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Aging, Oxidative Stress, and Cardiovascular Disorders

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Aging and Age-Related Disorders

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Abstract

Aging is a progressive decay of the physiologic efficiency of an organism as well as a major risk factor for the development of cardiovascular disease. Due to constant birth rates and increasing life expectancy, the proportion of elderly people is steadily growing in most developed countries, thus the need to better understand aging and its molecular basis is becoming a central issue. Accumulation of oxidative stress with age is hypothesized to be the primary causative mediator of age-associated diseases. Among different tissues, aging vessels are known to accumulate oxidative damage and undergo functional impairment. Oxidative stress affects the availability and/or balance of key regulators of vascular homeostasis and favors the development of cardiovascular disease. Reactive oxygen species are generated by different intracellular molecular pathways principally located in the cytoplasm and in the mitochondria. The mitochondrial protein p66Shc and the deacetylase enzyme Sirt1 were shown to be involved in different aspects of aging and age-dependent disease. This chapter focuses on the latest scientific advances in understanding aging and age-related disease and delineates the possible therapeutic implications of p66Shc and Sirt 1 in this process.

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Authors and Affiliations

  1. Cardiovascular Research, Center for Integrative Human Physiology (ZIHP), Institute of Physiology, University of Zurich, Zurich, Switzerland

    Yi Shi, Giovanni G. Camici & Thomas F. Lüscher

  2. Department of Cardiology, Cardiovascular Center, University Hospital, Zurich, Switzerland

    Thomas F. Lüscher

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  1. Yi Shi
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  2. Giovanni G. Camici
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  3. Thomas F. Lüscher
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Correspondence to Thomas F. Lüscher .

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  1. Center for Occupational & Environmental, Department of Medicine, University of California, Irvine, Room 320, Med Surge II, Irvine, 92697, California, USA

    Stephen Bondy

  2. New Jersey Medical School, Department of Neurology and Neuroscience, University of Medicine & Dentistry of Ne, South Orange Avenue 185, Newark, 07101, New Jersey, USA

    Kenneth Maiese

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Shi, Y., Camici, G.G., Lüscher, T.F. (2010). Aging, Oxidative Stress, and Cardiovascular Disorders. In: Bondy, S., Maiese, K. (eds) Aging and Age-Related Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-602-3_12

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