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Pancreas Cancer

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Intraoperative Irradiation

Part of the book series: Current Clinical Oncology ((CCO))

Abstract

Despite its infrequency, pancreatic cancer is the fourth leading cause of cancer death in USA with an estimated 42,140 new cases and 36,800 deaths projected in the USA for 2010 [1]. Although mortality rates have slightly improved in recent years, overall, outcomes after surgical resection remain poor despite attempts to improve survival through multimodality therapy including extended lymphadenectomies and novel biologic agents in addition to conventional neoadjuvant and adjuvant chemotherapy and radiotherapy. Surgery remains the mainstay of potentially curative therapy, although few patients, 10–15%, present with resectable disease. Figure 13.1 illustrates an unresectable head of pancreas carcinoma where resection is impossible because of vascular encasement. Survival in most large surgical series remains less than 20% for long-term survivors [2–5].

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Authors and Affiliations

  1. Department of Radiation Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Robert C. Miller

  2. Department of Radiotherapy, Universita Cattolica del Sacro Cuore, Rome, Italy

    Vincenzo Valentini & Giuseppe R. D’Agostino

  3. Division of General Surgery Mayo Clinic in Arizona, Scottsdale, AZ, USA

    Adyr Moss

  4. Department of Radiation Oncology, Mayo Clinic College of Medicine and Mayo Clinic Arizona, Scottsdale, AZ, USA

    Matthew D. Callister & Leonard L. Gunderson

  5. Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA

    Theodore S. Hong

  6. Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA

    Christopher G. Willett

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Correspondence to Robert C. Miller .

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Editors and Affiliations

  1. Department of Radiation Oncology, Mayo Clinic, East Shea Blvd 13400, Scottsdale, 85259, Arizona, USA

    Leonard L. Gunderson

  2. Dept. Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA

    Christopher G. Willett

  3. Gregorio Marañón, Depto. Radiación de Oncología, Hospital General Universitario, C/ Dr. Esquerdo 46, Madrid, 28007, Spain

    Felipe A. Calvo

  4. Albert Einstein College of Medicine, Radiation Oncology, Beth Israel Medical Center, Union Square East 10, New York, 10003, New York, USA

    Louis B. Harrison

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Miller, R.C. et al. (2011). Pancreas Cancer. In: Gunderson, L., Willett, C., Calvo, F., Harrison, L. (eds) Intraoperative Irradiation. Current Clinical Oncology. Humana Press. https://doi.org/10.1007/978-1-61779-015-7_13

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