1-61779-015-7_7

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  • DOI: https://doi.org/10.1007/978-1-61779-015-7_7

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-014-0

  • Online ISBN: 978-1-61779-015-7

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