Chapter

National Institute of Allergy and Infectious Diseases, NIH

Part of the series Infectious Disease pp 387-402

Date:

Structural Biology and the Design of Effective Vaccines for HIV-1 and Other Viruses

  • Peter D. KwongAffiliated withStructural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH
  • , Gary J. NabelAffiliated withVirology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH
  • , Priyamvada AcharyaAffiliated withStructural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH
  • , Jeffrey C. BoyingtonAffiliated withVirology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH
  • , Lei ChenAffiliated withStructural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH
  • , Chantelle HoodAffiliated withVirology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH
  • , Albert KimAffiliated withStructural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH
  • , Leopold KongAffiliated withStructural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH
  • , Young Do KwonAffiliated withStructural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH
    • , Shahzad MajeedAffiliated withStructural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH
    • , Jason McLellanAffiliated withStructural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH
    • , Gilad OfekAffiliated withStructural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH
    • , Marie PanceraAffiliated withStructural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH
    • , Mallika SastryAffiliated withStructural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH
    • , Anita ChangelaAffiliated withStructural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH
    • , Jonathan StuckeyAffiliated withStructural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH
    • , Tongqing ZhouAffiliated withStructural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH

Abstract

Structural biology provides a wealth of information about the three-dimensional organization and chemical makeup of proteins. An understanding of atomic-level structure offers enormous potential to design rationally proteins that stimulate specific immune responses. Yet current vaccine development efforts makes little use of structural information. At the Vaccine Research Center, a major goal is to apply structural techniques to vaccine design for challenging pathogens, that include human immunodeficiency virus type 1 (HIV-1) and other enveloped viruses such as influenza, Ebola, and respiratory syncytial viruses. Our three-part strategy involves 1.) the definition of the functional viral spike at the atomic level 2.) achieving a structural understanding of how neutralizing antibodies recognize the spike, and 3.) rational development of proteins that can elicit a specific antibody response. Overall, our strategy aims to incorporate information about viral spike-antibody interactions, to assimilate immunogenic feedback, and to leverage recent advances in immunofocusing and computational biology.