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Natural and Surgical Menopause

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Amenorrhea

Part of the book series: Contemporary Endocrinology ((COE))

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Women outnumber men among older adults. In 2002, 33 million women in the US civilian population were aged 55 years and older, with a gender ratio of 81 men per 100 women [1]. By 2030, more than 1.2 billion women in the world will be at least 50 years old [2]. This increasing proportion of the female population will be experiencing the menopausal transition with its accompanying physiology and pathophysiology.

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References

  1. Smith D (2003) The older population in the United States: March 2002. U.S. Census Bureau current population reports (Report No. P20-546). US Census Bureau, Washington, DC

    Google Scholar 

  2. World Health Organization (1996) Research on the menopause in the 1990s: Report of a WHO scientific group. WHO Technical Report Series 866. WHO, Geneva

    Google Scholar 

  3. Weiss G, Skurnick JH, Goldsmith LT et al (2004) Menopause and hypothalamic-pituitary sensitivity to estrogen. JAMA 292:2991–2996

    Article  PubMed  CAS  Google Scholar 

  4. McKinlay SM, Brambilla D, Posner JG (2008) The normal menopause transition. Maturitas 61:4–16

    Article  PubMed  Google Scholar 

  5. Bromberger JT, Matthews KA, Kuller LH et al (1997) Prospective study of the determinants of age at menopause. Am J Epidemiol 145:124–133

    Article  PubMed  CAS  Google Scholar 

  6. Gold EB, Bromberger J, Crawford S et al (2001) Factors associated with age at natural menopause in a multiethnic sample of midlife women. Am J Epidemiol 153:865–874

    Article  PubMed  CAS  Google Scholar 

  7. Soules MR, Sherman S, Parrott E et al (2001) Executive summary: stages of reproductive aging workshop (STRAW). Fertil Steril 76:874–878

    Article  PubMed  CAS  Google Scholar 

  8. WHO Scientific Group (1996) Research on the menopause in the 1990’s: a report of the WHO Scientific Group, vol. 866. World Health Organization, Geneva. pp 1–79

    Google Scholar 

  9. Brambilla DJ, McKinlay SM, Johannes CB (1994) Defining the perimenopause for application in epidemiologic investigations. Am J Epidemiol 140:1091–1095

    PubMed  CAS  Google Scholar 

  10. Gracia CR, Sammel MD, Freeman EW et al (2005) Defining menopause status: creation of a new definition to identify the early changes of the menopausal transition. Menopause 12:128–135

    Article  PubMed  Google Scholar 

  11. Scheffer GJ, Broekmans FJ, Dorland M et al (1999) Antral follicle counts by transvaginal ultrasonography are related to age in women with proven natural fertility. Fertil Steril 72:845–851

    Article  PubMed  CAS  Google Scholar 

  12. Santoro N, Isaac B, Neal-Perry G et al (2003) Impaired folliculogenesis and ovulation in older reproductive aged women. J Clin Endocrinol Metab 88:5502–5509

    Article  PubMed  CAS  Google Scholar 

  13. Giacobbe M, Mendes Pinto-Neto A et al (2004) The usefulness of ovarian volume, antral follicle count and age as predictors of menopausal status. Climacteric 7:255–260

    Article  PubMed  CAS  Google Scholar 

  14. Richardson SJ, Senikas V, Nelson JF (1987) Follicular depletion during the menopausal transition: evidence for accelerated loss and ultimate exhaustion. J Clin Endocrinol Metab 65:1231–1237

    Article  PubMed  CAS  Google Scholar 

  15. de Vet A, Laven JS, de Jong FH et al (2002) Antimüllerian hormone serum levels: a putative marker for ovarian aging. Fertil Steril 77:357–362

    Article  PubMed  Google Scholar 

  16. Santoro N (2004) Can a blood test predict the onset of menopause? Menopause 11:585–586

    Article  PubMed  Google Scholar 

  17. Sherman BM, Korenman SG (1975) Hormonal characteristics of the human menstrual cycle throughout reproductive life. J Clin Investig 55:699–706

    Article  PubMed  CAS  Google Scholar 

  18. McLachlan RI, Robertson DM, Healy DL (1987) Circulating immunoreactive inhibin levels during the normal human menstrual cycle. J Clin Endocrinol Metab 65:954–961

    Article  PubMed  CAS  Google Scholar 

  19. Metcalf MG, Donald RA, Livesy JH (1981) Pituitary-ovarian function in normal women during the menopausal transition. Clin Endocrinol 14:245–255

    Article  CAS  Google Scholar 

  20. Metcalf MG, Donald RA, Livesey JH (1981) Classification of menstrual cycles in pre- and perimenopausal women. J Endocrinol 91:1–10

    Article  PubMed  CAS  Google Scholar 

  21. Metcalf MG, Donald RA, Livesey JH (1982) Pituitary-ovarian function before, during and after the menopause: a longitudinal sudy. Clin Endocrinol 17:489–494

    Article  CAS  Google Scholar 

  22. Metcalf MG (1988) The approach of menopause: a New Zealand study. N Z Med J 101: 103–106

    PubMed  CAS  Google Scholar 

  23. Santoro N, Brown JR, Adel T et al (1996) Characterization of reproductive hormonal dynamics in the perimenopause. J Clin Endocrinol Metab 81:1495–1501

    Article  PubMed  CAS  Google Scholar 

  24. O’Connor KA, Ferrell RF, Brindle E et al (2009) Total and unopposed estrogen exposure across stages of the transition to menopause. Cancer Epidemiol Biomarkers Prev 18:828–836

    Article  PubMed  Google Scholar 

  25. Taffe JR, Dennerstein L (2002) Menstrual patterns leading to the final menstrual period. Menopause 9:32–40

    Article  PubMed  Google Scholar 

  26. Miro F, Parker SW, Aspinall LJ et al (2004) Origins and consequences of the elongation of the human menstrual cycle during the menopausal transition: the FREEDOM study. J Clin Endocrinol Metab 89:4910–4915

    Article  PubMed  CAS  Google Scholar 

  27. Santoro N, Crawford SL, Lasley WL et al (2008) Factors related to declining luteal function in women during the menopausal transition. J Clin Endocrinol Metab 93:1711–1721

    Article  PubMed  CAS  Google Scholar 

  28. Randolph JF Jr, Sowers MF, Gold EB et al (2003) Reproductive hormones in the early menopausal transition: relationship to ethnicity, body size, and menopausal status. J Clin Endocrinol Metab 88:1516–1522

    Article  PubMed  CAS  Google Scholar 

  29. Randolph JF Jr, Sowers MF, Bondarenko IV et al (2004) Change in estradiol and follicle-stimulating hormone across the early menopausal transition: effects of ethnicity and age. J Clin Endocrinol Metab 89:1555–1561

    Article  PubMed  CAS  Google Scholar 

  30. Su HI, Sammel MD, Freeman EW et al (2008) Body size affects measures of ovarian reserve in late reproductive age women. Menopause 15:857–861

    Article  PubMed  Google Scholar 

  31. Groome NP, Illingworth PG, O’Brien M et al (1996) Measurement of dimeric inhibin B throughout the human menstrual cycle. J Clin Endocrinol Metab 81:1401–1405

    Article  PubMed  CAS  Google Scholar 

  32. Burger HG, Cahir N, Robertson DM et al (1998) Serum inhibins A and B fall differentially as FSH rises in perimenopausal women. Clin Endocrinol 48:809–813

    Article  CAS  Google Scholar 

  33. MacNaughton J, Banah M, McCloud P et al (1992) Age related changes in follicle stimulating hormone, luteinizing hormone, oestradiol and immunoreactive inhibin in women of reproductive age. Clin Endocrinol 36:339–345

    Article  CAS  Google Scholar 

  34. Klein NA, Illingworth PJ, Groome NP et al (1996) Decreased inhibin B secretion is associated with the monotropic FSH rise in older, ovulatory women: a study of serum and follicular fluid levels of dimeric inhibin A and B in spontaneous menstrual cycles. J Clin Endocrinol Metab 81:2742–2745

    Article  PubMed  CAS  Google Scholar 

  35. Muttukrishna S, Child T, Lockwood GM et al (2000) Serum concentrations of dimeric inhibins, activin A, gonadotrophins and ovarian steroids during the menstrual cycle in older women. Hum Reprod 15:546–556

    Google Scholar 

  36. Santoro N, Adel T, Skurnick JH (1999) Decreased inhibin tone and increased activin A secretion characterize reproductive aging in women. Fertil Steril 71:658–662

    Article  PubMed  CAS  Google Scholar 

  37. Welt CK, McNicholl DJ, Taylor AE et al (1999) Female reproductive aging is marked by decreased secretion of dimeric inhibin. J Clin Endocrinol Metab 84:105–111

    Article  PubMed  CAS  Google Scholar 

  38. Ream NE, Wyman TL, Phillips DJ et al (1998) Net increase in stimulatory input resulting from a decrease in inhibin B and an increase in activin A may contribute in part to the rise in follicular phase follicle-stimulating hormone of aging cycling women. J Clin Endocrinol Metab 83:3302–3307

    Article  Google Scholar 

  39. Ying SY (1988) Inhibins, activins and follistatins: gonadal proteins modulating the secretion of follicle-stimulating hormone. Endocr Rev 9:267–293

    Article  PubMed  CAS  Google Scholar 

  40. Van Look PF, Hunter WM, Fraser IS et al (1995) Impaired estrogen-induced luteinizing hormone release in young women with anovulatory dysfunctional uterine bleeding. J Clin Endocrinol Metab 80:608–613

    Article  Google Scholar 

  41. Santoro N, Lasley B, McConnell D et al (2004) Body size and ethnicity are associated with menstrual cycle alterations in women in the early menopausal transition: the Study of Women’s Health Across the Nation (SWAN) Daily Hormone Study. J Clin Endocrinol Metab 89:2622–2631

    Article  PubMed  CAS  Google Scholar 

  42. Gill S, Sharpless JL, Rado K et al (2002) Evidence that GnRH decreases with gonadal steroid feedback but increases with age in postmenopausal women. J Clin Endocrinol Metab 87:2290–2296

    Article  PubMed  CAS  Google Scholar 

  43. National Institutes of Health (2005) National Institutes of Health State-of the Science Conference statement: management of menopause-related symptoms. Ann Intern Med 142:1003–1013

    Google Scholar 

  44. Freeman EW, Sammel MD, Lin H et al (2007) Symptoms associated with menopausal transition and reproductive hormones in midlife women. Obstet Gynecol 110:230–240

    Article  PubMed  Google Scholar 

  45. Miller SA, Santoro N, Lo Y et al (2005) Menopause symptoms in HIV-infected and drug-using women. Menopause 12:348–356

    Article  PubMed  Google Scholar 

  46. Freeman EW, Sammel MD, Lin H et al (2008) Symptoms in the menopausal transition: hormone and behavioral correlates. Obstet Gynecol 111:127–136

    Article  PubMed  CAS  Google Scholar 

  47. Dennerstein L, Dudley E, Hopper JL et al (2000) A prospective population-based study of menopausal symptoms. Obstet Gynecol 96:351–358

    Article  PubMed  CAS  Google Scholar 

  48. Kronenberg F (1994) Hot flashes: phenomenology, quality of life, and search for treatment options. Exp Gerontol 29:319–336

    Article  PubMed  CAS  Google Scholar 

  49. Guthrie JR, Dennerstein L, Hopper JL et al (1996) Hot flashes, menstrual status and hormone levels in a population-based sample of midlife women. Obstet Gynecol 88:437–442

    Article  PubMed  CAS  Google Scholar 

  50. Overlie I, Moen MH, Holte A et al (2002) Androgens and estrogens in relation to hot flashes during the menopausal transition. Maturitas 41:69–77

    Article  PubMed  CAS  Google Scholar 

  51. Rapkin AJ (2007) Vasomotor symptoms in menopause: physiologic condition and central nervous system approaches to treatment. Am J Obstet Gynecol 196:97–106

    Article  PubMed  Google Scholar 

  52. Col NF, Guthrie JR, Politi M et al (2009) Duration of vasomotor symptoms in middle-aged women: a longitudinal study. Menopause 16:453–457

    Article  PubMed  Google Scholar 

  53. Gold EB, Colvin A, Avis N et al (2006) Longitudinal analysis of the association between vasomotor symptoms and race/ethnicity across the menopausal transition: Study of Women’s Health Across the Nation. Am J Public Health 96:1226–1235

    Article  PubMed  Google Scholar 

  54. Freeman EW, Sammel MD, Grisso JA et al (2001) Hot flashes in the late reproductive years: risk factors for African American and Caucasian women. J Womens Health Gend Based Med 10:67–76

    Article  PubMed  CAS  Google Scholar 

  55. Miller SR, Gallicchio LM, Lewis LM et al (2006) Association between race and hot flashes in midlife women. Maturitas 54:260–269

    Article  PubMed  Google Scholar 

  56. Gold EB, Block G, Crawford S et al (2004) Lifestyle and demographic factors in relation to vasomotor symptoms: baseline results from the study of women’s health across the nation. Am J Epidemiol 159:1189–1199

    Article  PubMed  Google Scholar 

  57. Gallicchio L, Miller SR, Visvanathan K et al (2006) Cigarette smoking, estrogen levels, and hot flashes in midlife women. Maturitas 53:133–143

    Article  PubMed  CAS  Google Scholar 

  58. Gallicchio L, Visvanathan K, Miller SM et al (2005) Body mass index, estrogen levels, and hot flashes in midlife women. Am J Obstet Gynecol 193:1353–1360

    Article  PubMed  CAS  Google Scholar 

  59. Whiteman MK, Staropoli CA, Langenberg PW et al (2003) Smoking, body mass, and hot flashes in midlife women. Obstet Gynecol 101:264–272

    Article  PubMed  Google Scholar 

  60. Hutton JD, Jacobs HS, Murray MS et al (1978) Relation between plasma oestrone and oestradiol and climacteric symptoms. Lancet 1:678–681

    Article  PubMed  CAS  Google Scholar 

  61. Skurnick JH, Weiss G, Goldsmith LT et al (2009) Longitudinal changes in hypothalamic and ovarian function in perimenopausal women with anovulatory cycles: relationship with vasomotor symptoms. Fertil Steril 91:1127–1134

    Article  PubMed  Google Scholar 

  62. Casper RF, Yen SSC, Wilkes MM (1979) Menopausal flashes: a neuroendocrine link with pulsatile luetinizing hormone secretion. Science 205:823–825

    Article  PubMed  CAS  Google Scholar 

  63. Mulley G, Mitchell JRA, Tattarsall RB (1977) Hot flashes after hypophysectomy. Br Med J 2(6094):1062

    Article  PubMed  CAS  Google Scholar 

  64. Casper RF, Yen SSC (1981) Menopausal flashes: effect of pituitary gonadotropin desensitization by a potent luteinizing hormone-releasing factor agonist. J Clin Endocrinol Metab 53:1056–1058

    Article  PubMed  CAS  Google Scholar 

  65. Meldrum DR, Defazio JD, Erlik Y et al (1984) Pituitary hormones during the menopausal hot flash. Obstet Gynecol 64:752–756

    PubMed  CAS  Google Scholar 

  66. Weiner RJ, Ganong WF (1978) Role of brain monoamines and histamine in regulation of anterior pituitary secretion. Physiol Rev 58:905–976

    PubMed  CAS  Google Scholar 

  67. Bhattacharya AN, Dierschke DJ, Yamaji T et al (1972) The pharmacological blockade of the circhoral mode of LH secretion in the ovariectomized rhesus monkey. Endocrinol 90:778–786

    Article  CAS  Google Scholar 

  68. Cox B, Lomax P (1977) Pharmacologic control of temperature regulation. Ann Rev Pharmacol Toxicol 17:341–353

    Article  CAS  Google Scholar 

  69. Stearns V, Ullmer L, Lopez JF et al (2002) Hot flashes. Lancet 360:1851–1861

    Article  PubMed  CAS  Google Scholar 

  70. Berendsen HH (2000) The role of serotonin in hot flashes. Maturitas 36:155–164

    Article  PubMed  CAS  Google Scholar 

  71. Freedman RR (2005) Pathophysiology and treatment of menopausal hot flashes. Semin Reprod Med 23:117–125

    Article  PubMed  Google Scholar 

  72. Rossouw JE, Anderson GL, Prentice RL et al (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA 288:321–333

    Article  PubMed  CAS  Google Scholar 

  73. Manson JE, Hsia J, Johnson KC et al (2003) Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med 349:523–534

    Article  PubMed  CAS  Google Scholar 

  74. Chlebowski RT, Hendrix SL, Langer RD et al (2003) Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women’s Health Initiative Randomized Trial. JAMA 289:3243–3253

    Article  PubMed  CAS  Google Scholar 

  75. Anderson GL, Limacher M, Assaf AR et al (2004) Effects of conjugated equine estrogen in postmenopausal women with hysterectomy. The Women’s Health Initiative randomized control trial. JAMA 291:1701–1712

    Article  PubMed  CAS  Google Scholar 

  76. Sikon A, Thacker HL (2004) Treatment options for menopausal hot flashes. Clev Clin J Med 71:578–582

    Article  Google Scholar 

  77. Greendale GA, Reboussin BA, Hogan P et al (1998) Symptom relief and side effects of postmenopausal hormones: results from the Postmenopausal Estrogen/Progestin Interventions trial. Obstet Gynecol 92:982–988

    Article  PubMed  CAS  Google Scholar 

  78. Utian WH, Shoupe D, Bachmann G et al (2001) Relief of vasomotor symptoms and vaginal atrophy with lower doses of conjugated equine estrogens and medroxyprogesterone acetate. Fertil Steril 75:1065–1079

    Article  PubMed  CAS  Google Scholar 

  79. Pickar JH, Yeh IT, Wheeler JE et al (2003) Endometrial effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate: two-year substudy results. Fertil Steril 80:1234–1240

    Article  PubMed  Google Scholar 

  80. Archer DF, Dorin M, Lewis V et al (2001) Effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate on endometrial bleeding. Fertil Steril 75:1080–1087

    Article  PubMed  CAS  Google Scholar 

  81. Lobo RA, Bush T, Carr BR et al (2001) Effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate on plasma lipids and lipoproteins, coagulation factors, and carbohydrate metabolism. Fertil Steril 76:13–24

    Article  PubMed  CAS  Google Scholar 

  82. Bachmann GA, Schaefers M, Uddin A et al (2007) Lowest effective transdermal 17β (beta)-estradiol dose for relief of hot flashes in postmenopausal women. Obstet Gynecol 110:771–779

    Article  PubMed  CAS  Google Scholar 

  83. Johnson SR, Ettinger B, Macer JL et al (2005) Uterine and vaginal effects of unopposed ultralow-dose transdermal estradiol. Obstet Gynecol 105:779–787

    Article  PubMed  CAS  Google Scholar 

  84. Ettinger B, Ensrud KE, Wallace R et al (2004) Effects of ultralow-dose transdermal estradiol on bone mineral density: a randomized clinical trial. Obstet Gynecol 104:443–451

    Article  PubMed  CAS  Google Scholar 

  85. Loprinzi CL, Sloan JA, Perez EA et al (2002) Phase III evaluation of fluoxetine for treatment of hot flashes. J Clin Oncol 6:1578–1583

    Article  Google Scholar 

  86. Stearns V, Beebe KL, Iyengar M et al (2003) Paroxetine controlled release in the treatment of menopausal hot flashes: a randomized control trial. JAMA 289:2827–2834

    Article  PubMed  CAS  Google Scholar 

  87. Stearns V, Slack R, Greep N et al (2005) Paroxetine is an effective treatment for hot flashes: results from a prospective randomized clinical trial. J Clin Oncol 28:6919–6930

    Article  CAS  Google Scholar 

  88. Nemeroff CB, Owens MJ (2004) Pharmacologic differences among the SSRIs: focus on monoamine transporters and the HPA axis. CNS Spectr 9(6 suppl 4):23–31

    PubMed  Google Scholar 

  89. Loprinzi CL, Kugler JW, Sloan JA et al (2000) Venlafaxine in management of hot flashes in survivors of breast cancer: a randomized control trial. Lancet 356:2059–2063

    Article  PubMed  CAS  Google Scholar 

  90. Evans ML, Pritts E, Vittinghoff E et al (2005) Management of postmenopausal hot flashes with venlafaxine hydrochloride: a randomized, controlled trial. Obstet Gynecol 105:161–166

    Article  PubMed  CAS  Google Scholar 

  91. Jenkins MR, Sikon AL (2008) Update on nonhormonal approaches to menopausal management. Clev Clin J Med 75(suppl 4):S17–S24

    Article  Google Scholar 

  92. Archer DF, Dupont CM, Constantine GD et al (2009) Desvenlafaxine for the treatment of vasomotor symptoms associated with menopause: a double-blind, randomized, placebo-­controlled trial of efficacy and safety. Am J Obstet Gynecol 200:238e1–238e10

    Google Scholar 

  93. Butt DA, Lock M, Lewis JE et al (2008) Gabapentin for the treatment of menopausal hot flashes: a randomized controlled trial. Menopause 15:310–318

    Article  PubMed  Google Scholar 

  94. Reddy SY, Warner H, Guttuso T et al (2006) Gabapentin, estrogen and placebo for treating hot flashes: a randomized controlled trial. Obstet Gynecol 108:41–48

    Article  PubMed  CAS  Google Scholar 

  95. Suckling J, Lethaby A, Kennedy R (2006) Local oestrogen for vaginal atrophy in postmenopausal women. Cochrane Database Syst Rev (4):CD001500

    Google Scholar 

  96. Kanis JA, Melton LJ III, Christiansen C et al (1994) The diagnosis of osteoporosis. J Bone Miner Res 9:1137–1141

    Article  PubMed  CAS  Google Scholar 

  97. Eastell R (1998) Treatment of postmenopausal osteoporosis. N Engl J Med 338:736–746

    Article  PubMed  CAS  Google Scholar 

  98. Lips P, Graafmans WC, Ooms ME et al (1996) Vitamin D supplementation and fracture incidence in elderly persons: a randomized, placebo-controlled clinical trial. Ann Intern Med 124:400–406

    PubMed  CAS  Google Scholar 

  99. Chapuy MC, Arlot ME, Delmas PD et al (1994) Effect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women. Br Med J 308:1081–1082

    Article  CAS  Google Scholar 

  100. Dawson-Hughes B, Harris SS, Krall EA et al (1997) Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 337:670–676

    Article  PubMed  CAS  Google Scholar 

  101. Greendale GA, Wells B, Marcus R et al (2000) How many women lose bone mineral density while taking hormone replacement therapy? Results from the Postmenopausal Estrogen/Progestin Interventions Trial. Arch Intern Med 160:3065–3071

    Article  PubMed  CAS  Google Scholar 

  102. Fitzpatrick LA, Litin SC, Bell MR (2000) The Women’s Health Initiative: a heart to HRT conversation. Mayo Clin Proc 75:559–561

    Article  PubMed  CAS  Google Scholar 

  103. Torgerson DJ, Bell-Syer SE (2001) Hormone replacement therapy and prevention of nonvertebral fractures: a meta-analysis of randomized trials. JAMA 285:2891–2897

    Article  PubMed  CAS  Google Scholar 

  104. Papapoulos SE, Quandt SA, Liberman UA et al (2005) Meta-analysis of the efficacy of alendronate for the prevention of hip fractures in postmenopausal women. Osteoporos Int 16:468–474

    Article  PubMed  CAS  Google Scholar 

  105. Bone HG, Greenspan SL, McKeever C et al (2000) Alendronate and estrogen effects in postmenopausal women with low bone mineral density. J Clin Endocrinol Metab 85:720–726

    Article  PubMed  CAS  Google Scholar 

  106. Harris ST, Eriksen EF, Davidson M et al (2000) Effect of combined risedronate and hormone replacement therapies on bone mineral density in postmenopausal women. J Clin Endocrinol Metab 86:1890–1897

    Article  Google Scholar 

  107. Riggs BL, Hartmann LC (2003) Selective estrogen-receptor modulators-mechanism of action and application to clinical practice. N Engl J Med 348:618–629

    Article  PubMed  CAS  Google Scholar 

  108. Delmas PD, Ensrud KE, Adachi JD et al (2002) Efficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis: four-year results from a randomized clinical trial. J Clin Endocrinol Metab 87:3609–3617

    Article  PubMed  CAS  Google Scholar 

  109. Seeman E, Crans GG, Diez-Perez A et al (2006) Anti-vertebral fracture efficacy of raloxifene: a meta-analysis. Osteoporos Int 17:313–316

    Article  PubMed  Google Scholar 

  110. Ensrud KE, Stock JL, Barrett-Connor E et al (2008) Effects of Raloxifene on fracture risk in postmenopausal women: the Raloxifene Use for the Heart Trial. J Bone Miner Res 23:112–120

    Article  PubMed  CAS  Google Scholar 

  111. Keshavarz H, Hillis SD, Kieke BA et al (2002) Hysterectomy surveillance: United States, 1994–1999. MMWR CDC Surveill Summ 51(SS-5):1–8

    Google Scholar 

  112. Hendrix SL (2005) Bilateral oophorectomy and premature menopause. Am J Med 118:131S–135S

    Article  Google Scholar 

  113. Siddle N, Sarrel P, Whitehead M (1987) The effect of hysterectomy on the age at ovarian failure: identification of a subgroup of women with premature loss of ovarian function and literature review. Fertil Steril 47:94–100

    PubMed  CAS  Google Scholar 

  114. Bachmann G (2001) Physiologic aspects of natural and surgical menopause. J Reprod Med 46:307–315

    PubMed  CAS  Google Scholar 

  115. Oldenhave A, Jaszmann LJ, Everaerd WT et al (1993) Hysterectomized women with ovarian conservation report more severe climacteric complaints than do normal climacteric women of similar age. Am J Obstet Gynecol 168:765–771

    PubMed  CAS  Google Scholar 

  116. Judd HL, Judd GE, Lucas WE et al (1974) Endocrine function of the postmenopausal ovary: concentration of androgens and estrogens in ovarian and peripheral vein blood. J Clin Endocrinol Metab 39:1020–1024

    Article  PubMed  CAS  Google Scholar 

  117. Fogle RH, Stanczyk FZ, Zhang X et al (2007) Ovarian androgen production in postmenopausal women. J Clin Endocrinol Metab 92:3040–3043

    Article  PubMed  CAS  Google Scholar 

  118. Laughlin GA, Barrett-Connor E, Kritz-Silverstein DK et al (2000) Hysterectomy, oophorectomy, and endogenous sex hormone levels in older women: the Rancho Bernado Study. J Clin Endocrinol Metab 85:645–651

    Article  PubMed  CAS  Google Scholar 

  119. Couzinet B, Meduri G, Lecce MG et al (2001) The postmenopausal ovary is not a major androgen-producing gland. J Clin Endocrinol Metab 86:5060–5066

    Article  PubMed  CAS  Google Scholar 

  120. Jabara S, Christenson LK, Wang CY et al (2003) Stromal cells of the human postmenopausal ovary display a distinctive biochemical and molecular phenotype. J Clin Endocrinol Metab 88:484–492

    Article  PubMed  CAS  Google Scholar 

  121. Sherwin BB (2002) Randomized clinical trials of combined estrogen-androgen preparations: effects on sexual functioning. Fertil Steril 77(suppl 4):S49–S54

    Article  PubMed  Google Scholar 

  122. Rivera CM, Grossardt BR, Rhodes DJ et al (2009) Increased cardiovascular mortality after early bilateral oophorectomy. Menopause 16:15–23

    Article  PubMed  Google Scholar 

  123. Atsma F, Bartelink ML, Grobbee DE et al (2006) Postmenopausal status and early menopause as independent risk factors for cardiovascular disease: a meta-analysis. Menopause 13:265–279

    Article  PubMed  Google Scholar 

  124. Parker WH, Broder MS, Chang E et al (2009) Ovarian conservation at the time of hysterectomy and long-term health outcomes in the Nurses’ Health Study. Obstet Gynecol 113:1027–1037

    PubMed  Google Scholar 

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  1. Department of Obstetrics, Gynecology and Women’s Health, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA

    Sara Morelli

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  1. Sara Morelli
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  2. Gerson Weiss
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    Nanette F. Santoro

  2. , Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Ullman 1211, Bronx, 10461, New York, USA

    Genevieve Neal-Perry

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Morelli, S., Weiss, G. (2010). Natural and Surgical Menopause. In: Santoro, N., Neal-Perry, G. (eds) Amenorrhea. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-864-5_9

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