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PKC and Resistance to Chemotherapeutic Agents

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Protein Kinase C in Cancer Signaling and Therapy

Part of the book series: Current Cancer Research ((CUCR))

Abstract

Despite considerable efforts that have been invested in identifying novel therapeutic targets for the treatment of cancer, conventional chemotherapeutic drugs continue to be the major treatment option for cancer patients. However, intrinsic and acquired resistance to these antineoplastic drugs is the major cause of therapy failure. Understanding the molecular basis of chemoresistance is critical to manage this disease successfully. The mechanism(s) of chemoresistance is(are) often multifactorial. The protein kinase C (PKC) family plays an important role in regulating cell proliferation and cell death. Numerous studies have implicated members of the PKC family as contributors of chemoresistance. Thus, the PKC signaling pathway could be exploited to overcome chemoresistance. The objective of this chapter is to provide a comprehensive review of literature on the involvement of PKC in classical multiple drug resistance (MDR), cisplatin resistance, and resistance to apoptosis, which may affect the sensitivity of tumor cells to numerous anticancer drugs.

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Acknowledgment

The author wishes to thank Shalini Persaud and Anindita Basu Sempere for critical reading of this chapter. We apologize if we inadvertently left out any major contribution in this field. The author is supported by a grant CA071727 from the National Cancer Institute.

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  1. Department of Molecular Biology and Immunology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX, 76107, USA

    Alakananda Basu

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    Marcelo G. Kazanietz

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Basu, A. (2010). PKC and Resistance to Chemotherapeutic Agents. In: Kazanietz, M. (eds) Protein Kinase C in Cancer Signaling and Therapy. Current Cancer Research. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-543-9_21

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