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Nitrite and Nitrate in Human Breast Milk: Implications for Development

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Nitrite and Nitrate in Human Health and Disease

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References

  1. Heinig MJ. The American Academy of Pediatrics recommendations on breastfeeding and the use of human milk. J Hum Lact. 1998;14(1):2–3.

    Article  PubMed  CAS  Google Scholar 

  2. Gartner LM, Morton J, Lawrence RA, Naylor AJ, O’Hare D, Schanter RJ, et al. Breastfeeding and the use of human milk. Pediatrics. 2005;115(2):496–506.

    Article  PubMed  Google Scholar 

  3. Hoddinott P, Tappin D, Wright C. Breast feeding. BMJ. 2008;336(7649):881–7.

    Article  PubMed  Google Scholar 

  4. James DC, Lessen R. Position of the American Dietetic Association: promoting and supporting breastfeeding. J Am Diet Assoc. 2009;109(11):1926–42.

    Article  PubMed  Google Scholar 

  5. Ip S, Chung M, Raman G, Chew P, Magula N, DeVine D, et al. Breastfeeding and maternal and infant health outcomes in developed countries. Evidence report/technology assessment. Rockville, MD: Tufts-New England Medical Center Evidence-based Practice center, under Contract NO. 290-02-0022; 2007.

    Google Scholar 

  6. Centre for Disease Control and Prevention (CDC). Breastfeeding trends and updated national health objectives for exclusive breastfeeding–United States, birth years 2000-2004. MMWR Morb Mortal Wkly Rep. 2007;56(30):760–3.

    Google Scholar 

  7. Greer FR, Shannon M. Infant methemoglobinemia: the role of dietary nitrate in food and water. Pediatrics. 2005;116(3):784–6.

    Article  PubMed  Google Scholar 

  8. Johnson CJ, Kross BC. Continuing importance of nitrate contamination of groundwater and wells in rural areas. Am J Ind Med. 1990;18(4):449–56.

    Article  PubMed  CAS  Google Scholar 

  9. McKnight GM, Duncan CW, Leifert C, Golden MH. Dietary nitrate in man: friend or foe? Br J Nutr. 1999;81(5):349–58.

    Article  PubMed  CAS  Google Scholar 

  10. Fan AM, Steinberg VE. Health implications of nitrate and nitrite in drinking water: an update on methemoglobinemia occurrence and reproductive and developmental toxicity. Regul Toxicol Pharmacol. 1996;23(1 Pt 1):35–43.

    Article  PubMed  CAS  Google Scholar 

  11. Dusdieker LB, Getchell JP, Liarakos TM, Hausler WJ, Dungy CI. Nitrate in baby foods. Adding to the nitrate mosaic. Arch Pediatr Adolesc Med. 1994;148(5):490–4.

    PubMed  CAS  Google Scholar 

  12. Kross BC, Ayebo AD, Fuortes LJ. Methemoglobinemia: nitrate toxicity in rural America. Am Fam Physician. 1992;46(1):183–8.

    PubMed  CAS  Google Scholar 

  13. Cornblath M, Hartmann AF. Methhemoglobinaemia in young infants. J Pediatr. 1948;33:421–5.

    Article  PubMed  CAS  Google Scholar 

  14. Kortboyer J, Olling M, Zeilmaker MJ. The oral bioavailability of sodium nitrite investigated in healthy adult volunteers. Bilthoven, tHE Netherlands: National Institute of Public Health and the Environment; 1997.

    Google Scholar 

  15. Dejam A, Hunter CJ, Tremonti C, Pluta RM, Han YY, Grimes G, et al. Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation. Circulation. 2007;116(16):1821–31.

    Article  PubMed  CAS  Google Scholar 

  16. L’Hirondel JL, Avery AA, Addiscott T. Dietary nitrate: where is the risk? Environ Health Perspect. 2006;114(8):A458–9; author reply A459–61.

    Google Scholar 

  17. Powlson DS, Addiscott TM, Benjamin N, Cassman KG, de kok TM, van Grinsven H, et al. When does nitrate become a risk for humans? J Environ Qual. 2008;37(2):291–5.

    Article  PubMed  CAS  Google Scholar 

  18. L’Hirondel JL. Nitrate and man: toxic, harmless or beneficial? Wallingford, UK: CABI; 2001.

    Book  Google Scholar 

  19. Authority EFS. Nitrate in vegetables: scientific opinion of the panel on contaminants in the food chain. EFSA J. 2008;289:1–79.

    Google Scholar 

  20. World Health Organization. Recommendations; nitrate and nitrite. In: Guidelines for drinking water quality. 3rd ed. Geneva, Switzerland: WHO; 2004.

    Google Scholar 

  21. National Primary Drinking Water Regulations: Final Rule, 40. In: Agency USEP, editor Vol CFR parts 141–143. Federal Register; 1991:3526–97.

    Google Scholar 

  22. Newton ER. Breastmilk: the gold standard. Clin Obstet Gynecol. 2004;47(3):632–42.

    Article  PubMed  Google Scholar 

  23. Hawkes JS, Neumann MA, Gibson RA. The effect of breast feeding on lymphocyte subpopulations in healthy term infants at 6 months of age. Pediatr Res. 1999;45(5 Pt 1):648–51.

    Article  PubMed  CAS  Google Scholar 

  24. Hawkes JS, Gibson RA. Lymphocyte subpopulations in breast-fed and formula-fed infants at six months of age. Adv Exp Med Biol. 2001;501:497–504.

    PubMed  CAS  Google Scholar 

  25. Fulhan J, Collier S, Duggan C. Update on pediatric nutrition: breastfeeding, infant nutrition, and growth. Curr Opin Pediatr. 2003;15(3):323–32.

    Article  PubMed  Google Scholar 

  26. Shu XO, Linet MS, Steinbuch M, Wen WQ, Buckley JD, Neglia JP, et al. Breast-feeding and risk of childhood acute leukemia. J Natl Cancer Inst. 1999;91(20):1765–72.

    Article  PubMed  CAS  Google Scholar 

  27. Singhal A. Early nutrition and long-term cardiovascular health. Nutr Rev. 2006;64(5 Pt 2):S44–49; discussion S72–91.

    Google Scholar 

  28. Martin RM, Gunnell D, Smith GD. Breastfeeding in infancy and blood pressure in later life: systematic review and meta-analysis. Am J Epidemiol. 2005;161(1):15–26.

    Article  PubMed  Google Scholar 

  29. Rich-Edwards JW, Stampfer MJ, Manson JE, Rosner B, Hu FB, Michels KB, et al. Breastfeeding during infancy and the risk of cardiovascular disease in adulthood. Epidemiology. 2004;15(5):550–6.

    Article  PubMed  Google Scholar 

  30. Brook I, Barrett CT, Brinkman III CR, Martin WJ, Finegold SM. Aerobic and anaerobic bacterial flora of the maternal cervix and newborn gastric fluid and conjunctiva: a prospective study. Pediatrics. 1979;63(3):451–5.

    PubMed  CAS  Google Scholar 

  31. Morelli L. Postnatal development of intestinal microflora as influenced by infant nutrition. J Nutr. 2008;138(9):1791S–5.

    PubMed  CAS  Google Scholar 

  32. Favier CF, Vaughan EE, De Vos WM, Akkermans AD. Molecular monitoring of succession of bacterial communities in human neonates. Appl Environ Microbiol. 2002;68(1):219–26.

    Article  PubMed  CAS  Google Scholar 

  33. West PA, Hewitt JH, Murphy OM. Influence of methods of collection and storage on the bacteriology of human milk. J Appl Bacteriol. 1979;46(2):269–77.

    PubMed  CAS  Google Scholar 

  34. Martin R, Langa S, Reviriego C, Jiminez E, Marin ML, Xaus J, et al. Human milk is a source of lactic acid bacteria for the infant gut. J Pediatr. 2003;143(6):754–8.

    Article  PubMed  CAS  Google Scholar 

  35. Neville MC. Physiology of lactation. Clin Perinatol. 1999;26(2):251–79; v.

    Google Scholar 

  36. Hamosh M. Bioactive factors in human milk. Pediatr Clin North Am. 2001;48(1):69–86.

    Article  PubMed  CAS  Google Scholar 

  37. Garofalo R. Cytokines in human milk. J Pediatr. 2010;156(2 Suppl):S36–40.

    PubMed  CAS  Google Scholar 

  38. Kosaka N, Izumi H, Sekine K, Ochiya T. microRNA as a new immune-regulatory agent in breast milk. Silence. 2010;1(1):7.

    Article  PubMed  Google Scholar 

  39. Admyre C, Johansson SM, Qazi KR, Filén JJ, Lahesmaa R, Norman M, et al. Exosomes with immune modulatory features are present in human breast milk. J Immunol. 2007;179(3):1969–78.

    PubMed  CAS  Google Scholar 

  40. Ohta N, Tsukahara H, Ohshima Y, Nishii M, Ogawa Y, Sekine K, et al. Nitric oxide metabolites and adrenomedullin in human breast milk. Early Hum Dev. 2004;78(1):61–5.

    Article  PubMed  CAS  Google Scholar 

  41. Hord NG, Ghannam JS, Garg HK, Berens PD, Bryan NS. Nitrate and nitrite content of human, formula, bovine and soy milks: implications for dietary nitrite and nitrate recommendations. Breastfeed Med. 2010 Oct 19.[Epub ahead of print].

    Google Scholar 

  42. Iizuka T, Sasaki M, Oishi K, Uemura S, Koike M, Shinozaki M. Non-enzymatic nitric oxide generation in the stomachs of breastfed neonates. Acta Paediatr. 1999;88(10):1053–5.

    Article  PubMed  CAS  Google Scholar 

  43. Fujita K, Murono K. Nosocomial acquisition of Escherichia coli by infants delivered in ­hospitals. J Hosp Infect. 1996;32(4):277–81.

    Article  PubMed  CAS  Google Scholar 

  44. Mandar R, Mikelsaar M. Transmission of mother’s microflora to the newborn at birth. Biol Neonate. 1996;69(1):30–5.

    Article  PubMed  CAS  Google Scholar 

  45. Petersson J, Carlstrom M, Schreiber O, Phillipson M, Christoffersson G, Jagare A, et al. Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash. Free Radic Biol Med. 2009;46(8):1068–75.

    Article  PubMed  CAS  Google Scholar 

  46. Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, et al. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension. 2008;51(3):784–90.

    Article  PubMed  CAS  Google Scholar 

  47. Cekmen MB, Balat A, Balat O, Aksoy F, Yurekli M, Erbagci AB, et al. Decreased adrenomedullin and total nitrite levels in breast milk of preeclamptic women. Clin Biochem. 2004;37(2):146–8.

    Article  PubMed  CAS  Google Scholar 

  48. Dusdieker LB, Stumbo PJ, Kross BC, Dungy CI. Does increased nitrate ingestion elevate nitrate levels in human milk? Arch Pediatr Adolesc Med. 1996;150(3):311–4.

    PubMed  CAS  Google Scholar 

  49. Jansson EA, Huang L, Malkey R, Govoni M, Nihten C, Olssor A, et al. A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis. Nat Chem Biol. 2008;4(7):411–7.

    Article  PubMed  CAS  Google Scholar 

  50. Dalsgaard T, Simonsen U, Fago A. Nitrite-dependent vasodilation is facilitated by hypoxia and is independent of known NO-generating nitrite reductase activities. Am J Physiol Heart Circ Physiol. 2007;292(6):H3072–8.

    Article  PubMed  CAS  Google Scholar 

  51. Li H, Cui H, Kundu TK, Alzawahra W, Zweier JL. Nitric oxide production from nitrite occurs primarily in tissues not in the blood: critical role of xanthine oxidase and aldehyde oxidase. J Biol Chem. 2008;283(26):17855–63.

    Article  PubMed  CAS  Google Scholar 

  52. Feelisch M, Fernandez BO, Bryan NS, Garcia-Saura MF, Bauer S, Whitlock DR, et al. Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems. J Biol Chem. 2008;283(49):33927–34.

    Article  PubMed  CAS  Google Scholar 

  53. Zweier JL, Wang P, Samouilov A, Kuppusamy P. Enzyme-independent formation of nitric oxide in biological tissues. Nat Med. 1995;1(8):804–9.

    Article  PubMed  CAS  Google Scholar 

  54. Bryan NS, Calvert JW, Elrod JW, Gundewar S, Ji SY, Lefer DJ. Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury. Proc Natl Acad Sci USA. 2007;104(48):19144–9.

    Article  PubMed  CAS  Google Scholar 

  55. Abadeh S, Killacky J, Benboubetra M, Harrison R. Purification and partial characterization of xanthine oxidase from human milk. Biochim Biophys Acta. 1992;1117(1):25–32.

    PubMed  CAS  Google Scholar 

  56. Brown AM, Benboubetra M, Ellison M, Powell D, Reckless JD, Harrison R. Molecular activation-deactivation of xanthine oxidase in human milk. Biochim Biophys Acta. 1995;1245(2):248–54.

    PubMed  Google Scholar 

  57. Stevens CR, Millar TM, Clinch JG, Kanczler JM, Bodamyali T, Blake DR. Antibacterial properties of xanthine oxidase in human milk. Lancet. 2000;356(9232):829–30.

    Article  PubMed  CAS  Google Scholar 

  58. Hancock JT, Salisbury V, Ovejero-Boglione MC, Cherry R, Hoare C, Eisenthal R, et al. Antimicrobial properties of milk: dependence on presence of xanthine oxidase and nitrite. Antimicrob Agents Chemother. 2002;46(10):3308–10.

    Article  PubMed  CAS  Google Scholar 

  59. Iizuka T, Sasaki M, Oishi K, Uemura S, Koike M, Minatogawa Y. Nitric oxide may trigger lactation in humans. J Pediatr. 1997;131(6):839–43.

    Article  PubMed  CAS  Google Scholar 

  60. Iizuka T, Sasaki M, Oishi K, Uemura S, Koike M. The presence of nitric oxide synthase in the mammary glands of lactating rats. Pediatr Res. 1998;44(2):197–200.

    Article  PubMed  CAS  Google Scholar 

  61. Lacasse P, Farr VC, Davis SR, Prosser CG. Local secretion of nitric oxide and the control of mammary blood flow. J Dairy Sci. 1996;79(8):1369–74.

    Article  PubMed  CAS  Google Scholar 

  62. Authority EFS. Nitrate in vegetables: scientific opinion of the panel on contaminants in the food chain. EFSA J. 2008;689:1–79.

    Google Scholar 

  63. Lundberg JO, Feelisch M, Bjorne H, Jansson EA, Weitzberg E. Cardioprotective effects of vegetables: is nitrate the answer? Nitric Oxide. 2006;15(4):359–62.

    Article  PubMed  CAS  Google Scholar 

  64. Hord NG, Tang Y, Bryan NS. Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr. 2009;90(1):1–10.

    Article  PubMed  CAS  Google Scholar 

  65. Schack-Nielsen L, Michaelsen KF. Breast feeding and future health. Curr Opin Clin Nutr Metab Care. 2006;9(3):289–96.

    Article  PubMed  Google Scholar 

  66. Davis MK. Review of the evidence for an association between infant feeding and childhood cancer. Int J Cancer Suppl. 1998;11:29–33.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Brown Foundation Institute of Molecular Medicine, The University of Texas, Health Science Center at Houston, 1825 Pressler Street 530C, Houston, TX, 77030, USA

    Nathan S. Bryan

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  1. Pamela D. Berens
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  1. Health Science Center, Houston, Inst. Molecular Medicine, University of Texas, Pressler Street 1825, Houston, 77030, Texas, USA

    Nathan S. Bryan

  2. Brigham & Women's Hospital, Harvard Medical School, Francis St. 75, Boston, 02115, Massachusetts, USA

    Joseph Loscalzo

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Berens, P.D., Bryan, N.S. (2011). Nitrite and Nitrate in Human Breast Milk: Implications for Development. In: Bryan, N., Loscalzo, J. (eds) Nitrite and Nitrate in Human Health and Disease. Nutrition and Health. Humana Press. https://doi.org/10.1007/978-1-60761-616-0_9

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  • DOI: https://doi.org/10.1007/978-1-60761-616-0_9

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