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Autoantibodies and Autoantigens in Sjögren’s Syndrome

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Sjögren’s Syndrome

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Abstract

Over the past 30 plus years since the identification of the now classic anti-SS-A/Ro and anti-SS-B/La autoantibodies in Sjögren’s syndrome, there have been a few new and interesting autoantibodies including anti-fodrin, anti-M3 muscarinic receptor, anti-NA14, and other autoantibodies that are reported to be closely linked to this disease. This chapter describes the current data available for the specificities of these antibodies, their usefulness in diagnosis and prognosis of the disease, and hypotheses on the nature of autoantibody production.

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Abbreviations

AGAs:

anti-Golgi complex antibodies

APCs:

antigen-presenting cells

ANA:

santi-nuclear antibodies

CHB:

congenital heart block

GC:

germinal center

M3R:

muscarinic type 3 receptor

NA14:

nuclear autoantigen 14 kDa

PM/DM:

polymyositis/dermatomyositis

RA:

rheumatoid arthritis

SLE:

systemic lupus erythematosus

SS:

Sjögren’s syndrome

SSc:

scleroderma

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Acknowledgments

This work was supported in part by NIH Grant AI47859.

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Authors and Affiliations

  1. Department of Rheumatology and Internal Medicine, Urayasu Hospital Juntendo University, Chiba, Japan

    Kazuhisa Nozawa

  2. Institute for Environment and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan

    Kazuhisa Nozawa

  3. Department of Rheumatology, Juntendo Urayasu Hospital, Chiba, Japan

    Kazuhisa Nozawa

  4. Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL, USA

    Minoru Satoh

  5. Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA

    Minoru Satoh

  6. Department of Oral Surgery and Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL, USA

    Seunghee Cha

  7. Department of Oral Biology, University of Florida College of Dentistry, Gainesville, FL, USA

    Seunghee Cha & Edward K. L. Chan

  8. Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

    Yoshinari Takasaki

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  1. Kazuhisa Nozawa
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Correspondence to Edward K. L. Chan .

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  1. Research Foundation, Rheumatology Clinic, Scripps Memorial Hospital &, Caminito Sinnecock 6565, La Jolla, 92037, California, USA

    Robert I. Fox

  2. Research Foundation, Rheumatology Clinic, Scripps Memorial Hospital &, Caminito Sinnecock 6565, La Jolla, 92037, California, USA

    Carla M. Fox

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Nozawa, K., Satoh, M., Cha, S., Takasaki, Y., Chan, E.K.L. (2011). Autoantibodies and Autoantigens in Sjögren’s Syndrome. In: Fox, R., Fox, C. (eds) Sjögren’s Syndrome. Springer, New York, NY. https://doi.org/10.1007/978-1-60327-957-4_9

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