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Dietary Supplements: Current Knowledge and Future Frontiers

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Notes

  1. 1.

    The findings and views reported in this chapter represent those of the contributing authors and not necessarily those of the National Institutes of Health and are not intended to constitute an “authoritative statement” under the Food and Drug Administration rules and regulations.

References

  1. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE, Falconer G, Green CL. Rates of bone loss in postmenopausal women randomly assigned to one of two dosages of vitamin D. Am J Clin Nutr 1995; 61:1140–5.

    PubMed  CAS  Google Scholar 

  2. Chapuy MC, Arlot ME, Duboeuf F, et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med 1992; 327(23):1637–42.

    Article  PubMed  CAS  Google Scholar 

  3. Jackson RD, LaCroix AZ, Gass M, et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 2006; 354(7):669–83.

    Article  PubMed  CAS  Google Scholar 

  4. Grant AM, Avenell A, Campbell MK, et al. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 2005; 365(9471):1621–8.

    Article  PubMed  CAS  Google Scholar 

  5. O'Brien. Combined calcium and vitamin D supplementation reduces bone loss and fracture incidence in older men and women. Nutr Rev 1998; 56:148–58.

    Article  PubMed  Google Scholar 

  6. Brouwer IA, van Dusseldorp M, Thomas CM, et al. Low-dose folic acid supplementation decreases plasma homocysteine concentrations: a randomized trial. Am J Clin Nutr 1999; 69:99–104.

    PubMed  CAS  Google Scholar 

  7. Bostom AG, Rosenberg IH, Silbershatz H, et al. Nonfasting plasma total homocysteine levels and stroke incidence in elderly persons: the Framingham Study. Ann Intern Med 1999; 131(5):352–5.

    PubMed  CAS  Google Scholar 

  8. Durga J, van Boxtel MPJ, Schouten EG, et al. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007; 369(9557):208–16.

    Article  PubMed  CAS  Google Scholar 

  9. Picciano MF, Yetley EA, Coates PM. Folate and health. In: CAB Rev Perspect Agric Vet Sci Nutr Nat Resour 2007:No. 018.

    Google Scholar 

  10. Refsum H, Ueland PM, Nygard O, Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med 1998; 49:31–62.

    Article  PubMed  CAS  Google Scholar 

  11. Tawakol A, Migrino RQ, Aziz KS, et al. High-dose folic acid acutely improves coronary vasodilator function in patients with coronary artery disease. J Am Coll Cardiol 2005; 45:158–64.

    Article  CAS  Google Scholar 

  12. Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357(3):266–81.

    Article  PubMed  CAS  Google Scholar 

  13. Mason JB, Dickstein A, Jacques PF, et al. A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev 2007; 16(7):1325–9.

    Article  PubMed  CAS  Google Scholar 

  14. Oubre AY, Carlson TJ, King SR, Reaven GM. From plant to patient: an ethnomedical approach to the identification of new drugs for the treatment of NIDDM. Diabetologia 1997; 40:614–7.

    Article  PubMed  CAS  Google Scholar 

  15. Schmidt BM, Ribnicky DM, Lipsky PE, Raskin I. Revisiting the ancient concept of botanical therapeutics. Nat Chem Biol 2007; 3(7):360–6.

    Article  PubMed  CAS  Google Scholar 

  16. Cragg GM, Newman DJ. Plants as a source of anti-cancer agents. J Ethnopharmacol 2005; 100(1–2):72–9.

    Article  PubMed  CAS  Google Scholar 

  17. Eisenberg DM, Davis RB, Ettner SL, et al. Trends in alternative medicine use in the United States, 1990–1997: Results of a follow-up national survey. JAMA 1998; 280:1569–75.

    Article  PubMed  CAS  Google Scholar 

  18. Nutrition Business Journal. NBJ's Supplement Business Report 2006: an analysis of markets, trends, competition and strategy in the U.S. dietary supplement industry. Boulder, CO: New Hope Natural Media, 2006.

    Google Scholar 

  19. Sloane E. Why people use vitamin and mineral supplements. Nutr Today 2007; 42(2):55–61.

    Article  Google Scholar 

  20. HealthFocus International. The 2005 HealthFocus Trend Report: A National Study of Public Attitudes and Actions Toward Shopping and Eating. St. Petersburg, FL: HealthFocus International, 2005.

    Google Scholar 

  21. Ervin RB, Wright JD, Kennedy-Stephenson J. Use of dietary supplements in the United States, 1988–94. Vital Health Stat 11 1999; 244(i–iii):1–14.

    Google Scholar 

  22. Radimer K, Bindewald B, Hughes J, Ervin B, Swanson C, Picciano MF. Dietary supplement use by US adults: data from the National Health and Nutrition Examination Survey, 1999–2000. Am J Epidemiol 2004; 160(4):339–49.

    Article  PubMed  Google Scholar 

  23. Timbo BB, Ross MP, McCarthy PV, Lin CTJ. Dietary supplements in a national survey: prevalence of use and reports of adverse events. J Am Diet Assoc 2006; 106(12):1966–74.

    Article  PubMed  CAS  Google Scholar 

  24. Bardia A, Nisly NL, Zimmerman BM, Gryzlak BM, Wallace RB. Use of herbs among adults based on evidence-based indications: findings from the National Health Interview Survey. Mayo Clin Proc 2007; 82(5):561–6.

    Google Scholar 

  25. Current Good Manufacturing Practice in Manufacturing, Packaging, Labeling, or Holding Operations for Dietary Supplements; Final Rule. Fed Regis 72(121):34751–958. Washington, DC: Food and Drug Administration, 2007. (Accessed August 3, 2007, at www.cfsan.fda.gov/∼lrd/fr07625a.html)

  26. Krucoff MW, Costello RB, Mark D, Vogel JHK. Complementary and alternative medical therapy in cardiovascular care. In: Fuster V, O'Rourke RA, Walsh R, et al., eds. Hurst's the Heart. New York: McGraw Hill, 2007.

    Google Scholar 

  27. Foreman J. St. John’s Wort: Less than Meets the Eye. Globe Analysis Shows Popular Herbal Antidepressant Varies Widely in Content, Quality. Boston Globe 2002 January 10, Sect. C1.

    Google Scholar 

  28. Harkey MR, Henderson GL, Gershwin ME, Stern JS, Hackman RM. Variability in commercial ginseng products: an analysis of 25 preparations. Am J Clin Nutr 2001; 73(6):1101–6.

    PubMed  CAS  Google Scholar 

  29. Draves AH, Walker SE. Analysis of the hypericin and pseudohypericin content of commercially available St John's Wort preparations. Can J Clin Pharmacol 2003; 10(3):114–8.

    PubMed  Google Scholar 

  30. Ernst E. Adulteration of Chinese herbal medicines with synthetic drugs: a systematic review. J Intern Med 2002; 252(2):107–13.

    Article  PubMed  CAS  Google Scholar 

  31. Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs: a systematic review. Drugs 2001; 61:2163–75.

    Article  PubMed  CAS  Google Scholar 

  32. Hu Z, Yang X, Ho PC, et al. Herb-drug interactions: a literature review. Drugs 2005; 65:1239–82.

    Article  PubMed  CAS  Google Scholar 

  33. Wolsko PM, Solondz DK, Phillips RS, Schachter SC, Eisenberg DM. Lack of herbal supplement characterization in published randomized controlled trials. Am J Med 2005; 118(10):1087–93.

    Article  PubMed  Google Scholar 

  34. Gagnier JJ, Boon H, Rochon P, et al. Reporting randomized, controlled trials of herbal interventions: an elaborated CONSORT statement. Ann Intern Med 2006; 144(5):364–7.

    PubMed  Google Scholar 

  35. Barton MB, Miller T, Wolff T, et al. How to read the new recommendation statement: methods update from the U.S. Preventive Services Task Force. Ann Intern Med 2007; 147(2):123–7.

    PubMed  Google Scholar 

  36. Balk EM, Tatsioni A, Lichtenstein AH, Lau J, Pittas AG. Effect of chromium supplementation on glucose metabolism and lipids: a systematic review of randomized controlled trials. Diabetes Care 2007; 30(8):2154–63.

    Article  PubMed  CAS  Google Scholar 

  37. Coates PM. Evidence-based reviews in support of health policy decisions. J Natl Cancer Inst 2007; 99(14):1059.

    Article  PubMed  Google Scholar 

  38. Evidence-Based Review System for the Scientific Evaluation of Health Claims. Draft Guidance. Washington, DC: Office of Nutrition, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 2007. (Accessed August 3, 2007, at www.cfsan.fda.gov/∼dms/hclmgui5.html)

  39. Murphy SP, Poos MI. Dietary Reference Intakes: summary of applications in dietary assessment. Public Health Nutr 2002; 5(6A):843–9.

    Article  PubMed  Google Scholar 

  40. Barr SI. Applications of dietary reference intakes in dietary assessment and planning. Appl Physiol Nutr Metab 2006; 31(1):66–73.

    Article  PubMed  CAS  Google Scholar 

  41. Barr SI, Murphy SP, Poos MI. Interpreting and using the dietary references intakes in dietary assessment of individuals and groups. J Am Diet Assoc 2002; 102(6):780–8.

    Article  PubMed  Google Scholar 

  42. Vitolins MZ, Tooze JA, Golden SL, et al. Older adults in the rural South are not meeting healthful eating guidelines. J Am Diet Assoc 2007; 107(2):265–72.e3.

    Article  PubMed  Google Scholar 

  43. Gao X, Martin A, Lin H, Bermudez OI, Tucker KL. Alpha-Tocopherol intake and plasma concentration of Hispanic and non-Hispanic white elders is associated with dietary intake pattern. J Nutr 2006; 136(10):2574–9.

    PubMed  CAS  Google Scholar 

  44. Boeckner LS, Pullen CH, Walker SN, Oberdorfer MK, Hageman PA. Eating behaviors and health history of rural midlife to older women in the midwestern United States. J Am Diet Assoc 2007; 107(2):306–10.

    Article  PubMed  Google Scholar 

  45. Roberts SB, Hajduk CL, Howarth NC, Russell R, McCrory MA. Dietary variety predicts low body mass index and inadequate macronutrient and micronutrient intakes in community-dwelling older adults. J Gerontol A Biol Sci Med Sci 2005; 60(5):613–21.

    Article  PubMed  Google Scholar 

  46. Sebastian RS, Cleveland LE, Goldman JD, Moshfegh AJ. Older adults who use vitamin/mineral supplements differ from nonusers in nutrient intake adequacy and dietary attitudes. J Am Diet Assoc 2007; 107(8):1322–32.

    Article  PubMed  CAS  Google Scholar 

  47. American Dietetic Association. Position of the American Dietetic Association: Food fortification and dietary supplements. J Am Diet Assoc 2001; 101:115–25.

    Article  Google Scholar 

  48. Bronstrup A, Hages M, Pietrzik K. Lowering of homocysteine concentrations in elderly men and women. Int J Vitam Nutr Res 1999; 69(3):187–93.

    Article  PubMed  CAS  Google Scholar 

  49. Selhub J, Jacques PF, Wilson PF, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 1993; 270:2693–8.

    Article  PubMed  CAS  Google Scholar 

  50. Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. JAMA 1995; 274(13):1049–57.

    Article  PubMed  CAS  Google Scholar 

  51. Lonn E, Yusuf S, Arnold MJ, et al. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 2006; 354(15):1567–77.

    Article  PubMed  CAS  Google Scholar 

  52. Bønaa KH, Njolstad I, Ueland PM, et al. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med 2006; 354(15):1578–88.

    Article  PubMed  Google Scholar 

  53. Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and alzheimer's disease. N Engl J Med 2002; 346:476–83.

    Article  PubMed  CAS  Google Scholar 

  54. Tucker KL, Qiao N, Scott T, Rosenberg I, Spiro A, III. High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study. Am J Clin Nutr 2005; 82(3):627–35.

    PubMed  CAS  Google Scholar 

  55. McMahon JA, Green TJ, Skeaff CM, Knight RG, Mann JI, Williams SM. A controlled trial of homocysteine lowering and cognitive performance. N Engl J Med 2006; 354(26):2764–72.

    Article  PubMed  CAS  Google Scholar 

  56. Gillette Guyonnet S, Abellan Van Kan G, Andrieu S, et al. IANA task force on nutrition and cognitive decline with aging. J Nutr Health Aging 2007; 11:132–52.

    PubMed  CAS  Google Scholar 

  57. Malouf R, Grimley Evans J. The effect of vitamin B6 on cognition. Cochrane Database of Systematic Reviews 2003; Issue 4. Art. No.: CD004393. DOI: 10.1002/14651858.CD004393.

    Google Scholar 

  58. Doncheva N, Penkov A, Velcheva A, Boev M, Popov B, Niagolov Y. Study of homocysteine concentration in coronary heart disease patients and comparison of two determination methods. Ann Nutr Metab 2007; 51(1):82–7.

    Article  PubMed  CAS  Google Scholar 

  59. Peeters AC, van Aken BE, Blom HJ, Reitsma PH, den Heijer M. The effect of homocysteine reduction by B-vitamin supplementation on inflammatory markers. Clin Chem Lab Med 2007; 45(1):54–8.

    Article  PubMed  CAS  Google Scholar 

  60. Ravaglia G, Forti P, Maioli F, et al. Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am J Clin Nutr 2005; 82(3):636–43.

    PubMed  CAS  Google Scholar 

  61. Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS. Associations of vegetable and fruit consumption with age-related cognitive change. Neurology 2006; 67(8):1370–6.

    Article  PubMed  CAS  Google Scholar 

  62. Morris MC, Evans DA, Bienias JL, et al. Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons. Arch Neurol 2005; 62(4):641–5.

    Article  PubMed  Google Scholar 

  63. Bottiglieri T. Folate, vitamin B12, and neuropsychiatric disorders. Nutr Rev 1996; 54(12):382–90.

    Article  PubMed  CAS  Google Scholar 

  64. Hin H, Clarke R, Sherliker P, et al. Clinical relevance of low serum vitamin B12 concentrations in older people: the Banbury B12 study. Age Ageing 2006; 35(4):416–22.

    Article  PubMed  Google Scholar 

  65. Shirodaria C, Antoniades C, Lee J, et al. Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease. Circulation 2007; 115(17):2262–70.

    Article  PubMed  CAS  Google Scholar 

  66. Kim YI. Folate, colorectal carcinogenesis, and DNA methylation: lessons from animal studies. Environ Mol Mutagen 2004; 44(1):10–25.

    Article  PubMed  CAS  Google Scholar 

  67. Giovannucci E. Epidemiologic studies of folate and colorectal neoplasia: a review. J Nutr 2002; 132(8 Suppl):2350S–5S.

    PubMed  CAS  Google Scholar 

  68. van den Donk M, Pellis L, Crott JW, et al. Folic acid and vitamin B-12 supplementation does not favorably influence uracil incorporation and promoter methylation in rectal mucosa DNA of subjects with previous colorectal adenomas. J Nutr 2007; 137(9):2114–20.

    PubMed  Google Scholar 

  69. Stolzenberg-Solomon RZ, Chang SC, Leitzmann MF, et al. Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am J Clin Nutr 2006; 83(4):895–904.

    PubMed  CAS  Google Scholar 

  70. Kim YI. Does a high folate intake increase the risk of breast cancer? Nutr Rev 2006; 64(10 Pt 1):468–75.

    Article  PubMed  Google Scholar 

  71. Mulligan JE, Greene GW, Caldwell M. Sources of folate and serum folate levels in older adults. J Am Diet Assoc 2007; 107:495–99.

    Article  PubMed  CAS  Google Scholar 

  72. Dereska NH, McLemore EC, Tessier DJ, Bash DS, Brophy CM. Short-term, moderate dosage Vitamin E supplementation may have no effect on platelet aggregation, coagulation profile, and bleeding time in healthy individuals. J Surg Res 2006; 132(1):121–9.

    Article  PubMed  CAS  Google Scholar 

  73. Meydani SN, Meydani M, Blumberg JB, et al. Assessment of the safety of supplementation with different amounts of vitamin E in older adults. Am J Clin Nutr 1998; 68:311–8.

    PubMed  CAS  Google Scholar 

  74. Morinobu T, Ban R, Yoshikawa S, Murata T, Tamai H. The safety of high-dose vitamin E supplementation in healthy Japanese male adults. J Nutr Sci Vitaminol (Tokyo) 2002; 48(1):6–9.

    Article  CAS  Google Scholar 

  75. National Institutes of Health. National Institutes of Health State-of-the-Science Conference statement: management of menopause-related symptoms. Ann Intern Med 2005; 142:1003–13.

    Google Scholar 

  76. Buring JE. Aspirin prevents stroke but not MI in women: vitamin E has no effect on CV disease or cancer. Cleve Clin J Med 2006; 73(9):863–70.

    Article  PubMed  Google Scholar 

  77. Heinonen OP, Albanes D, Virtamo J, et al. Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. J Natl Cancer Inst 1998; 18:440–6.

    Article  Google Scholar 

  78. Virtamo J, Pietinen P, Huttunen JK, et al. Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supplementation: a postintervention follow-up. JAMA 2003; 290(4):476–85.

    Article  PubMed  CAS  Google Scholar 

  79. Wright ME, Lawson KA, Weinstein SJ, et al. Higher baseline serum concentrations of vitamin E are associated with lower total and cause-specific mortality in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Am J Clin Nutr 2006; 84(5):1200–7.

    PubMed  CAS  Google Scholar 

  80. Cho E, Hunter DJ, Spiegelman D, et al. Intakes of vitamins A, C and E and folate and multivitamins and lung cancer: a pooled analysis of 8 prospective studies. Int J Cancer 2006; 118(4):970–8.

    Article  PubMed  CAS  Google Scholar 

  81. Blumberg JB. An update: vitamin E supplementation and heart disease. Nutr Clin Care 2002; 5(2):50–5.

    Article  PubMed  Google Scholar 

  82. Traber MG. Heart disease and single-vitamin supplementation. Am J Clin Nutr 2007; 85(1):293S–9S.

    PubMed  CAS  Google Scholar 

  83. Lee IM, Cook NR, Gaziano JM, et al. Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA 2005; 294(1):56–65.

    Article  PubMed  CAS  Google Scholar 

  84. Glynn RJ, Ridker PM, Goldhaber SZ, Zee RY, Buring JE. Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women's Health Study. Circulation 2007; 116(13):1497–503.

    Article  PubMed  CAS  Google Scholar 

  85. Lonn E, Bosch J, Yusuf S, et al. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA 2005; 293(11):1338–47.

    Article  PubMed  Google Scholar 

  86. Vivekananthan DP, Penn MS, Sapp SK, Hsu A, Topol EJ. Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet 2003; 361(9374):2017–23.

    Article  PubMed  CAS  Google Scholar 

  87. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 2007; 297(8):82–57.

    Article  Google Scholar 

  88. Miller III ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005; 142(1):37–46.

    Google Scholar 

  89. Huang HY, Caballero B, Chang S, et al. Multivitamin/Mineral Supplements and Prevention of Chronic Disease. (Prepared by The Johns Hopkins University Evidence-based Practice Center, under Contract No. 290-02-0018). Rockville, MD: Agency for Healthcare Research and Quality, 2006.

    Google Scholar 

  90. Shekelle PG, Morton SC, Jungvig LK, et al. Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease. J Gen Intern Med 2004; 19(4):380–9.

    Article  PubMed  Google Scholar 

  91. Hathcock JN, Azzi A, Blumberg J, et al. Vitamins E and C are safe across a broad range of intakes. Am J Clin Nutr 2005; 81(4):736–45.

    PubMed  CAS  Google Scholar 

  92. Mezzetti A, Zuliani G, Romano F, et al. Vitamin E and lipid peroxide plasma levels predict the risk of cardiovascular events in a group of healthy very old people. J Am Geriatr Soc 2001; 49(5):533–7.

    Article  PubMed  CAS  Google Scholar 

  93. Appel LJ, Brands MW, Daniels SR, Karanja N, Elmer PJ, Sacks FM. Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association. Hypertension 2006; 47(2):296–308.

    Article  PubMed  CAS  Google Scholar 

  94. Sacks FM, Obarzanek E, Windhauser MM, et al. Rationale and design of the Dietary Approaches to Stop Hypertension trial (DASH). A multicenter controlled-feeding study of dietary patterns to lower blood pressure. Ann Epidemiol 1995; 5(2):108–18.

    Article  PubMed  CAS  Google Scholar 

  95. Sacks FM, Appel LJ, Moore TJ, et al. A dietary approach to prevent hypertension: a review of the Dietary Approaches to Stop Hypertension (DASH) Study. Clin Cardiol 1999; 22(7 Suppl):III6–10.

    PubMed  CAS  Google Scholar 

  96. Lien LF, Brown AJ, Ard JD, et al. Effects of PREMIER lifestyle modifications on participants with and without the metabolic syndrome. Hypertension 2007:HYPERTENSIONAHA.107.089458.

    Google Scholar 

  97. Health Claim Notification for Potassium Containing Foods. Washington, DC: Office of Nutritional Products, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 2000. (Accessed August 3, 2007, at www.cfsan.fda.gov/∼dms/hclm-k.html)

  98. Piekutowski K, Makarewicz R, Zachara BA. The antioxidative role of selenium in pathogenesis of cancer of the female reproductive system. Neoplasma 2007; 54:374–8.

    PubMed  CAS  Google Scholar 

  99. Li H, Stampfer MJ, Giovannucci EL, et al. A prospective study of plasma selenium levels and prostate cancer risk. J Natl Cancer Inst 2004; 96(9):696–703.

    Article  PubMed  CAS  Google Scholar 

  100. Chen Y, Hall M, Graziano JH, et al. A prospective study of blood selenium levels and the risk of arsenic-related premalignant skin lesions. Cancer Epidemiol Biomarkers Prev 2007; 16(2):207–13.

    Article  PubMed  CAS  Google Scholar 

  101. Brinkman M, Reulen RC, Kellen E, Buntinx F, Zeeers M. Are men with low selenium levels at increased risk of prostate cancer? Eur J Cancer 2006; 42:2463–71.

    Article  PubMed  CAS  Google Scholar 

  102. Greenwald P, Anderson D, Nelson SA, Taylor PR. Clinical trials of vitamin and mineral supplements for cancer prevention. Am J Clin Nutr 2007; 85(1):314S–7.

    PubMed  CAS  Google Scholar 

  103. Bleys J, Navas-Acien A, Guallar E. Serum selenium and diabetes in U.S. adults. Diabetes Care 2007; 30(4):829–34.

    Article  PubMed  CAS  Google Scholar 

  104. Stranges S, Marshall JR, Trevisan M, et al. Effects of selenium supplementation on cardiovascular disease incidence and mortality: secondary analyses in a randomized clinical trial. Am J Epidemiol 2006; 163:694–9.

    Article  PubMed  Google Scholar 

  105. Stranges S, Marshall JR, Natarajan R, et al. Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial. Ann Intern Med 2007; 147:217–23.

    PubMed  Google Scholar 

  106. Health Claims: Calcium and Osteoporosis. 21 CFR 101.72. Washington, DC: Food and Drug Administration, 1993. (Accessed August 3, 2007, at www.cfsan.fda.gov/∼lrd/cf101-72.html)

  107. Gass M, Dawson-Hughes B. Preventing osteoporosis-related fractures: an overview. Am J Med 2006; 119(4):S3–S11.

    Article  PubMed  Google Scholar 

  108. Bone Health and Osteoporosis: A Surgeon General's Report: Fact Sheets. Washington DC: Office of the Surgeon General, Department of Health and Human Services, 2004. (Accessed August 3, 2007, at www.surgeongeneral.gov/library/bonehealth/factsheet.html)

  109. Optimal Calcium Intake. NIH Consensus Statement Online 1994 June 6–8; 12(4):1–31 Bethesda, MD: NIH Consensus Development Program, 1994. (Accessed September 21, 2007, at consensus.nih.gov/1994/1994OptimalCalcium097html.htm)

  110. Bolland MJ, Barber PA, Doughty RN, et al. Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial. BMJ 2008; 336(7638):262–6.

    Article  PubMed  CAS  Google Scholar 

  111. Holick MF. The role of vitamin D for bone health and fracture prevention. Curr Osteoporos Rep 2006; 4(3):96–102.

    Article  PubMed  Google Scholar 

  112. Heaney RP, Dowell MS, Hale CA, Bendich A. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Am Coll Nutr 2003; 22(2):142–6.

    PubMed  CAS  Google Scholar 

  113. Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status. Osteoporos Int 2005; 16(7):713–6.

    Article  PubMed  CAS  Google Scholar 

  114. Cranney A, Horsley T, O’Donnell S, et al. Effectiveness and Safety of Vitamin D in Relation to Bone Health. (Prepared by University of Ottawa Evidence-based Practice Center, under Contract No. 290-02-0021). Rockville, MD: Agency for Healthcare Research and Quality, 2007.

    Google Scholar 

  115. Brown JP, Fortier M, Frame H, et al. Canadian consensus conference on osteoporosis, 2006 update. J Obstet Gynaecol Can 2006; 28(2 Suppl 1):S95–S112.

    PubMed  Google Scholar 

  116. Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press, 1997.

    Google Scholar 

  117. Your Guide to Lowering Your Blood Pressure with DASH, NIH Publication No. 06-4082. Bethesda, MD: National Heart, Lung, and Blood Institute, 2006. (Accessed August 3, 2007, at www.nhlbi.nih.gov/health/public/heart/hbp/dash/new_dash.pdf)

  118. Song Y, Sesso HD, Manson JE, Cook NR, Buring JE, Liu S. Dietary magnesium intake and risk of incident hypertension among middle-aged and older US women in a 10-year follow-up study. Am J Cardiol 2006; 98(12):1616–21.

    Article  PubMed  CAS  Google Scholar 

  119. Myers VH, Champagne CM. Nutritional effects on blood pressure. Curr Opin Lipidol 2007; 18(1):20–4.

    Article  PubMed  CAS  Google Scholar 

  120. Beyer FR, Dickinson HO, Nicolson DJ, Ford GA, Mason J. Combined calcium, magnesium and potassium supplementation for the management of primary hypertension in adults. Cochrane Database Syst Rev 2006; Issue 3. Art. No.: CD004805. DOI: 10.1002/14651858.CD004805.pub2.

    Google Scholar 

  121. Schulze MB, Schulz M, Heidemann C, Schienkiewitz A, Hoffman K, Boeing H. Fiber and magnesium intake and incidence of type 2 diabetes: a prospective study and meta-analysis. Arch Intern Med 2007; 167:956–65.

    Article  PubMed  CAS  Google Scholar 

  122. Ford ES, Li C, McGuire LC, Mokdad AH, Liu S. Intake of dietary magnesium and the prevalence of the metabolic syndrome among U.S. adults. Obesity (Silver Spring) 2007; 15(5):1139–46.

    Article  CAS  Google Scholar 

  123. Nielsen FH, Milne DB, Klevay LM, Gallagher S, Johnson L. Dietary magnesium deficiency induces heart rhythm changes, impairs glucose tolerance, and decreases serum cholesterol in post menopausal women. J Am Coll Nutr 2007; 26:121–32.

    PubMed  CAS  Google Scholar 

  124. Hunt CD, Johnson L. Magnesium requirements: new estimations for men and women by cross-sectional statistical analyses of metabolic magnesium balance data. Am J Clin Nutr 2006; 84:843–52.

    PubMed  CAS  Google Scholar 

  125. Calder PC. Polyunsaturated fatty acids and inflammation. Prostaglandins Leukot Essent Fatty Acids 2006; 75(3):197–202.

    Article  PubMed  CAS  Google Scholar 

  126. de Lorgeril M. Essential polyunsaturated fatty acids, inflammation, atherosclerosis and cardiovascular diseases. Subcell Biochem 2007; 42:283–97.

    Article  PubMed  Google Scholar 

  127. Burr ML, Fehily AM, Gibert JF, et al. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet 1989; 2(8666):757–61.

    Article  PubMed  CAS  Google Scholar 

  128. Burr ML, Ashfield-Watt PAL, Dunstan FDJ, et al. Lack of benefit of dietary advice to men with angina: results of a controlled trial. Eur J Clinl Nutr 2003; 57(2):193–200.

    Article  CAS  Google Scholar 

  129. Ness AR, Ashfield-Watt PAL, Whiting JM, Smith GD, Hughes J, Burr ML. The long-term effect of dietary advice on the diet of men with angina: the diet and angina randomized trial. J Hum Nutr Diet 2004; 17(2):117–9.

    Article  PubMed  CAS  Google Scholar 

  130. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet 1999; 354:447–55.

    Article  Google Scholar 

  131. Yokoyama M, Origasa H, Matsuzaki M, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 2007; 369:1090–8.

    Article  PubMed  CAS  Google Scholar 

  132. Hooper L, Thompson RL, Harrison RA, et al. Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review. BMJ 2006 332:752–60.

    Article  PubMed  CAS  Google Scholar 

  133. Smith Jr, SC, Allen J, Blair SN, et al. AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update: endorsed by the National Heart, Lung, and Blood Institute. Circulation 2006; 113(19):2363–72.

    Article  PubMed  Google Scholar 

  134. Introduction to the TLC Diet. Bethesda, MD: National Heart, Lung, and Blood Institute, 2006. (Accessed August 3, 2007, at www.nhlbi.nih.gov/cgi-bin/chd/step2intro.cgi)

  135. McKenney JM, Sica D. Role of prescription omega-3 fatty acids in the treatment of hypertriglyceridemia. Pharmacotherapy 2007; 5:715–28.

    Article  Google Scholar 

  136. Kushi LH, Byers T, Doyle C, et al. American Cancer Society Guidelines on Nutrition and Physical Activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin 2006; 56:254–81.

    Article  PubMed  Google Scholar 

  137. Larsson SC, Kumlin M, Ingelman-Sundberg J, Wolk A. Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms. Am J Clin Nutr 2004; 79(6):935–45.

    PubMed  CAS  Google Scholar 

  138. Pardini RS. Nutritional intervention with omega-3 fatty acids enhances tumor response to anti-neoplastic agents. Chem Biol Interact 2006; 162(2):89–105.

    Article  PubMed  CAS  Google Scholar 

  139. MacLean CH, Newberry SJ, Mojica WA, et al. Effects of omega-3 fatty acids on cancer risk: a systematic review. JAMA 2006; 295(4):403–15.

    Article  PubMed  CAS  Google Scholar 

  140. McKay DL, Perrone G, Rasmussen H, Dallal G, Blumberg JB. Multivitamin/mineral supplementation improves plasma B-vitamin status and homocysteine concentration in healthy older adults consuming a folate-fortified diet. J Nutr 2000; 130:3090–6.

    PubMed  CAS  Google Scholar 

  141. McKay DL, Perrone G, Rasmussen H, et al. The effects of a multivitamin/mineral supplement on micronutrient status, antioxidant capacity and cytokine production in health older adults consuming a fortified diet. J Am Coll Nutr 2000; 19:613–21.

    PubMed  CAS  Google Scholar 

  142. McNeill G, Avenell A, Campbell M, et al. Effect of multivitamin and multimineral supplementation on cognitive function in men and women aged 65 years and over: a randomised controlled trial. Nutr J 2007; 6(1):10.

    Article  PubMed  CAS  Google Scholar 

  143. Burdette JE, Liu J, Chen SN, et al. Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor. J Agric Food Chem 2003; 51(19):5661–70.

    Article  PubMed  CAS  Google Scholar 

  144. Newton KM, Reed SD, LaCroix AZ, Grothaus LC, Ehrlich K, Guiltinan J. Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial. Ann Intern Med 2006; 145(12):869–79.

    PubMed  Google Scholar 

  145. ClinicalTrials.gov: Use of Black Cohosh and Red Clover for the Relief of Menopausal Symptoms. Bethesda, MD: National Library of Medicine, National Institutes of Health, 2007. (Accessed August 3, 2007, at clinicaltrials.gov/ct/show/NCT00066144?order3)

  146. Rosenfeldt F, Hilton D, Pepe S, Krum H. Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure. Biofactors 2003; 18(1–4):91–100.

    Article  PubMed  CAS  Google Scholar 

  147. Sander S, Coleman CI, Patel AA, Kluger J, White CM. The impact of coenzyme Q10 on systolic function in patients with chronic heart failure. J Card Fail 2006; 12(6):464–72.

    Article  PubMed  CAS  Google Scholar 

  148. Davidson M, McKenney J, Stein E, et al. Comparison of one-year efficacy and safety of atorvastatin versus lovastatin in primary hypercholesterolemia. Am J Cardiol 1997; 79(11):1475–81.

    Article  PubMed  CAS  Google Scholar 

  149. Caso G, Kelly P, McNurlan MA, Lawson WE. Effect of coenzyme Q10 on myopathic symptoms in patients treated with statins. Am J Cardiol 2007; 99:1409–12.

    Article  PubMed  CAS  Google Scholar 

  150. Marcoff L, Thompson PD. The role of coenzyme Q10 in statin-associated myopathy: a systematic review. J Am Coll Cardiol 2007; 49:2231–7.

    Article  PubMed  CAS  Google Scholar 

  151. Engelsen J, Nielsen JD, Winther K. Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients. A randomised, double blind, placebo-crossover trial. Thromb Haemost 2002; 87(6):1075–6.

    PubMed  CAS  Google Scholar 

  152. Shults CW, Oakes D, Kieburtz K, et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 2002; 59(10):1541–50.

    Article  PubMed  Google Scholar 

  153. Shults CW, Flint Beal M, Song D, Fontaine D. Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease. Exp Neurol 2004; 188(2):491–4.

    Article  PubMed  CAS  Google Scholar 

  154. Storch A, Jost WH, Vieregge P, et al. Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease. Arch Neurol 2007; 64(7):938–44.

    Article  PubMed  Google Scholar 

  155. Learning About Huntington's Disease. 2007. (Accessed December 10, 2007, at www.genome.gov/10001215)

  156. Huntington Study Group. A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. Neurology 2001; 57(3):397–404.

    Google Scholar 

  157. Oken BS, Storzbach DM, Kaye JA. The efficacy of ginkgo biloba on cognitive function in Alzheimer's disease. Arch Neurol 1998; 55:1409–15.

    Article  PubMed  CAS  Google Scholar 

  158. Ernst E, Pittler MH. Ginkgo biloba for dementia: a systematic review of double-blind placebo controlled trials. Clin Drug Invest 1999; 17:301–8.

    Article  Google Scholar 

  159. Fugh-Berman A. Herb-drug interactions. Lancet 2000; 355:134–8.

    Article  PubMed  CAS  Google Scholar 

  160. Wolf HR. Does Ginkgo biloba special extract EGb 761 provide additional effects on coagulation and bleeding when added to acetylsalicylic acid 500 mg daily? Drugs R D 2006; 7(3):163–72.

    Article  PubMed  CAS  Google Scholar 

  161. DeKosky ST, Williamson JD, Fitzpatrick AL, et al; Ginkgo Evaluation of Memory (GEM) Study Investigators. Ginkgo biloba for prevention of dementia: a randomized controlled trial. JAMA. 2008; 300(19):2253–62.

    Article  PubMed  Google Scholar 

  162. Nahin RL, Fitzpatrick AL, Williamson JD, et al. Use of herbal medicine and other dietary supplements in community-dwelling older people: baseline data from the ginkgo evaluation of memory study. J Am Geriatr Soc 2006; 54:1725–35.

    Article  PubMed  Google Scholar 

  163. Fitzpatrick AL, Fried LP, Williamson J, et al. Recruitment of the elderly into a pharmacologic prevention trial: the Ginkgo Evaluation of Memory study experience. Contemp Clin Trials 2006; 27(6):541–53.

    Article  PubMed  Google Scholar 

  164. Vellas B, Andrieu S, Ousset PJ, Ouzid M, Mathiex-Fortunet H, GuidAge Study Group. The GuidAge study: methodological issues. A 5-year double-blind randomized trial of the efficacy of EGb 761 for prevention of Alzheimer disease in patients over 70 with a memory complaint. Neurology 2006; 67(9 Suppl 3):S6–11.

    Article  PubMed  CAS  Google Scholar 

  165. Health: it's all in the bark. 2006. (Accessed December 15, 2007, at www.newsweek.com/id/44416)

  166. Natural Medicines Comprehensive Database. Therapeutic Research Center, 1999 – (Accessed December 11, 2007, at www.naturaldatabase.com. Subscription required.)

  167. ClinicalTrials.gov: Understanding Pine Bark Extract as an Alternative Treatment (UPBEAT) Study. Bethesda, MD: National Library of Medicine, National Institutes of Health, 2007. (Accessed August 3, 2007, at www.clinicaltrials.gov/ct/show/NCT00425945?order=2)

  168. Schulz V, Hänsel R, Tyler VE. Rational Phytotherapy: A Physicians' Guide to Herbal Medicine, 4th ed. Berlin: Springer Verlag, 2001.

    Google Scholar 

  169. Koch E, Biber A. Pharmacological effects of sabal and urtica extracts as basis for a rational drug therapy in benign prostate hyperplasia Urologe – Ausgabe B 1994; 34(2):90–5.

    Google Scholar 

  170. Bent S, Kane C, Shinohara K, et al. Saw palmetto for benign prostatic hyperplasia. N Engl J Med 2006; 354(6):557–66.

    Article  PubMed  CAS  Google Scholar 

  171. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalomol 2001; 119(10):1417–36.

    Article  Google Scholar 

  172. Tan JSL, Wang JJ, Flood V, Rochtchina E, Smith W, Mitchell P. Dietary antioxidants and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. Am Acad Ophthalmol 2007(July 28):[epub ahead of print].

    Google Scholar 

  173. ClinicalTrials.gov: Age-Related Eye Disease Study 2 (AREDS2). Bethesda, MD: National Library of Medicine, National Institutes of Health, 2007. (Accessed August 3, 2007, at www.clinicaltrials.gov/ct2/show/NCT00345176?term=areds&rank=1)

  174. Rein DB, Saaddine JB, Wittenborn JS, et al. Cost-effectiveness of vitamin therapy for age-related macular degeneration. Ophthalmology 2007; 114:1319–26.

    Article  PubMed  Google Scholar 

  175. Cohen MH, Hrbek A, Davis RB, Schachter SC, Eisenberg DM. Emerging credentialing practices, malpractice liability policies, and guidelines governing complementary and alternative medical practices and dietary supplement recommendations: a descriptive study of 19 integrative health care centers in the United States. Arch Intern Med 2005; 165(3):289–95.

    Article  PubMed  Google Scholar 

  176. Bazzie KL, Witmer DR, Pinto B, Bush C, Clark J, Deffenbaugh Jr, J. National survey of dietary supplement policies in acute care facilities. Am J Health Syst Pharm 2006; 63(1):65–70.

    Article  PubMed  Google Scholar 

  177. Qualified Health Claims Subject to Enforcement Discretion: B Vitamins & Vascular Disease. Washington, DC: Office of Nutritional Products, Labeling, and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 2000. (Accessed February 2, 2007, at www.cfsan.fda.gov/∼dms/qhc-sum.html#bvitamins)

  178. Lichtenstein AH, Appel LJ, Brands M, et al. Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation 2006; 114:82–96.

    Article  PubMed  Google Scholar 

  179. Vogel JHK, Bolling SF, Costello RB, et al. Integrating complementary medicine into cardiovascular medicine. A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (Writing Committee to Develop an Expert Consensus Document on Complementary and Integrative Medicine). J Am Coll Cardiol 2005; 46(1):184–221.

    Article  PubMed  Google Scholar 

  180. Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press, 1998.

    Google Scholar 

  181. U.S. Department of Health and Human Services and U.S. Department of Agriculture. Dietary Guidelines for Americans, 6th ed. Washington, DC: U.S. Government Printing Office, 2005.

    Google Scholar 

  182. Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes: Water, Potassium, Sodium, Chloride, and Sulfate. Washington, DC: National Academy Press, 2004.

    Google Scholar 

  183. Qualified Health Claims Subject to Enforcement Discretion: Selenium & Cancer. Washington, DC: Office of Nutritional Products, Labeling, and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 2003. (Accessed February 2, 2007, at www.cfsan.fda.gov/∼dms/qhc-sum.html#selenium)

  184. Qualified Health Claims Subject to Enforcement Discretion: Omega-3 Fatty Acids & Coronary Heart Disease. Washington, DC: Office of Nutritional Products, Labeling, and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 2004. (Accessed February 2, 2007, at www.cfsan.fda.gov/∼dms/qhc-sum.html#omega3)

  185. A Food Labeling Guide – Appendix C. Washington, DC: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 2000. (Accessed August 3, 2007, at www.cfsan.fda.gov/∼dms/flg-6c.html)

  186. Qualified Health Claims Subject to Enforcement Discretion: Calcium and Colon/Rectal Cancer & Calcium and Recurrent Colon/Rectal Polyps. Washington, DC: Office of Nutritional Products, Labeling, and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 2005. (Accessed August 3, 2007, at www.cfsan.fda.gov/∼dms/qhcca2.html)

  187. Ziegler D, Nowak H, Kempler P, Vargha P, Low PA. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis. Diabet Med 2004; 21(2):114–21.

    Article  PubMed  CAS  Google Scholar 

  188. Sauer J, Tabet N, Howard R. Alpha lipoic acid for dementia. Cochrane Database Syst Rev 2004; Issue 1. Art. No.: CD004244. DOI: 10.1002/14651858.CD004244.pub2.

    Google Scholar 

  189. Bjelakovic G, Nagorni A, Nikolova D, Simonetti RG, Bjelakovic M, Gluud C. Meta-analysis: antioxidant supplements for primary and secondary prevention of colorectal adenoma. Aliment Pharmacol Ther 2006; 24(2):281–91.

    Article  PubMed  CAS  Google Scholar 

  190. Hardy M, Coulter I, Shekelle P, et al. Effect of the Supplemental Use of Antioxidants Vitamin C, Vitamin E, and Coenzyme Q10 for the Prevention and Treatment of Cancer. (Prepared by Southern California-RAND Evidence-based Practice Center, under Contract No. 290-97-0001). Rockville, MD: Agency for Healthcare Research and Quality, 2003.

    Google Scholar 

  191. Bleys J, Miller III ER, Pastor-Barriuso R, Appel LJ, Guallar E. Vitamin-mineral supplementation and the progression of atherosclerosis: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2006; 84:880–7.

    PubMed  CAS  Google Scholar 

  192. Shekelle P, Morton S, Hardy M, et al. Effect of Supplemental Antioxidants Vitamin C, Vitamin E, and Coenzyme Q10 for the Prevention and Treatment of Cardiovascular Disease. (Prepared by Southern California-RAND Evidence-based Practice Center, under Contract No. 290-97-0001). Rockville, MD: Agency for Healthcare Research and Quality, 2003.

    Google Scholar 

  193. Evans JR. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane Database Syst Rev 2006; Issue 2. Art. No.: CD000254. DOI: 10.1002/14651858.CD000254.pub2.

    Google Scholar 

  194. Qualified Health Claims Subject to Enforcement Discretion: Antioxidant Vitamins & Cancer. Washington, DC: Office of Nutritional Products, Labeling, and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 2003. (Accessed February 2, 2007, at www.cfsan.fda.gov/∼dms/qhc-sum.html#antioxidant)

  195. U.S. Preventive Services Task Force. Routine vitamin supplementation to prevent cancer and cardiovascular disease: recommendations and rationale. Ann Intern Med 2003; 139:51–5.

    Google Scholar 

  196. American Diabetes Association. Nutrition Recommendations and Interventions for Diabetes: a position statement of the American Diabetes Association. Diabetes Care 2007; 30(Suppl 1):S48–65.

    Article  CAS  Google Scholar 

  197. Hardy M, Coulter I, Venuturupalli S, et al. Ayurvedic Interventions for Diabetes Mellitus: A Systematic Review. (Prepared by Southern California Evidence-Based Practice Center/RAND, under Contract No. 290-97-0001). Rockville, MD: Agency for Healthcare Quality and Research, 2001.

    Google Scholar 

  198. Lethaby AE, Brown J, Marjoribanks J, Kronenberg F, Roberts H, Eden J. Phytoestrogens for vasomotor menopausal symptoms. Cochrane Database of Systematic Reviews 2007; Issue 4. Art. No.: CD001395. DOI: 10.1002/14651858.CD001395.pub3.

    Google Scholar 

  199. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association’s Botanical Safety Handbook Boca Raton: CRC Press, 1997.

    Google Scholar 

  200. Blumenthal M, Busse WR, Goldberg A, et al., eds. Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin, TX: American Botanical Council, 1998.

    Google Scholar 

  201. American College of Obstetricians and Gynecologists Committee on Practice Bulletins – Gynecology. ACOG Practice Bulletin. Clinical Management Guidelines for Obstetrician-Gynecologists. Use of botanicals for management of menopausal symptoms. Obstet Gynecol 2001; 97(6):S1–11.

    Google Scholar 

  202. Belisle S, Blake J, Basson R, et al. Canadian consensus conference on menopause, 2006 update. J Obstet Gynaecol Can 2006; 28(2 Suppl 1):S7–S94.

    PubMed  Google Scholar 

  203. United States Pharmacopeial Convention, Committee of Revision. The United States Pharmacopeia. Rockville, MD: United States Pharmacopeial Convention, Inc., 2007.

    Google Scholar 

  204. Montgomery SA, Thal LJ, Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. Int Clin Psycholpharmacol 2003; 18(2):61–71.

    Article  Google Scholar 

  205. Hudson S, Tabet N. Acetyl-l-carnitine for dementia. Cochrane Database Syst Rev 2003; Issue 2. Art. No.: CD003158. DOI: 10.1002/14651858.CD003158.

    Google Scholar 

  206. Alesci S, Manoli I, Costello R, et al. Carnitine. The science behind a conditionally essential nutrient. Proceedings of a conference. March 25–26, 2004. Bethesda, Maryland, USA. Ann NY Acad Sci 2004; 1033(ix–xi):1–197.

    Google Scholar 

  207. Hirsch AT, Haskal ZJ, Hertzer NR, et al. ACC/AHA 2005 Practice Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease): endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-Society Consensus; and Vascular Disease Foundation. Circulation 2006; 113(11):e463–654.

    Article  PubMed  Google Scholar 

  208. Althuis MD, Jordan NE, Ludington EA, Wittes JT. Dietary chromium supplements and glucose and insulin response: the results of a meta-analysis. Am J Clin Nutr 2002; 76(1):148–55.

    PubMed  CAS  Google Scholar 

  209. Qualified Health Claims Subject to Enforcement Discretion: Chromium Picolinate & Diabetes. Washington, DC: Office of Nutritional Products, Labeling, and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 2005. (Accessed February 2, 2007, at www.cfsan.fda.gov/∼dms/qhc-sum.html#chromium)

  210. Suchowersky O, Gronseth G, Perlmutter J, Reich S, Zesiewicz T, Weiner WJ. Practice parameter: neuroprotective strategies and alternative therapies for Parkinson disease (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2006; 66:976–82.

    Article  PubMed  CAS  Google Scholar 

  211. Parkinson's Disease: National Clinical Guideline for Diagnosis and Management in Primary and Secondary Care. London: National Collaborating Centre for Chronic Conditions, National Institute for Health and Clinical Excellence, 2006. (Accessed August 3, 2007, at www.nice.org.uk/cg035)

  212. Schoop R, Klein P, Suter A, Johnston SL. Echinacea in the prevention of induced rhinovirus colds: a meta-analysis. Clin Ther 2006; 28(2):174–83.

    Article  PubMed  Google Scholar 

  213. Shah SA, Sander S, White CM, Rinaldi M, Coleman CI. Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis. Lancet Infect Dis 2007; 7(7):473–80.

    Article  PubMed  Google Scholar 

  214. Linde K, Barrett B, Wolkart K, Bauer R, Melchart D. Echinacea for preventing and treating the common cold. Cochrane Database Syst Rev 2006; Issue 1. Art. No.: CD000530. DOI: 10.1002/14651858.CD000530.pub2.

    Google Scholar 

  215. Stevinson C, Pittler MH, Ernst E. Garlic for treating hypercholeresterolemia. A meta-analysis of randomized clinical trials. Ann Intern Med 2000; 133:420–9.

    PubMed  CAS  Google Scholar 

  216. Silagy CA, Neil HA. A meta-analysis of the effect of garlic on blood pressure. J Hypertens 1994; 12(4):463–8.

    Article  PubMed  CAS  Google Scholar 

  217. Warshafsky S, Kamer RS, Sivak SL. Effect of garlic on total serum cholesterol. A meta-analysis. Ann Intern Med 1993; 119(7 Pt 1):599–605.

    PubMed  CAS  Google Scholar 

  218. Mulrow C, Lawrence V, Ackermann R, et al. Garlic: Effects on Cardiovascular Risks and Disease, Protective Effects Against Cancer, and Clinical Adverse Effects. (Prepared by San Antonio Evidence-based Practice Center, under Contract No. 290-97-0012). Rockville, MD: Agency for Healthcare Quality and Research, 2000.

    Google Scholar 

  219. Jepson RG, Kleijnen J, Leng GC. Garlic for peripheral arterial occlusive disease. Cochrane Database Syst Rev 1997; Issue 2. Art. No.: CD000095. DOI: 10.1002/14651858.CD000095.

    Google Scholar 

  220. Fleischauer AT, Poole C, Arab L. Garlic consumption and cancer prevention: meta-analyses of colorectal and stomach cancers. Am J Clin Nutr 2000; 72(4):1047–52.

    PubMed  CAS  Google Scholar 

  221. Fletcher B, Berra K, Ades P, et al. Managing abnormal blood lipids: a collaborative approach. Circulation 2005; 112(20):3184–209.

    Article  PubMed  Google Scholar 

  222. Hopfenmuller W. Evidence for a therapeutic effect of Ginkgo biloba special extract. Meta-analysis of 11 clinical studies in patients with cerebrovascular insufficiency in old age. Arzneimittelforschung 1994; 44(9):1005–13.

    PubMed  CAS  Google Scholar 

  223. Birks J, Grimley EV, Evans J. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst Rev 2007; Issue 2. Art. No.: CD003120. DOI: 10.1002/14651858.CD003120.pub2.

    Google Scholar 

  224. Horsch S, Walther C. Ginkgo biloba special extract EGb 761 in the treatment of peripheral arterial occlusive disease (PAOD) – a review based on randomized, controlled studies. Int J Clin Pharmcol Ther 2004; 42(2):63–72.

    CAS  Google Scholar 

  225. Pittler MH, Ernst E. Ginkgo biloba extract for the treatment of intermittent claudication: a meta-analysis of randomized trials. Am J Med 2000; 108(4):276–81.

    Article  PubMed  CAS  Google Scholar 

  226. Moher D, Pham B, Ausejo M, Saenz A, Hood S, Barber GG. Pharmacological management of intermittent claudication: a meta-analysis of randomised trials. Drugs 2000; 59(5):1057–70.

    Article  PubMed  CAS  Google Scholar 

  227. Schneider B. Ginkgo biloba extract in peripheral arterial diseases. Meta-analysis of controlled clinical studies. Arzneimittelforschung 1992; 42(4):428–36.

    PubMed  CAS  Google Scholar 

  228. McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA 2000; 283(11):1469–75.

    Article  PubMed  CAS  Google Scholar 

  229. Richy F, Bruyere O, Ethgen O, Cucherat M, Henrotin Y, Reginster JY. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Arch Intern Med 2003; 163(13):1514–22.

    Article  PubMed  CAS  Google Scholar 

  230. Towheed TE, Maxwell L, Anastassiades TP, et al. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev 2005; Issue 2. Art. No.: CD002946. DOI: 10.1002/14651858.CD002946.pub2.

    Google Scholar 

  231. Efficacy of Glucosamine and Chondroitin Sulfate May Depend on Level of Osteoarthritis Pain: Press Release, February 22, 2006. (Accessed December 10, 2007, at nccam.nih.gov/news/2006/022206.htm)

  232. Letter Regarding the Relationship Between the Consumption of Glucosamine and/or Chondroitin Sulfate and a Reduced Risk of: Osteoarthritis; Osteoarthritis-related Joint Pain, Joint Tenderness, and Joint Swelling; Joint Degeneration; and Cartilage Deterioration (Docket No. 2004P-0059). Washington, DC: Office of Nutritional Products, Labeling, and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 2004. (Accessed October 5, 2007, at www.cfsan.fda.gov/∼dms/qhcosteo.html)

  233. Coates PM, Blackman MR, Cragg GM, Levine M, Moss J, White JD, eds. Encyclopedia of Dietary Supplements. New York, NY: Marcel Dekker, 2007.

    Google Scholar 

  234. Taubert D, Roesen R, Schomig E. Effect of cocoa and tea intake on blood pressure: a meta-analysis. Arch Intern Med 2007; 167(7):626–34.

    Article  PubMed  CAS  Google Scholar 

  235. Seely D, Mills EJ, Wu P, Verma S, Guyatt GH. The effects of green tea consumption on incidence of breast cancer and recurrence of breast cancer: a systematic review and meta-analysis. Integr Cancer Ther 2005; 4(2):144–55.

    Article  PubMed  Google Scholar 

  236. Sun CL, Yuan JM, Koh WP, Yu MC. Green tea, black tea and breast cancer risk: a meta-analysis of epidemiological studies. Carcinogenesis 2006; 27(7):1310–5.

    Article  PubMed  CAS  Google Scholar 

  237. Sun CL, Yuan JM, Koh WP, Yu MC. Green tea, black tea and colorectal cancer risk: a meta-analysis of epidemiologic studies. Carcinogenesis 2006; 27(7):1301–9.

    Article  PubMed  CAS  Google Scholar 

  238. Qualified Health Claims: Letter of Denial – Green Tea and Reduced Risk of Cardiovascular Disease (Docket No. 2005Q-0297). Washington, DC: Office of Nutritional Products, Labeling, and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 2006. (Accessed September 25, 2006, at www.cfsan.fda.gov/∼dms/qhcgtea2.html)

  239. Qualified Health Claims Subject to Enforcement Discretion: Green Tea & Cancer. Washington, DC: Office of Nutritional Products, Labeling, and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 2005. (Accessed February 2, 2007, at www.cfsan.fda.gov/∼dms/qhc-sum.html#gtea)

  240. Siebert U, Brach M, Sroczynski G, Berla K. Efficacy, routine effectiveness, and safety of horsechestnut seed extract in the treatment of chronic venous insufficiency. A meta-analysis of randomized controlled trials and large observational studies. Int Angiol 2002; 21(4):305–15.

    PubMed  CAS  Google Scholar 

  241. Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev 2006; Issue 1. Art. No.: CD003230. DOI: 10.1002/14651858.CD003230.pub3.

    Google Scholar 

  242. Chong EW, Wong TY, Kreis AJ, Simpson JA, Guymer RH. Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. BMJ 2007; 335(7623):755.

    Article  PubMed  Google Scholar 

  243. Kavanaugh CJ, Trumbo PR, Ellwood KC. The U.S. Food and Drug Administration's evidence-based review for qualified health claims: tomatoes, lycopene, and cancer. J Natl Cancer Inst 2007; 99(14):1074–85.

    Article  PubMed  CAS  Google Scholar 

  244. Herxheimer A, Petrie KJ. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev 2002; Issue 2. Art. No.: CD001520. DOI: 10.1002/14651858.CD001520.

    Google Scholar 

  245. Buscemi N, Vandermeer B, Pandya R, et al. Melatonin for Treatment of Sleep Disorders. (Prepared by University of Alberta Evidence-based Practice Center, under Contract No. 290-02-0023). Rockville, MD: Agency for Healthcare Quality and Research, 2004.

    Google Scholar 

  246. Brzezinski A, Vangel MG, Wurtman RJ, et al. Effects of exogenous melatonin on sleep: a meta-analysis. Sleep Med Rev 2005; 9:41–50.

    Article  PubMed  Google Scholar 

  247. Buscemi N, Vandermeer B, Hooton N, et al. Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis. BMJ 2006; 332:385–93.

    Article  PubMed  CAS  Google Scholar 

  248. Jacobs BP, Dennehy C, Ramirez G, Sapp J, Lawrence VA. Milk thistle for the treatment of liver disease: a systematic review and meta-analysis. Am J Med 2002; 113(6):506–15.

    Article  PubMed  Google Scholar 

  249. Mulrow C, Lawrence V, Jacobs B, et al. Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects. (Prepared by San Antonio Evidence-based Practice Center, under Contract No. 290-97-0012). Rockville, MD: Agency for Healthcare Quality and Research, 2000.

    Google Scholar 

  250. Rambaldi A, Jacobs BP, Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Cochrane Database Syst Rev 2005; Issue 2. Art. No.: CD003620. DOI: 10.1002/14651858.CD003620.pub2.

    Google Scholar 

  251. Tamayo C, Diamond S. Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum [L.] Gaertn.). Integr Cancer Ther 2007; 6(2):146–57.

    Article  PubMed  CAS  Google Scholar 

  252. Chen JT, Wesley R, Shamburek RD, Pucino F, Csako G. Meta-analysis of natural therapies for hyperlipidemia: plant sterols and stanols versus policosanol. Pharmacotherapy 2005; 25(2):171–83.

    Article  PubMed  CAS  Google Scholar 

  253. Qualified Health Claims Subject to Enforcement Discretion: Phosphatidylserine & Cognitive Dysfunction and Dementia. Washington, DC: Office of Nutritional Products, Labeling, and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 2003. (Accessed February 2, 2007, at www.cfsan.fda.gov/∼dms/qhc-sum.html#phosphat)

  254. Boyle P, Robertson C, Lowe F, Roehrborn C. Updated meta-analysis of clinical trials of Serenoa repens extract in the treatment of symptomatic benign prostatic hyperplasia. BJU Int 2004; 93(6):751–6.

    Article  PubMed  CAS  Google Scholar 

  255. Wilt TJ, Ishani A, Rutks I, MacDonald R. Phytotherapy for benign prostatic hyperplasia. Public Health Nutr 2000; 3(4A):459–72.

    Article  PubMed  CAS  Google Scholar 

  256. Wilt T, Ishani A, Stark G, MacDonald R, Mulrow C, Lau J. Serenoa repens for benign prostatic hyperplasia. Cochrane Database Syst Rev 2000; Issue 3. Art. No.: CD001423. DOI: 10.1002/14651858.CD001423:CD001423.

    Google Scholar 

  257. Chapter 1: Diagnosis and treatment recommendations. American Urological Association, 2003. (Accessed August 3, 2007, at www.auanet.org/guidelines/main_reports/bph_management/chapt_1_appendix.pdf)

  258. Berges R. The impact of treatment on lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) progression. Eur Urol Suppl 2004; 3(4):12–7.

    Article  Google Scholar 

  259. Bressa GM. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl 1994; 154:7–14.

    Article  PubMed  CAS  Google Scholar 

  260. Hardy M, Coulter I, Morton SCPD, et al. S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease. (Prepared by Southern California Evidence-Based Practice Center, under Contract No. 290-97-0001). Rockville, MD: Agency for Healthcare Research and Quality, 2006.

    Google Scholar 

  261. Frezza M. A meta-analysis of therapeutic trials with ademetionine in the treatment of intrahepatic cholestasis. Ann Ital Med Int 1993; 8(Suppl):48S–51S.

    PubMed  Google Scholar 

  262. Rambaldi A, Gluud C. S-adenosyl-L-methionine for alcoholic liver diseases. Cochrane Database Syst Rev 2006; Issue 2. Art. No.: CD002235. DOI: 10.1002/14651858.CD002235.pub2.

    Google Scholar 

  263. Reynolds K, Chin A, Lees KA, Nguyen A, Bujnowski D, He J. A meta-analysis of the effect of soy protein supplementation on serum lipids. Am J Cardiol 2006; 98(5):633–40.

    Article  PubMed  CAS  Google Scholar 

  264. Anderson JW, Johnstone BM, Cook-Newell ME. Meta-analysis of the effects of soy protein intake on serum lipids. N Eng J Med 1995; 333:276–82.

    Article  CAS  Google Scholar 

  265. Zhan S, Ho SC. Meta-analysis of the effects of soy protein containing isoflavones on the lipid profile. Am J Clin Nutr 2005; 81(2):397–408.

    PubMed  CAS  Google Scholar 

  266. Balk E, Chung M, Chew P, et al. Effects of Soy on Health Outcomes. (Prepared by Tufts-New England Medical Center Evidence-based Practice Center under Contract No. 290-02-0022). Rockville, MD: Agency for Healthcare Research and Quality, 2005.

    Google Scholar 

  267. Taku K, Umegaki K, Sato Y, Taki Y, Endoh K, Watanabe S. Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials. Am J Clin Nutr 2007; 85(4):1148–56.

    PubMed  CAS  Google Scholar 

  268. Zhuo XG, Melby MK, Watanabe S. Soy isoflavone intake lowers serum LDL cholesterol: a meta-analysis of 8 randomized controlled trials in humans. J Nutr 2004; 134(9):2395–400.

    PubMed  CAS  Google Scholar 

  269. Weggemans RM, Trautwein EA. Relation between soy-associated isoflavones and LDL and HDL cholesterol concentrations in humans: a meta-analysis. Eur J Clin Nutr 2003; 57(8):940–6.

    Article  PubMed  CAS  Google Scholar 

  270. Nelson HD, Vesco KK, Haney E, et al. Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis. JAMA 2006; 295(17):2057–71.

    Article  PubMed  CAS  Google Scholar 

  271. Kasper S, Dienel A. Cluster analysis of symptoms during antidepressant treatment with Hypericum extract in mildly to moderately depressed out-patients. A meta-analysis of data from three randomized, placebo-controlled trials. Psychopharmacology (Berlin) 2002; 164(3):301–8.

    Article  CAS  Google Scholar 

  272. Kim HL, Streltzer J, Goebert D. St. John's wort for depression: a meta-analysis of well-defined clinical trials. J Nerv Ment Dis 1999; 187(9):532–8.

    Article  PubMed  CAS  Google Scholar 

  273. Röder C, Schaefer M, Leucht S. Meta-analysis of effectiveness and tolerability of treatment of mild to moderate depression with St. John's Wort. Fortschr Neurol Psychiatr 2004; 72(6):330–43.

    Article  PubMed  Google Scholar 

  274. Whiskey E, Werneke U, Taylor D. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review. Int Clin Psychopharmacol 2001; 16(5):239–52.

    Article  PubMed  CAS  Google Scholar 

  275. Linde K, Mulrow CD, Berner M, Egger M. St. John's Wort for depression. Cochrane Database Syst Rev 2005; Issue 2. Art. No.: CD000448. DOI: 10.1002/14651858.CD000448.pub2.

    Google Scholar 

  276. Depression: management of depression in primary and secondary care, NICE Clinical Guideline 23. London: National Collaborating Centre for Mental Health, National Institute for Health and Clinical Excellence, 2004. (Accessed August 3, 2007, at guidance.nice.org.uk/CG23).

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Acknowledgments

The authors thank Abby Ershow, Sc.D., Lora Wilder, Sc.D., R.D., and Joseph Betz, Ph.D, for their valuable comments on the manuscript and Susan Pilch, Ph.D., M.L.S, for her expertise and technical editing.

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Appendix: Reference Sources for Information on Dietary Supplements and Herb–Drug Interactions

Appendix: Reference Sources for Information on Dietary Supplements and Herb–Drug Interactions

1.1 Monographs

  • American Herbal Pharmacopeia and Therapeutic Compendium (AHP)

    Monographs are available through their Web site by to writing the American Herbal Pharmacopeia PO Box 5159, Santa Cruz, and CA 95063. Phone: 831-461-6318, e-mail: ahpadmin@got.net. Web address: http://www.herbal-ahp.org.

  • The Complete German Commission E Monographs

    Blumenthal M, Goldberg A, Brinkmann J, eds. Herbal Medicine-Expanded Commission E Monographs. American Botanical Council, Austin, TX, 1999.

    The American Botanical Council, PO Box 201660 Austin, TX 78720. Phone: 512-33 1-8868 and Web address: www.herbalgram.org.

  • WHO Monographs on Selected Medicinal Plants

    The World Health Organization (WHO) monographs are published in “WHO Monographs on Selected Plants,” vol. 1, by WHO, Geneva, Switzerland, 1999, ISBN 92-4154517-8. The WHO Web site is http://www.who.org.

1.2 Books and Publications

  • Barrett M. The Handbook of Clinically Tested Herbal Remedies. Haworth Herbal Press, 2004. 2-volume set. ISBN: 0-789-02723-2.

  • Coates PM, Blackman MR, Cragg GM, Levine M, Moss J, and White JD, eds. Encyclopedia of Dietary Supplements. New York, NY: Marcel Dekker, 2005. ISBN: 0-824-75504-9.

  • Fugh-Berman A. The 5-Minute Herb and Dietary Supplement Consult. Philadelphia, PA: Lippincott Williams & Wilkins, 2003, 475 pp. ISBN: 0-683-30273-6.

  • Institute of Medicine of the National Academies. Dietary DRI Reference Intakes: The Essential Guide to Nutrient Requirements. Washington, DC: National Academies Press, 2006. ISBN: 0-309-10091-7, Web site: www.iom.edu/CMS/3788/29985/37065.aspx

    Description: A reference volume which reviews each nutrient and recommendations  for daily intake.

  • Newall CA, Anderson LA, Philpson JD. Herbal Medicines—A Guide for Health-Care Professionals. London, UK: The Pharmaceutical Press, 1996.

  • Schulz V, Hansel R, Tyler VE. Rational phytotherapy: A Reference Guide for Physicians and Pharmacists, 5th ed. Berlin: Springer-Verlag, 2004.

1.3 Databases

  • Consumer Labs

    www.consumerlabs.com

    Consumer labs evaluates commercially available dietary supplement products for composition, potency, purity, bioavailability, and consistency of products. The Natural Pharmacist database offers consumer-oriented information. Products that meet their criteria can receive a ConsumerLab seal of approval (annual subscription fee of $29.95).

  • MedlinePlus

    MedlinePlus Health Information, National Library of Medicine, National Institutes of Health.

    Herbal Information page contains up-to-date, quality health care information on herbs and herbal medicine. Dietary Supplements page provides links, including the latest research, on dietary supplements.

    Herbal Information: http://www.nlm.nih.gov/medlineplus/herbalmedicine.html

    Dietary Supplements: http://www.nlm.nih.gov/medlineplus/dietarysupplements.html

  • Natural Medicines Comprehensive Database

    www.naturaldatabase.com

    Created by the publishers of the Pharmacist’s Letter. You can search by DS or commercial product name. Monographs include extensive information about common uses, evidence of efficacy and safety, mechanisms, interactions, and dosage. It is extensively referenced and updated daily. Also CME, listserv, and interactions information available (individual subscriber $92/year).

  • Natural Standard

    www.naturalstandard.com

    This is an independent collaboration of international clinicians and researchers who created a database which can be searched by CAM subject or by medical condition. Quality of evidence is graded for each supplement (individual subscriber $99/year).

  • International Bibliographic Information on Dietary Supplements (IBIDS)

    ods.od.nih.gov/Health_Information/IBIDS.aspx. IBIDS is produced by the Office of Dietary Supplements, NIH, along with the Food and Nutrition Information Center, National Agricultural Library, and USDA. The IBIDS database provides access to bibliographic citations and abstracts from published, international, and scientific literature on dietary supplements. IBIDS contains over 750,000 citations on the topic of dietary supplements from four major database sources: biomedical-related articles from MEDLINE, botanical and agricultural science from AGRICOLA, worldwide agricultural literature through AGRIS, and selected nutrition journals from CAB Abstracts and CAB Health. IBIDS is easy to search and available free of charge through the Internet.

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Costello, R.B., Leser, M., Coates, P.M. (2009). Dietary Supplements: Current Knowledge and Future Frontiers. In: Bales, C., Ritchie, C. (eds) Handbook of Clinical Nutrition and Aging. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-385-5_28

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