Skip to main content

Autoimmune Diseases

  • Chapter
  • First Online:
Challenging Cases in Allergy and Immunology

Abstract

Autoimmune diseases are characterized by autoantibody formation and visceral involvement that is often of an inflammatory nature. Rheumatoid arthritis (RA) is a classic immune complex disease characterized by antibody formation and inflammatory arthritis. Extra-articular manifestations of RA may also occur. Systemic sclerosis (scleroderma, SSc) is another autoimmune disease and includes autoantibody formation as well as visceral involvement; however, the visceral manifestations in SSc relate to excessive collagen deposition and/or a ­vasculopathy. Internal organ inflammatory changes are typically seen in other autoimmune diseases; however, these do not typically occur in SSc.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 149.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Lawrence, R.C., et al, Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum. 1998. 41(5): pp. 778–99.

    Article  PubMed  CAS  Google Scholar 

  2. MacGregor, A.J., et al, Rheumatology, Fourth edn, M. Hochberg (ed.). Elsevier, Philadelphia, PA. 2008, pp.755–61.

    Google Scholar 

  3. Doran, M.F., et al, Trends in incidence and mortality in rheumatoid arthritis in Rochester, Minnesota, over a forty-year period. Arthritis Rheum. 2002. 46(3): pp. 625–31.

    Article  PubMed  Google Scholar 

  4. Vallbracht, I. and K. Helmke, Additional diagnostic and clinical value of anti-cyclic citrullinated peptide antibodies compared with rheumatoid factor isotypes in rheumatoid arthritis. Autoimmun Rev. 2005. 4(6): pp. 389–94.

    Article  PubMed  CAS  Google Scholar 

  5. McQueen, F.M. and M. Ostergaard, Established rheumatoid arthritis – New imaging modalities. Best Pract Res Clin Rheumatol, 2007. 21(5): pp. 841–56.

    Article  PubMed  Google Scholar 

  6. Combe, B. Early rheumatoid arthritis: Strategies for prevention and management. Best Pract Res Clin Rheumatol, 2007. 21: pp. 27–42.

    Article  PubMed  Google Scholar 

  7. Steen, V.D. and T.A. Medsger, Jr., The palpable tendon friction rub: An important physical examination finding in patients with systemic sclerosis. Arthritis Rheum, 1997. 40(6): pp. 1146–51.

    Article  PubMed  CAS  Google Scholar 

  8. Masi, A.T., G.P. Rodnan, and T.A. Medsger, Jr., et al, Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum, 1980. 23: pp. 581–90.

    Article  Google Scholar 

  9. Steen, V.D., D.L. Powell, and T.A. Medsger, Jr., Clinical correlations and prognosis based on serum autoantibodies in patients with systemic sclerosis. Arthritis Rheum, 1988. 31(2): pp. 196–203.

    Article  PubMed  CAS  Google Scholar 

  10. Blockmans, D., G. Beyens, and R. Verhaeghe, Predictive value of nailfold capillaroscopy in the diagnosis of connective tissue diseases. Clin Rheum, 1996. 15(2): pp. 148–53.

    Article  CAS  Google Scholar 

  11. Reimer, G., et al, Correlates between autoantibodies to nucleolar antigens and clinical features in patients with systemic sclerosis (scleroderma). Arthritis Rheum, 1988. 31(4): pp. 525–32.

    Article  PubMed  CAS  Google Scholar 

  12. Steen, V.D., et al, Severe restrictive lung disease in systemic sclerosis. Arthritis Rheum, 1994. 37(9): pp. 1283–9.

    Article  PubMed  CAS  Google Scholar 

  13. Steen, V.D., et al, Isolated diffusing capacity reduction in systemic sclerosis. Arthritis Rheum, 1992. 35(7): pp. 765–70.

    Article  PubMed  CAS  Google Scholar 

  14. Tashkin, D.P., et al, Cyclophosphamide versus placebo in scleroderma lung disease. N Engl J Med, 2006. 354(25): pp. 2655–66.

    Article  PubMed  CAS  Google Scholar 

  15. Steen, V.D. and T.A. Medsger, Jr., Case-control study of corticosteroids and other drugs that either precipitate or protect from the development of scleroderma renal crisis. Arthritis Rheum, 1998. 41(9): pp. 1613–19.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Marcy B. Bolster .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Humana Press, a part of Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Bolster, M.B. (2009). Autoimmune Diseases. In: Mahmoudi, M. (eds) Challenging Cases in Allergy and Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-443-2_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-60327-443-2_18

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60327-442-5

  • Online ISBN: 978-1-60327-443-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics